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All Journal Damianus Journal of Medicine Jurnal Manajemen Kesehatan Indonesia The Indonesian Biomedical Journal Jurnal Kesehatan Interdental Jurnal Kedokteran Gigi (IJKG) Journal of Urban Health Research Jurnal Kedokteran Meditek Journal of Medicine and Health Cermin Dunia Kedokteran Jurnal Kesehatan Masyarakat
Lonah, Lonah
Department Of Pharmacology, School Of Medicine And Health Sciences, Universitas Katolik Indonesia Atma Jaya, Jl. Pluit Raya No 2, Jakarta 14440
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Jurnal Manajemen Kesehatan Indonesia

 1 
ECONOMIC EVALUATION OF PHARMACOGENETIC-GUIDED PRESCRIBING IN PRECISION MEDICINE FOR CARDIOVASCULAR DISEASES: AN EVIDENCE SYNTHESIS FROM ASIAN COUNTRIES Halilintar, Via Dolorosa; Lonah, Lonah; Pujiyanto, Pujiyanto
Jurnal Manajemen Kesehatan Indonesia Vol 12, No 3 (2024): Desember 2024
Publisher : Magister Kesehatan Masyarakat, Fakultas Kesehatan Masyarakat, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jmki.12.3.2024.252-265

Abstract

Precision medicine, particularly pharmacogenetic-guided approaches, has emerged as a promising tool to optimize treatment strategies for cardiovascular disease. However, the economic evaluation of these approaches in Asian populations remains underexplored. This review study aimed to synthesize evidence on the implementation, methodology, research gaps, and limitations of pharmacogenetic-guided precision medicine in cardiovascular disease among the Asian population. A comprehensive search of electronic databases (Pubmed, Embase, Google Scholar and Cochrane Library) was conducted to identify relevant studies. The data were extracted and synthesized to address the study objectives A total of 12 studies were included in the analysis. Economic evaluation studies of pharmacogenetic-guided precision medicine in cardiovascular disease management in Asian countries are still limited, with precision medicine interventions often requiring high resources. The sampling process remains a challenge in conducting economic evaluation studies, and there are limitations in obtaining clinical outcome descriptions from real-world evidence, as most studies rely on literature reviews or modeling-based approaches. Furthermore, most studies use a provider or healthcare cost perspective, limiting the comprehensiveness of cost information. This evidence synthesis highlights the potential for pharmacogenetic-guided precision medicine in cardiovascular disease management among the Asian population, as well as the current challenges and limitations in conducting economic evaluations. Further research is needed to address these issues, develop more robust sampling strategies, obtain real-world clinical outcome data, and provide comprehensive cost information to inform clinical practice and healthcare policy in the region.
Co-Authors Anastasia, Cindy Andarisuta, Putu Suwarastra Andrew Liputra Budiyanti, Ecie Divara Ariesta Sekar Suryadi, Made Edward Surjono Edward Surjono, Edward Evi Ulina Margaretha Situmorang Fan, Tan Fei Fenny Mariska Ferbian Milas Siswanto Freggy Spicano Joprang Halilintar, Via Dolorosa Hendrik, Antonia J Irawan, Robi Jennifer Jhonvini, Lessya Jonny Setiawan Jonny Setiawan Jonny Setiawan Jonny Setiawan Kurniawan, Sandy Vitria Latumahina, Cleo Michaela Laurentius Aswin Pramono Lauwly, Edlyn Edrea Lieputra, Andrew Adhytia Linawati Hananta Linawati Hananta, Linawati Margareta Amelia Maria Dara Novi Handayani, Maria Dara Novi Mariani Santosa, Mariani Meiliyana Wijaya Monalisa Heryani Muhaji, J. Antonio Nathaniel, Bryan Oktaria, Indriani Prayoga Tjendratama, Jason Pujiyanto Pujiyanto Puspa Bunardi, Dewi Rita Dewi Rita Dewi Rita Dewi Vallerie Satyadi, Richelle Via Dolorosa Halilintar Wijaya, Meiliyana Yantho, Erwin Yuliana Yuliana Zita Arieselia