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All Journal Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan
Dwi Kurnia Putri
Universitas Bengkulu
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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FORMULASI DAN UJI EFEKTIVITAS ANTI NYAMUK MAT ELEKTRIK EKSTRAK ETANOL 96% KULIT BUAH DURIAN (Durio Zibenthinus L.): FORMULASI DAN UJI EFEKTIVITAS ANTI NYAMUK MAT ELEKTRIK EKSTRAK ETANOL 96% KULIT BUAH DURIAN (Durio Zibenthinus L.) Rose Intan Perma Sari Rose; Havis Arya Perdana; Suci Rahmawati; Dwi Kurnia Putri; Putri Mulia
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 8 No. 1 (2025)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v8i1.61363

Abstract

ABSTRACT The composition of electric mosquito repellent contains the active ingredient d-allethrin which is a group of pyrethroids, metofluthrin, cyphenothrin which are very dangerous for health if used for a long period of time. Durian skin extract is a natural insecticide that can be an alternative ingredient as a substitute for chemicals from mosquito repellent products. This study aims to formulate an electric mosquito repellent preparation and to determine the ability of the preparation as a repellent. The preparation is made in four formulas, namely, F0 (0%), F1 (25%), F2 (35%) and F3 (45%). The preparation was then tested for physical properties including organoleptic, water content, density, weight uniformity, burning time test and repellent effectiveness. The results showed that the preparation met the parameters for testing physical properties. The effectiveness test using 25 mosquitoes exposed for 1 hour to the electric mat mosquito repellent preparation at F0, F1 and F2 did not meet the effectiveness value as a repellent because it was <80%, while at F3 it met the effectiveness value as a repellent of 82.7%. Keywords: Durian Fruit Peel, Extract, Mosquito Repellent, Electric Mat ABSTRAK Komposisi anti nyamuk elektrik mengandung bahan aktif d-allethrin yang merupakan golongan dari pyrethroid, metoflutrin, sifenotrin yang sangat berbahaya bagi kesehatan tubuh apabila digunakan dalam jangka waktu yang panjang. Ekstrak kulit durian merupakan bahan insektisida alami yang bisa menjadi bahan alternatif sebagai pengganti bahan kimia dari produk pengusir nyamuk. Penelitian ini bertujuan untuk memformulasi sediaan anti nyamuk mat elektrik dan untuk mengetahui kemampuan sediaan sebagai repellent. Sediaan dibuat dalam empat formula yaitu, F0 (0%), F1 (25 %), F2 (35%) dan F3 (45 %). Sediaan kemudian dilakukan pengujian sifat fisik meliputi organoleptis, kadar air, kerapatan, keseragaman bobot, uji lama bakar dan efektivitas repellent. Hasil penelitian menunjukan bahwa sediaan memenuhi parameter pengujian sifat fisik. Uji efektivitas menggunakan 25 ekor nyamuk yang dipaparkan selama 1 jam pada sediaan anti nyamuk mat elektrik pada F0, F1 dan F2 tidak memenuhi nilai efektivitas sebagai repellent karena < 80%, sedangkan pada F3 memenuhi nilai efektivitas sebagai repellent 82,7%. Kata kunci: Kulit Buah Durian, Ekstrak, Anti Nyamuk, Elektrik Mat
Potensi Saponin Rumput Laut Merah (Eucheuma Spinosum) sebagai Bahan Aktif Alami: Analisis Kadar Berdasarkan Perbedaan Variasi Konsentrasi Pelarut Shanata Prilsie Haryono; Dwi Kurnia Putri; Ikhsan Ikhsan; Rose Intan Perma Sari; Encik Putri Ema Komala
Jurnal Ventilator Vol. 4 No. 2 (2026): Juni : Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v4i2.2368

Abstract

This study aims to analyze and compare the effectiveness of 70% and 96% ethanol solvents in extracting saponin compounds from red seaweed (Eucheuma spinosum) from Panjang Beach, Bengkulu City. Saponin is a secondary metabolite that has important biological activities such as antioxidants, antimicrobials, and anticancer potential for the health sector. Extraction was carried out using the maceration method followed by quantitative analysis of UV-Vis spectrophotometry at a wavelength of 495 nm. The results showed that the crude drug had a drying loss value of 89.36%. The 70% ethanol solvent produced a higher extract yield (22.95%) compared to 96% ethanol (12.45%). However, the determination of saponin content showed different results; the 70% ethanol extract had a higher average content of 89.10% (891 mg DE/g) compared to 96% ethanol which was only 88.51% (885.1 mg DE/g). Statistical analysis of the independent sample t-test showed a significance value of 0.861 and 0.862 (p > 0.05), indicating no significant difference between the two solvents. It was concluded that 70% ethanol is a more optimal and selective solvent in extracting saponin compounds from E. spinosum for the purpose of standardizing natural active ingredients.
Kajian Komparatif Kadar Metabolit Sekunder Saponin pada Anggur Laut (Caulerpa racemosa) : Analisis Variasi Konsentrasi Etanol dengan Metode Spektrofotometri Ayummi Halimah Dhyani; Dwi Kurnia Putri; Tri Danang Kurniawan; Rose Intan Perma Sari; Oky Hermansyah
Jurnal Ventilator Vol. 4 No. 2 (2026): Juni : Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v4i1.2370

Abstract

Sea grapes (Caulerpa racemosa) are green algae that contain secondary metabolites, including saponins, which have potential as bioactive compounds. This study aimed to determine the saponin content in 70% and 96% ethanol extracts and to analyze the differences in saponin levels between the two solvents using the UV-Vis spectrophotometric method.This research was an experimental laboratory study involving sample preparation, extraction by maceration using 70% and 96% ethanol, qualitative saponin testing, and quantitative determination of saponin levels using the vanillin–sulfuric acid method. Measurements were carried out at a maximum wavelength of 495 nm using a standard calibration curve with concentrations of 20–100 ppm.The results showed that the saponin content in the 70% ethanol extract was 954.06 ± 11.0 mg QE/g, while in the 96% ethanol extract it was 938.06 ± 8.9 mg QE/g. Statistical analysis using an independent t-test indicated no significant difference between the two extracts (p > 0.05).In conclusion, both 70% and 96% ethanol solvents are capable of extracting saponins from Caulerpa racemosa, but there is no significant difference in the saponin content obtained.  
Co-Authors Ayummi Halimah Dhyani Encik Putri Ema Komala Havis Arya Perdana Ikhsan Ikhsan Oky Hermansyah Putri Mulia Rose Intan Perma Sari Rose Intan Perma Sari Rose Shanata Prilsie Haryono Suci Rahmawati Tri Danang Kurniawan