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All Journal Journal Pharmaceutical Science and Application (JPSA) Jurnal Penelitian Pendidikan IPA (JPPIPA) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JURNAL FARMASIMED (JFM) Bali Medika Jurnal Indonesian Journal of Global Health research Widya Kesehatan Medfarm: Jurnal Farmasi dan Kesehatan Indonesian Journal of Pharmaceutical Education Jurnal Pengabdian dan Pengembangan Masyarakat Indonesia Jurnal Kesehatan Terpadu Jurnal Farmasetis Innovative: Journal Of Social Science Research Benzena Pharmaceutical Scientific Journal Bali Medical and Wellness Journal UNBI Mengabdi
Putu Yudhistira Budhi Setiawan
Universitas Bali Internasional
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Green Synthesis of Silver Nanoparticles Using Gempur Batu Leaf Extract (Ruellia napifera) as Antibacterial, Antibiofilm, and Antioxidant Aryasa, I Wayan Tanjung; Artini, Ni Putu Rahayu; Setiawan, Putu Yudhistira Budhi
Jurnal Penelitian Pendidikan IPA Vol 10 No 12 (2024): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i12.9356

Abstract

Silver Nanoparticles basically focus on the synthesis of nano-sized particles produced through chemical, physical, and biological processes, which contribute significantly to the control of plant and animal diseases and have shown considerable promise in improving the quality of human living conditions and health. The method of making silver nanoparticles, namely Green synthesis, involves the use of plants for the synthesis process of various types of nanoparticles. Green synthesis has the advantages of a simple method, environmentally friendly, non-polluting, antitoxic, and cost-effective. The purpose of this study was to determine the antibacterial and antioxidant activities of AgNPs. In the spectrophotometer absorption spectrum appears at a wavelength of 450 nm. FTIR measurements were used to determine the presence of bioactive molecules that may be responsible for the stabilization that acts as a capping agent. The absorption spikes at 3256, 1552, 1048, and 934 cm−1 were determined for gempur batu leaf extract, while silver nanoparticles showed absorption spikes at 3369, 1576, 1080, and 822 cm−1. The results of XRD analysis of AgNPs showed that they had been successfully synthesized, which can be seen from the formation of narrow peaks indicating the crystalline nature of the formed nanoparticles. The results of TEM analysis of AgNPs in this study are a mixture of spherical, hexagonal, and triangular shapes of silver nanoparticles. The antibacterial activity test of silver nanoparticles with gempur batu leaf extract with variations in AgNO3 solution concentration has been successful, which is indicated by the formation of inhibition zones for Eschericia coli and Staphylococcus aureus bacteria. The results of antioxidant activity in AgNPss show an increasing percentage of inhibition along with increasing concentration of AgNPss increasing from 1 to 15 ppm and ascorbic acid increasing from 1 to 5 ppm. Antibiofilm activity in AgNPs has a good ability to inhibit the formation of biofilm layers in Staphylococcus aureus and Escherichia coli bacteria by having a biofilm inhibition percentage of more than 50%.
POTENSI SENYAWA XANTHORRHIZOL SEBAGAI ANTIFUNGI : NARATIF REVIEW Setiawan, Putu Yudhistira Budhi
BENZENA Pharmaceutical Scientific Journal Vol 2 No 01 (2023): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v2i01.3110

Abstract

Xanthorrhizol adalah salah satu fitokimia yang banyak diisolasi dari tanaman Curcuma xanthorrhiza berbagai yang manfaat aktivitas biologis telah dieksplorasi salah satunya sebagai antifungi. Infeksi fungi sering terjadi pada daerah tropis yang menyebabkan penyakit kulit, terjadinya banyak penyakit dan dampak buruk akibat infeksi fungi dalam jangka panjang salah satunya terjadi  resistensi obat. Mengingat jamur adalah eukariota seperti inang manusia, target terapi dan keamanan  untuk pengembangan antijamur perlu dilakukan. Maka dilakukan pencarian alternatif agen antifungi yang baru seperti  xanthorrhizol.  Pada tulisan bertujuan untuk mengkaji efek xanthorrhizol sebagai antifungi dari berbagai jenis spesies fungi. Database elektronik seperti Pubmed, ScienceDirect dan Proquest digunakan dalam penulisan ini. Pencarian jurnal dilakukan pada Bulan Mei 2023 yang fokus meneliti senyawa xanthorrhizol sebagai antifungi dengan data nilai MIC sebgai besaran aktivitasnya. Temuan dari tulisan ini menunjukkan bahwa xanthorrhizol menunjukkan penghambatan yang signifikan terhadap fungi panthogen termasuk Candida sp,  Malassezia sp, dan Aspergillus sp. Aktivitas xanthorrizol sebagai antifungi dengan menargetkan biofilm dan mengubah morfologi fungi. Efek sinergis diperlihatkan xanthorrizol jika digabungkan dengan ketokonasol dan amphotericin B.  Studi mengeksplorasi penggunaan xanthorrhizol sebagai obat potensial untuk pencegahan dan pengobatan berbagai spesias fungi telah menunjukkan hasil yang menjanjikan. Namun, lebih banyak penelitian yang perlu dilakukan terutama di bidang-bidang seperti  studi in vitro, in vivo dan klinis
Co-Authors Ahmad Fudholi Ahmad Fudholi anggarini, Dewi Astuti, Ni Wayan Purnami Darmayanti, Ni Putu Ovy Dewa Ayu Putu Satrya Dewi Dewa Ayu Putu, Satrya Dewi Dhiancinantyan Windydaca Brata Putri Dwi Agustyarini, Pande Kadek Febryanti, Ekanur I Gusti Ayu Agung Septiari I Gusti Lanang Made Rudiartha I Gusti Ngurah Agung Windra Wartana Putra I Gusti Septiari I Putu Gede Adi Purwa Hita I Putu Gede Adi Purwa Hita I Putu Riska Ardinata I Putu Tangkas Suwantara I Wayan Tanjung Aryasa Maharianingsih, Ni Made Ni Kadek Arinda Ni Putu Aryati Suryaningsih Ni Putu Juli Martasari Ni Putu Rahayu Artini Ni Putu Widayanti Ni Wayan Yuliasih Oktaviani, Fatikhatul Putri Purwa Hita, I Putu Gede Adi Satibi Satibi Satibi Satibi Suryaningsih , Ni Putu Aryati Sutema, Ida Ayu Manik Partha Wartana Putra, I G.N.A Windra Wartana Putra, I Gusti Ngurah Agung Windra Widowati , I Gusti Ayu Rai Widowati, I Gusti Ayu Rai - Wintariani, Ni Putu Wintariani, Ni Putu Aryati