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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JURNAL FARMASIMED (JFM) Bali Medika Jurnal Indonesian Journal of Global Health research Widya Kesehatan Medfarm: Jurnal Farmasi dan Kesehatan Indonesian Journal of Pharmaceutical Education Jurnal Pengabdian dan Pengembangan Masyarakat Indonesia Jurnal Kesehatan Terpadu Jurnal Farmasetis Innovative: Journal Of Social Science Research Benzena Pharmaceutical Scientific Journal Bali Medical and Wellness Journal UNBI Mengabdi Journal Pharmaceutical Science and Application (JPSA)
Putu Yudhistira Budhi Setiawan
Universitas Bali Internasional
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Green Synthesis of Silver Nanoparticles Using Gempur Batu Leaf Extract (Ruellia napifera) as Antibacterial, Antibiofilm, and Antioxidant I Wayan Tanjung Aryasa; Ni Putu Rahayu Artini; Putu Yudhistira Budhi Setiawan
Jurnal Penelitian Pendidikan IPA Vol 10 No 12 (2024): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i12.9356

Abstract

Silver Nanoparticles basically focus on the synthesis of nano-sized particles produced through chemical, physical, and biological processes, which contribute significantly to the control of plant and animal diseases and have shown considerable promise in improving the quality of human living conditions and health. The method of making silver nanoparticles, namely Green synthesis, involves the use of plants for the synthesis process of various types of nanoparticles. Green synthesis has the advantages of a simple method, environmentally friendly, non-polluting, antitoxic, and cost-effective. The purpose of this study was to determine the antibacterial and antioxidant activities of AgNPs. In the spectrophotometer absorption spectrum appears at a wavelength of 450 nm. FTIR measurements were used to determine the presence of bioactive molecules that may be responsible for the stabilization that acts as a capping agent. The absorption spikes at 3256, 1552, 1048, and 934 cm−1 were determined for gempur batu leaf extract, while silver nanoparticles showed absorption spikes at 3369, 1576, 1080, and 822 cm−1. The results of XRD analysis of AgNPs showed that they had been successfully synthesized, which can be seen from the formation of narrow peaks indicating the crystalline nature of the formed nanoparticles. The results of TEM analysis of AgNPs in this study are a mixture of spherical, hexagonal, and triangular shapes of silver nanoparticles. The antibacterial activity test of silver nanoparticles with gempur batu leaf extract with variations in AgNO3 solution concentration has been successful, which is indicated by the formation of inhibition zones for Eschericia coli and Staphylococcus aureus bacteria. The results of antioxidant activity in AgNPss show an increasing percentage of inhibition along with increasing concentration of AgNPss increasing from 1 to 15 ppm and ascorbic acid increasing from 1 to 5 ppm. Antibiofilm activity in AgNPs has a good ability to inhibit the formation of biofilm layers in Staphylococcus aureus and Escherichia coli bacteria by having a biofilm inhibition percentage of more than 50%.
IMPACT OF HOME PHARMACY CARE ON MEDICATION ADHERENCE IN HYPERTENSIVE PATIENTS: A QUASIEXPERIMENTAL STUDY Kesumadewi, Ayu; Dewa Ayu Putu, Satrya Dewi; Putri, Dhiancinantyan Windydaca Brata; Setiawan, Putu Yudhistira Budhi
Journal Pharmaceutical Science and Application Vol. 7 No. 2 (2025): Journal Pharmaceutical Science and Application
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2025.v07.i02.p05

Abstract

Background: Acne vulgaris is a common skin problem that often affects adolescents and young adults, caused by the bacteria Cutibacterium acnes and Staphylococcus epidermidis. The use of synthetic antibiotics for acne treatment can lead to resistance; therefore, it is necessary to develop alternative natural ingredients that can act as a companion or complementary therapy, such as fennel plants (Foeniculum vulgare Mill.). Objective: To identify and compare the antibacterial activity of ethanol extracts of fennel leaves and stems against C.acnes and S.epidermidis. Methods: Extraction is carried out by maceration using 96% ethanol. Antibacterial tests were carried out in vitro using disc diffusion methods with concentrations of 50%, 75%, and 100%. Tetracycline 1% is used as a positive control, and DMSO 10% as a negative control. Results: Extracts of fennel leaves and stems exhibited antibacterial activity. The diameter of the inhibition zone increased with increasing extract concentration, with the leaves extract showing greater antibacterial activity than the stems extract. Conclusion: The results of the antibacterial activity test showed that ethanol extracts of leaves and fennel stems were able to inhibit the growth of C. acnes and S. epidermidis, with an average inhibition zone of leaf extract that was more optimal than that of stems.
Co-Authors Ahmad Fudholi Ahmad Fudholi anggarini, Dewi Astuti, Ni Wayan Purnami Darmayanti, Ni Putu Ovy Dewa Ayu Putu Satrya Dewi Dewa Ayu Putu, Satrya Dewi Dhiancinantyan Windydaca Brata Putri Dwi Agustyarini, Pande Kadek Febryanti, Ekanur I Gusti Ayu Agung Septiari I Gusti Lanang Made Rudiartha I Gusti Ngurah Agung Windra Wartana Putra I Gusti Septiari I Putu Gede Adi Purwa Hita I Putu Gede Adi Purwa Hita I Putu Riska Ardinata I Putu Tangkas Suwantara I Wayan Tanjung Aryasa Kesumadewi, Ayu Maharianingsih, Ni Made Ni Kadek Arinda Ni Putu Aryati Suryaningsih Ni Putu Juli Martasari Ni Putu Rahayu Artini Ni Putu Widayanti Ni Wayan Yuliasih Oktaviani, Fatikhatul Putri Purwa Hita, I Putu Gede Adi Satibi Satibi Satibi Satibi Suryaningsih , Ni Putu Aryati Sutema, Ida Ayu Manik Partha Wartana Putra, I G.N.A Windra Wartana Putra, I Gusti Ngurah Agung Windra Widowati, I Gusti Ayu Rai - Wintariani, Ni Putu Wintariani, Ni Putu Aryati