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Phenytoin Topical as Pain Neuropathic Therapy: A Scoping Review Sulistyani, S; Rosyidah, Devi Usdiana; Rahmawati, Nailena Widya; Nugrahaen, Sarwasri Fajra; Goprani, Lidya; Sulistiyo, Azka Hafiy; Prameswari, Elza; Hutami, Norma Putri; Azwar, Muhammad Thoriq; Amalia, Riza
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5500

Abstract

Background: Neuropathic pain is a type of pain that can cause prolonged pain in patients. Oral treatment takes a long time and can cause side effects, which can further reduce patient compliance with therapy. Topical treatment is a more acceptable alternative because it has minimal systemic side effects. Phenytoin is an anticonvulsant drug that can be used as a therapy for neuropathic pain. The side effects of oral phenytoin are minimized by using topical preparations. Objective: To obtain information on the effectiveness of topical phenytoin in neuropathic pain. Long-term goal, conduct clinical trials in patients and make topical phenytoin preparations in collaboration with one of the PBF (Large Pharmaceutical Companies) in Indonesia. Methods: Three electronic databases were searched on January 13, 2022: Google Scholar. PubMed and ScienceDirect. All relevant literature was included after screening according to the PRISMA statement. Data obtained were synthesized based on PICO (population, interventions, comparisons, and outcomes). Results: This paper examines case reports, case series, and pre-existing research articles in which topical phenytoin significantly reduces neuropathic pain. Conclusion: Topical phenytoin may be an alternative in the selection of neuropathic pain therapy due to its minimal side effects compared to oral therapy. However, further studies need to be conducted to compare with other topical anticonvulsants.
Vertigo as A Manifestation of Cervical Rib: Case Report Sulistyani, S; Hutami, Norma Putri; Sulistiyo, Azka Hafiy; Prameswari, Elza; Azwar, Muhammad Thoriq; Setiawan, Iwan
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5528

Abstract

Background: A cervical rib is a congenital anomaly of a cervical spine vertebra, occurring in about 0.5% to 1% of the population. It is most commonly associated with the seventh cervical vertebra. Cervical ribs can lead to localized pain and affect surrounding structures, presenting with a variety of clinical symptoms. Objective: To demonstrate that a cervical rib can cause vertigo, particularly central vertigo. Case: A 55-year-old woman experienced vertigo and nausea for approximately ten years. Physical examination revealed her head tilted to the left, with an inability to maintain a straight position. Positive cerebellar signs were observed. Imaging studies showed a cervical rib on the seventh cervical vertebra in the X-ray and bilateral cerebellar infarctions in a CT scan. Discussion: The patient, a female, had a cervical rib on the right side. The vertigo was linked to a cerebellar stroke caused by the cervical rib. The underlying mechanism likely involved compression of the subclavian artery and poor posture. Conclusion: Vertigo can be a clinical manifestation of cerebellar stroke, resulting from subclavian artery compression due to a cervical rib.
Deteksi Dini Risiko Sindrom Metabolik pada Remaja di Daerah Urban dan Rural: Early Detection of Metabolic Syndrome Risk in Adolescents in Urban and Rural Areas Aisyah, Riandini; Jatmiko, Safari Wahyu; Bestari, Rochmadina Suci; Supraba, Intan Pratiwi; Utami, Indari; Wibowo, Haryo Kunto; Mapa, Anna Rochim; Utami, Aurelia Ratna; Anggitaratri, Zakia Novi; Haliza, Sheli Nur; Fitri, Alifah Aulia; Anam, Ilham Hafizha Maulana; Azenta, Moch. Tabriz; Syahida, Safira; Sulistiyo, Azka Hafiy; Brilliantama, Fandy Akbar; Maulida, Amira Hasna; Wafiq, Muhammad Azzim; Kamila, Aulida Azkia; Rohman, Raihan Fadzlur
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 8 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i8.9733

Abstract

Metabolic syndrome is a collection of metabolic disorders that are closely related to an increased risk of developing diabetes mellitus and cardiovascular diseases in obese adolescents. Metabolic syndrome in adolescents is still reversible with varying timeframes. In adolescents with metabolic syndrome, the transition from homeostasis with normal blood sugar levels to type 2 diabetes occurs more rapidly compared to adults. Early diagnosis of metabolic syndrome is essential for prevention through lifestyle changes. Living in urban areas has a higher risk of obesity compared to living in rural areas after controlling for other variables. This activity aims to initially screen metabolic syndrome in middle school adolescents in urban and rural areas. The measurement of metabolic syndrome parameters involved 107 students, consisting of 47 middle school students in urban areas and 60 in rural areas. The measurement and data analysis results showed significant differences in body mass index (p<0,001), waist size (p=0.03), waist circumference (p=0.007), and upper arm circumference (p=0.002) between students in urban and rural areas, while blood sugar levels, blood pressure, and neck circumference did not show significant differences.