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All Journal Hemera Zoa Jurnal Sain Veteriner METAMORFOSA Journal of Biological Sciences Jurnal Veteriner AL KAUNIYAH Biosfer: Jurnal Tadris Biologi Prosiding Seminar Biologi Bioeksperimen: Jurnal Penelitian Biologi Edumatsains BERITA BIOLOGI Jurnal Pendidikan Biologi BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Biodjati BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Jurnal Pembelajaran dan Biologi Nukleus Sciscitatio : Journal for Biological Science Jurnal Kedokteran Meditek
Vinsa Cantya Prakasita
Universitas Kristen Duta Wacana
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary Other

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Antidiabetic Potential of Ethanol Extract from Moringa oleifera Leaves in Streptozotocin-Nicotinamide-Induced Female Mus musculus Prakasita, Vinsa Cantya; Theodora, Nadya Aprina; Susilowati, Enjelin Anjung; Aditiyarini, Dwi; Prasetyaningsih, Aniek
Jurnal Biodjati Vol 9 No 1 (2024): May
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v9i1.30699

Abstract

Type 2 diabetes mellitus (DM) is a chronic metabolic dis­order characterized by elevated blood glucose levels due to insulin resistance. Type 2 diabetes is considerably more prevalent than oth­er forms (85–90%). The risk of type 2 diabetes is higher in women (53.2%). There is an urgent requirement for better and more afforda­ble treatment options considering DM therapy is expensive and may have adverse health effects. The study's objective is to examine how acute toxicity, blood glucose levels, and body weight are affected by Moringa leaf ethanol extract (MLEE). Maceration was employed to eliminate the leaves of the moringa plant. Phytochemical screening was completed to assess the total flavonoid content and screen for alkaloids, flavonoids, phenolics, saponins, and tannins. Acute toxicity testing was performed following OECD guideline 423. Clinical symp­toms of acute toxicity were observed every 30 minutes for the first 24 hours post-treatment, followed by observations every 24 hours up to 14 days. The estimated LD50 range was determined. Streptozotocin/ nicotinamide-induced female Mus musculus was administered to eval­uate the antidiabetic potential of MLEE. Six groups of mice were uti­lized, which included a healthy control group (aquades not induced), a negative control group (induced aquades), a positive control group (induced glimepiride 0.8 mg/kg BW), and three treatment groups with varying dosages of MLEE (induced; 0, 100, and 150 mg/kg BW). A semi-auto chemical analyzer was employed on days 0 through 31 to determine blood glucose levels. An analytical digital balance was utilized to calculate the body weight. With a total flavonoid concen­tration of 20.75%, MLEE incorporated alkaloids, flavonoids, pheno­lics, saponins, and tannins. MLEE demonstrated a significant effect in lowering blood glucose levels at a dose of 100 mg/kg BW (P<0.05). A significant positive correlation has been identified between body weight and blood glucose levels (P<0.05).
Aktivitas Antibakteri Ekstrak Kulit Batang Belimbing Wuluh Terhadap Escherichia coli Penyebab Diare Septhimoranie, Jade; Aditiyarini, Dwi; Prakasita, Vinsa Cantya
Bioeksperimen: Jurnal Penelitian Biologi Vol 8, No 2: September 2022
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v8i2.15749

Abstract

Diare merupakan salah satu gejala infeksi pada saluran cerna, yang dapat disebabkan oleh adanya organisme (bakteri, virus, dan/atau parasit), sehingga menyebabkan feses menjadi lebih cair dan frekuensinya lebih sering dari biasanya. Escherichia coli memiliki presentase yang tinggi dibandingkan bakteri lain pada feses penderita diare. Pengobatan yang dilakukan biasanya dengan menggunakan antibiotik, namun sekarang ini banyak ditemukan antibiotik yang telah resisten. Tanaman obat-obatan dapat digunakan sebagai alternatif dalam mengatasi diare. Salah satunya ialah kulit batang Belimbing Wuluh. Adanya kandungan senyawa yang bersifat antibakteri pada kulit batang Belimbing Wuluh dimungkinkan dapat menghambat pertumbuhan E. coli penyebab diare. Tujuan penelitian adalah untuk mengetahui aktivitas antibakteri ekstrak kulit batang Belimbing Wuluh terhadap E. coli penyebab diare. Pada penelitian ini menggunakan metode ekstraksi dekoktasi. Uji fitokimia dilakukan terhadap flavonoid, alkaloid, dan saponin. Uji total fenol dilakukan dengan menggunakan metode Folin-Ciocalteu. Uji antibakteri dilakukan dengan menggunakan disk diffusion method Kirby-Bauer, dilanjutkan uji MIC dengan metode mikrodilusi serta uji MBC. Analisis data dengan One-Way ANOVA dan post-hoc Duncan. Kulit batang Belimbing Wuluh mengandung senyawa saponin, alkaloid, flavonoid, dan fenol. Hasil rata-rata dari nilai total fenol adalah 25,12 ± 7,73(mg GAE)⁄g. Hasil uji aktivitas antibakteri menunjukkan bahwa ekstrak kulit batang Belimbing Wuluh dengan konsentrasi 2,5% masih dapat menghambat E. coli secara signifikan (P≤0,05).
Co-Authors Adrenalin, Sruti Listra Agnesia Endang Tri H. Wahyuni Agnesia Endang Tri Hastuti Wahyuni Agustina Dwi Wijayanti Agustina Viktoria Tae Ajiguna Ajiguna Anak Agung Gede Sugianthara Angelia Astria Aniek Prasetyaningsih Aniek Prasetyaningsih Aniek Prasetyaningsih Aniek Prasetyaningsih Anjela Noya CHARIS AMARANTINI Charles Rangga Tabbu Christine Stefani Tamelan Dessy Imelda Nirmasari Siregar Dhira Satwika Djoko Rahardjo Djoko Rahardjo Dwi Aditiyarini Enjelin Anjung Susilowati Eunnike Adelina Fauziah, Ima Feblicya Palimbunga Ilham, Jessika Ima Fauziah Ima Fauziah Ima Fauziah Imanjati, Lynda Nugrahaning Inggrid, Annabelle Marie Irein Kusuma Angreini Jade Septhimoranie Jeffi Chandra Kukuh Madyaningrana Laurentia Henrieta Permita Sari Purba Lynda Nugrahaning Imanjati Lynda Nugrahaning Imanjati Lynda Nugrahaning Imanjati Maria Trivonia Sema Marlin Cindy Claudya Malelak Nadya Aprina Theodora Nita Sonia Sipayung Pepiana, Marlen Aviati Sarah Prasetya, Heribertus Sigit Priskila Melinia Wuni Relisantika Yulia Sinaga Sema, Maria Trivonia Septhimoranie, Jade Setiawan, Dwi Cahyo Budi Setya Harianto Sidna Artanto Sipayung, Nita Sonia Sitarina Widyarini Sitarina Widyarini Sruti Listra Adrenalin Sruti Listra Adrenalin Sruti Listra Adrenalin Susilowati, Enjelin Anjung Tara Inastu Kandarp Tati Aryani Theodora, Nadya Aprina Thomas Emanuel Manggotu Nahak Yovita Devina Yovita Devina