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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Global Medical and Health Communication The Indonesian Biomedical Journal Jurnal Gizi Klinik Indonesia Jurnal Kedokteran dan Kesehatan PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat International Journal of Basic and Applied Science Jurnal Katalisator Media Penelitian dan Pengembangan Kesehatan
Ismawati ismawati
Universitas Riau
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Journal : International Journal of Basic and Applied Science

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α-glucosidase Inhibitory Activity of Probiotic Isolate LBSU9 Isolated from Traditional Food “Trites”: a Preliminary Study Edy Fachrial; Ismawati Ismawati; Titania T Nugroho; Saryono Saryono
International Journal of Basic and Applied Science Vol. 12 No. 4 (2024): March: Basic and Applied Science
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/ijobas.v12i4.293

Abstract

As the prevalence of type 2 diabetes mellitus continues to increase over the years, research into antidiabetic drugs needs to continue. Probiotics are non-pathogenic microorganisms that have potential as α-glucosidase inhibitors. This study aimed to characterize and determine the α-glucosidase inhibitor activity of LBSU9 isolate, a probiotic isolated from "trites," a traditional food of North Sumatra. The results showed that LBSU9 had bacillus morphology, Gram positive, negative catalase test, TSIA (Triple Sugar Iron Agar) A/A test and non-hemolysis. LBSU9 had good tolerance to simulated gastric acid and bile salts, with growth percentages of 66.54% and 64.74%. LBSU9 also has potent antimicrobial activity against S.aureus and E.coli, with 20 mm and 17 mm inhibition zones, respectively. The alpha-glucosidase inhibitor activity of LBSU9 was 98.4% greater than that of acarbose, which was 97%. Based on the results of this study, it is concluded that LBSU9 isolate has the potential to be a complementary therapy to prevent or treat type 2 diabetes mellitus
Co-Authors Angel Chen Dhea Ayu Kartini Surya Putri Dyna, Fitri Edy Fachrial Elfima Aditya Utami Enikarmila Asni Erwin Christianto Esy Maryanti Ilhami Romus Ilhami Romus Ilhami Romus Ilhami Romus, Ilhami Imelda Tresia Pardede Indah Putri Arwandi Isnani Kurniyanti Ligat Pribadi Sembiring Luthfianty, Elfiah M Derillovyandra Dwi Anugrah Muhammad Fadhillah Arif Mukhyarjon Noviardi Noviardi, Noviardi Permatasari, Nopi Putra, Amrullah Syah Rijalun Arridho Saputra, Nicko Pisceski Kusika Saryono Saryono Saryono Sonia Dinda Paramitha Sri Yanti Titania Tjandrawati Nugroho Veni Dayu Putri Winarto Winarto