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All Journal HAYATI Journal of Biosciences Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Journal of Noncommunicable Diseases (JOND)
Ritha Pratiwi
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Tadulako University, Sulawesi Tengah 94148, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Journal of Islamic Pharmacy

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PHYTOCHEMICAL SCREENING, TOTAL FLAVONOID, ANTIOXIDANT ACTIVITY, AND TOXICITY OF ETHANOL EXTRACT Cleome gynandra L. HERB Widodo, Agustinus; Pratiwi, Ritha
Journal of Islamic Pharmacy Vol 3, No 2 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i2.6101

Abstract

Cleome gynandra L. is one of the plants that the people of Palu, Central Sulawesi use as food ingredients. This plant is empirically used in traditional medicine. This study aims to determine phytochemical constituents, total flavonoid, antioxidant activity, and toxicity of 96% ethanol extract of C. gynandra herb. C. gynandra herb extract was obtained by maceration. Phytochemical screening of the ethanol extract was carried out qualitatively according to the standard methods. Determination of total flavonoid using AlCl3 then determined by Spectrophotometric UV-Vis. Antioxidant activity using the DPPH method and determined IC50 value. Toxicity test was assessed using shrimp lethality as an indicator of toxicity. Phytochemical screening showed 96% ethanol extract containing alkaloid compounds, flavonoids, saponins, steroids, and tannins. Total flavonoid of the 96% ethanol extract was 4,778 ± 0,522 mg QE/g extract. Antioxidant activity (IC50) of the ethanol 96% extract was 189,455 µg/ml. Lethal concentration 50% of the 96% ethanol extract was 472,648 mg/L (toxic). The results of this study indicate that 96% ethanol extract of C. gynandra herb has antioxidant activity and has the potential to be further tested as an anticancer activity.
Co-Authors Abd. Rahman Razak Agustinus Widodo Andi Atirah Masyita Arisca, Windhy Nur Armini Syamsidi Arwinda Alitsia Hasyim Djaleha, Helena Fransisca Evi Sulastri Gemini Alam Herlina Rante Iklima Indriani, Meri Feki Muh. Nasrum Massi Nandiska Maladjili Nuur Aanisah Syaputra, Gunawan Syariful Anam Tunreng, Muh. Fadil Usman Yuliet Yuliet Yusriadi Yusriadi