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Jurnal Ilmiah Kedokteran Wijaya Kusuma

JIKW
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Published by Universitas Wijaya Kusuma Surabaya

ISSN : 19782071 EISSN : 25805967 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

Jurnal Ilmiah Kedokteran Wijaya Kusuma (JIKW) is a periodically scientific publication that contains articles written in Indonesia or english. JIKW receive articles in the scope of Biomedical Sciences, degenerative diseases, infections, congenital abnormalities and public health. JIKW published twice a year. The articles will be published in JIKW only manuscript that has never be published or published in other journal. Writers who will publish the article please follow the JIKW guidelines. The entire management process both admission and review the article is done by online.

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Articles 390 Documents

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Apoptosis pada Ovarium sebagai mekanisme kematian sel fisiologis Paul S. Poli
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 2, No 3 (2011): Volume Edisi Khusus Desember 2011
Publisher : Universitas Wijaya Kusuma Surabaya

Dalam rangka untuk mengontrol perkembangan embrio dan juga untuk memeprtahankan, proses apoptosis jaringan dewasa diperlukan.

Case Report: Gastric Wall Thickening: Radiological Diagnostic Challenges in Gastric Malignancy Putu Ayu Winda Wirastuti Giri; Nyoman Srie Laksminingsih; Firman Parulian Sitanggang; I Gusti Ayu Sri Mahendra Dewi; I Wayan Juli Sumadi; Luh Putu Iin Indrayani Maker
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 10, No 1 (2021): MARET 2021
Publisher : Universitas Wijaya Kusuma Surabaya

Gastric abnormalities show nonspecific gastrointestinal symptoms and similarly radiological findings. Intra and extra luminal gastric wall thickening are the most common finding in benign and malignant pathologic process. This aim of this case report was to describe several characteristics such as the location and size of the lesion, involvement of the gastric wall and surrounding structures, calcifications, and contrast enhancement pattern which can assist in radiological diagnosis. Several cases at our institution have similar gastrointestinal complaints, however, there were different lesions characteristic found in contrast enhanced abdominal CT scan. The first case 72-years-old man experienced hematemesis with radiologic finding diffuse gastric mucosal thickening as well as homogenous contrast enhancement but without calcification. The second case 37-years-old man complaint dizziness and melena with radiologic finding large tumor more than 10 cm in size, amorph calcification and heterogenous contrast enhancement. The last 60-years-old man case experienced melena and hematemesis, from abdominal CT scan showed irregular gastric mucosal thickening with heterogenous contrast enhancement and fat stranding around the lesion, without calcification. Methods used in these cases were contrast-enhanced abdominal CT scan, esophagogastroduodenoscopy (EGD), and biopsy in order to determine the diagnosis. Contrast-enhanced abdominal CT scan plays a vital role in describing the lesion characteristics which affects the determination of treatment options and future prognosis.

ISOLASI DAN KARAKTERISASI ENZIM SELULASE masfufatun masfufatun
Jurnal Ilmiah Kedokteran Wijaya Kusuma 2009: edisi khusus Desember 2009
Publisher : Universitas Wijaya Kusuma Surabaya

Carboxy Methyl Cellulose (CMC) is a derivative of cellulose soluble in water. Therefore, CMC easily hydrolyzed into simple sugars by the enzyme cellulase. Snails are animals soft, easy to breed and utilize cellulose as a source of energy and protein content is high enough. Therefore, snails can be used as a source of cellulase enzyme to hydrolyze carboxy Methyl Cellulose (CMC) This research aims to isolate cellulase enzyme from the snail, Achatina fulica and determine itscharacterization. Glucose levels produced from cellulose enzyme activity were analyzed by using the method Semogy-Nelson. From this research it turns out cellulase enzyme isolated from hepatopankreas snail, Achatina fulica has a specific activity of 2.85 U / mg protein and activity 50oCdan temperature optimum at pH 5.16 and have had kinetic parameters Vm price of 0.23 mg / mLper minute and Km is 0.53 mg / mL. Part enzyme cellulose getting fed at a concentration of 4%.

A Sago Positive Character: A Literature Review Budhi Setiawan; Fetriyuna Fetriyuna; Sri Murniani Angelina Letsoin; Ratna Chrismiari Purwestri; Ignasius Radix A.P. Jati
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 2 (2022): SEPTEMBER 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Sago is a carbohydrate-rich food that contains resistant starch. In some parts of Indonesia, Malaysia, and Papua New Guinea, sago is a common staple food. Studies have been performed to elucidate the physicochemical and structural properties of sago starches. The paper's objective is to review potential positive physiological responses to sago-based product consumption from previous records. This study is a literature review of preceding published articles related to sago intake in human subjects’ research. The literature search was performed through databases with assigned keywords combination and then selection of the articles based on the criteria. The outcomes of this review concluded that sago had a lower glycemic index with immediate intestinal absorption. Sago-based products could provide a suitable energy source for sustaining physical performance and promoting faster recovery after exercise. It can be an appropriate alternative as an energy source for active healthy individuals.

Pengaruh Pemberian Ekstrak Kayu Manis Terhadap Gambaran Histopatologi Ginjal Pada Tikus Putih Jantan Yang Diinduksi Parasetamol Rachma Eka Rani; Fitri Handajani; Eva Pravitasari Nefertiti
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 10, No 2 (2021): SEPTEMBER 2021
Publisher : Universitas Wijaya Kusuma Surabaya

AbstrakLatar Belakang : Kayu manis (Cinnamomun burmannii) mengandung flavonoid dan sinamaldehid yang berguna sebagai antioksidan dan bersifat renal protektor. Parasetamol berguna sebagai antipiretik dan analgesik. Parasetamol dimetabolisme oleh sitokrom P450 di sel hepar membentuk glukoronida, sulfat, dan NAPQI. NAPQI merupakan hasil metabolit yang sangat reaktif dan mengakibatkan stres oksidatif. Penelitian ini bertujuan untuk engetahui efek pemberian ekstrak kayu manis yang dapat mencegah kerusakan sel tubulus ginjal tikus putih jantan yang diinduksi parasetamol.Metode : 30 ekor tikus yang dibagi menjadi 3 kelompok; (1) kelompok kontrol negatif tanpa perlakuan, (2) kelompok kontrol positif yang diinduksi parasetamol dosis tunggal 1750 mg/kgBB pada hari ke 14, (3) kelompok perlakuan yang diberi ekstrak kayu manis dosis 400 mg/kgBB selama 14 hari lalu diinduksi parasetamol dosis tunggal 1750 mg/kgBB pada hari ke 14. Pada hari ke 17 hewan coba dikorbankan, dilakukan pengambilan ginjal dan dipemeriksa secara mikroskopik. Selanjutnya dilakukan uji Kruskal-Wallis dan uji Mann-Whitney U.Hasil : Uji Kruskal-Wallis menunjukkan terdapat perbedaan derajat kerusakan ginjal yang signifikan. Uji Mann-Whitney U menunjukkan perbedaan yang bermakna antara kelompok kontrol negatif dan kelompok kontrol positif p=0,001 (p<a); kelompok kontrol negatif dan kelompok perlakuan p=0,001 (p<a); juga antara kelompok kontrol positif dan kelompok perlakuan p=0,001 (p<a).Kesimpulan : Terdapat pengaruh pemberian ekstrak kayu manis gambaran histopatologi ginjal tikus putih jantan yang diinduksi parasetamol.Kata Kunci : Ekstrak kayu manis (Cinnamomum burmannii), parasetamol, gambaran histopatologi ginjal AbstractBackground: Cinnamon (Cinnamomum burmannii) contains flavonoids and cinnamaldehyde which are useful as antioxidants and renal protectors. Paracetamol is useful as an antipyretic and analgesic. Paracetamol is metabolized by cytochrome P450 in liver cells to form glucuronide, sulfate, and NAPQI. NAPQI is the result of highly reactive metabolites and cause oxidative stress. This study aim to know the effect of cinnamon extract which can prevent damage of renal tubular cell rats male induced by paracetamol.Method: 30 rats used and divided into 3 groups (1) untreated group, (2) rats which were induced by single dose paracetamol 1750 mg/kgBW on 14th day, and (3) rats were which given cinnamon extract dose 400 mg/kgBW for 14 days then induced single dose paracetamol 1750 mg/kgBW on day 14th. On the 17th day the kidneys are taken and microscopic examination is performed. Data analysis uses the Kruskal-Wallis test and the Mann-Whitney U test.Result: The Kruskal-Wallis test showed a significant difference in the degree of kidney damage. The Mann-Whitney U test showed a significant difference between the negative control group and the positive control group p=0.001 (p <); negative control group and the treatment group p=0.001 (p <); also between the positive control group and the treatment group p=0.001 (p <).Conclusion: There is an effect of administration of cinnamon extract on the histopathological picture of the kidney of white rats male induced by paracetamol.Keyword: Cinnamon extract (Cinnamomum burmannii), paracetamol, renal histopathology.

PROTOONCOGENE Lusiani Tjandra
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 2, No 1 (2010): Edisi Januari 2010
Publisher : Universitas Wijaya Kusuma Surabaya

Genes that promote autonomous cell growth in cqncer cells are called oncogenes, and their normal cellular counterparts are called protooncogenes. Protooncogenes are physiologic regulators of cell proliferation and differentiation,oncogenes are characterized by the ability to promote cell growth in the absence of normal mitogenic signals. Their products, called oncoproteins, resemble the normal products of protooncogenes with the exception that oncoproteins are devoid of important regulatory elements.Their production in the transformed cells becomes constitutive, that is, not dependent on growth factors or other external signal. Each of the cancer genes has a specific function, the dysregulation of which contributes to the origin or progression of malignancy. It traditional to describe cancer- causing genes on the basis of their presumed function.Mutations in genes that regulate these cellular traits are seen in every cancer. However, the precise genetic pathways that give rise to these attributes differ between cancers, even within the same orhan. It is widely believed that the occurrence of mutations in cancer-causing genes is conditioned by the robustness of the DNA repair machinery of the cell. When genes that normally sense andrepair DNA demage are impaired or lost, thevresultant genomic instability favors mutations in genes that regulate the other acquired capabilities of cancer cells.

Cover Volume 11 Nomer 11 tahun 2022 Putu Oky Ari Tania
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 1 (2022): MARET 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Studi Antibodi Poliklonal Anti-TBC dan Potensinya sebagai Rapid Test Kit pendeteksi TBC Muzaijadah Retno Arimbi
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 5, No 2 (2016): Edisi September 2016
Publisher : Universitas Wijaya Kusuma Surabaya

Tuberculosis (TB) is one of the long-known diseases and is still the leading cause of death in the world. A variety of detection methods have been and are being implemented in order to suppress TB prevalence. The aim of this study was to isolate protein from serum pulmonary tuberculosis patients with sputum BTA (+), isolate protein from serum pulmonary tuberculosis patients with sputum BTA (-), and to know the level of antibody specificity in serum pulmonary tuberculosis patients with sputum BTA (+) and serum pulmonary tuberculosis patients with sputum BTA (-). The type of research used was laboratory experimental in Wistar rat experimental animals with Control Group Post Test Design research design. The research design was used with 3 different treatment groups, ie Control Group (without treatment), Group I (treated with isolate protein from serum of Pulmonary TB patients with sputum BTA (+)), and Group II (treated with protein isolate from serum of Pulmonary TB patient with sputum BTA (-) From collected data After dot blot is complete, tabulation of diagnostic test result (dot blot.) To obtain a standard in assessing the results of dot in each of these studies used CorelPhotopaint X4 program to obtain accurate data about the thickness of thin black spots (nilaimean) on the nitrocellulose membrane quantitatively.The data collected is processed using software (software) statistics SPSS version 11.5 From the electrophoresis test results of an exciting protein sample m of Pulmonary TB patients with BTA (+) and protein from serum of Pulmonary TB patients with AFB (-), obtained specific protein with molecular weight of 39 kDa. From the serum 1 serum easternbloting test result from pulmonary TB patients with BTA (+) and serum 2 protein derived from serum of Pulmonary TB patients with BTA (-), positive reaction occurred between antibodipoliklonal (anti 39 kDa) and serum protein of Pulmonary TB with BTA (+), or proteins from serum patients with pulmonary TB with AFB (-). The anti-tuberculosis polyclonal antibody in the study appears to be quite sensitive as Rapid tuberculosis detection test, but no specificity as evidenced by statistical calculation has significance> 0.05, so the anti-tuberculosis polyclonal antibody in this study is quite sensitive, but not specifically used as an MTb detection device Keywords: tuberculosis, specific protein, polyclonal antibody, specificity test Tuberculosis (TB) is one of the long-known diseases and is still the leading cause of death in the world. A variety of detection methods have been and are being implemented in order to suppress TB prevalence. The aim of this study was to isolate protein from serum pulmonary tuberculosis patients with sputum BTA (+), isolate protein from serum pulmonary tuberculosis patients with sputum BTA (-), and to know the level of antibody specificity in serum pulmonary tuberculosis patients with sputum BTA (+) and serum pulmonary tuberculosis patients with sputum BTA (-). The type of research used was laboratory experimental in Wistar rat experimental animals with Control Group Post Test Design research design. The research design was used with 3 different treatment groups, ie Control Group (without treatment), Group I (treated with isolate protein from serum of Pulmonary TB patients with sputum BTA (+)), and Group II (treated with protein isolate from serum of Pulmonary TB patient with sputum BTA (-) From collected data After dot blot is complete, tabulation of diagnostic test result (dot blot.) To obtain a standard in assessing the results of dot in each of these studies used CorelPhotopaint X4 program to obtain accurate data about the thickness of thin black spots (nilaimean) on the nitrocellulose membrane quantitatively.The data collected is processed using software (software) statistics SPSS version 11.5 From the electrophoresis test results of an exciting protein sample m of Pulmonary TB patients with BTA (+) and protein from serum of Pulmonary TB patients with AFB (-), obtained specific protein with molecular weight of 39 kDa. From the serum 1 serum easternbloting test result from pulmonary TB patients with BTA (+) and serum 2 protein derived from serum of Pulmonary TB patients with BTA (-), positive reaction occurred between antibodipoliklonal (anti 39 kDa) and serum protein of Pulmonary TB with BTA (+), or proteins from serum patients with pulmonary TB with AFB (-). The anti-tuberculosis polyclonal antibody in the study appears to be quite sensitive as Rapid tuberculosis detection test, but no specificity as evidenced by statistical calculation has significance> 0.05, so the anti-tuberculosis polyclonal antibody in this study is quite sensitive, but not specifically used as an MTb detection device

PENGARUH DOSIS RADIASI 125I TERHADAP DIAMETER INTI SPERMATOGONIUM I Nyoman Suratma
Jurnal Ilmiah Kedokteran Wijaya Kusuma No 1 (2011): Edisi Juli 2011
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v0i1.2148

Penelitian ini menggunakan 48 dua bulan tikus putih jantan berumur. Tikus-tikus putih kelompok kedalam enam kotak plastik besar dengan diameter 30 cm, sehingga setiap kotak berisi 8 tikus putih. Tikusputih diobati dengan radioaktif sebagai berikut:Kotak 1 dan kotak 2 digunakan sebagai kontrol 16 dan 32 hari.ci dosis 5 untuk 16 hari.Kotak 3 diobati dengan radiasi radio aktifci dosis 5 untuk 32 hari.Kotak 4 diobati dengan radiasi radio aktifci dosis selama 16 hari.Kotak 5 diobati dengan radiasi radio aktif 10ci dosis untuk 32 hari.Kotak 6 diobati dengan radiasi radio aktif 10Setelah waktu yang ditetapkan berakhir, testis dilakukan pemeriksaan. Tikus putih dibunuh dengan eterdan kemudian dua testis diambil dificsasi dengan formalin 10% untuk preparat histologi ditandai, intiberdiameter spermatogonium pemeriksaan dilakukan. Semua putih tikus dibunuh dengan eter dankemudian dua testis diambil difisasi dengan formalin 10% untuk preparat histologi ditandai, dan diameterinti dihitung. Hasilnya, dengan analisis statistik menunjukkan bahwa jumlah rata-rata berarti diameter intikontrol yang spermatogonium adalah = 1.571 u dan SD = 0.191, sementara jumlah rata-rata (mean) darispermatogonium inti berdiameter setelah radiasi adalah = 4,46 u dan sd adalah = 0.372.Hal ini ditemukan bahwa tikus putih jantan dengan radiasi radioaktif 125I memiliki rata-rata lebih besardari diameter inti dari yang kontrol. Analisis statistik menunjukkan bahwa varian alpha = 0,05 berarti p<0,05.

Pengaruh Pemberian Teh Hijau (Camellia Sinensis) terhadap Aktivitas Superoksida Dismutase (SOD) Ma'rifat Istiqa Mukty
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 2 (2018): Edisi September 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Stres oksidatif dapat dipicu oleh paparan stres psikologis. Stres oksidatif dapat dikurangi dengan konsumsi zat antioksidan eksogen, teh hijau dianggap mampu menurunkan stres oksidatif. Tujuan penelitian ini untuk menguji pengaruh pemberian seduhan teh hijau terhadap glukosa darah, MDA dan aktivitas SOD pada tikus putih jantan Strain Wistar yang dipapar stres psikologis. Rancang bangun yang digunakan pada penelitian ini adalah Randomized Post Test Only Group Design. Terdapat 5 kelompok tikus, 2 adalah kelompok kontrol normal dan kelompok kontrol stres, serta 3 kelompok perlakuan. Sebelumnya tikus diberikan stres psikologis 1 x 24 jam berupa gangguan pola tidur jaga, sehingga didapatkan kondisi hewan coba yang mengalami stres oksidatif, kemudian dilakukan pemberian seduhan teh hijau pada kelompok perlakuan dengan dosis tunggal 3,6 ml/ekor pada jam ke-1 pada kelompok perlakuan 1, jam ke-6 pada kelompok perlakuan 2 dan jam ke-24 pada kelompok perlakuan 3. Analisis statistik menggunakan uji Manova. Hasil Berdasarkan analisis statistik menunjukkan bahwa terdapat perbedaan glukosa darah, dimana kelompok perlakuan menurun setelah jam ke-1 pemberian seduhan teh hijau, dan tetap bertahan di jam ke-6 dan ke-24, begitu pula dengan MDA, kelompok perlakuan menurun setelah jam ke-1 pemberian seduhan teh hijau, dan tetap bertahan di jam ke-6 dan ke-24. Sedangkan aktivitas SOD meningkat pada jam ke-1, kembali meningkat pada jam ke-6 dan meningkat maksimal pada jam ke-24 setelah pemberian teh hijau. Dosis tunggal seduhan teh hijau pada hewan coba yang mengalami stres oksidatif terbukti dapat menetralisir stres oksidatif pada jam ke-1 setelah pemberian teh hijau dan aktivitas antioksidannya masih bertahan sampai 24 jam.

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