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Jurnal Farmasi Sains dan Komunitas
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 247 Documents
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Effect of Antihypertensive Therapy Compliance Using Medication Possession Ratio Method on Blood Pressure in Patients with Hypertension Afriani Ireineldis Anugera; Christianus Heru Setiawan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 1 (2022)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (465.701 KB) | DOI: 10.24071/jpsc.003672

Abstract

Hypertension is a circulatory system disorder that causes an increase in blood pressure, specifically systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg. Hypertension can cause serious medical conditions such as damage to various organs. The complications caused by hypertension can be prevented with treatment regularly to achieve controlled blood pressure. This study determines the relationship between antihypertensive therapy compliance to blood pressure in hypertensive patients. This type of research is analytical observational with retrospective cohort design and purposive sampling techniques. The data were obtained from patients’ medical records, including demographic data, blood pressure, and prescribed drugs. The subject's compliance was measured using the Medication Possession Ratio (MPR). A total of 124 subjects met the inclusion criteria. The data were analyzed using a chi-square test with Yates correction. Most patients had uncontrolled blood pressure as much as 101 patients. The statistical analyses show that antihypertensive therapy compliance affects controlled blood pressure in patients with hypertension (p= 0.00). More efforts to support adherence to hypertensive treatment should be initiated to have greater effect on therapy compliance.
Characterization of 1H NMR and 13C NMR Spectrometry and Antibacterial Activities of 4-tert-Butylbenzoyl Amoxicillin Hadi Barru Hakam Fajar Siddiq; Dewi Rashati; Siti Nur Azizah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 1 (2022)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (763.591 KB) | DOI: 10.24071/jpsc.002183

Abstract

The synthesis of 4-tert-butylbenzoyl amoxicillin has been done by reacting amoxicillin with 4-tert-butylbenzoyl chloride. The product was characterized using proton and carbon-13 spectrometry. Antibacterial activity of 4-tert-butylbenzoyl amoxicillin against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus was tested using paper disk diffusion method. Results showed that 4-tert-butylbenzoyl amoxicillin had a specific spectrum activity. Antibacterial test of 4-tert-butylbenzoyl amoxicillin showed clear zones around the disc paper for Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. The study results indicated 4-tert-butylbenzoyl amoxicillin has antimicrobial properties but is categorized as a less-effective antibiotic agent based on the response to bacterial growth inhibition.
Synthesis of Silver Nanoparticles Using Premna serratifolia Linn. Leaf Extract as Reducing Agent and Their Antibacterial Activity Chris Octavianus; Imelda Hotmarisi Silalahi; Gusrizal Gusrizal
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 19, No 1 (2022)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (611.172 KB) | DOI: 10.24071/jpsc.003185

Abstract

Premna serratifolia Linn. leaf extract has been used as a reducing agent in the synthesis of silver nanoparticles (AgNPs). Various synthesis parameters such as reaction time, concentration and the pH of the Premna serratifolia Linn. leaf extract, and silver nitrate concentration were investigated. In addition, the stability of synthesized AgNPs and their activity against Staphylococcus aureus and Escherichia coli have also been investigated. The results of the experiment showed that Premna serratifolia Linn. leaf extract reduced silver ions resulting in AgNPs. In addition, the AgNPs colloid showed a gradual change in color from transparent green to yellow. At the same time, its ultraviolet (UV)-Visible spectra exhibited the typical surface plasmon resonance peak at around 400-415 nm. The optimum reaction conditions in the formation of AgNPs are 40 minutes of reaction time using silver nitrate 1.5x10-4 M and Premna serratifolia Linn leaf extract 80 ppm at pH 10. The particle size of synthesized AgNPs distributes from 48.3-157 nm with an average size of 58.7±14.4 nm and is stable at least for 1-month storage under ambient conditions. The antibacterial test shows that synthesized AgNPs are effective against both Escherichia coli and Staphylococcus aureus.
The Association Between Medication Adherence and Blood Pressure Control in End-Stage Renal Disease Patients with Hemodialysis Pande Made Desy Ratnasari; Ketut Tia Pran Anggar Yani; Agustina Nila Yuliawati; Anak Agung Ngurah Putra Riana Prasetya
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004141

Abstract

End-Stage Renal Disease (ESRD) is a severe kidney disorder that contributes to an increased risk of mortality in the world. This condition is often related with hypertension. Low medication adherence was affecting uncontrolled blood pressure in ESRD. The research aimed to analyze the association between medication adherence and blood pressure control in ESRD patients. This cross-sectional study with 77 respondents was conducted in September 2020 at the Dialysis Unit of the Private Hospital “X” Buleleng Bali by purposive sampling technique. The respondents must be ≥18 years, diagnosed with ESRD and hypertension, underwent hemodialysis (HD) twice a week, received the same antihypertensive for 3 months, have complete medical record data, and signed the informed consent form. Patients with cognitive impairment, unable to communicate, pregnant or breastfeeding, and received the Erythropoiesis Stimulating Agent (ESA) treatment were excluded. Kruskal-Wallis test was used in data analysis. Most of the patients were 65 years (80.52%), male (70.13%), primary education (57.14%), without complications (57.1%), and duration of illness 5 years (89.61%). Patients were in the high adherence (61.04%) and 66.23% of patients had uncontrolled blood pressure. The association between medication adherence and blood pressure control was not significant (p=0.478). However, these results show that high medication adherence could impact on good blood pressure control.
The Effect of Education Models on Changed Misconceptions About Long-Term Medication Inducing Renal Impairment Vitarani Dwi Ananda Ningrum; Rahma Yuantari; Irwan Nuryana Kurniawan; Devi Wahyuni
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.003888

Abstract

Medication misconceptions become a factor for nonadherence. Education for Posbindu cadres is required as a community empowerment to reduce predispositions to chronic kidney disease caused by medication nonadherence. This quasi-experimental research involved one group pretest-posttest design aiming to compare four education models for Posbindu cadres in PHCs in Yogyakarta with changes in misconceptions about antihypertensives and antidiabetics in long-term use-induced renal impairment. All models employed the cadre smart module with models 3 and 4 involving health-worker collaboration. The added educational media were posters (model 1), leaflets (model 2), and posters-leaflets (model 4). Misconception changes were assessed using a validated questionnaire. Eighty-six female cadres aged 43.7±8.6 years were involved with the majority being at least high-school graduates without hypertension and diabetes mellitus risk factors. Model 3 significantly affected all knowledge domains with discussion and clarification of understanding becoming the strength of the techniques used therein. The results proved the importance of health-worker collaboration in health promotion to increase public knowledge of health and drug use, but varied education media could give no guarantee of improvements in such misconceptions. Interactive techniques through knowledge construction assisted by health-workers, especially for unfamiliar domains among society, are recommended to improve the effectiveness of similar education.
Wound Healing Effectivity of Ageratum conyzoides L. Leaf Ethanolic Extract (Purple Flower Type), Centella asiatica (L.) Urban Leaf Ethanolic Extract, and Astaxanthin Combination Gel Preparation in Diabetic Animal Model Sarah Sahila; Hendy Suhendy; Yedy Purwandi Sukmawan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.003319

Abstract

The diabetic wounds are one of the global burden diseases. In our previous study, Ageratum conyzoides L. leaf ethanolic extract (purple flower type) 10%, Centella asiatica (L.) Urban leaf ethanolic extract 5%, and astaxanthin 0.1% combination gel preparation showed remarkable wound healing effectivity. However, this wound healing effectivity in the diabetic condition is still unknown. There were three groups used, namely negative group (placebo/gel base), positive group (oxoferin/tetrachlorodecaoxide), and test group (Ageratum conyzoides L. leaf ethanolic extract (purple flower type) 10%, Centella asiatica (L.) Urban leaf ethanolic extract 5%, and astaxanthin 0.1%). Each group consisted of three male Wistar rats. We conducted diabetes induction with alloxan (175 mg/Kg BW i.p) and followed by an incision 1.5 cm on the back. All of these groups were given treatment once daily and monitored for 14 days. The results of the study showed the test group indicated significantly better effectivity than positive and negative groups (p0.05). The percentages of the wound healing effectivity of the test, positive and negative groups were 62.74%, 51.77%, and 41.65%, respectively. Ageratum conyzoides L. leaf ethanolic extract (purple flower type) 10%, Centella asiatica (L.) Urban leaf ethanolic extract 5%, and astaxanthin 0.1% combination gel preparation has excellent potential to be developed as a commercial product to treat diabetic wound conditions..
Gastroprotective Effects of the Combination of Chromolaena odorata L. and Pachyrhizus erosus L. Extracts on Rats with Gastric Ulcer Model Reza Pertiwi; Reza Rahmawati; Aanisah Hanuun; Noval Kurnia Wati; Tesa Pebiani; Ridho Kurnia; Wafa Syahidah; Risky Hadi Wibowo; Doni Notriawan
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004521

Abstract

Gastroprotective effects are caused by compounds that can protect the gastric mucosa. Gastroprotective activity provided by plants is due to the presence of a group of secondary metabolite compounds found in the plants. The types of secondary metabolite compounds are flavonoids, tannins, alkaloids and saponins. Chromolaena odorata L. contains tannins, phenols, flavonoids, saponins and steroids, while Pachyrhizus erosus L. is known to contain flavonoids and saponins. This study aimed to determine the gasprotective activity of the combination of Chromolaena odorata L. and Pachyrhizus erosus L. extracts in ethanol-induced rats by observing the parameters of the number of peptic ulcers, protection ratio, and images of gastric histopathology. The research method was to make a combination of Chromolaena odorata L. and Pachyrhizus erosus L. extracts which were given to six treatment groups: normal group without treatment; negative control group; positive control group given sucralfate; and three groups given a combination treatment of Chromolaena odorata L. and Pachyrhizus erosus L. extract with a dose of 100, 200, and 400 mg/kgBW. Treatment was done by oral administration for 14 days. On Day 14, after one hour of treatment, 96% ethanol induction was given orally at a dose of 2 ml/200 gBW except for the normal group. The ulcer index produced by negative control, positive control, the treatment with doses of 100, 200, and 400 were 4.18; 2.98; 2.49; 1.64; and 0.78, respectively. The combination of Chromolaena odorata L. and Pachyrhizus erosus L. extracts can prevent gastric damage in rats caused by ethanol induction.
Optimization of Stearic Acid and Triethanolamine in The Antibacterial Cream Staphylococcus aureus Ethanol Extract of Papaya Seeds (Carica papaya L.): Factorial Design Method Yakub, Jacinda; Setyani, Wahyuning
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.002396

Abstract

The ethanol extraction of papaya seeds provides a synergistic inhibitory effect on Staphylococcus aureus thorugh alkaloids, flavonoids, tannins and saponins. In this research, the ethanol extract of papaya seeds was formulated in cream preparations and optimized. The optimization of stearic acid as the oil phase and TEA as the water phase resulted in a cream with good physical properties and stability. The parameters used to observe the physical properties and stability of the ethanol extract cream of papaya seeds were organoleptic, homogeneity, pH, centrifugation, viscosity, spreadability, and adhesion. Optimization data analysis using Design Expert 12 free trial. The result of optimization is stearic acid contributed most dominantly to the response to increase viscosity by 73.739% and adhesion by 91.695%, while TEA contributed to the increased in dispersibility by 13.107%. The optimum amount of composition used for stearic acid was 5 grams and TEA was 2 grams. The research showed that inhibitory activity of papaya seed ethanol extract at a concentration of 20% was classified as moderate. However, at concentrations of 40%, 60%, 80%, and 100%, the inhibitory activity is quite strong.
Molecular Dynamics Study of Human MTHFR Wild-Type and A222V Mutant-Type: A Computational Approach Michael Resta Surya Yanuar; Dita Maria Virginia; Enade Perdana Istyastono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005727

Abstract

Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme for the homeostasis and metabolism of intracellular folate. However, it is known that one of the commonly found MTHFR gene SNPs (A222V) causes a decrease in activity which decreases folate levels and increases the accumulation of homocysteine in the blood. The purpose of this study was to investigate the molecular dynamics of MTHFR wild-type protein and MTHFR A222V mutant protein in silico. After some preparations, the crystal structure of MTHFR with code 6FCX obtained from the Protein Data Bank was used as the input file for molecular dynamics (MD) simulations. YASARA-Structure was employed for performing 50 ns production run of MD simulations. The deviation of the root-mean-squared deviation value of the backbone atoms (∆RMSDBb) of MTHFR wild-type is consistently less than 2 Å from the beginning of the MD simulations production runs. On the other hand, there is a sudden spike of ∆RMSDBb of MTHFR A222V from 15.01 to 20.00 ns of 2.221 Å. According to the analysis of ∆RMSDBb, MTHFR wild-type protein is considered stable and the MTHFR A222V mutant protein is considered unstable which may lead to various clinical problems for the person possessing this mutation.
Duration of Zidovudine Consumption Correlates with Anemia in People Living with HIV Danis Pertiwi; Muchlis Achsan Udji Sofro; Tri Indah Winarni; Ari Natalia Probandari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004331

Abstract

Anemia is the most common hematological disorder associated with Human Immunodeficiency Virus (HIV). WHO recommends zidovudine (AZT) as one of the first-line drugs for this infection. It is important to note that the drug has the adverse effect of causing anemia. Therefore, this study correlates AZT consumption duration and the incidence of anemia in HIV-infected individuals. This cross-sectional study was conducted at health service facilities using 213 participants. The data were obtained from medical records, and the assessed parameter was hemoglobin (Hb) level after less or more than a year of zidovudine administration. Furthermore, they were analyzed using a Pearson’s coefficient contingency test (p0.05) to evaluate the correlation between groups with and without anemia at each period of drug administration. The results showed a significant correlation (p0.05) between sex and age with anemia incidence in HIV patients administered AZT. The duration of this drug intake in HIV-infected individuals was correlated with anemia (p= 0.024; OR=0.369). This indicates the use of AZT for at least one year may be a protective factor for the incidence of anemia in patients with HIV compared to the group consuming this drug for less than one year.

Page 16 of 25 | Total Record : 247

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