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Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)

Galenika
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Published by Universitas Tadulako

ISSN : 24427284 EISSN : 24428744 DOI : https://doi.org/10.22487/j24428744

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (E-ISSN: 2442-8744) (p-ISSN: 2442-7284), is an open access journal (print and e-journal) focusing on the scientific works in the field of Pharmacy and Pharmaceutical Science. The articles of this journal are published every six months, that is March and October (2 issues per year). This journal is developed by Department of Pharmacy, Faculty of Mathematics and Natural Science, Tadulako University and has been identified in Crossref with the DOI Number : 10.22487/j24428744. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) has been accredited by Kemenristekdikti as Sinta 3 starting from Volume 5 No 1 2019.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 12 Documents

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Search results for , issue "Vol. 1 No. 2 (2015): (October 2015)" : 12 Documents clear

GEL ANTI JERAWAT EKSTRAK DAUN BUTA-BUTA (Excoecaria agallocha L.) DAN PENGUJIAN ANTIBAKTERI Staphylococcus epidermidis Ika Olivia Borman; Yusriadi Yusriadi; Evi Sulastri
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Buta-Buta (Excoecaria agallocha L.) leaf is a type of mangrove plants that has antibacterial activity againtsbacteriacausing acne, Staphylococcus epidermidis,. This study aims to formulate buta-buta leaf extract with the concentration of 12.5 % into anti-acne gel using two gels, namely HPMC 8% (Formula 1) and Carbopol 940 2%(Formula 2). Antibacterial activity test was carried out by agar diffusion method using well. The stability and antibacterial activity data during 28 days were analyzed statistically using unpaired t-student with a degree of confidence of 95% (α = 0.05). The evaluation results of anti-acne gel form of buta-buta leaf extract in Formula 2 showedbetter characteristics than Formula 1, which include organoleptic examination, homogenity, pH and viscosity during 28 days. The antibacterial test showed the diameter of inhibition zone of Formula 2 is 11.03 mm ±0,01. The statistic analysis showed a significant difference between Formula 2 with a positive control (klindamisin gel).

FORMULASI TABLET EKSTRAK DAUN SAMBILOTO (Andrographis paniculata N.) SECARA KEMPA LANGSUNG DENGAN KOMBINASI MANITOL – SORBITOL SEBAGAI BAHAN PENGISI Lutfiana Kusumawati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

It has been conducted research about Tablets Formulation of Creat (Andrographis paniculata N.) Leaves Extract in Directly Compressed with Combination of Manitol-Sorbitol as Filler Materials. The result of test shows that every formula fulfills test conditions of quality for uniformity of weight, brittleness, size measure and hardness, such as those which qualified by Farmacope Indonesia and other monographs. Statistical test using Ansira (Variance Design Analysis) indicates that usage of filler materials combinations mannitol – sorbitol for formula I, II and III respectively 50% : 50%, 75% : 25% dan 25% : 75%, yield no significant effect for physical quality tablet

STUDI ETNOFARMASI TUMBUHAN BERKHASIAT OBAT PADA SUKU BUTON DI KECAMATAN BINONGKO, KABUPATEN WAKATOBI, SULAWESI TENGGARA Wa Ode Irma Indrayangingsih; Nurlina Ibrahim; Syariful Anam
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Herbal plant ethno pharmacy study in Butonse has been coducted from January to april2014 in Binongko Sub-districtm Wakatobi Regency of South East Sulawesi. This research aimed tofind out various species and plant organs used, kinds of diseases healed, and the way to use the herbalplants by Butonese in Binongko Sub-district. This was a descripive research using qualitativemethod.The sample was taken through snowball technique with 17 informans by using questiomnaire.Based on the research result, it was obtained 53 species of plants and divided into 35 families thatused as medicine.The most used plants were family of Euphorbiaceae of 6 species. It was found 3kinds of unique plants used such as tali putri, daun picah, and kayu kuda. The organs used were leaf,fruit, stem, tuber, root, rhozome. Latex, flower, stem skin, and wood skin. The most used plant’sorgan was the leaves of 56%. The wey is by boiling, pounding, chewing, squeezing, slicing, smearing,burning, dropping, soaking, consuming directly, gratting, attachng, and having smoke. The most wayused is by boiling and pounding for 34% each.

STUDI ETNOFARMASI TUMBUHAN BERKHASIAT OBAT PADA SUKU KAILI LEDO DI KABUPATEN SIGI, PROVINSI SULAWESI TENGAH Ian Dianto; Syariful Anam; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Ethnomedicinal study on LedoKaili tribe has been conducted from January to April 2015 in Sigi Regency, Central Sulawesi. This study aims to know and to inventory the various species of plants, their parts, and ways of utilization used to treat any types of disease and how the by the tribe. This research is descriptive using qualitative methods and snowball sampling technique through open-ended interviews to 10 informants by using questionnaire. Based on the study results, plants used as medicine were known as many as 86 species coming from 37 familia in which four species have notbeen identified yet. The most widely used plants are from familia Zingiberaceae (8 species). Plant parts used include leaf, stem, fruit, root, rhizome, tuber, herb, bark, sap, and flower. Leafisthe part of the plant used with the highest percentage (53%). Local people use medicinal plants for purposes of chronic, infectious, and non-infectious diseases. Besides being able to treat people's illnesses,the plants were also used for body health care as well as dietary supplements. Ways of processing medicinal plants is done by boiling, crushing, squeezing, shredding and soaking. The most widely is boiled with percentage of 60%. As for how to use medicinal plants, the people use them in ways of drinking, eating, rubbing, dropping, and tapping/attaching. Drinking is the most usual way to use them with a percentage of 74%

STUDI ETNOFARMASI SUKU DONDO KECAMATAN DONDO KABUPATEN TOLITOLI SULAWESI TENGAH Mohammad Fajrin; Nurlina Ibrahim; Arsa Wahyu Nugrahani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

This study aims to inventory and to record plants and their parts used as medicine by Dondo Tribe in Dondo Subdistrict, Tolitoli Regency, Central Sulawesi. This research is a descriptive study using qualitative methods and snowball sampling technique through open-ended interviews to 4 informants using questionnaire. The results showed that 56 plant species divided into 32 familia were used as medicine. The most widely used plant was from Euphorbiaceae family as much as 11%. Parts of plant which were used included leaf, petiole, stem, bark, flower, fruit, seed, rhizomes, tuber, and herb. Part of plant widely used was the leaf with percentage of utilization as much as 62%. The people of Dondo Tribe in Tolitoli District use the plants for treatment of illness, recovery, and maintenance of health. The methods of processing included decocting, mashing, roasting, burning, squeezing, and brewing the parts of the plant. The ways of using included drinking, eating, chewing, smearing, dropping, affixing/compressing, attaching, and rubbing the plant preparations on the sore spot as well as inhaling the fumes, and mixing it with water for bathing

EFEKTIVITAS ANTIDIABETES EKSTRAK DAUN RAMBUSA (Passiflora foetida L.) PADA MENCIT (Mus musculus) DENGAN INDUKSI GLUKOSA Khildah Khaerati; Ihwan Ihwan; Musdalifah S Maya
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Passiflora foetida leaves used by the society for generations as a natural antidiabetic drug research aims to test the effectiveness of the leaf extract of Passiflora foetida with variations of a dose of 250 mg / kg, 500 mg / kg, and 750 mg / kg in lowering blood sugar levels in mice. Passiflora foetida leaves were extracted by sokhletasi method with 70% ethanol, the extract was tested on 15 mice, the test animals were randomized into 5 groups consist of negative control group given 0.5% Na-CMC, positive control group was given glibenclamide 0, 65 mg / kg, and the treatment group were given the leaf extract of Passiflorafoetida with variations of each dose of 250 mg / kg, 500 mg / kg, 750 mg / kg. To increase blood sugar levels in mice induced glucose 50%. Measurement of blood sugar levels in mice were performed using an easy touch glucometer and blood is taken via the lateral tail vein. The results showed that the percentage of blood sugar levels drop to a negative control is 13.1%, for a dose of 250 mg / kg body weight of 29.52%, for a dose of 500 mg / kg was 38.79%, to dosis750 mg / kg was 49, 21%, and 48.1% for the positive control. The results showed that the leaf extract of Passiflorafoetida at a dose of 750 mg / kg is most effective as an antidiabetic

AKTIVITAS DIURETIK KOMBINASI EKSTRAK BIJI PEPAYA (Carica papaya L) DAN BIJI SALAK (Salacca zalacca varietas zalacca (Gaert.)Voss) PADA TIKUS JANTAN GALUR WISTAR (Rattus norvegicus L) Nurihardiyanti Nurihardiyanti; Yuliet Yuliet; Ihwan Ihwan
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Research on diuretic activity of seed extract combination of papaya (Carica papaya L) and snake fruit (Salacca zalacca (Gaert.) Voss) to male wistar strain rats (Rattus norvegicus L.) has been conducted. This study aimed to determine the diuretic effect of the seed extract combination and its effective dose combination as diuretics. The extract was prepared by maceration method using ethanol 96%. Diuretic activity test was divided into 5 treatment groups. Each group consisted of 5 rats. Group 1 (negative control) was given suspension of Na-CMC 0.5%; Group 2 (positive control) was given furosemide 3.6 mg/kgBW; Group 3, 4, and 5 were given dose combination of snake fruit seed extract and papaya seed extract successively at “37.5 mg/kgBW + 7.5 mg/kgBW”; “70 mg/kgBW + 15mg/kgBW”; and “140 mg/kgBW + 30 mg/kgBW”. Each rat was then orally given warm distilled water (70°C) 10ml/100gBW as loading dose. The excreted urine volume was measured and recorded every 30 minutes for 6 hours which was continued to cumulative urine volume calculation. Furthermore, sample was taken from the cumulative urine to measure levels of sodium (Na), potassium (K), and the pH of the urine. Data were statistically analyzed using ANOVA (Analysis of Variance). The results showed that the effective extract dose combination was found in Group 5’s dose (140 mg/kgBW of snake fruit seed extract and 30 mg/kgBW papaya seed extract) with diuretic activity index of 1.48; urine pH of 7.52; sodium saluretic index of 1.62; and potassium saluretik index of 1.56

UJI AKTIVITAS REPELAN LOTION EKSTRAK ETANOL KULIT BUAH LANGSAT (Lansium parasiticum Osbeck.) TERHADAP NYAMUK Aedes aegypti Pebrianti Pebrianti; Yusriadi Yusriadi; Ingrid Faustine
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Repellents are substances that can provide protection from nuisance insects by interfering with its sensory function. Lanzones fruit is known to contain triterpenoids which have activity as repelan. This study was to examine the repellent activity and to determine protection capacity of lotion containing ethanol extract of lanzones (Lansium parasiticum) peel against Aedes aegypti mosquitoes. The ethanol extract was obtained by macerating the peel with 96% ethanol. The lotion is prepared in three extract concentrations, 15%; 20%; and 25% followed by its physical stability evaluation and activity examination. Data of pH, viscosity and dispersive capacity evaluation obtained were statistically analyzed using paired samples t-test. The results showed that the lotion preparations are stable on organoleptic observation and homogeneity evaluation. The statistical analysis of pH, viscosity, and the dispersive capacity evaluations showed that their results are significantly different after day 0 to day 28 storage (p> 0.05). Repellent activity examination of the lotion was carried out for 4 hours, using the Aedes aegypti mosquitoes. Of the three concentrations examined, each concentration has different repellent activity that concentration of 15% and 20% indicated a 100% protection up to 1 minute, and concentration of 25% indicated up to 135 minutes

UJI AKTIVITAS ANTIINFLAMASI KOMBINASI DEKOKTA AKAR BELUNTAS (Pluchea indica L.) DAN INFUSA DAUN JAMBU BIJI (Psidium guajava L.) TERHADAP TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI KARAGENAN Ersamukti Rahmatullah Achmad; Yuliet Yuliet; Lutfiana Kusumawati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Marsh fleabane roots (Pluchea indica L.) and guava leaves (Psidium guajava L.) are traditionally used as an anti-inflammatory. The research has been conducted with the aim of knowing the anti-inflammatory effect of the combination of decoction of Marsh fleabane roots (Pluchea indica L.) and infusion of guava leaves (Psidium guajava L.), and also determining the effective concentration of such combination. The research used artificial edema method in white rat's leg ( Rattus norvegicus) with the observation for 6 hours on the change of leg volume in white rat. The measurement of white rat's leg volume used a pletismometer. The type of treatment was devided into 5 groups: negative control (Aquadest), positive control (Na Diclofenac), combination 1 (MFR 10% : IGL 8%), combination 2 (MFR 5% : IGL 5%), and combination 3 (MFR 8% : IGL 10%). The data obtained were processed using One-Way ANOVA method with the result seen on the percent inhibition of inflammation resulting concentration of MFR 5%: IGL 5% amounting to 23.47%, and subsequently combined with a concentration of MFR 10% : IGL 8% and concentrations MFR 8% : IGL 10% respectively by the percent inhibition of inflammation by 20.70% and 13.75%. The data obtained show the combination with a concentration of 5% : 5% have anti- inflammatory effect are better than the other combinations as well as comparable to the positive control

UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN PISANG AMBON (Musa paradisiaca L.) TERHADAP TIKUS PUTIH (Rattus norvegicus L.) YANG DIINDUKSI KARAGENAN Sukmawati Sukmawati; Yuliet Yuliet; Ririen Hardani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Anti-inflammatory activity test of ethanolic extract of banana leaf (Musa Paradisiaca L.) on carrageenan-induced paw edema in white male rats (Rattus novergicus L.) has been conducted. It was aimed to investigate and to determine the anti-inflammatory activity and its effective dose. The extract was prepared by maceration method using ethanol 96%. Anti-inflammatory activity test was performed in five different groups. Each group consisted of 5 rats. The 1st group (negative control) was given 0.5% CMC-Na suspension; the 2nd group (positive control) was given diclofenac sodium 9 mg/KgBW; the 3rd, 4th, and 5th groups were successively given the banana leaf extract as much as 500, 750 and 1000 mg/KgBW. Each rat was then induced by 1% carrageenan and tested using subplantar method. The inflamed paw diameter was measured using a calliper while the inflamed paw volume using pletysmometer. The measurements were done for 6 hours long with intervals of 60 minutes. The data was statistically analyzed using ANOVA (analysis of variance). The results showed that the negative control had a significant difference with the other treatment groups which did not show any anti-inflammatory effect. In conclusion, ethanolic extract of banana leaf has effective anti-inflammatory activity at a dose of 750 mg/KgBW

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Muhammad Sulaiman Zubair

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+6285242083654

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jurnalgalenika.farmasiuntad@gmail.com

Editorial Address
Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Location
Kota palu,

Sulawesi tengah

INDONESIA

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muhammad Sulaiman Zubair

Contact Email sulaiman_zubair80@yahoo.co.id

Phone +6285242083654

Journal Mail Official jurnalgalenika.farmasiuntad@gmail.com

Editorial Address Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Location Kota palu, Sulawesi tengah INDONESIA

Abstract

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Abstract

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Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Sulaiman Zubair

Contact Email
sulaiman_zubair80@yahoo.co.id

Phone
+6285242083654

Journal Mail Official
jurnalgalenika.farmasiuntad@gmail.com

Editorial Address
Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Location
Kota palu,

Sulawesi tengah

INDONESIA