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Jurnal Fitofarmaka Indonesia
Published by Universitas Muslim Indonesia
ISSN : 23560398     EISSN : 25412329     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
Jurnal Fitofarmaka Indonesia merupakan salah satu jurnal yang dikelola oleh Laboratorium Farmakognosi-Fitomikia Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Januari 2014. Jurnal Fitofarmaka Indonesia merupakan jurnal ilmiah yang terbit secara on-line dan cetakan serta menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.
Arjuna Subject : -
Articles 150 Documents
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POTENSI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAN FRAKSI N-HEKSAN BUAH JERUK PAMELO (Citrus maxima (Burm) Merr) ASAL KABUPATEN PANGKEP Masdiana Tahir; Asriani Suhaenah; Yulinda Rahim
Jurnal Fitofarmaka Indonesia Vol 7, No 2 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v7i2.488

Abstract

Pomelo citrus (Citrus maxima (Burm) Merr) is a fruit plant that has the potential to be developed for health. Pomelo fruit contains lycopene, flavonoids and vitamin C which can provide antioxidant activity. The purpose of this study was to determine the potential antioxidant activity of ethanol extract and fraction of n-hexane of pomelo citrus using quercetin as a comparison. Extraction of pomelo citrus fruit using the maceration method with liquid-liquid fractionation using water and n-hexane (1: 3 v / v). Testing of antioxidant activity using the DPPH (1,1-Diphenyl-2-picrylhidrazil) method is based on the ability of the sample to capture DPPH free radicals which are characterized by purple to yellow discoloration and a decrease in the absorbance value of DPPH which has reacted with samples in certain concentrations. Absorbance measurements using a UV-Vis spectrophotometer at a wavelength of 514,942 nm. The results showed that the IC50 value of quercetin was 6.55 µg / mL which was a strong antioxidant, while the IC50 value of the ethanol extract of pomelo citrus fruit was 2882.26 µg / mL and IC50 value of the n-hexane fraction of pomelo orange was 3668,44 µg / mL which is a weak antioxidant category. Kata kunci : Antioxidants, Ethanol Extract, n-Hexane Fraction, Pomelo citrus (Citrus maxima (Burm) Merr
Screening of Antibacterial Activities of the Endophytic Fungi Isolated from the Leaves of Medinilla speciosa Blume Puteri Amelia; Rachma Ayunda; Saiful Bahri
Jurnal Fitofarmaka Indonesia Vol 8, No 3 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i3.729

Abstract

Endophytes or endophytic fungi have been investigated as a store house of bioactive compound. This study was aimed to evaluate the potential antibacterial activity of endophytic fungi isolated from Medinilla speciosa Blume. The antibacterial test was determined by measuring the inhibition zone with disk-diffusion method. Twenty endophytes were isolated from the leaves of Medinilla speciosa Blume and identified morphologically. The results demonstrated that ten isolates showed variation in their antibacterial activity against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Bacillus subtilis ATCC 6633, and Shigella dysenteriae ATCC 13313. Further investigation will be needed to explore and identify the bioactive molecules of the isolated endophytic fungi.
AKTIVITAS ANTIBAKTERI ISOLAT BAKTERI ENDOFIT TANAMAN KUNYIT (Curcuma longa L.) TERHADAP PERTUMBUHAN Staphylococcus aureus Saskya Maulidya Astari; Ambar Rialita; Mahyarudin Mahyarudin
Jurnal Fitofarmaka Indonesia Vol 8, No 2 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i2.644

Abstract

Staphylococcus aureus is a commensal bacterial  of the body that can become pathogen at any time. Along with the increase of antibacterial resistant cases, it is necessary to explore the new potential metabolites as antibacterial. Endophytic bacteria that live on turmeric (Curcuma longa L.) are thought to be able to produce secondary metabolites that are similar and even more varied than their host plants.To determine the antibacterial effect of secondary metabolite compounds of turmeric (Curcuma longa L.) endophytic bacteria on Staphylococcus aureus. Endophytic bacterial isolates were subcultured on NA media with a streak plate method. Antibacterial activity test useds disk diffusion method. Potential endophytic bacterial isolates were characterized based on colony morphology, cell morphology and biochemical properties and secondary metabolite compounds produced are identified with a ciulei method. A total of 17 endophytic bacterial isolates were successfully subcultured. All endophytic bacterial isolates had antibacterial activity range from 7.4-13.76 mm. One of the most potential isolates was M8 isolate which had similarity with a genus Pseudomonas. The secondary metabolites that was produced bt M8 isolates were alkaloids, terpenoids and saponins. The most potential endophytic bacteria as antibacterial belong to the genus Pseudomonas and had alkaloids, terpenoids and saponins.
EFEK HEPATOPROTEKTOR ANDROGRAPHOLIDE TERHADAP AKTIVITAS ALANIN AMINOTRANSFERASE DALAM SERUM Rattus norvegicus JANTAN GALUR WISTAR YANG DIINDUKSI KARBON TETRAKLORIDA Dewinta Putri Utami; Andriani Andriani; Mardhia Mardhia; Virhan Novianry; Mistika Zakiah
Jurnal Fitofarmaka Indonesia Vol 8, No 1 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i1.582

Abstract

Background: Andrographolide is a diterpenoid bioethanol that effectively prevent liver injury by reducing liver oxidative stress response. Method :  The research was randomized experimental design with pretest-posttest design. Thirty male wistar rats was randomly divided into 6 groups, normal control, negative control (0,2 ml CCl4), and positive control (500 mg/kgBW curcumin), dose I (50 mg/kgBW), dose II (100 mg/kgBW), dose III (200 mg/kgBW) given for 8 days and induced by 0,2 ml CCl4 on the first day. Data was analyzed by One-Way Anova test, LSD  Post-Hoc test and paired T test. Results :All groups induced by CCl4 shows elevated of ALT activity. The posttest results shows significant differences of ALT activity between groups (p<0,05). Conclusion :  Andrographolide shows hepatoprotector effect by decrease the activity of ALT in male wistar rats induced by CCl4. The effective dose of andrographolide is 200 mg/kgBW.
Spectrophotometric Determination of Total Flavonoid Content in Biancaea Sappan (Caesalpinia sappan L.) Leaves Nurlinda Nurlinda; Virsa Handayani; Faradiba Abdul Rasyid
Jurnal Fitofarmaka Indonesia Vol 8, No 3 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i3.712

Abstract

AbstractBiancaea sappan  (BS) is traditionally used to treat anticonvulsants, anti-inflammatory, antiproliferative, anticoagulant, antiviral, immunostimulant, antioxidant, and antimicrobial treatments. Flavonoids are found in Secang; flavonoids are secondary metabolites that have antioxidant activity. This study aims to identify the flavonoids using TLC and determination of flavonoids content in BS leaves. Initially, The methanol extract of BS was obtained by maceration with ethanol. The qualitative analysis of flavonoid was using TLC and visualization by sprayed with AlCl3. The determination of total flavonoid content is conducted based on the AlCl3 method with total flavonoids expressed in QE (Quercetin equivalent) at the maximum wavelength of 431 nm. The research results showed that BS leaves contain flavonoids and the total flavonoid content of BS leaf extract is 1.0318 mg QE / g extract.Keywords: Caesalpinia sappan; Flavonoid content, Spectrophotometric
Formulasi Sediaan Lipstik Dengan menggunakan Kombinasi Pewarna Alami Kulit Buah Jamblang (Syzigiumcuminii L) Dan VCO Citra Pratiwi; Teti Indrawati; Ratna Djamil
Jurnal Fitofarmaka Indonesia Vol 8, No 2 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i2.653

Abstract

The 96% ethanol extract of jamblang fruit peel has anthocyanin which has the potential to be used as a coloring agent for lipstick products. Jamblang fruit peel was extracted with 96% ethanol by kinetic maceration and tested for standard extract quality test, phytochemical screening, total anthocyanin values measured at 510nm and 700nm and antioxidant IC50 by DPPH method. The lipstick is made in 3 pH variations (Acid, Neutral and Alkali). Melting point, hardness, stability test with cycle test method, changes in shape, color and odor, smear test, pH test and skin irritation of male albino rabbits were also carried out in this study. Results showed that Jamblang fruit extract had antioxidant activity IC50 of 196.30 g/mL (average activity), total Anthocyanin value 0.2642%. Free from heavy metal content. The anthocyanin color in the extract of Syzigium cuminii L also changed according to the change in pH. The lipstick preparation is easy to apply, stable in three test cycles and does not irritate the skin of the shaved male albino rabbit. The conclusion, Jamblang fruit peel extract can be used as a natural dye in lipstick preparations.
Aktivitas Antijamur Ekstrak Etanol Daun Cengkodok (Melastoma malabathricum) Terhadap Pertumbuhan Malassezia furfur Willy Sanjaya; Ambar Rialita; Mahyarudin Mahyarudin
Jurnal Fitofarmaka Indonesia Vol 8, No 1 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i1.614

Abstract

Pityriasis versicolor (PV) is an infection on epidermal layer of skin and the common caused by a type of yeast that live on the skin named Malassezia furfur. The increasing of fungal resistant against antifungal and high reccurence rate after cured in 2 years about 80%, requires alternative treatment that come from plants. Cengkodok leaves (Melastoma malabathricum) is used conventionally as an alternative medicine. Cengkodok leaf produces secondary metabolites which have antifungal activity. The aim of this study was to investigate the antifungal activity of ethanolic extract Melastoma malabathricum leaves (EEMML). Phytochemical screening of EEMML were performed using Thin Layer Chromatography (TLC). Melastoma malabathricum leaves were extracted with maceration method using 96% ethanol. The testing of antifungal activity was determined using disc-diffusion method with the concentration of 5; 20; 50; 100; 250; 500 ppm. Ketoconazole 10 ug/disc and Itraconazole 8ug/disc was used as positive control while negative control used 10% dimethyl sulfoxide (DMSO). EEMML didn’t showed zone of inhibition against Malassezia furfur although 100% concentration extract used. EEMML have no antifungal activity against Malassezia furfur
Radiolabeled curcumin as β amyloid imaging and tumor targeting imaging agents Nurmaya Effendi
Jurnal Fitofarmaka Indonesia Vol 8, No 3 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i3.708

Abstract

Curcumin, a polyphenolic compound, derived from the rhizomes of Curcuma longa L. Curcumin shows potential pharmacological action against numerous disorders, including cancer, neurodegenerative, and infection diseases. Curcumin-based molecular imaging agents could be useful for early detection of Alzheimer Disease and tumor and monitor the progress of therapy. Radiolabeled curcumin and its derivatives become promising compounds as imaging agents. In this review, radiolabeled curcumin bearing radionuclides including fluorine-18, Technetium-99m, Iodine-125, and Gallium-68 are reviewed as an effort to develop curcumin-based probes not only for β amyloid imaging but also for tumor imaging.
Isolasi Dan Identifikasi Senyawa Kimia Monoterpen Dari Fraksi Etilasetat Daun Keji Beling (Strobilanthes crispa (L.) Blume) Yang Mempunyai Daya Sitotoksik Lilik Sulastri; Ristanti Mega Lestari; Partomuan Simanjuntak
Jurnal Fitofarmaka Indonesia Vol 8, No 1 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i1.721

Abstract

Isolation and identification one of chemical compound mono-terpene from Keji beling plant (local name) (Strobilanthes crispa) has been done. Extraction was carried out by maceration of the keji beling leaf powder with ethanol 96%, then partitioned with water-ethyl acetate. Ethylacetate extract was isolated and purified by a cytotoxic guide fractionation system with Brine Shrimp Lethality Test (BSLT) on column chromatography (SiO2; n-hexane - ethylacetate = 20 : 1); and preparative Thin Layer Chromatography (TLC) (SiO2; n-hexane - ethylaseate = 10 : 1) which gave one compound in oily form.  Based on identification by infra red spectra and gas chromatography-mass spectra (GC-MS), the compound is a monoterpene D-limone which has a cytotoxic power of 73,11 ppm.
AKTIVITAS EKSTRAK ETANOL DAUN SALAM [Syzygium polyanthum (Wight) Walp.] SEBAGAI PENGHAMBAT ENZIM α-GLUKOSIDASE DAN STUDI SECARA IN SILICO Rakhmat Ramdhani Alwie; Esti Mumpuni; Lilik Sulastri; Partomuan Simanjuntak
Jurnal Fitofarmaka Indonesia Vol 8, No 2 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i2.750

Abstract

Diabetes Mellitus (DM) is a degenerative disease that can cause various complications such as cardiovascular, stroke, and hypertension. Antidiabetic drugs that are commonly circulated in the market, have side effects that can harm other organs such as liver, kidneys and other organs. Bay leaves have properties as inhibitors of the α-glucosidase enzyme in vitro and in vivo. The aims of this study was determine the activity of ethanolic extract of bay leaves by ultrasonic extraction method in inhibiting the α-glucosidase enzyme in vitro and in silico. Bay leaves were extracted using 70% and 96% ethanol by ultrasonic method for 15 minutes, and filtered and concentrated using a rotary vacuum evaporator 4 times. The extract obtained was tested for phytochemical content and the activity of α-glucosidase inhibitory assay. The extract with the best IC50 value was then separated using column chromatography (SiO2, dichloromethane, methanol) and produced 7 fractions and tested for α-glucosidase enzyme inhibition. The best fraction (fraction 6) was analyzed by Liquid Chromatography Mas Spectra (LCMS-MS). The results showed that bay leaf extract containing alkaloids, flavonoids, tannins, steroids, phenols, and fraction-6 had the best IC50 of 30.82 ppm. The results of LCMS-MS analysis of chemical compounds as inhibitors of the α-glucosidase enzyme were delphinidin (m/z 303) and had a rerank score of -75.59. In the in silico test using PLANTS docking software.

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