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Jurnal Fitofarmaka Indonesia

fitofarmakaindo
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Published by Universitas Muslim Indonesia

ISSN : 23560398 EISSN : 25412329 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology

Jurnal Fitofarmaka Indonesia merupakan salah satu jurnal yang dikelola oleh Laboratorium Farmakognosi-Fitomikia Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Januari 2014. Jurnal Fitofarmaka Indonesia merupakan jurnal ilmiah yang terbit secara on-line dan cetakan serta menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.

Arjuna Subject : -

Articles 150 Documents

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SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOLIK BUAH BUNI (Antidesma bunius (L.) SPRENG) Arif Rahman; Abd Malik; Aktsar Roskiana Ahmad
Jurnal Fitofarmaka Indonesia Vol 3, No 2 (2016): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Free radicals play a role in the occurrence of various degenerative diseases that require free-radical scavengers or antioxidants. Buni fruit (Antidesma bunius (L.) Spreng) has the bioactive components are Anthocyanins (flavonoids) that serves to the free radicals. This study aimed to measure the antioxidant activity of theethanol extract contained 70% fruit Buni obtained by using the method of nitric oxide. Simplicia buni macerated dried fruit with 70% ethanol. Extracts were obtained in the test antioxidant activity against nitric oxide radicals. The antioxidant activity against free radical absorbance measured by means of UV-Vis spectrophotometry at a wavelength of 546 nm and calcul ated IC50 values. The results shows that the fruit buni has potential as a free radical with IC50 value of 2.28 µg/mL and a comparison of quercetin with IC50 value of 5.88 µg/mL.

Efek Perbedaan Pelarut terhadap Uji Toksisitas Ekstrak Pineung Nyen Teusalee Hilka Yuliani; Maya Indra Rasyid
Jurnal Fitofarmaka Indonesia Vol 6, No 2 (2019): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Smoked young areca nut seed or pineung nyen teusalee is a material commonly used by the Acehnese as medicine, especially diabetes medicine. This study aims to determine the phytochemical content and toxicity level of pineung nyen teusalee extracted using ethanol and aquadest. The concentration of pineung nyen teusalee extract solution used as the toxicity test concentration was 0 mg / L, 50 mg / L, 100 mg / L, 500 mg / L, and 1000 mg / L. Qualitative methods were used in testing phytochemical compounds while the toxicity level of LC50 using probit analysis using SPSS version 16.0 software. From the results of phytochemical analysis tests (flavonoids, tannins, and saponins) positive results were obtained for ethanol extract and aquadest extract for all phytochemical test parameters. Probit analysis showed that the concentration of ethanol extract of pineung nyen teusalee had a toxic effect on 50% of the population of Artemia salina Leach larvae with LC50 values of 115.71 mg/L. While the concentration of aquadest extract of pineung nyen teusalee gave an LC50 value of 338.40 mg/L.

AKTIVITAS ANTIJAMUR EKSTRAK ETANOL DAUN KESUM (Polygonum minus Huds.) TERHADAP Microsporum canis Vica Vionita Rosalim; Syarifah Nurul Yanti Rizki Syahab Asseggaf; Diana Natalia; Mahyarudin Mahyarudin
Jurnal Fitofarmaka Indonesia Vol 6, No 2 (2019): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Dermatophytosis is a fungal infection caused by one of the superfixial mycoses, namely dermatophytes. Microsporum canis is one of the dermatophyte species that can infect hair, skin, leg and thighs. Kesum plants (Polygonum minus Huds.) are endemic plants of West Kalimantan that have many bioactive compounds from the roots to the leaves. The leaves of kesum contain secondary metabolites which can inhibit fungi growth. This research had purpose to know the antifungal activity of kesum leaves’ ethanol extracts on Microsporum canis. The kesum leaves’ extraction used maceration method with 96% ethanol as a solvent. Analysis secondary matbolites of kesum leaves’ secondary metabolites used tube test and thin layer chromatography. Antifungal activity test used Kirby-Bauer disk diffusion method with 5 extract concentration variantions i.e. 80, 40%, 20%, 10%, and 5%. Itraconazole 8 µg/disk was used as a positive control and DMSO 10% was used as a negative control. Kesum leaves’ ethanol extract was obtained saponin, flavonoid, alkaloid, therpenoid, and phenol. Ethanol extracts of kesum leaves did not create zone of inhibition against Microsporum canis. Ethanol extracts of kesum leaves didn’t have antifungal activity against Microsporum canis.

UJI TOKSISITAS EKSTRAK ETANOL TERPURIFIKASI BIJI MAHONI (Switenia mahagoni) Virsa Handayani; Ahmad Najib; Rezki Amriati Syarif; Abdullah Mahmud; La Hamidu; Aktsar Roskiana Ahmad
Jurnal Fitofarmaka Indonesia Vol 6, No 2 (2019): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Mahoni is a medical plant which have the potential as drug. The aims of this research were to analysis phytochemical content and to test the toxicity of ethanol extract of seed from Mahoni. The Phytochemicals that analyzed were total phenolic, total flavonoid and condensed tannin. Toxicity test was assessed using BSLT method. Extraction was done by maseration method using ethanol as the solvent. In BSLT method, the shrimp larvae were placed in a series of test solution of varied concentration. The value of LC50 were obtained based on calculation of shrimp larvae lethality percentage using probit analysis. LC50 values of ethanol extract were 0,95 ppm.

ANALISIS KADAR TANIN TOTAL EKSTRAK ETANOL BUNGA CENGKEH (Syzygium aromaticum L.) MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS Mamat Pratama; Raiz Razak; Vivien Sandra Rosalina
Jurnal Fitofarmaka Indonesia Vol 6, No 2 (2019): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Clove flower (Syzygium aromaticum L.) contain saponins, tannins, alkaloids, glycosides and flavonoids. The research aimed to qualitatively and quantitatively determine the existence of tannins in ethanol extract of clove flower by UV-Vis Spectrophotometry. The extraction process used was maceration using ethanol of 30% with the yield value of 4.26%. The extract obtained was measured by UV-Vis Spectrophotometer at the maximum wavelength of 649.9 nm using tanic acid as the standard. The value of the measurement result of tannin content obtained in the ethanol extract of clove flower was 300.826 mg TAE/g extract or 30.0826% b/b TAE.

Pengaruh Tempat Tumbuh dan Lama Penyulingan secara Hidrodestilasi terhadap Rendemen dan Profil Kandungan Kimia Minyak Atsiri Daun Kemangi (Ocimum canum Sims L.) Syamsu Nur; Junaedy Aryanto Baitanu; Sahibuddin A Gani
Jurnal Fitofarmaka Indonesia Vol 6, No 2 (2019): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Kemangi (Ocimum canum Sims L.) is one of the plants producing essential oils. Kemangi essential oil is taken from the stem and leaves. This study aims to determine the precentage of the yield of kemangi leaf oil and to identify the content of the chemical compounds of essential oils found in kemangi leaves based on the comparison of the place of growth and duration of distillation. Kemangi leaf samples were obtained from the Bontoala sub-district and from Tinggimoncong sub-district of South Sulawesi. The extraction method of essential oils of kemangi leaves is done by the method of distilation/hydrodestilation using three variations of distillation time, namely 6 hours, 12 hours and 18 hours. Based on the results of the study, it can be concluded that the kemangi leaf essential oil which has the highest yield is from Tinggimoncong sub-district of South Sulawesi, which is 3.325 % with distilation time for 18 hours, GC-MS identification results also show that kemangi leaves essential oil from Tinggimoncong sub-district of South Sulawesi has 93 components of chemical compounds with 5 main components, namely: 5-heptene-2-one, 6-methyl, 1,6-octadien-3-ol, 3,7-dimethyl, α-Terpeniol, 2,6-octadienal, 3,7-dimethy (E), eugenoland also has a component of minor compounds, namely: citral, lynalil acetate, eucalyptol, geraniol, verbenol, carveol, and trans-isoeugenol.

Pengembangan Mikrogranul Mukoadhesif Ekstrak Kayu Manis Dengan Kombinasi Polimer Karbopol Dan Gelatin Sri Wardatun; Erni Rustiani; Opi Damahyanti
Jurnal Fitofarmaka Indonesia Vol 7, No 1 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Senyawa bahan alam umumnya memiliki kelarutan yang rendah dan absorpsi yang lemah dalam tubuh. Pengembangan formula mikrogranul mukoadhesif dari ekstrak kayu manis dengan polimer karbopol dan gelatin bertujuan untuk meningkatkan kelarutan dan absorpsi ekstrak kayu manis dalam tubuh. Pada penelitian ini, mikrogranul mukoadhesif diformulasikan menggunakan ekstrak kayu manis dengan tiga formulasi yang berbeda yaitu penggunaan karbopol 934 P 5%: gelatin tipe B 4% (F1), karbopol 934P 5%: gelatin tipe B 5% (F2) dan karbopol 934 5%: gelatin tipe B 6% (F3). Hasil penelitian menunjukkan bahwa kombinasi karbopol 934P 5%: gelatin tipe B 5% (F2)merupakan formulasi mikrogranul mukoadhesif yang menghasilkan kadar asam sinamat paling tinggi setelah uji wash off menggunakan jaringan lambung (6,48%) dan usus tikus (55,21%). Hasil evaluasi fisik terhadap mikrogranul meliputi uji sudut diam, kadar air, laju alir granul, uji wash off, morfologi dan ukuran partikel menunjukkan bahwa mikrogranul mukoadhesif dari F2 menghasilkan kualitas granul paling baik.

Uji Aktivitas Antiplasmodium Dari Isolat Kulit Batang Kayu Tammate (Lannea coromandelica Houtt. Merr.) Secara In-Vitro Karlina Amir Tahir; Haeria Haeria; Alifia Putri Febriyanti; St. Chadijah; Nursalam Hamzah
Jurnal Fitofarmaka Indonesia Vol 7, No 1 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

One of the main causes of death and a major public health problem is malaria. Some drug resistance and the limited number of effective drugs have given the community a sense of worry. This makes the discovery of new antimalarial compounds very necessary. Based on the results of exploration of natural materials, Javanese wood is one of the plants that is efficacious as an antimicrobial and is thought to be efficacious as antiplasmodium. This study was then conducted to find hexan and ethyl acetate isolates from the Java wood fraction (Lannea coromandelica Houtt. Merr.) Which effectively inhibited the development of Plasmodium falciparum in vitro. This research is a follow-up study from previous studies in testing the fraction of Javanese bark against antioxidant activity. The procedure starts from hexan and ethyl acetate isolates with five concentrations of 10 (µg / ml), 1 (µg / ml), 0.1 (µg / ml), 0.01 (µg / ml) and 0.001 (µg / ml) 3D7 strain of Plasmodium falciparum was measured based on the average percent resistance. The results of this study indicate that etil asetat isolate have IC50 2,727 µg/ml, its mean moderate activity as antiplasmodium. While hexan isolate have IC50 >10 µg/ml its mean not have or low antiplasmodium activity.

Pengembangan Sediaan Serbuk Antidiabetes dari Kombinasi Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.) dan Ekstrak Daun Salam (Syzygium polyanthum (Wight) Walp.) Rizki Yulianti; Partomuan Simanjuntak; Anny Victor Purba
Jurnal Fitofarmaka Indonesia Vol 7, No 1 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Diabetes mellitus is a metabolic disease characterized by hyperglicemic. Mangosteen (Garcinia mangostana L.) and Salam (Syzygium polyanthum (Wight) Walp.) are plants which recognized as blood glucose controller. The study aims to determine the effectiveness of the combination of the two extract in decreasing blood sugar levels of diabetic rats. The rats divided into 6 groups: group I (normal control) without treatment, group II (negative control), group III (positive control), group IV (extract of mangosteen with dose of 400 mg), group V (extract of salam leaf with dose of 400 mg) and group VI (combination of mangosteen 200 mg and salam leaf 200 mg). Data were analyzed by One-Way Anova, followed by PostHoc Bonferroni analysis. Then the combination of the extract was formulated in powder dosage form blended with PVP, Sucralose and Lactose. The evaluation included physical test are organoleptic, water content and flowability time. The results showed that the combination of the extracts of mangosteen and salam leaf comprising half doses of eact extract could lower blood glucose levels significantly (P<0.05) with better efficacy than each single extract and the combination of extracts able to produce powder dosage form with the requirement (organoleptic, water content and flowability time).

Potensi Ekstrak Buah Buni (Antidesma bunius (L) Spreng) Sebagai Inhibitor Enzim α-Glukosidase La Hamidu; Partomuan Simanjuntak; Rizna Triana Dewi
Jurnal Fitofarmaka Indonesia Vol 7, No 1 (2020): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Diabetes mellitus is still a global health problem that continues to increase rapidly and become one of the major metabolic diseases throughout the world. This study aims to determine the potential of Buni fruit as an α-glucosidase inhibitor. α-glucosidase inhibition test is carried out on a blank solution (test solution without sample/standard), acarbose solution as a comparison standard and samples are carried out in accordance with the optimization conditions obtained. The rendemen percent of green and red buni fruit extract yields are 6.35% and 3.09%, respectively. The results of the identification of secondary metabolites using TLC showed that green and red buni fruit extract contains flavonoid, phenolic and alkaloid compounds. The results of the α-glucosidase enzyme inhibition test showed that the red buni fruit extract had the highest activity compared to green buni fruit extract with an IC50 value of 85.27 ppm.

Page 7 of 15 | Total Record : 150

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