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INDONESIA
Jurnal Fitofarmaka Indonesia
Published by Universitas Muslim Indonesia
ISSN : 23560398     EISSN : 25412329     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
Jurnal Fitofarmaka Indonesia merupakan salah satu jurnal yang dikelola oleh Laboratorium Farmakognosi-Fitomikia Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Januari 2014. Jurnal Fitofarmaka Indonesia merupakan jurnal ilmiah yang terbit secara on-line dan cetakan serta menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.
Arjuna Subject : -
Articles 150 Documents
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Kadar Fenolik Dan Flavonoid Total Dalam Ekstrak Metanol Daun Cemba (Acacia rugata (Lam.) Fawc. Rendle) Andi Amaliah Dahlia; Nur Qadri Amima; Aulya Rachma Arum; Rezki Amriati Syarif; Aktsar Roskiana Ahmad
Jurnal Fitofarmaka Indonesia Vol 9, No 1 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i1.808

Abstract

This study aims to determine and compare the phenolic and flavonoid content of methanol extract in Acacia rugata (Lam.) Fawc. Rendle leaves using UV-Vis spechtrophotometer and TLC-densitometry. The Acacia rugata (Lam.) Fawc. Rendle extracted by using maceration applied sonicator. The quantitative analysis measured by UV-Vis spectrophotometer at wavelength 430 nm. The TLC–densitometry performed at wavelength of 254 nm and quercetin was as a standard. The results showed that the phenolic total showed 0.506 gGAE/g extract and 0.879 gGAE/g extract. The flavonoid total showed 0.44 gQE/g extract and 0.73 gQE/mg extract respectively.
Efek Pemberian Ekstrak Etanol Daun Sembukan (Paederia foetida L.) Terhadap Penurunan Kadar Asam Urat Tikus Putih (Rattus norvegicus) Jantan Suwahyuni Mus; Maulita Indrisari; Fadhillah Maryam; Surida Surida
Jurnal Fitofarmaka Indonesia Vol 9, No 1 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i1.809

Abstract

Sembukan leaf is a medicinal plant that is widely used by the community, one of which is as an anti-inflammatory. This study aims to determine the effect of giving sembukan leaves (Paederia foetida L.) to decrease uric acid levels in male white rats (Rattus norvegicus). The study was carried out by testing 5 groups of white rats, namely positive control (Allopurinol 100 mg), negative control (Na.CMC suspension 0.5%), the dose of ethanol extract of sembukan leaves 10 mg/KgBB, 20 mg/KgBB, and 40 mg/KgBB. Each treatment group measured initial uric acid levels (before induction), after induction of chicken liver juice and after giving treatment or test samples using test strips. The results showed that uric acid levels in all groups decreased with the percentage decrease in uric acid levels at a dose of 10 mg/Kg BB, 20 mg/Kg BB and 40 mg/Kg BB, respectively by 13.2%, 24.5% and 54.3%. The results of the One Way Anova statistical test showed a significant difference with P value = 0.010 (α <0.05). The concentration of the extract that gave the greatest reducing effect was the extract dose of 40mg/kgBB.
Optimasi Dan Identifikasi Fitokimia Serta Uji Efek Hipoglikemik Kombinasi Ekstrak Daun Dandang Gendis (Clinacanthus nutans) Dan Ekstrak Ciplukan (Physalis angulata L.) Secara In Vitro U. Widayat; Chaidir Chaidir; Siswa Setyahadi
Jurnal Fitofarmaka Indonesia Vol 9, No 1 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i1.810

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglicemic. Dandang Gendis (Clinacanthus nutans) and Ciplukan (Physalis angulata L.) are plants which recognized as blood glucose controller. The study aims to determine the effectiveness of the combination of the two extracts in decreasing blood sugar levels in vitro. The leaves of dandang gendis and ciplukan were extracted with various solvents (hot water, cold water, 96% ethanol, 75% ethanol, 50% ethanol and 30% ethanol were used as solvents), then tested the quality of the simplicia and extract, then the phytochemical test of each extract, after that the hypoglycemic activity of each extract was tested, made several variations of the dose, then tested the antidiabetic activity of the combination extract, calculated percent protection and percent effectiveness of single extract and a combination of leaf extract of dandang gendis (Clinacanthus nutans) and ciplukan (Physalis angulata L).The results showed that inhibition of the α-amylase enzyme by extracts of Dandang Gendis, Ciplukan and their combinations included the combination of EE96% 10 mg (1:1) of 1.25 ppm; Combination of EE96% 10mg (1:2) of 6.340 ppm; Combination of EE96% 10mg (2:1) of 5.808 ppm; The combination of EE96% 10mg (2:2) was 7.115 ppm and the IC50 acarbose value was 4.23 ppm. Dandang Gendis extract, Ciplukan and their combination had α-amylase inhibitory activity which was not significantly different between the extract and the control Acarbose. Inhibition of α-amylase enzyme activity could be influenced by metabolites and total phenolic extracts of Gendis, Ciplukan and their combinations.
Efek Antihiperglikemik Infusa Daun Benalu Kersen (Dendrophthoe pentandra (L.) Miq) Pada Tikus Putih Jantan Yang Diinduksi Aloksan Fatihah Az Zahra; Subandrate Subandrate; Safyudin Safyudin; Sadakata Sinulingga
Jurnal Fitofarmaka Indonesia Vol 9, No 1 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i1.806

Abstract

Kersen parasite leaves (Dendropthoe pentandra (L.) Miq) is a type of parasite that is hemiparasite and contains active compounds, namely, flavonoids, terpenoids and tannins. This compound has benefits as an antihyperglycemic. The aim of this study is to determine the effect of lowering blood glucose levels from the infusion of Kersen parasite leaves (Dendrophthoe pentandra (L.) Miq) in white male rats induced by alloxan. This research was a laboratory experimental study with a randomized pre- and posttest one group design. The study used alloxan-induced male rats which were divided into 3 dosage groups (38 mg/kgBW, 77 mg/kgBW, and 154 mg/kgBW). In the results of the mean blood glucose levels of rats, there was a decrease in blood glucose levels on the 0th day of treatment, on the 7th day after the treatment there was an increase in blood glucose levels and on the 14th day after the treatment there was a decrease in blood glucose levels except in the dose II group and III. In this study, Kersen parasite leaf infusion had no effect on reducing blood glucose levels of alloxan-induced male white rats.
Aktivitas Fraksi Air Kulit Batang Mahoni (Swietenia macrophylla King.) Dan Studi In Silico Senyawa Kimia Penghambat Enzim α-Glukosidase Arini Khaerunnisa; Ratna Djamil; Lilik Sulastri; Partomuan Simanjuntak
Jurnal Fitofarmaka Indonesia Vol 9, No 1 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i1.807

Abstract

Inhibition of the α-glucosidase can be used as antidiabetic therapy because it can reduce postprandial blood sugar levels. The stem bark of mahogany (Swietenia macrophylla King.) have properties as inhibitors of enzyme α-glucosidase. The purpose of this study was to determine the active compound of mahogany stem bark againstα-glucosidase enzyme in vitro and in silico. 96% ethanol extract of mahogany stem bark was partitioned with n-hexane, ethyl acetate and water. Testing of inhibition of α-glucosidase enzyme work done with substrate p-nitrophenyl-α-D-glucopyranoside. The water fraction was separated on silica gel column chromatography (SiO2 : dichloromethane-methanol = 10 : 1 ~ 1 : 1 and methanol).Molecular docking using AutoDock 4.2.6 was performed to predict the binding modes of α-glucosidase enzyme with chemical compound from water subfraction of stem bark mahogany. The results showed that water fraction of stem bark mahogany have antidiabetic activity with IC50 value of 1.51 µg/mL. Fraction Fr-1 gave an inhibition of 83.61 ± 1.11 %. Fr-1 contains chemical compound catechin, evodionol and swietenitin K. In silico study showed that catechin and evodionol free energy value (ΔG) -6.98 and -6.25 Kcal/mol and inhibition constanta (Ki) 7.61 and 26.18 µM.
Formulasi Sediaan Serum Anti Aging dengan Kombinasi dari Ekstrak Buah Tomat (Lycopersicum esculentum L.) dan Ekstrak Kulit Buah Semangka (Citrullus lanatus Thunb.) Rima Apria Purwanti; Yunahara Farida; Shelly Taurhesia
Jurnal Fitofarmaka Indonesia Vol 9, No 2 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i2.864

Abstract

Aging is a problem for everyone, especially those who have entered middle age and above. Aging can be caused by various factors, namely factors that come from within the body and from outside the body. One of the extrinsic factors were sun exposure, temperature / humidity and free radicals. Skin aging is mostly caused by free radicals, one of which is sunlight radiation. This study aims to produce a serum preparation that functions as an antioxidant with a combination of tomato extract and watermelon rind. The antioxidant activity of tomato extract, watermelon rind extract and combination extract was carried out using the DPPH method, then the anti aging serum was formulated using hydroxy ethyl cellulose, glycerin, DMDM hydantoin, ethoxy diglycol and aqua DM. Evaluation of serum preparations includes physical evaluation (organoleptic examination, dispersibility, homogeneity, viscosity, irritation test), chemistry (pH), and microbiology. Data were analyzed using one way Anova, the results differed significantly when the p-value was less than 0.05 (p <0.05). The results showed that the combination extract had a better IC50 value of 59.19 ppm, tomato extract 69.89 ppm, watermelon rind extract 79.29 ppm. Combined serum preparation at F1 (T: S / 1: 1) IC50 value was 97.37 ppm, F2 (T: S / 1: 2) 80.70 ppm, F3 (T: S / 2: 1) 69.81 ppm so it is included in the category of strong antioxidants.
Aktivitas Penyembuhan Luka Infeksi Krim Kombinasi Daun Sirsak (Annona muricata L.) Dan Daun Sirih (Piper betle L.) Dengan Bakteri Staphylococcus aureus Pada Punggung Kelinci New Zealand White Secara In Vivo Indah Ana Resti; Dwi Ningsih
Jurnal Fitofarmaka Indonesia Vol 9, No 2 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i2.879

Abstract

Several types of tropical plants in Indonesia that contain anti-bacterial chemical compounds such as tannins, flavonoids and saponins, namely betel (Piper betle L.) leaves and soursop (Annona muricata L.) leaves. Objectives of the research was to determine activity of cream from soursop (Annona muricata L.) leaves ethanol extract and betel (Piper betle L.) leaves ethanol extract on the backs of rabbits infected with Staphylococcus aureus bacteria. In addition, the research conducted could also determine the stability of cream that produced and its pharmacological effects. Data analysis technique using ANOVA method, significance value did not reach 0.05. Extraction process using 70% ethanol as solvent with extraction method, namely maceration. Parameters of cream preparation were from level of storage duration for 0 days and concentration used. Then the level of cream preparation effectiveness in wounds healing could be seen from observations of wounds and pus drying time as well as edema and erythema loss. Cream preparation from combination of soursop (Annona muricata L.) leaves ethanol extract and betel (Piper betle L.) ethanol extract in formula 6 with concentration ratio of 10%: 12.5%, resulted better and faster healing rate against Staphylococcus aureus infection than other formulas. Required recovery time interval was 10 days and cream preparation had good stability.
Standarisasi Ekstrak Etanol Buah Bintaro (Cerbera odollam Gaertn.) Sebagai Obat Tradisional Rezki Amriati Syarif; Virsa Handayani; Alfirah Angraeni
Jurnal Fitofarmaka Indonesia Vol 9, No 2 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i2.592

Abstract

This research was conducted with the aim of examining the utilization of bintaro fruit extract (Cerbera odollam Gaertn.) as a traditional medicine that meets quality standards, so that the extract standardization process was carried out by determining specific and non-specific parameters.Based on the enormous potential of the Bintaro plant as a natural ingredient that can be used as traditional medicine, it is necessary to standardize the Bintaro fruit extract to determine the quality and safety of the extract raw materials used to support health. The research was conducted by determining the standardization of data on the determination of specific and non-specific parameters. The specific parameters that have been carried out include the identity of the extract, organoleptic test, the content of water soluble compounds 19.7%, the content of ethanol soluble compounds 6.96%, the content of positive extract compounds containing alkaloids, flavonoids, terpenoids, tannins and saponins. Non-specific parameters that have been carried out include drying shrinkage of 0.197%, moisture content of 2.124%, total ash content of 3.65%, acid soluble ash content of 1.3%, metal contamination of Pb and Cd 0.02 µg/g, microbial contamination of ALT bacteria. 0 colonies and 20 colonies of yeast. The results of the study met the standardization of extract quality.The data that will be obtained is expected to be additional information about the ethanolic extract of bintaro fruit (Cerbera odollam Gaertn.) that meets quality standards as traditional medicine, so as to maintain consistency and uniformity of efficacy and keep active compounds consistently measurable between treatments, and can maintain safety on consumers.
Aktivitas Iron Chelator Ekstrak Etanol Dan Fraksi Daun Putri Malu (Mimosa pudica L) Terhadap Pasien Thalasemia Menggunakan Metode Fic (Ferrous Ion Chelating) M. Wahyu Ariawan; Ana Indrayati; Supriyadi Supriyadi
Jurnal Fitofarmaka Indonesia Vol 9, No 2 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i2.838

Abstract

Thalasemia merupakan penyakit genetik yang disebabkan oleh defisiensi rantai globin α dan β yang menyusun hemoglobin. Penelitian ini bertujuan untuk mengetahui adanya kandungan senyawa mimosin dan konsentrasi optimum mimosin pada tanaman Mimosa pudica L sebagai agen pengkhelat besi pada pasien thalasemia secara in-vitro. Penelitian diawali dengan melakukan ekstraksi dan fraksinasi daun putri malu selanjutnya menguji kadar feritin menggunakan uji Ferrous Ion Chelating (FIC). Pengujian dilakukan sebanyak tiga kali. Selanjutnya dihitung kadar feritin dengan ELISA reader. Tahap akhir, yaitu mengukur kadar mimosin. Mimosin dengan konsentrasi 500 ppm memiliki aktivitas pengkhelat besi dengan persentase penurunan kadar feritin sebesar 84,48%.  Fraksi n-heksan dengan  konsentrasi  500 ppm memiliki aktivitas pengkhelat besi dengan penurunan aktivitas feritin sebesar 81,27%.
Uji Aktivitas Antibateri Ekstrak Etanol Daun Kenikir (Cosmos caudatus kunth.) Terhadap Staphylococcus aureus Maulana Tegar AdityaNugraha; Kiki Siti Fatimah; Dwi Larasati; Ferli Eko Kurniantoro
Jurnal Fitofarmaka Indonesia Vol 9, No 2 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i2.861

Abstract

Infeksi bakteri dapat terjadi pada manusia dan menyerang berbagai sistem organ pada tubuh, antara lain infeksi saluran pernapasan, infeksi kulit, infeksi saluran pencernaan, dan infeksi saluran urinarius. Bakteri penyebab infeksi kulit antara lain disebabkan oleh Staphylococcus aureus. Salah satu tanaman yang berkhasiat sebagai antibakteri yaitu daun kenikir (Cosmos caudatus Kunth.) karena mengandung senyawa aktif berupa minyak atsiri, steroid, tanin, flavonoid, dan alkaloid. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dan konsentrasi minimum ekstrak etanol daun kenikir (Cosmos caudatus Kunth.) yang menunjukkan aktivitas antibakteri terhadap Staphylococcus aureus. Jenis penelitian ini adalah penelitian eksperimental, dengan menggunakan  metode difusi sumuran dan diameter zona hambat. Konsentrasi ekstrak etanol daun kenikir yang digunakan pada penelitian ini adalah 20%, 30%, dan 40%. Uji dilakukan untuk mengamati ada tidaknya zona hambat dari ekstrak daun kenikir (Cosmos caudatus Kunth.) terhadap Staphylococcus aureus, setelah 24 jam inkubasi. Analisis yang digunakan adalah analisis deskriptif. Hasil penelitian menunjukkan ekstrak etanol daun kenikir (Cosmos caudatus Kunth.) dengan konsentrasi 20%, 30%, dan 40% dapat menghambat pertumbuhan bakteri Staphylococcus aureus dengan rerata masing-masing 14,11mm, 14,86mm, dan 16,05mm dari hasil peneltian konsentrasi 40% esktrak etanol daun kenikir memiliki aktivitas terbaik dalam penghambatan pertumbuhan bakteri Staphylococcus aureus

Page 11 of 15 | Total Record : 150

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