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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 459 Documents
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Pharmacological activities of pyrazolone derivatives Parajuli, Rishi Ram; Pokhrel, Priyanka; Tiwari, Amish Kumar; Banerjee, Janmajoy
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
Publisher : Creative Pharma Assent

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Abstract

Pyrazoline is a five member heterocyclic ring which is a versatile lead compound for designing potent bioactive agents. The review of the literature shows that the pyrazoline derivatives are quite stable and has inspired the chemists to synthesize the new pyrazoline derivatives. The past studies of pyrazoline derivative revealed that they are useful in pharmaceutical and agrochemical research. Pyrazoline derivatives display various pharmacological activities such as antitumor, antitubercular, antimicrobial, antibacterial, anti-inflammatory and antioxidant etc. and the pharmacological activities of different synthesized compound are reviewed in the present article.
Development of reverse phase high performance liquid chromatographic method and method validation of paracetamol by using economical single mobile phase Saha, S.; Dey, B. K.; Chakrabotry, S.; Choudhury, T.
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
Publisher : Creative Pharma Assent

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Abstract

The computerization of method development and validation are useful in analysis of pharmaceuticals in pharmaceutical industry. In this article a simple, sensitive, and precise high performance liquid chromatographic (HPLC) method for the analysis of Paracetamol with ultraviolet detection at 257 nm has been developed, validated, and used for the determination of compounds in commercial pharmaceutical products. Paracetamol tablet dosage form (two brands) was purchased from market and was from Glaxo Smith Kline (Calpol) and from IPCA (Pacimol) respectively. The compounds were well separated on a Hypersil ODS C18 reversed-phase column by use of a mobile phase consisting of methanol and water (90:10v/v at a flow rate of 1.0 ml.min). The linearity ranges were 20- 100µg/ ml for Paracetamol. Limits of detection (LOD) obtained 3.298g/ml limit of quantitation (LOQ) were 9.875g/ml Paracetamol. The study showed that reversed-phase liquid chromatography is sensitive and selective for the determination of Paracetamol using single mobile phase.
Pharmacognostical and preliminary phytochemical screening of the corm of Stephania hernandifolia (Willd.) Walp. Sharma, U.; Nandi, R. P.
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
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Abstract

The aim of the study is to cover the pharmacognostical and preliminary phytochemical screening of the corm of Stephania hernandifolia (Willd.) Walp. Stephania hernandifolia (Willd.) Walp. belonging to the family Menispermaceae is a natural taxon. The plant was collected from the Darjeeling district of West Bengal, India, during summer and was authenticated by the botanist. Pharmacognostical study included macroscopical characters, microscopical characters, physico-chemical constants and fluorescence analysis. Preliminary phytochemical screening includes phytochemical extraction, phytochemical testing and thin layer chromatography (TLC). In macroscopical studies of the corm, it was found that, it’s shape was spherical, size was about 8 to 20 cm in length and 10 to 20 cm broad, colour was brown (Rusty), surface was rough, odour was not specific, taste was bitter, direction of growth was vertical, the surface has many circular and slightly raised spots. In microscopical studies of corm, it were found that it has periderm, vascular bundles, thin phelloderm cells, ground parenchymatous cells, dense masses of starch grains and wide circular secretory cavities were seen. In powder microscopy, sclereids and vessel elements have been observed with short sclerenchyma. Physico-chemical parameters like total ash value (13 % w/w), acid insoluble ash value (2.66 %w/w), water-soluble ash value (2.50 %w/w) and sulphated ash value (3.33 %w/w) were observed. Alcohol soluble extractive value (7.23 %w/w), water-soluble extractive value (10.84 %w/w) were also observed and loss on drying was observed as 2.50 %w/w. The foaming index was found to be 111.11. Preliminary phytochemical studies show the presence of alkaloids, carbohydrates, Steroids, Saponin, tannin and phenolic compounds flavanoids, and lignin in ethanolic extract and carbohydrates, Saponin, tannin and phenolic compounds flavanoids, and lignin in aqueous extract. Performing TLC of ethanolic extract using chloroform: ethanol (30:70) and methanol: water (70: 30) as solvent system, few spots were identified. The study helps in the correct identification of the plant. The presence of alkaloids and flavanoids explains that the plant must have valuable medicinal properties which must be explored.
Novel 1, 1-dimethyl-3-phenyl-3-(5-phenyl-1, 3, 4- thiadiazol-2-yl) urea derivative has potential antiproliferative activity against human leukemia cell lines - K562 Ahirwar, Khemkaran; Jain, Sanmati K.; Tamrakar, Bholenath
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
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Abstract

Cancer is thought to be caused by the interaction between genetic susceptibility and environmental toxins. Based on the DNA changes in cells, proliferating cycle of tumor cells can be divided into 4 phases. Pre-synthetic phase (Gap 1 phase or G1 phase). Cells chiefly make preparations for the synthesis of DNA. Synthetic phase (S phase). Cells are synthesizing their DNA. Post-synthetic phase (Gap 2 phases or G2 phase). DNA duplication has been finished and they are equally divided to the two of future sub-cells. Mitosis phase (M Phase). Each cell is divided into two sub-cells. Some of these new cells enter the new proliferating cycle, the others become non-proliferating cells. G0 phase cells have proliferation ability but do not divide temporally. When proliferating cells are suffered heavy casualties, G0 phase cells will get into proliferating cycle and become the reasons of tumor recurrence.G0 phase cells are usually not sensitive to antineoplastic drugs, which is the important obstacle to tumor.chemotherapy. The antiproliferative activities of these compounds wee evaluated against a Cytotoxicity analysis of compounds against leukemia cell line -K562 organism homo sapiens(human) organ bone – marrow, tissue - lymphoblast, disease – chronic myelogenous leukemia(CML) one human tumor cell lines(K562) by applying the MTT colorimetric assay. The 1, 3-disubstituted urea derivatives show good antiproliferative activity against human cancer cell lines (K562). The hydroxyl groups on the phenyl ring reduced the antiproliferative activities.
Formulation design and in vitro evaluation of metformin hydrochloride transdermal film using hydrophilic polymer Sinha, Neman; Gupta, Suchita; Choudhury, Ananta
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
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Abstract

The purpose of the experimental study was to design a sustained release film formulation of metformin hydrochloride. In this study a transdermal film has been prepared by incorporating hydrophilic polymers like HPMC and PVA in combination of different ratios. The prepared film were subjected for different evaluation parameters like swelling index study, surface pH, drug content analysis, thickness of film, folding endurance study, drug release study. Results of evaluation of all the film was found satisfactory. Again further study needs to be conducted to stabilize the formulations
Design and evaluation of floating microspheres of amoxicillin trihydrate by ionotropic gelation method Chakrabotry, S.; Dey, B. K.; Saha, S.; Kar, A.; Saha, B.
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
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Abstract

The purpose of this investigation was to design and develop floating microspheres of Amoxicillin Trihydrate by ionotropic gelation method with combination of two polymers and to get the best possible formulation out of that with the various aspects. Floating drug delivery system have a bulk density less than gastric fluids and so remains buoyant in the stomach without affecting gastric emptying rate for a prolonged period of time. The floating microspheres were prepared using Ethyl cellulose and Hydroxy propylmethyl cellulose K4M as polymer to achieve an extended retention in upper GIT and there by improved bioavailability. The microspheres were evaluated for particle size analysis, Drug Entrapment Efficiency, Drug Loading Capacity, Floating efficiency, Swelling Study, Loose Surface Crystal Study , drug entrapment efficiency, drug- polymer compatibility study, Micromeritic properties like Bulk Density, Tapped Density, Carr’s Index, and Hausner’s Ratio, In-vitro release studies and surface morphology characterized by Scanning electron microscopy (SEM). The Microspheres have an average size range of 743.00±7.000 to 837.00±8.544μm. The entrapment efficiency was found to be in the range of 66.96±1.944 to 82.03±0.657 %. The In-vitro release studies of the drug from the best formulation F6 exhibited a sustained release of 93.46±0.684 % as studied over 10hrs. Release was best explained by zero-order kinetics model and it shows that the drug release follows diffusion mechanism. FT-IR data revealed that, compatible and there was no interaction between the drug and excipients added in the formulation. The data obtained in this study thus suggest that a floating microspheres of Amoxicillin Trihydrate are promising for sustained drug delivery which can reduce dosing frequency.
Investigation of novel penetration enhancer Lawsonia inermis for drug delivery through nail plate Singh, Vikram; Gupta, R. D.; Teotia, U. V. S
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
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Abstract

Nail fungus infections may be very painful and can seriously harm through systemic circulation if untreated. In this study we try to find out and formulate the natural penetration enhancer(PEs). Lawsonia Inermis leafs were used as a penetration enhancer. To extract the penetration enhancer extraction was done with methanol and dried, which shows hundred percent penetrations across the nail plate. Human cadaver nail plate (dry weight 45.8 mg, thickness 220 µm) defatted with chloroform: methanol (2:1) was used for penetration study. Diffusion study with the help of franz diffusion cell with phosphate buffer saline. The transungual film F32 evaluated for the physical properties – %Drug Content 97.1±0.03, Weight variation 180±2.10, Thickness 0.21±0.01, Flatness 99%, Folding endurance 180±3, WVTR 3.143±0.436, %Moisture content3.823±0.23. The drug moved across the nail plate in near to first order manner and support by the pepass “n” value i.e. 0.87. The formulation with the Lawsonia Inermis’s extract penetrates the 2.09% more drug through nail plate. The present study can claim that the Lawsonia Inermis as a potent penetration enhancer for transungual delivery for which the penetration is a limiting factor.
Effect of solubilization technique on dissolution Das, Sujoy; Bahadur, Sanjib; Choudhury, Ananta; Saha, Suman
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
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Abstract

More than 40 percent of newly discovered drugs have little or no water solubility thus the present research aimed at the study of improvement of solublisation on dissolution by addition of different solublising agents and modification of methods. Irbesartan is the drug of choice. Effect of Solubility on dissolution was studied with some solubilizing agents like β-Cyclodextrins, PEG-6000, Polysorbate-80, Cremophore and Resins (Doshion). It was seen that Irbesartan give 90 percent release in 1hr with polysorbate-80 where cremophore containing tablets showed 97 % release in 1 hr in case of solid dispersion technique and in case of complexation technique respectively. Thus the present study concluded that, dissolution rate of poorly soluble drug can be increases by using solubilizing agent as well as using different techniques
Curcumin: a review Chauhan, Monika; Saha, Suman; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
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Abstract

The main objective of this review article is to overcome or to improve the problems related with curcumin with the help of new technologies or modifications to make a promising therapeutic agent which gives a good therapeutic response. Curcumin, a known natural polyphenolic compound obtained from dietary spice turmeric, possesses pharmacologic effects including anti-inflammatory, antioxidant, and many other activities. Clinical trials on curcumin have shown its safety and efficacy even at high doses in humans. But inspite of that it shows poor bioavailability (oral bioavailability) which is one of the major problems regarding curcumin. There are other reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. To improve the bioavailability of curcumin, numbers of approaches have been undertaken. These approaches involve, first, the use of adjuvant like piperine that interferes with glucuronidation; second, the use of liposomal curcumin; third, curcumin nanoparticles; fourth, the use of curcumin phospholipids complex; and fifth, the use of structural analogues of curcumin.
Antihyperlipidemic potential of herbals Yadav, Swati; Satapathy, Trilochan; Roy, Amit; Prasad, Pushpa
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
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Abstract

One of the most widespread diseases in the world is Coronary Heart Disease (CHD). It is also one of the most preventable. This review explores the management of CHD through changes in dietary modifications, lifestyle, and the use of dietary supplements and botanicals

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