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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 459 Documents
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Water-in-oil-in-water multiple emulsions of ibuprofen for paediatrics using african walnut seed oil Ogundipe, Omotola Deborah; Oladimeji, Francis Abiodun
Journal of Applied Pharmaceutical Research Vol 7 No 1 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (582.139 KB) | DOI: 10.18231/2348-0335.2018.0014

Abstract

Multiple emulsions (MEs) have been used to prolong drug release from formulations. Hence, this study formulated water-in-oil-in-water (w/o/w) MEs of ibuprofen using African walnut seed oil (AWSO) for paediatrics use. The MEs were prepared by a two-step emulsification method, using Span 80® and Tween 80® as primary and secondary emulsifiers, respectively. The physical properties, drug entrapment efficiency, stability and drug release profile of the MEs were determined. From the study, stable MEs of ibuprofen (100 mg / 5 ml) can be prepared with 25 % w/v Span 80® as the primary emulsifier, and 8, 10 or 12 % w/v Tween 80® as the secondary emulsifier. The optimum ratios of oil to water in the primary emulsion were 1:1 and 3:2, while that of primary emulsion to external aqueous phase were 1:1 and 1:2. The release of ibuprofen from the MEs was ? 35.6 % at 5 hours. The study offers ibuprofen emulsions which may require once daily dosing compared to other available paediatric dosage forms of the drug which require three to four times dosing daily. It also provides information on AWSO as a possible drug carrier in the formulation of w/o/w MEs of ibuprofen for paediatrics.
A review of wound healing activity on different wound models Verma, Renuka; Gupta, Pushpa Prasad; Satapathy, Trilochan; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 7 No 1 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.187 KB) | DOI: 10.18231/2348-0335.2018.0013

Abstract

Wound is an injury of living tissue or break in the epithelial integrity of the upper layer of skin.which may lead to disturbance of skin anatomical structure and their function. The normal wounds are starts to healing immediately after an injury. Healing process are involved a series of coordinated events (inflammatory response, proliferation, maturation phase).  Wound healing remains a challenging clinical problem therefore correct and efficient wound management is essential. The screening models are important biological tools to understand basic process of tissue repair and treatment of wounds. Wide varieties of in-vitro, ex-vivo and in-vivo models have been developed for evaluation of wound healing activity. The in-vitro models includes Chick chorioallantoic membrane assay, Fibroblast assay, Collagen assay, Scratch assay, Endothelial cell in vitro tube formation assay, Keratinocytes assay. ex-vivo models includes organotypic culture, human ex vivo skin culture, porcine model, Human organotypic skin explanted culture And the  in-vivo models includes Excision wound model, Incision wound Model, Burn wound model, Dead space wound model, Skin wound induction.the aim of this review is detailed study on different types of in-vitro, ex-vivo and in-vivo models for evaluation of wound healing activity.
INVESTIGATION OF OXIDATIVE POTENTIAL OF MAHASUDARSHAN CHURNA USING GOAT LIVER AS IN-VITRO EXPERIMENTAL MODEL Pandit, Bibhas; Satapathy, Trilochan; Bahadur, Sanjib; Dewangan, Jyoti
Journal of Applied Pharmaceutical Research Vol 7 No 2 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2019.002

Abstract

The American Medical Research Community sounded a heavy metal warning against some herbo-mineral Ayurvedic formulations from Indian System of Medicine sold in United States of America. The products were rejected by Unites States Food and Drug Administration due to the presence of high level of lead, mercury and arsenic as impurities, marked as toxicity inducers. This work has been design to investigate whether the toxicity produced by Mahasudarshan churna is due to the results of lipid peroxidation, as oxidative degradation of phospholipids is one of the causes of drug-induced toxicity. The level of malondialdehyde, reduced glutathione and nitric oxide were estimated in control, drug-treated, drug-antioxidant treated and only antioxidant-treated group at two hours and six hours of incubation time in goat liver homogenates. Ascorbic acid was used to compare the oxidative potentials of Mahasudarshan churna. The level of malondialdehyde was found to be decreased in the drug-treated, drug-antioxidant treated and only antioxidant treated group where as the level of reduced glutathione and nitric oxide increased when compared to control. Above all the Drug-antioxidant treated group showed maximum anti-oxidant properties when compared to other groups. The study was designed to investigate the lipid peroxidation induction capacity of Mahasudarshan churna as consequences of its toxicity and found that lipid peroxidation is not the contributing factor.
MICROSPHERE: A PROMISING APPROACH FOR DRUG DELIVERY Choudhury, Ananta; Deka, Debasish; Sonowal, Kashmiri; Laskar, Rahela Eyachmin
Journal of Applied Pharmaceutical Research Vol 7 No 2 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2019.001

Abstract

The recent evolution in new drug delivery systems plays a important role in pharmaceutical industries. There are various controlled release products, Microsphere is one among all due to the sustained release and controlled release properties.Microsphere are small spherical shape characteristically free flowing powders, with diameters typically ranging from 1 ?m to 1000 ?m (1 mm). Microspheres can be produced using several natural and synthetic polymeric materials. Depending on the method, solid or porous microspheres can be obtained for specific intended applications. The variety of methods for the production of microspheres offers numerous opportunities to control the aspects of administration of the API.  It provides the prolonged therapeutic action and reduce the dosing frequency, which improve the patient compliance. To get the desired effect the drug should deliver at the target tissue in an ideal amount in the right period of time with maximum therapeutic effect and minimum side effect. Now a day?s microspheres have been used to deliver drugs, vaccines etc. The article is mainly focus on the various aspect of microspheres drug delivery system along with their method of preparation, technique to evaluate its efficiency and pharmaceutical application of microspheres.
FORMULATION, OPTIMIZATION AND EVALUATION OF QUICK DISPERSIBLE TABLETS OF SUMATRIPTAN Baghel, Pragya; Roy, Amit; Chandrakar, Shashikant; Bahadur, Sanjib; Bhairam, Monika
Journal of Applied Pharmaceutical Research Vol 7 No 3 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2019.004

Abstract

The main objective of this study was to prepare Quick Dispersible Tablets of drug Sumatriptan Succinate, which can rapidly disintegrate in the saliva using three different Superdisintegrants that is, Sodium Starch Glycolate, Crospovidone, and Croscarmallose Sodium with Taste Masking Polymer Beta-Cyclodextrin and Aspartame as a Sweetener. The taste masking of the drug was done by mixing it with the polymer beta-cyclodextrin using Solvent Evaporation method and then mixing optimized quantity of aspartame to it. The Quick Dispersible tablets were prepared by Direct Compression Technique using taste masked drug and other formulation excipients. The effect of various Superdisintegrants in three different concentrations has been studied. The prepared tablets were evaluated for wetting time, In-vitro Disintegration time, strength, and in-vitro Dissolution time. As per the results obtained, it was found that the formulation batch no. 4 was found to be the best formulation, as the data?s obtained by it was found to be in the required range of mouth dissolving tablets.
FLOATING DRUG DELIVERY SYSTEM: AN OUTLOOK Dey, Biplab Kumar; Choudhury, Ananta; Renthlei, Lalmalsawmi; Dewan, Manjima; Ahmed, Raju; Barakoti, Himal
Journal of Applied Pharmaceutical Research Vol 7 No 3 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2019.003

Abstract

Floating drug delivery is considered as the most effective amongst the several approaches of gastro retentive drug delivery systems. The short gastric residence times (GRT) and unpredictable gastric emptying times (GET) are the two most important parameters that play a vital role in improving the bioavailability of drugs those are having an absorption window at the stomach. The floating drug delivery approach is a low-density system that may be effervescent or Non-Effervescent type with sufficient buoyancy to flow over the gastric contents and remain buoyant in the stomach without affecting the stomachic emptying rate for a prolonged duration. Floating dosage forms include tablets, granules, capsules, microspheres, microparticle, etc. are few formulations available commercially. A comprehensive summary of different floating drug delivery and its present status has been highlighted in this review.
Formulation and evaluation of transdermal delivery system of an anti-hypertensive drug Goswami, D. S.; Uppal, N.
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
Publisher : Creative Pharma Assent

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Abstract

The present study was aims to formulate and evaluate transdermal drug delivery for sustained release of an anti-hypertensive drug Captopril, it is considered as drug of choice in anti hypertensive therapy and is reported for potential administration through transdermal route. The investigation was carried out to study the effect of different proportion of ethyl cellulose and PVP a hydrophobic and hydrophilic polymer respectively. Transdermal patches were prepared using different combination of the two polymers by solvent evaporation technique. Polyvinyl alcohol was used to prepare the backing membrane and dibutyl phthalate as a plasticizer. Several Physicochemical parameter like moisture content, moisture loss, thickness, film folding endurance, tensile strength, flatness were studied. For all the formulations, in vitro drug release was studied using modified diffusion cell. Formulations with highest proportion of polyvinyl pyrolidone shows faster release whereas increasing proportion of ethyl cellulose produces a prolonged regimen of sustained drug delivery through transdermal route for a period of 24 hrs.
Preparation and characterization of mucoadhesive tablets of amoxicillin using natural and synthetic polymers Goswami, Dhruba; Sharma, M.
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
Publisher : Creative Pharma Assent

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Abstract

Purpose of this research was to study mucoadhesive tablets of Amoxicillin trihydrate using Neem gum as mucoadhesive natural polymer. The conventional oral dosage form of this drug has low half life and high dosing frequency. Plant gums and mucilages are being used due to their abundance in nature, safety and economy. So in The present investigation was an effort to study the suitability of gum obtained from Azadirachta indica as mucoadhesive polymer. The present study aims to reduce the dosing frequency by using single and combinations of synthetic and natural polymers for preparation of mucoadhesive tablets. Various approaches to combine synthetic (HPMC K4M, carbopol 934P and sodium alginate) and natural (neem gum) polymers have been made to prepare total ten formulations. Further, different evaluation studies like friability, content uniformity, surface pH, wash-off and dissolution tests was done for all formulations. Results for in vitro drug release and wash-off studies suggest that the formulation (F1) containing neem gum has shown better mucoadhesive property. Other studies have shown satisfactory results in all ten formulations. Thus, the present investigation suggests that neem gum is suitable for preparation of mucoadhesive tablets
Standardization of herbal medicines – an overview Bhairam, Monika; Roy, Amit; Bahadur, Sanjib; Banafar, Alisha; Turkane, Dhanushram
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.877 KB)

Abstract

In the few decades, there has been exponentional growth in the field of herbal medicines. Most of the traditional systems of medicine are effective due to lack of standardization. So there is a need to develop a standardization technique. Standardization of herbal formulation is essential in order to assess the quality, purity, safety and efficacy of the drug. There is increasing awareness and general acceptability of the use herbal drugs in today’s medical practice. The world population depends on herbal medicines and product for healthy living. This rise in the use of herbal product has also given rise to various forms of adulteration of the products, which leading to consumers’ and manufacturers’ disappointment and in some instances fatal consequences. The challenge is innumerable and enormous, to fulfill the need of global herbal market. The standardization of this formulations like the organoleptic characters, physical properties, the various physic-chemical properties such as moisture content, ash values, extractive values need to be carried out along with Thin layer chromatography and heavy metal content study should also carried out to ascertain the quality, purity and safety of this herbal formulation.
Phyto-pharmacological review of Portulaca quadrifida Linn. Das, Mrinmay; D., Ashok Kumar
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
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Abstract

Portulaca quadrifida Linn. (Family: Portuleacea), commonly known as “Chicken Weed”, a traditional medicinal plant has been used in the Ayurvedic system of medicine for centuries, valued for its benefits in the management of urinary and inflammatory disorders. The juice of leaves is applied to abscesses and decoction is given in dysentery. The decoction of the plant can act as anthelminthic and used in the treatment of stomach complaints and gonorrhoea. Portulaca quadrifida has been reported to possess antifungal activity. The effect of ethanolic extract of Portulaca quadrifida on central and peripheral nervous system were studied by using spontaneous motor activity, in vivo muscle relaxant activity (Grip strength) and anticonvulsant activity and it is also found to have good effect on central nervous system. In this review, we have explored the Phyto-pharmacological properties of the Portulaca quadrifida plant and compiled its vast pharmacological applications to comprehend and synthesize the subject of its potential image of multipurpose medicinal agents.

Page 10 of 46 | Total Record : 459

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