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Journal of Applied Pharmaceutical Research
Published by Creative Pharma Assent
ISSN : -     EISSN : 23480335     DOI : 10.18231
Core Subject : Health,
Medicine & Pharmacology
Journal of Applied Pharmaceutical Research (JOAPR) is an official publication of Creative Pharma Assent (CPA). It is an open access, peer review online international journal. JOAPR is primarily focused on multiple discipline of pharmaceutical sciences (Pharmaceutics, Pharmaceutical Technology, Biopharmaceutics, Cosmetic Technology, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Herbal drugs/ formulations, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest) which publish quarterly. JOAPR also includes evaluation of pharmaceutical excipients & their practical application to research & industry based efforts. The aim of the scientific journal, JOAPR is to present a wide area for the current researchers to share their noble works and ideas in terms of the research papers, review articles and short communications. JOAPR only publish the original research works with a definite innovation and novelty after thorough reviewing. The paper must have a suitable and proper scientific background.
Arjuna Subject : -
Articles 459 Documents
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Statistical optimization of compression coated ketoprofen tablet using amylose/ethyl cellulose mixture for colonic delivery Devi, Nirmala; Sharma, Manju
Journal of Applied Pharmaceutical Research Vol 3 No 1 (2015)
Publisher : Creative Pharma Assent

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Abstract

In the present study the effect of two independent factors (amount of ethyl cellulose in coating layer and coating level) on ketoprofen release from compression coated tablet in order to optimize coated tablet for colonic delivery. 3 2 factorial design was used for designing coated formulation. Amount of ethyl cellulose (X1) and coating level (X2) were selected as independent variables. The studied responses were drug release at 5 hr (Y1) and drug release at 10 hr (Y2). The core tablets were compression coated with different ratio of amylose and ethylcellulose. In vitro drug release study was carried out in pH1.2 for 2 hr, pH 7.4 for 3 hr and goat caecal medium for 5 hr. Drug release revealed that amount of ethyl cellulose and coating level have antagonistic effect on drug release. Multiple regression analysis was used for generation of polynomial equation and optimization of formulation. The optimized formulation consisted of ethyl cellulose (14.33 %) and coating level (318 mg) provided a release profile that is closed to estimated values. The model is found to be accurate and robust for optimization of compression-coated tablet for colonic delivery of ketoprofen.
Preparation and characterization of mucoadhesive tablets of amoxicillin using natural and synthetic polymers Goswami, D. S.; Sharma, M.
Journal of Applied Pharmaceutical Research Vol 1 No 1 (2013)
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Abstract

Purpose of this research was to study mucoadhesive tablets of Amoxicillin trihydrate using Neem gum as mucoadhesive natural polymer. The conventional oral dosage form of this drug has low half life and high dosing frequency. Plant gums and mucilages are being used due to their abundance in nature, safety and economy. So in The present investigation was an effort to study the suitability of gum obtained from Azadirachta indica as mucoadhesive polymer. The present study aims to reduce the dosing frequency by using single and combinations of synthetic and natural polymers for preparation of mucoadhesive tablets. Various approaches to combine synthetic (HPMC K4M, carbopol 934P and sodium alginate) and natural (neem gum) polymers have been made to prepare total ten formulations. Further, different evaluation studies like friability, content uniformity, surface pH, wash-off and dissolution tests was done for all formulations. Results for in vitro drug release and wash-off studies suggest that the formulation (F1) containing neem gum has shown better mucoadhesive property. Other studies have shown satisfactory results in all ten formulations. Thus, the present investigation suggests that neem gum is suitable for preparation of mucoadhesive tablets
Pharmacognostic Evaluation and Physico-chemical Analysis of Ulmus wallichiana Planch. Bora, Kundan Singh; ., Akhilesh
Journal of Applied Pharmaceutical Research Vol 4 No 3 (2016)
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Abstract

The plant Ulmus wallichiana Planch. (Family: Ulmaceae) is found in Himalayan regions from Afghanistan to West Nepal. In India, it is found in Kumaun and Garhwal hills of Uttarakhand (India), locally known as Chamarmou. Bark of U. wallichiana is commonly used as Kumauni and Garhwali traditional healers for bone fracture of animals as well as human being. The current work was designed to establish the pharmacognostic parameters like macroscopic & microscopic characters, and physico-chemical analysis for U. wallichiana. WHO recommended methods and other standard procedures were employed for the establishment of pharmacognostic and physico-chemical parameters. Transverse section (TS) of the bark under the microscope showed periderm region showing cortex, mucilage canal, cork, phellogen and phelloderm. TS of the bark also showed secondary phloem region, medullary rays, stone cells and fibres. Longitudinal section showed medullary region, epidermal region and mucilage canal. Powder microscopy under the microscope showed calcium oxalate crystals, cork cells, phloem fibre, starch grains, stone cells and lignified phloem fibres. Physico-chemical analysis helps to identify pure plant material and detect adulteration. In the present study, total ash, water soluble ash, acid insoluble ash, sulphated ash and loss on drying were estimated to be 17%, 15%, 3.5%, 5%, 0.15% respectively. The findings of the present study could be useful in authentication of plant material and also in monograph preparation of U. wallichiana.
Preparation and evaluation of herbal cream Dubey, Aditi; Roy, Amit; Prasad, Pushpa
Journal of Applied Pharmaceutical Research Vol 2 No 2 (2014)
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Abstract

A herbal fairness cream was formulated using herbal extracts which have potential antioxidant activity. Creams were basically formulated using the hydro alcoholic extracts of Glycyrrhiza glabra (root and Stolons),Camellia sinensis (leaf), Pleurotus osttreatus (mushroom plant). The prepared formulation were subjected to different evaluation like spreadability, pH, appearance, viscosity, drug content, irritability and antioxidant properties. The prepared formulation was found stable and effective. Among the several combination Liquorice & Green Tea based preparation shows better results. From the results it was concluded that it is possible to develop creams containing herbal extracts having potent antioxidant and fairness property and can be used as the provision of a barrier to protect skin.   
Formulation and evaluation of colon targeted dosage form of prednisolone tablet using sterculia gum Raghuvanshi, Neha Singh; Goswami, Laxmi; Kothiyal, Preeti
Journal of Applied Pharmaceutical Research Vol 2 No 3 (2014)
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Abstract

Matrix tablets of Prednisolone were prepared by wet granulation method using various proportions of Sterculia gum with Carbopol 934P and Sterculia gum with Ethyl cellulose at 1:1, 1: .5 and 1:2 ratio. Coating was carried out by using 1:1 ratio of Eudragit L100 and Eudragit S100. All the preparation were evaluated for Pre compressional properties, Post compressional properties and in-vitro Dissolution study in different pH buffer of 0.1N HCL ,pH 7.4 , pH 6.8 in order to mimic GIT condition. Formulation shows good results with good percentage yield.
Recent advancement in daignosis of gastrointestinal diseases Saraswat, Pranit; Khare, Pragati; Tiwari, Ritesh Kumar
Journal of Applied Pharmaceutical Research Vol 3 No 4 (2015)
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Abstract

Gastrointestinal diseases refer to ulcerative disorders of the upper gastrointestinal tract. Stomach acids and some enzymes can damage the lining of the G.I. tract if natural protective factors are not functioning normally. Causes of gastrointestinal diseases are use of aspirin, alcohol and tobacco, poor diet (too many fried, fatty foods, sugar and refined foods), poor food combining, drinking with meals. Various diagnostic tests that can be performed for gastrointestinal diseases are Colonoscopy, ERCP, Flexible Sigmoidoscopy, Lower GI Series, Liver Biopsy, Upper GI Series, Upper Endoscopy.
Investigation of novel penetration enhancer lawsonia inermis for drug delivery through nail plate Singh, Vikram; Gupta, R. D.; Teotia, U. V. S.
Journal of Applied Pharmaceutical Research Vol 2 No 1 (2014)
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Abstract

Nail fungus infections may be very painful and can seriously harm through systemic circulation if untreated. In this study we try to find out and formulate the natural penetration enhancer(PEs). Lawsonia Inermis leafs were used as a penetration enhancer. To extract the penetration enhancer extraction was done with methanol and dried, which shows hundred percent penetrations across the nail plate. Human cadaver nail plate (dry weight 45.8 mg, thickness 220 µm) defatted with chloroform: methanol (2:1) was used for penetration study. Diffusion study with the help of franz diffusion cell with phosphate buffer saline. The transungual film F32 evaluated for the physical properties – %Drug Content 97.1±0.03, Weight variation 180±2.10, Thickness 0.21±0.01, Flatness 99%, Folding endurance 180±3, WVTR 3.143±0.436, %Moisture content3.823±0.23. The drug moved across the nail plate in near to first order manner and support by the pepass “n” value i.e. 0.87. The formulation with the Lawsonia Inermis’s extract penetrates the 2.09% more drug through nail plate. The present study can claim that the Lawsonia Inermis as a potent penetration enhancer for transungual delivery for which the penetration is a limiting factor.
Smart ungual biopenetrant from the roots of Beta vulgaris Madhav, Satheesh; Singh, Kirti
Journal of Applied Pharmaceutical Research Vol 5 No 2 (2017)
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Abstract

The main objective of the current research was to isolate biopenetrant from Beta vulgaris and formulate bioadhesive layers loaded with terbinafine using this biopenetrant for delivery through nail. Form the preparation of films, Rosa centifolia and Vitis vinifera were used as a biopolymer. Beta vulgaris was used as biopenetrant. The formulations prepared using Beta vulgaris biopenetrant were compared with formulations containing papain as standard penetrant. Four bio-adhesive films of different ratios were prepared by film casting method using each penetrant. The formulated films were evaluated for various parameters like weight, thickness, nail adhesivity, content uniformity, surface pH, folding endurance, and in-vitro drug permeation. The formulation LB4 (containing 1:4 Beta vulgaris biopenetrant) was found to be the best formulation having R2 value 0.990 with zero order as best fit model. The results obtained conclude that biopenetrants can be used as natural penetration enhancers.
Pharmacognostical, physiochemical and phytochemical evaluation of leaf, stem and root of orchid Dendrobium ochreatum Banerjee, Janmajoy; Chauhan, Neelmani; Dey, Biplab Kumar
Journal of Applied Pharmaceutical Research Vol 6 No 1 (2018)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/2348-0335.2018.0004

Abstract

The present work was aimed to carry out pharmacognosical and phytochemical evaluation of individual root, stem, and leaves of orchid “Dendrobium ochreatum.” The plant was sun dried and was grounded to fine powder using mechanical grinder followed by sieving. The fine powder was collected and subjected to different pharmacognostical studies like fluorescence analysis under uv light at different wavelength. Physiochemical parameters were also evaluated of the dried plant parts like ash values, loss on drying. Each part of plant like root, stem and leaves were separated and subjected to extraction using soxhletion using different polarity solvents i,e hexane, chloroform, ethanol in gradient elution technique. All total nine plant extracts were obtained, phytochemical screening revealed the presence of important phytoconstituents like alkaloid, glycoside, saponins etc whereas only chloroform extracts of stem exhibited the presence of steroid/phytosterol.
Effect of primary packaging on microbiological status of oral solid dosage form Khanna, Meenal; Teotia, U. V. S; Singh, Yogendra
Journal of Applied Pharmaceutical Research Vol 6 No 1 (2018)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/2348-0335.2018.0001

Abstract

The emergence of microbial contaminants in non-sterile drugs caused not only the degradation of many products, but also proved to be a potential risk to consumer health. The aim of this study was to test microbial load of non sterile solid pharmaceutical product and investigate the effects of different packaging system on microbial status of pharmaceutical product. A total of 18 sample of solid dosage form packaged in different packaging were procured from market. All samples have been tested for the presence of specific microorganisms, Total aerobic microbial counts (TAMC) and Total yeast and mold counts (TYMC) using compendial procedures. Out of 18 sample 72.22 % (n=13) had shown microbial growth and only 16 % (n=3) of samples were non-compliant. Sample containing herbal ingredients, were the most heavily contaminated, showing a bacterial load > 104 CFU/g. The result showed that all the tested samples were free from E. coli. There was no significant difference (p>0.05) in microbial load of product packaged in different primary packaging.

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