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Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya
Published by Universitas Muhammadiyah Surabaya
ISSN : 25412272     EISSN : 25489526     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Arjuna Subject : -
Articles 301 Documents
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Insomnia is not a Risk Factor for Impaired Cognitive Function in Elderly yudhiakuari sincihu; Nita Kurniawati
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 2 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (90.239 KB) | DOI: 10.30651/jqm.v2i2.1446

Abstract

Background: Elderly are often considered as a burden because of their physical limitations. Reduced cognitive function is one of the important causes for this physical limitation. Quality of sleep used to be associated with changes in cognitive function. Methods: A comparative analytic research to assess insomnia as a risk factor for the incidence of cognitive function impairment in the elderly. A case control study in elderly community at the nursing home St.Yosef, Surabaya. Result: Fifty respondents were taken by consecutive sampling and meeting the inclusion criteria. This study also excluded people with depression, schizophrenia, and users of psychotropic drugs. Eighty four percent of respondents with impaired cognitive function. Not much difference in percentage of insomnia disturbance in control group (37,5%) and case group (35,8%). Fisher's Exact Test show Sig.0,609 and OR=0.926 on CI [(0,194),(4,425)]. Conclusion: It was concluded that insomnia alone was not a risk factor for impaired cognitive modalities. Elderly exposed to sleep disorders have the same tendency to suffer cognitive impairment with unexposed.
Comparing Effectiveness of Hay Infusion and Sugar Fermentation Solution as Ovitrap's Attractans to Aedes aegypti Nastiti Widoretno
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 2 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v2i2.1232

Abstract

Dengue Hemorrhagic Fever (DHF) is still one of the major public health problems in the world and Indonesia. There are several methods of mosquito vector control, one of them is the use of ovitrap and the addition of attractants which is a compound that may attract gravid mosquitoes to lay eggs. Some examples of attractants are hay infusion and sugar fermentation solution. This research aimed to compare effectiveness of hay infusion  and sugar fermentation solution as Aedes aegypti attractants. This research type was true experimental laboratory with complete randomized design which is divided into 3 groups of ovitrap containing aquades as control, 20% hay infusion and 20% sugar fermentation solution. Ovitraps with those attractants were put into a mosquito coop containing 25 gravid female mosquitoes. Mosquito’s eggs counting was done after 2 days with 9 times repetition. The data were then analyzed using Kruskal-Wallis and Mann-Whitney test. It was found that the difference of mosquito’s eggs number in the ovitrap containing the fermentation solution of sugar and hay infusion had a significance value of 0.000 (p> 0,05). It means that hay infusion is more effective compared with sugar fermentation. Keywords                   : DHF, ovitrap, attractant, hay infusion, sugar fermentation solution
CA 125 dan Pemakaian Klinis Dalam Penatalaksanaan Kanker Ovarium Ninuk Dwi ariningtyas
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 2 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (77.71 KB) | DOI: 10.30651/jqm.v2i2.1657

Abstract

Today there are three types of ovarian cancer, namely epithelial cell tumors (70%), which are the largest part of the tumor, Germ cell tumors with a smaller frequency, and sex cord-stroma tumors which is the smallest proportion of about 8% of neoplasm. Ovarian cancer is characterized by unusual early symptoms, real symptoms at advanced stages and low survival rates. Therefore, ovarian cancer is the leading cause of death from gynecological cancer. Over the past decade, several studies have been directed at increasing outcomes of ovarian cancer by performing preclinical screening tests, determining the early stages of disease by using radiological examination or tumor marker serum. The purpose of screening for ovarian cancer is to reduce mortality by detection of stage 1 ovarian invasive epithelial cancer that is potential to be cured. Serum CA 125 measurements are often used to monitor disease status or predict residual disease. A number of cell surface antigens and serum proteins are produced by ovarian tumors and can be tested with monoclonal antibodies. Some of these tests have been clinically applied as a marker of disease and are useful in the detection of subclinical diseases and the diagnosis of recurrent ovarian cancer. Among the multiple biochemical markers in ovarian cancer, the most studied are CA 125. CA 125 is a surface glycoprotein detectable cells in more than 80% of cases of ovarian epithelial cancer. This test is clinically used in the evaluation of mass diagnostics in the ovaries, observation of response to treatment, and further evaluation of patients with ovarian cancer
Analisis Histopatologi Pembuluh Darah Tikus Berdasarkan Jarak Luka Masuk Pasca Paparan Listrik Annisa Sarfina Djunaedy; Ulfa Elfiah; Heni Fatmawati
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 2 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v2i2.1237

Abstract

Electrical injury merupakan suatu kerusakan pada jaringan atau organ tubuh akibat adanya aliran arus listrik yang melewati tubuh. Pembuluh darah merupakan salah satu jaringan yang mengalami kerusakan ketika terjadi electrical injury. Salah satu kerusakan pada pembuluh darah adalah adanya trombus yang dapat mengganggu aliran darah sehingga menyebabkan  tatalaksana electric injury menjadi kurang baik. Tujuan umum dari penelitian ini adalah menganalisis histopatologi pembuluh darah tikus berdasarkan jarak luka masuk pasca paparan listrik. Jenis penelitian yang digunakan adalah penelitian eksperimental sebenarnya dengan  rancangan post test only control group design. Penelitian ini menggunakan 25 ekor tikus wistar yang dibagi menjadi lima kelompok. Perlakuan yang diberikan berupa paparan listrik sebesar 140 V selama 17 detik. Kelompok kontrol merupakan kelompok yang tidak diberi paparan listrik, kelompok H0 diterminasi pada hari ke-0 pasca paparan listrik, kelompok  H3 diterminasi pada hari ke-3 pasca paparan listrik, kelompok H7 diterminasi pada hari ke-7 pasca paparan listrik, kelompok H10 diterminasi pada hari ke-10 pasca paparan listrik. Pada penelitian ini, hal yang diamati yaitu persentase trombus pada arteri saphena dekstra berdasaran jarak dari luka masuk. Hipotesis diterima apabila hasil analisis data menggunakan One Way Anova atau Kruskall Wallis menghasilkan p<0.05. Secara garis besar, pada hasil penelitian didapatkan bahwa bahwa persentase trombus semakin berkurang ketika semakin jauh dari luka masuk, kecuali pada kelompok H7. Selain itu, hasil penelitian  menunjukkan bahwa secara garis besar persentase trombus  bertambah  seiring berjalannya waktu dan menurun pada waktu tertentu. Namun, pada penelitian ini didapatkan bahwa tidak terdapat perbedaan yang signifikan secara statistik pada gambaran histopatologi pembuluh darah, khususnya trombus pasca paparan listrik berdasarkan jarak luka masuk di hari ke-0, ke-3, ke-7, dan ke-10.
Toksisitas Senyawa Tembaga(II)Klorida Dihidrat Terhadap Sel Kanker Payudara T74D Secara in vitro Teguh Hari Sucipto; Harsasi Setyawati; Fahimah Martak
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 2 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (90.624 KB) | DOI: 10.30651/jqm.v2i2.1433

Abstract

Cancer is a transformation of normal cells in the body into malignancy due to the induction of carcinogens. Breast cancer is the second leading cause of death in Indonesia. The field of treatment with inorganic compounds has been widely developed and shows better anticancer activity than organic compounds. This research aims to know the toxicity level of copper value of 29.021 μg/ml. The value of IC 50 obtained <100 μg/ml so that the copperCancer is a transformation of normal cells in the body into malignancy due to the induction ofcarcinogens. Breast cancer is the second leading cause of death in Indonesia. The field oftreatment with inorganic compounds has been widely developed and shows better anticanceractivity than organic compounds. This research aims to know the toxicity level ofcoppervalue of 29.021 μg/ml. The value of IC50obtained<100 μg/ml so that the copper
Triple Curve Scoliosis Presented with Developmental Dysplasia of the Left Hip in Marfan Syndrome Lukas Widhiyanto; Tri Wahyu Martanto; Febrian Brahmana
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 2 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v2i2.975

Abstract

Introduction: Marfan syndrome is an autosomal dominant disorder of connective tissue, and skeletal system involvements are the cardinal features.  Triple rigid large major curve in conjunction with developmental dysplasia of the hip in Marfan syndrome is rare then sagittal and coronal imbalance correction on this case is challengingCase Presentation: We reported a case of 12 years old female with Marfan syndrome presented triple rigid large Major curve scoliosis on left cervico-thoracal, right main  thoracal and left thorakolumbal, also developmental dysplasia of the left hip has been done correction surgery consist of open reduction following cast immobilization of the left hip, multiple ponte osteotomy and asymetrical pedicle substraction osteotomy to correct sagittal and coronal imbalance.Discussion: the treatment of scoliosis in patients with Marfan syndrome parallels that in patients with idiopathic scoliosis and spinal fusion and instrumentation should be considered for curves greater than 45 to 50 degrees. Posterior technique, Ponte osteotomy correct 10 to 20 degrees and pedicle substraction osteotomy correct 30 to 40 degrees at each segment are effective for managing sagittal and coronal imbalance in scoliosis. Open reduction developmental dysplasia of the hip to overcome complicated coronal balance correction.Conclusion : Detailed planning scoliosis surgery is needed to correct a rare the sagittal and coronal imbalance due to scoliosis complicated with developmental dysplasia of the hip in Marfan syndrome.
Ekstrak Etanol Teh Hijau (Camellia sinensis) Meningkatkan Kadar Folicle Stimulating Hormone (FSH) dan Jumlah Folikel Antral pada Tikus Betina yang Dipapar Sipermetrin Melati Puspita Sari; Sri Winarsih; Tri Yudani Mardining Raras; Karyono Mintaroem
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 2 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v2i2.1559

Abstract

Latar Belakang: Sipermetrin adalah insektisida jenis piretroid sintetik yang dapat menganggu sistem reproduksi. Sipermetrin juga mampu menghasilkan  reactive oxygene species (ROS) sehingga bertanggung jawab menimbulkan terjadinya stres oksidatif. Teh hijau (Camellia sinensis) mengandung polifenol sehingga dapat menghambat radikal hidroksil dan enzim prooksidan. Tujuan: Penelitian ini bertujuan untuk membuktikan pemberian ekstrak etanol teh hijau dapat meningkatkan kadar FSH dan jumlah folikel antral pada tikus betina yang dipapar sipermetrin. Metode: Penelitian yaitu true experimental pada 25 ekor tikus betina galur wistar (Rattus norvegicus) yang dibagi menjadi 5 kelompok; KN: tanpa perlakuan, KP: sipermetrin 20 mg/kgBB/hari, P1: sipermetrin 20 mg/kgBB/hari + ekstrak etanol teh hijau 7 mg/kgBB/hari, P2: sipermetrin 20 mg/kgBB/hari + ekstrak etanol teh hijau 14 mg/kgBB/hari, P3: sipermetrin 20 mg/kgBB/hari + ekstrak etanol teh hijau 28 mg/kgBB/hari per oral selama 28 hari. Kadar FSH diukur dengan metode ELISA dan organ ovarium diambil untuk pemeriksaan jumlah folikel antral dengan metode pewarnaan hematoxylin eosin. Hasil: Kadar FSH dan jumlah folikel antral pada tikus betina menunjukkan hubungan yang positif dan kuat dengan nilai koefisien korelasi 0,742 yang berarti peningkatan kadar FSH diikuti penambahan jumlah folikel antral. Ada perbedaan bermakna pada kadar FSH (p=0,005) dan jumlah folikel antral (p=0,001) antara kelompok kontrol dengan kelompok perlakuan. Kesimpulan: Pemberian ekstrak etanol teh hijau dapat meningkatkan kadar FSH dan jumlah folikel antral pada tikus betina yang dipapar sipermetrin.
The Effectiveness of Scaevola tacada Extract (Gaertn roxb) on the Level of Cytokine IL-10 of Strain Sprague dawly (Female Laboratory Rats) Induced by the Staphylococcus Aureus Bactera Andi Sitti Umrah
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 2 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (182.486 KB) | DOI: 10.30651/jqm.v2i2.1732

Abstract

Background: Staphylococcus aureus is a sort of bacteria causing mastitis on women, generally found after delivery and during breastfeeding. These bacteria stimulate the immune system to respond, during which Sitikon is released. IL-10 is an anti-inflmation that impedes cell damage on the body, so it is required to do a complementary therapy stemming from the extract of Scaevola Taccada extract (Gaertn Roxb), generally known as sea lettuce. This study aimed to examine the effectiveness of Scaevola Taccada extract (Gaertn Roxb) on the level of Sitokin Il-10 of Strain Strain Sprague Dawly (Female Laboratory Rat) induced by the Staphylococcus Aureus Bacteria.Methods: This true experimental study employing pre- and post-test control design used 18 Sprangue Dawley, laboratory rats, that weighed between 200-250g, and that were divided into three groups, each of which comprised of six rats. The negative control group, positive control group and expiremental group were respectively given 1ml of aqua pro injection/250grBB rats, 9.6mg/ml of antibiotic amoxicillin/250gramBB rats, and 9.6mg of antibiotic amoxicillin/250grBB + 400mg/ml of Scaevola Taccada extract (Gaertn Roxb)/kgBB rats for five days. The sea lettuce plants were taken from the district of Pinrang, South Sulawesi. All groups were induced by staphylococcus aureus 0.2 ml x108 ml/CFU. The level of IL-10 was investigated using R&D method system ELISA Rat, in which the data were analyzed using ANOVA + post hoc test formula with the significant value ρ ≤ 0.05 and CI 95%.Results: The empirical evidence showed that there was no a significant different of Sitokin IL-10 level, either before or after the induction of the bacteria staphylococcus aureus for the length of ± 24 hours of all groups (ρ > 0.05). It was also found that there was a different level of IL-10 after the treatment between all of the groups given the value ρ < 0.05. The increase of IL-10 level was higher in the experimental group (mean ± 72,8 pg/ml) compared to the positive control group (mean ± 41, pg/ml).Conclusions:  This research concluded that giving the extract of Scaevola taccada (Gaertn)Roxb) was effective in the boost of sitokin IL-10 level as an anti inflammation that plays central role in the stimulation of immune responses and the prevention of lichen imunopatologia development. The extract of sea lettuce (Scaevola taccada (Gaertn)Roxb)) can be given as a complementary therapy.
Laporan Kasus : Thymik Karsinoma dengan Efusi Perikard Mohammad Subkhan
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 1, No 02 (2017)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (119.903 KB) | DOI: 10.30651/qm.v1i02.632

Abstract

Proses Penyembuhan Luka Ditinjau dari Aspek Mekanisme Seluler dan Molekuler Nova Primadina; Achmad Basori; David S Perdanakusuma
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 3, No 1 (2019)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v3i1.2198

Abstract

ABSTRACTWound is the discontinue of the anatomical structure of the body tissue, the healing phase consists of 3 stages, they are the inflammatory phase, which is divided into early inflammation, and late inflammation that occurs from day 0 to day 5 after injury. The Proliferation phase, which includes three main processes, namely: Neoangiogenesis, fibroblast formation and re-epithelialization, occurs from day 3 to day 21 after injury. Maturation phase occurs from day 21 to 1 year after injury which aims to maximize the strength and structural integrity of new tissue fillings, epithelial growth and scar tissue formation. These three phases influence each other and many cells and cytokines play a role in each phase. The amount of research on the wound healing process to achieve satisfactory results with a shorter time than the nominal phase results in a theory of the process of wound healing that is increasingly detailed which will be explained from the aspects of cellular and molecular mechanisms.Keywords : wound healing, wound healing process, wound healing mechanism, cellular mechanism of wound healing, molecular mechanism of wound healingCorrespondence to  : novaprimadina@fk.um-surabaya.ac.id ABSTRAKLuka adalah terputusnya kontinuitas struktur anatomi jaringan tubuh, dimana fase penyembuhannya terdiri dari 3 tahap yaitu Fase Inflamasi yang dibagi menjadi early inflammation (Fase haemostasis), dan late inflammation yang terjadi sejak hari ke 0 sampai hari ke 5 pasca terluka. Fase Proliferasi, yang meliputi tiga proses utama yakni: Neoangiogenesis, pembentukan fibroblast dan re-epitelisasi, terjadi dari hari ke-3 sampai hari ke-21 pasca terluka. Fase Maturasi terjadi mulai hari ke-21 sampai 1 tahun pasca luka.yang bertujuan untuk memaksimalkan kekuatan dan integritas struktural jaringan baru pengisi luka, pertumbuhan epitel dan pembentukan jaringan parut. Ketiga fase ini saling mempengaruhi satu sama lain dan banyak sel dan sitokin yang berperan didalam setiap fase. Banyaknya penelitian tentang proses penyembuhan luka untuk mencapai hasil yang memuaskan dengan waktu yang lebih singkat dari fase nomal menghasilkan teori proses penyembuhan luka yang semakin detail yang akan dijelaskan dari aspek mekanisme seluler dan molekuler.Kata kunci  :penyembuhan luka, proses penyembuhan luka, mekanisme penyembuhan luka, mekanisme seluler penyembuhan luka, mekanisme molekuler penyembuhan lukaKorespondensi : novaprimadina@fk.um-surabaya.ac.id

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