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Smart Medical Journal

SMedJour
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Published by Universitas Sebelas Maret

ISSN : 26211408 EISSN : 26210916 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

Smart Medical Journal (SmedJour) is published by Faculty of Medicine Universitas Sebelas Maret. SMedJour publishes original research articles or article review in the basic medical sciences, clinic medical sciences, medical education and public health.

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Articles 100 Documents

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Pengaruh Usia Menarche terhadap Tinggi Badan Wanita di Daerah Endemis Gondok Muhammad Taufiq Hidayat; Selfi Handayani; Siti Munawaroh
Smart Medical Journal Vol 1, No 2 (2018): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Introduction: Height affected by various factor. One factor that can affect female’s height is menarcheal age. Sexual hormone in female’s body will be activated at menarche and it will stimulate the closure of epiphyseal plate. Final height in female with late menarche is higher than female with early menarche. While in goiter endemic areas with Iodine Deficiency Disorder especially in mountain area, it has earlier menarcheal age than normal female that live in non goiter endemic area. This study aimed to analyze the relationship between age at menarche and height endemic goiter.Methods: This study was an observational study with cross-sectional design. It was held in the goiter endemic Ngargoyoso, Karanganyar. Samples of women aged over 20 years with upright posture that live in Ngargoyoso were obtained by simple random sampling, then measuring the height using statometer and obtaining menarcheal age by questioner. Data were analyzed using Pearson correlation test (α = 0.05), which had previously been tested for normality by Kolmogorov Smirnov.Results: The mean age of menarche sample was 13.38 years with the lowest age of 11 years and the highest age of 18 years. While the average height was 156.8 cm samples with the lowest height was 139 cm and the highest was 168 cm. Pearson correlation test results showed that height was significantly associated with age at menarche woman endemic goiter (p = 0.001).Conclusions: Age of menarche associated with height in an endemic goiter area.The earlier age of menarche will affect the final height of the woman.

Faktor Risiko Kejadian Recurrent Respiratory Infection pada Anak Usia 2-5 Tahun NOPRIYAN PUJOKUSUMA; ETI PONCORINI PAMUNGKASARI; SETYO S RAHARDJO
Smart Medical Journal Vol 1, No 2 (2018): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Introduction: Acute Respiratory Infection (ARI) is the most prevalent disease with high mortality and morbidity on infant. ARI that happens more than five times annually is called Recurrent Respiratory Infection (RRI). Some mortality of ARI comes from kind of ARI that developed from diseases that could be prevented by immunization. This study aimed to find correlation between immunization status, nutritional status, crowding, smoker in house, mother education level, family income level and RRI incident on children age 2-5 years old in Sibela Primary Health Care (PHC) work area, Surakarta.Methods: This was an observational analytic study with cross-sectional approach. Sample for this study was children age 2-5 years old from Sibela PHC work area, Surakarta. Sample was taken by cluster sampling method as much as 121 children, the parent interviewed using questioner and children was measured for their height and weight. Data of immunization history was obtained from Kesehatan Ibu dan Anak (KIA) Book and PHC data information system for ARI diagnosis. Data was analyzed using chi-square and logistic regression.Result: Chi-square result shows significant correlation between incomplete immunization status and incident of RRI (p=0,000) and OR = 18,774. Logistic regression results shows significant correlation between immunization status and incident of RRI (p=0,000; OR=21,3). Conclusions: Incomplete immunization status significantly correlate to increasing RRI incident 21,3 times on children age 2-5 years old than children which acquired complete immunization status. Nutritional status, crowding, smoker in house, mother educational level, and family income level has no significant correlation with RRI incidence.

HUBUNGAN ANTARA MEROKOK dan AKTIFITAS FISIK DENGAN PREVALENSI HIPERTENSI DI INDONESIA (ANALISIS DATA RISKESDAS DAN PROFIL KESEHATAN 2013) balgis ali; Sumardiyono Sumardiyono
Smart Medical Journal Vol 2, No 1 (2019): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Introduction: Currently hypertension is a major health problem in the world, including in Indonesia. The prevalence of hypertension in various regions in Indonesia varies. several factors are thought to play a role in this variation including the health system, hypertension risk factors and the prevalence of diabetes mellitus. This study aims to analyze the relationship between the health system (health services, health personnel, finance), hypertension risk factors (smoking and physical activity) and the prevalence of diabetes mellitus with differences in the prevalence of hypertension in various provinces in Indonesia. Currently hypertension is a major health problem in the world, including in Indonesia. The prevalence of hypertension in various regions in Indonesia varies. several factors are thought to play a role in this variation including the health system, hypertension risk factors and the prevalence of diabetes mellitus. This study aims to analyze the relationship between the health system (health services, health personnel, finance), hypertension risk factors (smoking and physical activity) and the prevalence of diabetes mellitus with differences in the prevalence of hypertension in various provinces in Indonesia.Methods: This study used an observational analytic design with an ecological study approach. Data was obtained from 440 districts and 33 provinces in Indonesia. which is taken on a probability basis to size. Samples are men and women aged 18 and above. The independent variable is the prevalence of hypertension while the dependent variable is the health system (health services, health personnel, finance), hypertension risk factors (smoking and sedentary physical activity) and the prevalence of diabetes mellitus. The diagnosis of hypertension is made by a doctor. The data obtained were analyzed using multiple linear regression analysis.Results: Smoking (b = 0, 0.463; 95% CI = 0.042-0.884; p = 0.032), and sedentary physical activity of more than 6 hours (b = 0.196; 95% CI = 0.030-0.3362; p = 0.022) increased the prevalence of hypertension. R2 from the multiple liner regression model is = 27.1%, and overall the models differ significantly (p = 0.05).Conclusion: Smoking and sedentary physical activity are associated with the prevalence of hypertension

Hubungan Lingkar Pinggang dan Lingkar Panggul dengan Tekanan Darah pada Pasien Program Pengelolaan Penyakit Kronis (Prolanis) Sumardiyono Sumardiyono; Eti Poncorini Pamungkasari; Anton Giri Mahendra; Oki Saraswati Utomo; Devita Mahajana; Wakhid Ryan Cahyadi; Mila Ulfia
Smart Medical Journal Vol 1, No 1 (2018): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Introduction: Obesity is a state of excessive accumulation of fat in the body, which is a risk factor for cardiovascular disease. Obesity can be measured using anthropometric methods measuring waist circumference and hip circumference. This study aims to find the relationship between the size of waist circumference and hip circumference to blood pressure in prolanis participants in the working area of Kedawung I Public Health Center, Sragen Regency.Method: This study was an observational analytic study using a cross sectional design. The subjects were prolanis participant patient with a history of hypertension in the Kedawung I Community Health Center in Sragen in July 2017. Sampling was done by simple random sampling. The number of subject were 60 persons.Results: There were significant relationship between waist circumference and systolic/ diastolic blood pressure with weak strength (r = 0.304; p = 0.018 and r = 0.337; p = 0.008) and significant relationship between hip circumference with systolic/diastolic blood pressure with weak strength (r = 0.263; p = 0.042 and r = 0.306; p = 0.017).Conclusion: the increasing size of waist and hip circumference may increase blood pressure in prolanis participants.

Efektivitas Penggunaan Kombinasi Media Audio Visual dan Booklet dibanding Media Booklet terhadap Pengetahuan Toilet Training pada Ibu yang Memiliki Balita mayasari kurnianingsih
Smart Medical Journal Vol 2, No 1 (2019): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

ABSTRAK Toilet training perlu diperkenalkan secara dini untuk mengantisipasi reflek pengeluaran urin dan feses bayi pada waktu yang tepat. Di Indonesia, kegagalan toilet training menyebabkan 3-5% balita menderita ISK. Toilet training juga menyebabkan diaper rush, dan gangguan psikologi pada balita. Peran orang tua sangat berpengaruh terhadap keberhasilan toilet training. Tujuan penelitian ini adalah mencari media promosi kesehatan yang efektif terhadap pengetahuan toilet training pada ibu balita. Jenis penelitian ini quasi eksperimen dengan rancangan penelitian pretest and posttest with control group design. Teknik pengambilan sampel adalah simple random sampling. Jumlah sampel penelitian ini 66 orang dibagi menjadi dua kelompok, kelompok perlakuan (audio visual disertai booklet) dan kelompok kontrol (booklet). Alat ukur penelitian menggunakan kuisioner. Paired sampel t-test dan independent sampel t-test digunakan untuk menganalisis data. Terjadi peningkatan rerata pengetahuan toilet training setelah diberi perlakuan pada kelompok audio visual disertai booklet sebesar 9,68 dan p_value 0,00 serta pada kelompok kontrol booklet dengan rerata 8,85 dan p_value 0,00 (p<0,05). Selain itu, terdapat peningkatan skor rerata pengetahuan yang lebih tinggi pada kelompok audio visual disertai booklet dibandingkan dengan kelompok booklet (p=0,031). Promosi kesehatan toilet training dengan media audio visual disertai booklet lebih efektif dibandingkan dengan media booklet.

Sensitivitas Metode Pemeriksaan Mikroskopis Fluorokrom dan Ziehl-Neelsen untuk Deteksi Mycobacterium tuberculosis pada Sputum BETTY SURYAWATI; LELI SAPTAWATI; ASTARI FEBYANE PUTRI; JATU APHRIDASARI
Smart Medical Journal Vol 1, No 2 (2018): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Background: Detection of fast acid bacteria (FAB) using smear microscopy is used as a primary screening for tuberculosis diagnosis. Previous studies have shown that fluorochrome (Auroamine-rhodamine) staining showed better sensitivity compared to Ziehl-Neelsen (ZN) method in the detection of FAB in sputum. However this method has not been recommended for routine use including in Indonesia. This study aimed to evaluate the sensitivity and specificity of fluorochrome compared to ZN to detect FAB in patient’s sputum.Methods: This study analyzed 60 sputum samples from patients with tuberculosis and suspected pulmonary tuberculosis. Samples were obtained consecutively from microbiology laboratory Moewardi Hospital, Indonesia. Each sample was examined using ZN and fluorochrome staining and cultured in Lowenstein-Jensen (LJ) medium. Data were analyzed using sensitivity and spesificity tests.Results: ZN staining detected FAB in 12 samples (10%), while fluorochrome detected FAB in 17 samples (28%). The sensitivity and specificity of ZN staining were 70% and 90% while these for fluorochrome were 90% and 84%. Conclusions: The sensitivity of fluorochrome staining is better compared to ZN staining. This method can be recommended for early detection of tuberculosis.

Keefektifan Hipnoterapi Untuk Mengendalikan Nyeri Pada Pasien Yang Dilakukan Bronkoskopi Di RSUD Dr. Moewardi Surakarta feilin tanita; Teguh Budi Santosa; Debree Septiawan; Rochmaningtyas HS; Yusuf Subagio Sutanto
Smart Medical Journal Vol 2, No 1 (2019): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Pendahuluan: Bronkoskopi adalah pemeriksaan yang dilakukan secara rutin dalam pulmonologi dan dianggap tidak nyaman oleh hampir 60% pasien. Salah satu ketidaknyamanan yang dirasakan pasien saat bronkoskopi adalah nyeri. Kenyamanan pasien saat dilakukan bronkoskopi sangat penting, sebab akan mempengaruhi keberhasilan bronskoskopi. Intervensi nonfarmakologis, seperti hipnoterapi telah efektif dalam mengendalikan nyeri selama prosedur bedah dan memperpendek durasi operasi. Sehingga hipnoterapi diharapkan dapat mengendalikan nyeri pada pasien yang dilakukan bronkoskopi.Metode: Penelitian menggunakan desain experimental randomized pretest-post-test control group design. Teknik pengambilan sampel dengan consecutive sampling yang dilakukan di bangsal rawat inap RSUD Dr. Moewardi Surakarta. Diperoleh 37 subjek, 19 orang mendapat perlakuan hipnoterapi sebelum bronkoskopi dan 18 orang sebagai kontrol (tanpa hipnoterapi). Penilaian nyeri dengan menggunakan instrumen VAS (Visual Analogue Scale). Data dianalisis memakai Paired t test.Hasil: Dari 37 subjek penelitian, didapatkan skor pretest VAS kelompok perlakuan 39.47 ± 26.56 sedangkan pada kelompok kontrol 36.11 ± 26.60. Skor post test VAS pada kelompok perlakuan 28.95 ± 26.01 sedangkan pada kelompok kontrol 40.56 ± 25.08. Dari hasil analisis didapatkan perbedaan skor VAS nyeri (pre-post) antara kelompok perlakuan dan kontrol yang secara statistik bermakna dengan p= 0,006. Kesimpulan: Hipnoterapi efektif dalam mengendalikan nyeri selama bronkoskopi.Kata Kunci: Hypnotherapy; pain; bronchoscopy; VAS

Potensi Scopoletin sebagai Agonis Reseptor Transferin 2 untuk Pengembangan Terapi Anemia Defisiensi Besi Asti Swari Paramanindita; Dono Indarto; Balgis Balgis
Smart Medical Journal Vol 1, No 1 (2018): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Introduction: Iron Deficiency Anemia (IDA) is caused by imbalance between iron intake and iron loss in blood circulation. Increased hepcidin level plays an important role in the etiology of IDA. Normally, expression of hepcidin protein is controlled by three different pathways, one of them is interaction between holo Transferin (Holo-Tf) and Transferrin Receptor 2 (TfR-2). Recently, Indonesian herbal plants have widely been used as herbal medicine but there is no active compound that can activate TfR-2 for IDA therapy. The aim of this study was to explore phytochemicals derived from Indonesian herbal plants to interact with TfR-2.Methods: The study was a bioinformatics study with a molecular docking method. The SWISS-MODEL software was used to make TfR-2 protein modeling because the molecular structure of TfR-2 remains unknown. Holo-Tf was used as a standard ligand and obtained from Protein Data Bank with PDB ID 1SUV. All Indonesian phytochemicals which (1) registered at HerbalDB (2) had a three-dimensional molecular structure at PubChem (3) met Lipinski’s Rule of Five criteria were used in this study. AutoDock Vina 1.1.2 was used to analyze the binding affinity which was in kcal/mol. Phytochemical-TfR-2 binding complexes were visualized by using Chimera 1.10rc and or Pymol 1.7.Result: The docking scores of holo-Tf modification with TfR-2 were -6,4±0,1 kcal/mol at Arg466 and -3,4±0,1 kcal/mol at Arg689 respectively. Interaction of modification holo-Tf and TfR-2 was observed not only at Arg466 and Arg689 but also with Asp642 and Ile682. Docking scores of scopoletin were -7,1±0,1 kcal/mol at Arg466 and -5,4±0,1 kcal/mol at Arg689. Scopoletin could interact with TfR-2 at Arg466, Arg689, and Leu630 residues.Conclusions: Computationally, scopoletin is a potential TfR-2 agonist. In future studies, in vitro assay will be used to evaluate the agonist effect of scopoletin in TfR-2.

Efek Antihistamin Ekstrak Daun Jambu Biji (Psidium guajava) pada Tikus Putih (Rattus norvegicus) dengan Induksi Ovalbumin Wahyu Tri Kawuri; Ratih Dewi Yudhani; Novan Adi Setyawan
Smart Medical Journal Vol 2, No 1 (2019): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Pendahuluan: Data World Allergy Organization (WAO) tahun 2013 menunjukkan bahwa prevalensi alergi diperkirakan sekitar 30-40% dari populasi dunia. Reaksi alergi terjadi akibat pelepasan histamin oleh sel mast. Pengobatan alergi jangka panjang selama ini memiliki efek samping berupa ganggun kardiovaskuler, retensi urin, AGEP, dan gangguan saraf. Penelitian sebelumnya menunjukkan kuersetin mampu menghambat pelepasan histamin oleh sel mast. Pada analisis kimia, daun jambu biji mengandung kuersetin. Penelitian ini bertujuan untuk mengetahui efek antihistamin ekstrak daun jambu biji (Psidium guajava) pada tikus putih (Rattus norvegicus) yang diinduksi ovalbumin.Metode: Penelitian quasi experimental design dengan metode posttest only group design menggunakan 24 tikus yang dibagi kedalam 6 kelompok secara acak. Kelompok kontrol normal (KN) tanpa perlakuan, kontrol negatif (K-) yang hanya diinduksi ovalbumin, kontrol positif (K+) diberikan metilprednisolon, dan kelompok perlakuan (P1, P2, P3) diberikan ekstrak daun jambu biji dengan dosis, berikut 27 mg/200 gramBB, 54 mg/200 gramBB, dan 108 mg/200 gramBB. Pengamatan efek antihistamin berupa perhitungan rata-rata jumlah garuk tikus. Data dianalisis dengan menggunakan uji One-Way ANOVA dan dilanjutkan uji Post Hoc Tukey.Hasil: Hasil uji One-Way ANOVA menunjukkan perbedaan rata-rata jumlah garuk tikus antar kelompok perlakuan bermakna secara statistik (p=0,00). Berdasarkan hasil uji Tukey, kelompok K- (45,75±5,50) dibandingkan dengan kelompok KN (2,25±0,96) dan kelompok perlakuan ekstrak daun jambu biji berbagai dosis menunjukkan perbedaan rata-rata jumlah garuk tikus yang bermakna secara statistik (p=0,00). Hasil rata-rata jumlah garuk tikus pada kelompok KN (2,25±0,96) dibandingkan dengan P2 (9,00±0,82) tidak menunjukan perbedaan yang bermakna secara statistik (p=0,085).Kesimpulan: Ekstrak daun jambu biji (Psidium guajava) memiliki efek antihistamin pada tikus putih (Rattus norvegicus) yang diinduksi ovalbumin.

Korelasi Panjang Tulang Tibia Terhadap Tinggi Badan Pada Mahasiswa FK UMSU Putra Diandro Utama Ritonga; Hendra Sutysna
Smart Medical Journal Vol 1, No 1 (2018): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Introduction: Estimation of body height is one of the important parameter in the anthropology forensic, which the body height became the first action in identification. The regression formula using the tibia length, sex, and age might have valid approximation for body height which helpful in clinical context. Methods: The analytic descriptive researchwith the cross-sectional design was done on 112 subject consist of male and female satisfy inclusion and exclusion criteria. Sample was selected by total sampling technique.Results: Tibia length resulting correlation ranging between 0,488 and 0,968 (p<0,001). The linear regression formula showed Standard Error of the Estimate (SEE) ranging between 0,810 and 3,495 (p<0,001). Conclusion: A significant correlation between tibia length and body heightwas found with a strong correlation. Hence, a linear regression formula was derived for the estimation of body height from tibia length.Keywords: tibia length; body height; regression formula; anthropometry

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Contact Name
Nanang Wiyono

Contact Email
smjfkuns@gmail.com

Phone
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Journal Mail Official
smjfkuns@gmail.com

Editorial Address
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Location
Kota surakarta,

Jawa tengah

INDONESIA