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Acta Pharmaciae Indonesia : Acta Pharm Indo
Published by Universitas Jenderal Soedirman
ISSN : 23378433     EISSN : 26214520     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Journal of Acta Pharmaciae Indonesia is a journal published twice a year by Pharmacy Department, Jenderal Soedirman University, Purwokerto with the Number of ISSN 2337-8433 and E-ISSN 2621-4520. Our journal discusses various pharmaceutical fields in terms of Pharmaceutics & Pharmaceutical Technology, Pharmaceutical Biology, Pharmaceutical Chemistry, and Pharmacology & Clinical Pharmacy.
Arjuna Subject : -
Articles 137 Documents
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Hubungan Tingkat Pengetahuan Terhadap Manajemen Diri Pasien Prolanis Diabetes Mellitus Tipe 2 di Puskesmas 1 Purwokerto Timur Siti Rohimah Nurasyifa; Vitis Vini Fera RU; Hening Pratiwi
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.2.4250

Abstract

Diabetes mellitus is a disease characterized by blood glucose elevation and long-term illness that requires good self-management. Patient knowledge has important role to overcome self-management. This study aims to assess relationship between patient's knowledge level and self-management. This research used observational study with cross sectional approach. Patient knowledge level was measured by Diabetes Knowledge Questionnaire (DKQ-24) and self-management level was measured by Diabetes Self-Management Questionnaire (DSMQ). This study was held in East Purwokerto I Public Health Center and data sources were collected by accidental sampling technique. The sample used in this study was 35. The result showed that there was a correlation between patient knowledge level to self-management p = 0,000, r = 0,838 in diabetes mellitus type 2.
Perbandingan Efektivitas Sacubitril/Valsartan dengan Enalapril pada Pasien Gagal Jantung: Literature Review Jitayu Sekarininta Mumpun; Laksmi Maharani; Nialiana Endah Endriastuti
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.2.4408

Abstract

ARNI (Angiotensin Receptor-Neprilysin Inhibitor) is a new therapy for heart failure patients that have been approved since 2016, which is a combination of sacubitril (Neprilisin Inhibitor) and valsartan (ARB). The aim of this study was to review the comparison of the effectiveness sacubitril/valsartan and enalapril in heart failure patients through a literature review method. Database used were Cochrane and PubMed. Keywords search based on PICO (heart failure, sacubitril/valsartan or LCZ696, enalapril, and efficacy or effectiveness). The inclusion criteria were articles in English, available in full text and free access, published in 2010-2020, and RCT. The exclusion criteria were review articles. The searching was conducted from 10 July to 23 July 2020 and 20 December 2020. From this searching, researcher obtained 160 articles, after the process of selection and eligibility, 16 articles were included in the inclusion criteria as primary articles, and 2 articles were included as secondary articles. Studies showed that sacubitril/valsartan reduces the incidence of readmission and has a better QoL score than enalapril, and also decreases the risk of death. According to primary research of PARADIGM-HF and 15 advanced analysis article, it’s known that the usage of sacubitril/valsartan is more beneficial than enalapril in heart failure patients.
Gambaran Gambaran Pelayanan Swamedikasi Oleh Apoteker Di Kota Palu Nurintan Kurnia Manikam; Amelia Rumi; Firdawati Amir Parumpu
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.2.5144

Abstract

A good self-medication service is self-medication carried out by drug experts, namely pharmacists to optimize drug use and improve health. At the same time, pharmacists are also expected to be able to provide consultations to patients and monitor any problems that may occur during drug use, which are called drug-related problems (Medication error). The purpose of this study was to determine the description of self-medication services by pharmacists in the city of Palu based on the categories of extracting information, drug selection and drug information. The research method used is descriptive qualitative cross sectional and the sampling method is purposive sampling. The respondent's criteria are pharmacists who had activated SIPA and practised in pharmacies along are willing to signs an informed consent form. Based on these criteria, had obtained 86 samples of pharmacists in pharmacies in Palu City. The instrument used is using a questionnaire in the form of Google Form which had been tested for validity and reliability testing and the data obtained is evaluated descriptively. The results showed that pharmacists in pharmacies in Palu City had carried out self-medication services for extracting information by 83.60%, drug selection by 95.35% and providing drug information by 89.66%. The conclusion of this studied is that pharmacists in pharmacies had carried out self-medication serviced properly according to variables.
ANALISIS TINGKAT PENGETAHUAN DAN SIKAP TENAGA KEFARMASIAN DALAM MENCEGAH OBAT RUSAK DAN KADARLUARSA DI RSUD TORA BELO Nurul Ambianti; Muhamad Rinaldhi Tandah; Khusnul Diana; Ratu Balqis
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.2.5135

Abstract

Abstract The defective and expired drugs are one of the problems that can reflect the inaccuracy and poor of drug management in a Hospital Pharmacy Unit (HPU). This research was conducted to determine the level of knowledge and attitudes of pharmaceutical personnel in preventing defective and expired drugs at the Regional General Hospital (RGH) Tora Belo. This type of researched is a non-experimental study with cross sectional data collection. The data used are primary data obtained from the results of questionnaires that have been filled out by pharmacist at Tora Belo Hospital. The analysis used in this study is correlation analysis using the Spearman-Rho test, to determine the relationship between the level of knowledge and attitudes of pharmaceutical personnel in preventing defective and expired drugs. The number of samples is 33 people taken by total sampling. Time to collect research data during May-October 2020. From the results of the study, it is known that the level of knowledge of the respondents is dominated by the sufficient category, namely 17 respondents (71.1%), it is known that the attitude of the respondents was included in the very strong category of 18 respondents (85.78%), and the results of the correlation analysis the relationship between the level of knowledge and attitudes of pharmaceutical personnel in preventing defective and expired drugs obtained a significance value of 0.021. So it can be concluded there is a relation between the level of knowledge and attitude of pharmaceutical workers in preventing defective and expired drugs at Tora Belo Hospital.
Optimasi Konsentrasi Vaselin Album dan Adeps Lanae pada Formulasi Sediaan Salep Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Baiq Saomi Alfilaili; Wahida Hajrin; Yohanes Juliantoni
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.2.4084

Abstract

Cherry leaves (Muntingia calabura L.) contain secondary metabolites such as tannins, flavonoids, and saponins. This secondary metabolite compound functions as an antibacterial, especially Staphylococcus epidermidis bacteria that cause acne, so that it can be developed into a formula. One of the dosage forms that can be developed is the ointment dosage form. The choice of base concentration is very important because it can affect the physical properties and effectiveness of the preparation. The purpose of this study was to determine the optimum composition of the ethanol extract formula of cherry leaves with variations concentration of Vaseline album and adeps lanae, physical properties and level of acceptance of the consumer formula which was declared optimal. Cherry leaves were extracted by maceration method using ethanol 96% solvent. Determination of the optimum value was carried out using the Simplex Lattice Design method available in the Design Expert software Version 11. The results showed that the optimum ointment formula had a composition of vaseline albumin and adeps lanae of 73,29% and 9,71%, with a spreadability 3,10 ± 0,12 cm, adhesion 6,10 ± 0,53 seconds, pH 4,78 ± 0,08, and the acceptability value is 4,02. So it can be concluded that the formula declared optimum has physical properties that meet the requirements and are liked by the respondents.
Free Chlorine Determination in Disinfectant Product using Visible Spectrophotometry based on Prussian Blue Degradation Hendri Wasito; Defi Srium Siagian; Muhamad Salman Fareza
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.2.5371

Abstract

Disinfectant products with excessive chlorine could be dangerous for health and need quality control. It is important to develop an analytical method for monitoring product quality. The main objective of this work is to develop an alternative method and evaluate the analytical performance of visible spectrophotometry for determining free chlorine in disinfectant products based on the Prussian blue decomposition process. The capability of chlorine to oxidize ferrous to ferric ions makes the Prussian blue generated by ferrosulfate and potassium ferricyanide is decomposed and measured by spectrophotometer. The formation of Prussian blue was improved by optimizing some reaction conditions and assessing incubation time. Linearity, analytical concentration range, precision, accuracy, detection limit, and quantitation limit parameters were among the examined analytical parameters. The results showed that the optimum concentration of ferrosulfate, potassium ferysianide, and hydrochloric acid for Prussian blue formation was 2.0 mmol L-1, 3.0 mmol L-1, and 0.5 mol L-1, respectively, with 15 minutes incubation time after chlorine addition. Analytical performance parameters seemed appropriate for routine analysis purposes. The developed method can also be applied as an alternative analytical method to determine the free chlorine concentration of disinfection products in the market.
Potensi interaksi obat nutrasetikal pada epilepsi anak Nialiana Endah Endriastuti; Masita Wulandari Suryoputri; Dewi Latifatul Ilma; Tunggul Adi Purwonugroho
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.4352

Abstract

Background: The trend of using nutraceuticals in Indonesia increases every year. This study aims to describe nutraceuticals consumed in pediatrics with epilepsy as additional antiepileptic therapy and analyze their potential drug interactions. Methods: This research was a cross-sectional study with total sampling method which was carried out in the period of June to July 2020. Inclusion criteria were children with epilepsy aged 0-17 years who were members of the Indonesian Epilepsy Community, had a doctor's diagnosis of epilepsy, received oral antiepileptic medication, and took nutraceutical products/food supplements. Data were analyzed descriptively based on data obtained through electronic data filling sheets and interviews. Results: There were 106 participants from the Indonesian Epilepsy Community in total, with 14 children (13.2 %) using nutraceutical supplements. They were male (n=8; 57.1%), 2-12 years old (n=10; 71.4%), and good nutritional status (n=10; 71.4%). Most nutraceuticals consumed were dietary supplements containing vitamins (n=10; 71.4%). Of the eight potential drug interactions identified, 25% (n=2) were significant interactions, and 75% (n=6) were minor interactions. The potential for major interactions occurred in administering nutraceutical products containing vitamin D with the antiepileptic drug phenytoin and phenobarbital. Conclusion: In this study, nutraceuticals and antiepileptic drugs had a little clinically meaningful interaction effect.
Antibacterial activity of Cassia alata stems ethanol extract against Staphylococcus aureus Ahmad Mahdi Mar'ie; Irfan Zamzani; Siti Nashihah
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5462

Abstract

Background: Cassia alata leaves, also known as petai cina or gelinggang in Indonesia, are commonly used to treat skin ailments. Objective: The purpose of this study is to test whether stem of C. alata has antibacterial activity against Staphylococcus aureus. Methods: C. alata stems were extracted using an ultrasound-assisted extraction method. For antibacterial activity, disc diffusion was used with extract concentrations of 25%, 50%, 75%, and 100%. Results: The inhibition zones of the ethanol extract of C. alata stems at 25%, 50%, and 75% concentrations were 17.6 mm, 21 mm, and 22.6 mm, respectively, with the highest inhibition zone at 100% concentration at 25 mm. Conclusion: The ethanolic extract of C. alata stems has a strong inhibitory effect on Staphylococcus aureus.
Drug utilization of N-Acetylcysteine in COVID-19 inpatients at Santa Elisabeth Hospital, Purwokerto Heny Ekowati; Faradina Qorina Nadzif; Masita Wulandari Suryoputri
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5776

Abstract

Background: COVID-19 is associated to an oxidant-antioxidant imbalance, which leads to inflammation and tissue damage. N-Acetylcysteine (NAC), in addition to being a mucolytic, has been shown to be an effective antioxidant in the therapy of COVID-19. Objective: The purpose of this study is to evaluate at the NAC usage profile in COVID-19 inpatients at Santa Elisabeth Hospital in Purwokerto. Methods: A descriptive observational design was used to perform the study. Retrospective data were obtained from medical records from July 2020 to July 2021. All patients who met the inclusion criteria were sampled using the total sampling technique. Results: NAC was commonly administered to COVID-19 inpatients who have a mild illness of the disease. The most common symptoms were cough and fever. Patients with mild and moderate severity were given NAC orally (600 mg 3 times a day) and intravenously (5 gram/day), respectively. The duration of NAC administration was in the range of 8-14 days. Conclusion: NAC was one of the therapies used at Santa Elisabeth Hospital Purwokerto for COVID-19 inpatients.
Solvent optimization in moringa leaves' flavonoids extraction using simplex lattice design Siti Muhsonah Oktaviana; Wahida Hajrin; Nisa Isneni Hanifa
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5271

Abstract

Background: Flavonoids found mainly as pharmacologically active natural ingredient of moringa (Moringa oleifera L.). Therefore, optimizing the solvent to maximize the levels of flavonoid components is needed. Objective: This study was conducted to determine the optimum solvent composition for extracting flavonoid compounds from moringa leaves using the simplex lattice design (SLD). Methods: Moringa leaves were extracted using the sonication method with five combinations of 96% ethanol and water as the solvent. The solvent composition was optimized using Design-Expert version 11 software. Moreover, UV-Vis spectrophotometry was used to screen and identify flavonoid content. Results: Flavonoids were detected in moringa extract. Using the F test, a valid SLD equation, y= 440,243(A) + 142,983(B) - 47,324(A)(B), was obtained. This equation shows that the solvent ethanol 96% : water (100:0) was the best solvent and produced the maximum amount of moringa flavonoid content, which was 440,2427 mg QE/g extract. Conclusion: The flavonoid content was directly proportional to the high composition of 96% ethanol.

Page 8 of 14 | Total Record : 137

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