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Psidium guajava leaves extract decreased leukocytes and lymphocytes count in Complete Freund's Adjuvant-induced arthritis rats Hanif Nasiatul Baroroh; Rupa Lesty; Esti Dyah Utami; Nur Ayunie Zulkepli
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5789

Background: Psidium guajava is one of the herbal plants that has demonstrated antioxidant and anti-inflammatory properties. Objective: This study aimed to determine the effect of P. guajava leaves extract on leukocytes and lymphocytes in rats. Methods: Fifty rats were divided into five groups. Complete Freund’s Adjuvant (CFA) was employed to generate an animal model of arthritis. Group I (arthritis control) received CMC Na, group II (positive control) received dexamethasone 3 mg/kg BW, and groups III-V received 250, 500, and 750 mg/kg BW of the ethanol extract of P. guajava leaves orally. Total leukocyte counts were calculated on days 13 and 29, and on day 29, the histological joints were inspected. Results: The P. guajava leaves extract decreased the number of lymphocytes and total leukocytes. Before and after treatment, the group receiving doses of 250 mg/kg BW and 750 mg/kg BW of the extract showed a significant decrease in leukocytes. With treatment of 250, 500, and 750 mg/kg BW of P. guajava leaves ethanol extract, the lymphocyte count was also reduced. The P. guajava leaves extract at 750 mg/kg body weight showed the greatest effectiveness in suppressing leukocytes and lymphocytes. Conclusion: The extract of P. guajava leaves has the potential to be developed as an anti-inflammatory for arthritis.

Phytochemical screening and purification of n-hexane fraction of Calophyllum soulattri leaves Sunarto Sunarto; Agnes Yuliasari; Sri Sutji Susilowati; Hendri Wasito; Triyadi Hendra Wijaya; Muhamad Salman Fareza
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo (in progress)
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5858

Background: Calophyllum soulattri Burm F. is widely utilized in traditional medicine. It is necessary to identify secondary metabolites from C. soulattri leaves to determine the pharmacologically active chemicals. Objective: This study aimed to screen the phytochemical content and purify the n-hexane fraction of C. soulattri leaves from Banyumas, Indonesia. Methods: The n-hexane fraction was macerated with methanol, followed by liquid-liquid fractionation with n-hexane. The n-hexane fraction was tested for flavonoids, triterpenoids/steroids, saponins, and phenols using the test tube method. In addition, the compounds were purified using column chromatography. The purified compound was identified by the Liebermann-Burchard reagent, which was compared with commercially available steroid drugs as reference. Results: Phytochemical analysis revealed that the n-hexane fraction of C. soulattri leaves contained secondary metabolites such as flavonoid, steroid, and phenol compounds. Analyses with the Liebermann-Burchard reagent indicated that the purified compound was potentially a steroid. Conclusion: The compound extracted from the n-hexane fraction of C. soulattri leaves was expected as a steroid.

Optimizing effervescent granules of blue pea (Clitoria ternatea L) flower ethanol extract as antioxidant Tuti Sri Suhesti; Warsinah Warsinah; Pitra Wulandari
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5803

Background: Blue pea (Clitoria ternatea) contains secondary metabolites, including flavonoids, saponins, terpenoids, tannins, and anthocyanins which have antioxidant activity. Objective: This research aims to produce the effervescent granule preparations of the blue pea flower ethanol extract with the optimal concentrations of citric acid and tartaric acid. Methods: Blue pea flower was extracted using 70% ethanol. Effervescent granules were made using the wet granulation method in eight formulas containing citric acid and tartaric acid. The physical properties of granules were evaluated, including extract quality, flow rate, dissolution time, and pH. Results: The concentration of the mixed components of citric acid 48.65 mg and tartaric acid 576.30 mg was the most optimal combination of acid sources for effervescent granules of blue pea flower extract with a desirability value of 1,000. Conclusion: The variation in the concentration of citric acid and tartaric acid affected the effervescent granule preparation's flow rate, dissolution time, and pH.

Antifungal activity of Calophyllum soulattri leaf extract on fungal isolate of coconut neera Eka Prasasti Rachmani; Rehana Rehana; Novia Ayu Rahmawati
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo (in progress)
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5929

Background: Coconut neera is susceptible to fungus contamination. Some plants, such as Calophyllum soulattri, can function as natural preservatives with antifungal properties. Objective: This study aimed to evaluate the antifungal activity of C. soulattri leaf extract as measured by minimum inhibitory concentration (MIC) and minimum killing concentration (MKC). Methods: A dilution method was used to isolate the fungus that contaminated coconut neera. MIC and MKC antifungal activity were then evaluated using the liquid dilution method. Results: The results indicated that the contaminant fungi found in coconut neera belonged to the genus Penicillium. The MIC was 12.5%, while the MKC was 18.75%. Conclusion: C. soulattri leaf extract has the potential to be developed as an antifungals for food preservation.

Emulgel formulation of wild cherry leaves (Antidesma bunius L. Spreng) extract and its antioxidant activity Windah Anugrah Subaidah; Yayuk Andayani; Dewa Ayu Puspaning Kumaradewi
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo (in progress)
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.4036

Background: The ethanol extract of wild cherry leaves (Antidesma bunius L. Spreng) has been studied as a free anti-radical in an emulgel formulation. The purpose of this study is to determine the physical properties of an emulgel made from an ethanol extract of wild cherry leaves, as well as its anti-radical activity. Methods: The maceration method was used to extract wild cherry leaves in 96% ethanol, which were then evaporated with a rotary evaporator. An emulgel was prepared to contain a 3.56% thick extract. The physical properties of the emulgel were evaluated consisting of the organoleptic test, pH test, homogeneity test, spreadability test, and adhesion test. The DPPH was used to test free anti-radical activity. Results: The emulgel of the ethanol extract of wild cherry leaves had a yellowish-green, thick texture, a distinct aroma of the extract, was homogeneous, pH 6, spreadability ranged from 4.4-6.2 cm, and adhesion of 5.467 0.83 cm. Emulgel had a very weak antioxidant activity with an IC50 of 6238.41 ppm. Conclusion:

Optimizing effervescent granules of butterfly pea (Clitoria ternatea L) flower ethanol extract as antioxidant Suhesti, Tuti Sri; Warsinah, Warsinah; Wulandari, Pitra
Acta Pharmaciae Indonesia Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5803

Background: Butterfly pea (Clitoria ternatea) contains secondary metabolites, including flavonoids, saponins, terpenoids, tannins, and anthocyanins which have antioxidant activity. Objective: This research aims to produce the effervescent granule preparations of the butterfly pea flower ethanol extract with the optimal concentrations of citric acid and tartaric acid. Methods: Butterfly pea flower was extracted using 70% ethanol. Effervescent granules were made using the wet granulation method in eight formulas containing citric acid and tartaric acid. The physical properties of granules were evaluated, including extract quality, flow rate, dissolution time, and pH. Results: The concentration of the mixed components of citric acid 48.65 mg and tartaric acid 576.30 mg was the most optimal combination of acid sources for effervescent granules of butterfly pea flower extract with a desirability value of 1,000. Conclusion: The variation in the concentration of citric acid and tartaric acid affected flow rate, dissolution time, and pH of the effervescent granule preparation.

Antifungal activity of Calophyllum soulattri leaf extract on fungal isolate of coconut neera Rachmani, Eka Prasasti Nur; Baroroh, Hanif Nasiatul; Rehana, Rehana; Rahmawati, Novia Ayu
Acta Pharmaciae Indonesia Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5929

Background: Coconut neera is susceptible to fungus contamination. Some plants, such as Calophyllum soulattri, can function as natural preservatives with antifungal properties. Objective: This study aimed to evaluate the antifungal activity of C. soulattri leaf extract as measured by minimum inhibitory concentration (MIC) and minimum killing concentration (MKC). Methods: A dilution method was used to isolate the fungus that contaminated coconut neera. MIC and MKC antifungal activity were then evaluated using the liquid dilution method. Results: The results indicated that the contaminant fungi found in coconut neera belonged to the genus Penicillium. The MIC was 12.5%, while the MKC was 18.75%. Conclusion: C. soulattri leaf extract has the potential to be developed as an antifungals for food preservation.

Pengaruh Tingkat Pengetahuan Terhadap Kepatuhan Pasien Minum Obat Anti Tuberkulosis (OAT) di Puskesmas Kota Pekalongan Purgiantari, Purgiantari; Suryoputri, Masita Wulandari; Endriastuti, Nialiana Endah
Acta Pharmaciae Indonesia Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5661

Background: Adherence is one of the most critical factors in the success of pulmonary tuberculosis therapy. Non-compliance of patients taking anti-tuberculosis drug results in a high rate of treatment failure, increasing the risk of disease severity and death. Objective: This study aims to investigate the impact of knowledge level on patient compliance in taking anti-tubercular medication. Methods: This observational, cross-sectional study employed a total sampling method. The levels of knowledge and compliance were assessed using a validated questionnaire administered to patients with pulmonary tuberculosis at the Pekalongan City health center (Puskesmas). Results: Among the 52 participants, 44.23% (n=23) demonstrated a high level of knowledge, and 86.5% (n=45) exhibited good compliance. Spearman correlation test analysis revealed a significant influence of knowledge level on patient compliance in taking antituberculosis drugs (p=0.001, r=0.341), indicating that higher knowledge levels correspond to better patient compliance. Conclusion: The study suggests that patient compliance with antitubercular medication improves as knowledge level increases.

Potensi interaksi obat nutrasetikal pada epilepsi anak Endriastuti, Nialiana Endah; Suryoputri, Masita Wulandari; Ilma, Dewi Latifatul; Purwonugroho, Tunggul Adi
Acta Pharmaciae Indonesia Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.4352

Background: The trend of using nutraceuticals in Indonesia increases every year. This study aims to describe nutraceuticals consumed in pediatrics with epilepsy as additional antiepileptic therapy and analyze their potential drug interactions. Methods: This research was a cross-sectional study with total sampling method which was carried out in the period of June to July 2020. Inclusion criteria were children with epilepsy aged 0-17 years who were members of the Indonesian Epilepsy Community, had a doctor's diagnosis of epilepsy, received oral antiepileptic medication, and took nutraceutical products/food supplements. Data were analyzed descriptively based on data obtained through electronic data filling sheets and interviews. Results: There were 106 participants from the Indonesian Epilepsy Community in total, with 14 children (13.2 %) using nutraceutical supplements. They were male (n=8; 57.1%), 2-12 years old (n=10; 71.4%), and good nutritional status (n=10; 71.4%). Most nutraceuticals consumed were dietary supplements containing vitamins (n=10; 71.4%). Of the eight potential drug interactions identified, 25% (n=2) were significant interactions, and 75% (n=6) were minor interactions. The potential for major interactions occurred in administering nutraceutical products containing vitamin D with the antiepileptic drug phenytoin and phenobarbital. Conclusion: In this study, nutraceuticals and antiepileptic drugs had a little clinically meaningful interaction effect.

Psidium guajava leaves extract decreased leukocytes and lymphocytes count in Complete Freund's Adjuvant-induced arthritis rats Baroroh, Hanif Nasiatul; Lesty, Rupa; Utami, Esti Dyah; Zulkepli, Nur Ayunie
Acta Pharmaciae Indonesia Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5789

Background: Psidium guajava is one of the herbal plants that has demonstrated antioxidant and anti-inflammatory properties. Objective: This study aimed to determine the effect of P. guajava leaves extract on leukocytes and lymphocytes in rats. Methods: Fifty rats were divided into five groups. Complete Freund’s Adjuvant (CFA) was employed to generate an animal model of arthritis. Group I (arthritis control) received CMC Na, group II (positive control) received dexamethasone 3 mg/kg BW, and groups III-V received 250, 500, and 750 mg/kg BW of the ethanol extract of P. guajava leaves orally. Total leukocyte counts were calculated on days 13 and 29, and on day 29, the histological joints were inspected. Results: The P. guajava leaves extract decreased the number of lymphocytes and total leukocytes. Before and after treatment, the group receiving doses of 250 mg/kg BW and 750 mg/kg BW of the extract showed a significant decrease in leukocytes. With treatment of 250, 500, and 750 mg/kg BW of P. guajava leaves ethanol extract, the lymphocyte count was also reduced. The P. guajava leaves extract at 750 mg/kg body weight showed the greatest effectiveness in suppressing leukocytes and lymphocytes. Conclusion: The extract of P. guajava leaves has the potential to be developed as an anti-inflammatory for arthritis.

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Location Kab. banyumas, Jawa tengah INDONESIA

Abstract

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Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kab. banyumas,

Jawa tengah

INDONESIA