cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
M. Widyo Wartono
Contact Email
widyo@mipa.uns.ac.id
Phone
-
Journal Mail Official
alchemymipauns@gmail.com
Editorial Address
-
Location
Kota surakarta,
Jawa tengah
INDONESIA
ALCHEMY Jurnal Penelitian Kimia
Published by Universitas Sebelas Maret
ISSN : 14124092     EISSN : 24434183     DOI : -
Core Subject : Science, Social, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Materials Science & Nanotechnology
ALCHEMY Jurnal Penelitian Kimia is a chemistry journal published by Sebelas Maret University, Surakarta. ALCHEMY Jurnal Penelitian Kimia publishes original research articles or review articles in organic chemistry, inorganic chemistry, analytical chemistry, physical chemistry, biochemistry, and environmental chemistry.
Arjuna Subject : -
Articles 307 Documents
 27   28   29   30   31 
Phytochemical Examination, GC-MS Analysis, and Antibacterial Activity of Methanol Extract of Dadap Leaves (Erythrina variegata L.) Against Staphylococcus aureus and Escherichia coli Bacteria using Disc Diffusion Method Yulia Theodora Situmorang; Halimatussakdiah Halimatussakdiah; Ulil Amna; Vivi Mardina
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.99255.264-273

Abstract

This study examines the antibacterial activity of a methanol extract from the leaves of Dadap (Erythrina variegata L.) against Staphylococcus aureus and Escherichia coli. Bacterial infections are a major health issue in Indonesia, so the development of plant-based natural medicines is being pursued. The Dadap plant has the potential to treat bacterial infections. This study aims to identify the types of secondary metabolites in the methanol extract of Dadap leaves, analyze the active compounds using Gas Chromatography-Mass Spectroscopy (GC-MS), and evaluate their antibacterial activity. Extraction was performed by maceration with methanol, and antibacterial testing was conducted by disk diffusion on Mueller-Hinton Agar with extract concentrations of 5, 10, 20, and 40% (w/v). The extracts were diluted in sterile distilled water. The results exhibited antibacterial activity against S. aureus and E. coli, with inhibition zones of 14 mm (strong) and 8.8 mm (moderate) at a 40% concentration, respectively. These activities might be linked to the active compounds found in the Dadap leaves extract using phytochemical and GC-MS analysis. The phytochemical analysis showed that the E. variegata L. leaf extract contains alkaloids, steroids, terpenoids, saponins, flavonoids, phenols, and tannins. Furthermore, the GC-MS chromatogram identified 11 compounds, including 7 with antibacterial activity, such as neophytadiene, 3,7,11,15-tetramethyl-2-hexadecen-1-ol, hexadecanoic acid, methyl ester, n-hexadecanoic acid, phytol, methyl stearate, and stigmasterol. Overall, the crude extract of Dadap leaves showed a potential candidate for development as an antibiotic.
Phloroglucinol Compounds and Their Derivatives: Comparison of FTIR, NMR, and Bioactivity Characterization as Antibacterial, Antioxidant, and Anticancer Agents Sevi Dwi Cahyani; Triana Kusumaningsih; Maulidan Firdaus; Wahyu Eko Prasetyo
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.109425.1-39

Abstract

Research on phloroglucinol (PG) and its derivatives has been extensively pursued over the past three decades. PG compounds are found in many plants, such as in the genus Callopyillum, the genus Hypericum, Eucalyptus kino, and brown algae. PG compounds have a symmetrical compound structure and contain many electrons distributed across three active sites, making them very advantageous for electrophilic aromatic substitution. PG has biological activities, such as antibacterial, antioxidant, anticancer, antiviral, anti-inflammatory, and others. PG bioactivity can be increased by synthesizing PG derivatives using various synthetic methods. The addition of an active group to PG can affect its bioactivity, properties, and characteristics, as well as its polarity and lipophilicity. This study aims to collect data on (1) Comparison of Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) characterization of various PG derivative compounds, (2) Comparison of PG bioactivity and its derivatives as antibacterial, antioxidant, and anticancer compounds. PG compounds and their derivatives have been shown to exhibit antibacterial effects against several bacteria, including Staphylococcus aureus, Escherichia coli, and MRSA. Furthermore, PG derivatives exhibit antioxidant properties, as evidenced by their low IC50 values, and have demonstrated anticancer activity against cancer cell lines such as A549, MCF-7, and HTC-116. The findings of this study have the potential to assist researchers in developing new drugs.
Identification of Antioxidant Compounds using the DPPH Radical Scavenging Method from Ethanol and Methanol Extracts of the Leaves and Fruits of the Renggak Plant (Ammomum dealbatum R.) Rahmawati Rahmawati; Meliana Meliana; Lestia Furnapasta; Syarifa Wahidah Al Idrus; Baiq Fara Dwirani Sofia; Sya’ban Putra Adiguna; Jono Irawan
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.108082.217-227

Abstract

This study aims to screen antioxidant compounds from the renggak plant (Amomum dealbatum R.). Screening of phytochemicals was carried out on the leaves and peel of the renggak fruit by the extraction method using ethanol and methanol solvents. Extraction was carried out by maceration, and the antioxidant potential test was carried out by measuring the extract's scavenging activity against DPPH radicals. In the fruit peel, both ethanol and methanol extracts tested positive for all phytochemicals, while in the leaves, ethanol extract was positive only for tannins and alkaloids, and methanol extract for flavonoids, saponins, tannins, and alkaloids. The difference in results was caused by differences in solvent polarity. The results of the antioxidant test showed that the leaf extract had an IC₅₀ value of 44.31 µM, while the fruit peel extract had an IC₅₀ value of 144.57 µM. The lower IC₅₀ value in the leaf extract indicates that the bioactive compounds contained therein have higher antioxidant potential than the fruit peel, as they can inhibit 50% of free radical activity at lower concentrations. The results of this study provide additional phytochemical and antioxidant sources from plant sources, for use as raw materials in the pharmaceutical and cosmetic industries.
Synthesis and Characterization of Carrageenan-Chitosan Milkfish Scales-Based Hydrogel for Slow-Release Fertilizer Asri Azizah; Diana Triyanti; Putri Sahira; Anisa Putri; Retno Sulistyo Dhamar Lestari; Jayanudin Jayanudin
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.102933.157-169

Abstract

This study aims to develop a superabsorbent hydrogel as a slow-release fertilizer based on a combination of carrageenan-glucomannan and carrageenan-chitosan derived from milkfish (Chanos chanos) scale waste. The hydrogel was synthesized by chemical crosslinking with glutaraldehyde concentrations of 2%, 4%, 6%, and 8%. Hydrogel characterization included swelling ratio tests, gel fraction analysis, Fourier Transform Infrared (FTIR), Scanning Electron Microscopy (SEM), urea absorption (Xo), and urea release kinetics in both aqueous and soil media. The results indicate that a 8% glutaraldehyde concentration yielded optimal performance in both hydrogel systems, achieving the highest gel fractions (>90%) and maximum urea absorption capacities of 8.05 g/g for carrageenan-glucomannan and 13.31 g/g for carrageenan-chitosan. The carrageenan-glucomannan hydrogel exhibited a higher swelling ratio of 630% at 2% glutaraldehyde concentration and slower urea release in soil, ranging from 0.192% to 4.113% over 7 days. In contrast, the carrageenan-chitosan hydrogel demonstrated stronger chemical affinity for urea but released it more rapidly, ranging from 1.037% to 7.092% over the same period. SEM and FTIR analyses confirmed the formation of a three-dimensional network structure and chemical interactions among the components.
Modification of Chroman Derivative Compounds and Their In Silico Antibacterial Activities Jufrizal Syahri; Rahmiwati Hilma; Nurlaili Nurlaili
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.101625.117-126

Abstract

This study reports the alkaline reflux synthesis of 6-chloro-4-chromanone (Ch) with the secondary amine dimethylamine (DA) to obtain chromanone-derived compounds with potential antibacterial activity. Spectroscopic analyses confirmed that 6-chloro-3-((dimethylamino)methyl)chroman-4-one (Ch-DA) was successfully formed in 46.37% yield and corresponded to the targeted structure. In silico antibacterial studies were performed to evaluate the interaction between the synthesized compound and the target protein (PDB ID: 3VOB). Molecular docking results indicated that Ch-DA exhibits antibacterial potential through the formation of hydrogen bonds with key amino acid residues at the active site. The standard ligand (9PC) showed a CDOCKER energy of-46.4867 kcal/mol with seven hydrogen bonds involving residues VAL310, ASN263, VAL207, ASN208, GLY205, LEU209, and GLY196. Meanwhile, Ch-DA demonstrated a CDOCKER energy of -34.3506 kcal/mol with three hydrogen bonds at GLY196, THR265, and ASP199. The positive control, chloramphenicol, produced a CDOCKER energy of -48.0224 kcal/mol and formed three hydrogen bonds with THR309, GLY205, and GLY196, whereas the precursor compound (Ch) showed lower activity (-27.546 kcal/mol) without hydrogen bond formation. These results indicate that the incorporation of a secondary amine group enhances antibacterial activity, with docking performance comparable to the positive control, suggesting that Ch-DA has potential as antibiotic drugs.
Recent Developments of Biopolymer-Based Composite Membranes as Sustainable Separators for Lithium-Ion Batteries Tian Puspita Sari; Fitri Khoerunnisa; Asep Kadarohman
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.114118.40-59

Abstract

The increasing adoption of electric vehicles and large-scale energy storage systems has intensified demand for high-performance and sustainable lithium-ion battery separators. This review summarizes recent progress in biopolymer-based separators as environmentally friendly alternatives to conventional polypropylene/polyethylene membranes. Fourteen research articles published between 2020 and 2026 are analyzed, focusing on biopolymers such as bacterial cellulose, chitosan, lignin, alginate, silk fibroin, and poly(L-lactic acid). The discussion covers material classification, membrane fabrication techniques, and modification strategies, including composite formation and crosslinking. Overall, the reviewed studies indicate that biopolymer-based separators generally exhibit improved electrolyte wettability, enhanced ionic conductivity, and adequate thermal stability, leading to competitive electrochemical performance and good cycling stability. In addition to performance benefits, the use of biomass-derived materials and water-based fabrication processes offers sustainability and potential biodegradability advantages. This review highlights current research trends and outlines key challenges related to testing standardization and manufacturing scalability for future lithium-ion battery applications.
The Influence of Solvent and Heating Time Toward the Percent Yield of Sumbermanjing Pyrophyllite-Polyethylene Glycol (PEG) 6000 Composites Siti Mutrofin; Ekantoro Ekantoro; Rurini Retnowati; Hanisah Kamilah
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.104024.228-240

Abstract

The synthesis of clay-polymer composites has attracted considerable interest due to their promising potential properties. The composites were prepared from Sumbermanjing pyrophyllite and polyethylene glycol (PEG) 6000. This research aims to evaluate the influence of solvent and heating time on the percent yield of the composites. Pyrophyllite-PEG composites were synthesized via the casting and sol-gel methods with variations in solvent (demineralized water, methanol, acetone) and heating time (1, 1.5, and 2 hours). The highest yield (37.7239%) was achieved by a composite synthesized with acetone and a 2-hour heating treatment. The composite prepared with demineralized water showed poorer PEG diffusion into the pyrophyllite structure than did those prepared with methanol or acetone. A 2-hour treatment produced a more uniform, relatively smaller porous structure, despite subtle differences across various heating conditions. Statistical analysis revealed a significant difference among solvent treatments, but no significant difference among heating times. The melting points of the 1-hour and 2-hour composites were 120.7667 °C and 116.0333 °C, respectively, suggesting a successful composite synthesis. The successful composite synthesis was further confirmed by Fourier Transform Infrared (FTIR) spectra, which showed characteristic functional groups (O–H stretching, 3673.92 cm-1; C–H stretching, 2882.37 cm-1; Al–OH stretching, 1146.67 cm-1).
Synthesis and Characterization of an Adsorbent from Chicken Eggshell and Its Application for Methyl Orange Eka Sri Yusmartini; Mardwita Mardwita; Eko Ariyanto; Wahyu Triaji Rahadianto; Ikbal Oktaviansyah; Muhammad Dzaky Muzhaffar
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.96880.170-178

Abstract

Eggshell is a part that protects egg components from various external threats, including chemical, physical, and biological factors. This study aimed to obtain an adsorbent from chicken eggshells using physical and chemical activation techniques. The quality of the eggshell-derived adsorbent was assessed and compared with the Indonesian National Standard (SNI) 1995, with a focus on parameters such as ash content, moisture content, and iodine absorption. The adsorbent obtained was applied to a solution of methyl orange, and Fourier transform infrared spectroscopy (FTIR) analysis was conducted before and after the adsorption process. Furthermore, the study stages include adsorbent preparation, activation, and adsorption. The adsorbent weight for this process was 17 grams, with time intervals of 15, 30, 45, 60, and 75 minutes. The results showed that both physically activated as well as physical and chemical activated adsorbents met the SNI 1995 standard, based on the parameters of water content (1.73% and 2.86%), ash content (8.18% and 6.745), and iodine absorption (761.40 mg/g and 774.09 mg/g). FTIR analysis confirmed the presence of a hydrocarbon and an OH group in the structure before and after adsorption. The optimum methyl orange adsorption capacity was achieved at an adsorbent mass of 17 grams and a contact time of 60 minutes, resulting in removal efficiencies of 20.38% for physical activation and 24.11% for physical and chemical activation.
Kitolod (Isotoma longiflora Presi) Leaf Extract as a Bioreductor in Silver Nanoparticle Synthesis Alifiani Maulida; Gusrizal Gusrizal; Anis Shofiyani
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.109231.127-137

Abstract

Silver nanoparticles (AgNPs) were synthesized using kitolod (Isotoma longiflora Presi) leaf extract as a bioreductor. This research aims to investigate the ability of extracts to act as reducing agents in the formation of AgNPs and to characterize the resulting AgNPs. The synthesis was carried out under the following conditions: pH of extract 12, reaction time 90 minutes, silver nitrate concentration 2 × 10-4 M, and extract concentration 0.08%. Fourier transform infrared (FTIR) spectra confirmed the involvement of phytochemicals in the reduction of Ag+ to Ag0. The synthesized AgNPs were spherical, with an absorption peak at around 420 nm, an average particle size of 67.38 nm, a zeta potential of -23.6 mV, and a polydispersity index (PDI) of 0.697. Stability testing showed that the synthesized AgNPs remained stable for two months at room temperature.
In Silico Study of Moringa Leaf (Moringa oleifera L.) Compounds as an Antiproliferative in Hepatocellular Carcinoma against TGF-β Receptor Arnees Angzora; Athena Lilavya Putri; Johanna Felicia Susanto; Kathlia Putri Alyanisa; Debian Mydea Erliputeri; Nawadhir Fauzan; Shela Salsabila; Muchtaridi Muchtaridi
ALCHEMY Jurnal Penelitian Kimia Vol 22, No 1 (2026): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.22.1.105514.74-87

Abstract

Liver cancer is a condition in which liver cells grow uncontrollably. Liver cancer, also known as hepatoma, occurs when cells proliferate and acquire malignant properties. Liver cancer is among the types of cancer with a high contribution to global mortality rates each year. This study aims to predict and identify the activity of compounds isolated from Moringa leaves (Moringa oleifera L.) against liver cancer by targeting the TGF-β receptor using molecular docking. The research was conducted using software tools including LigandScout, ADMETlab 2.0, BIOVIA Discovery Studio Visualizer, and AutoDock Tools. The results showed that ten out of eleven test compounds from Moringa oleifera L. leaves met Lipinski's Rule of Five, indicating their potential as good oral drug candidates. Pharmacophore screening yielded an AUC100 value of 0.94 with three hit compounds: rutin, kaempferol, and isorhamnetin. In the molecular docking stage, the compound with the lowest binding energy was Isorhamnetin, with a binding energy of -8.18 kcal/mol against the TGF-β receptor, and it also demonstrated a favorable ADMET profile.

Page 30 of 31 | Total Record : 307

 27   28   29   30   31 

Filter by Year

2014 2026


Reset
Filter By Issues
All Issue Vol 22, No 1 (2026): March Vol 21, No 2 (2025): September Vol 21, No 1 (2025): March Vol 20, No 2 (2024): September Vol 20, No 1 (2024): March Vol 19, No 2 (2023): September Vol 19, No 1 (2023): March Vol 18, No 2 (2022): September Vol 18, No 1 (2022): March Vol 17, No 2 (2021): September Vol 17, No 1 (2021): March Vol 16, No 2 (2020): September Vol 16, No 1 (2020): March Vol 15, No 2 (2019): September Vol 15, No 1 (2019): March Vol 14, No 2 (2018): September Vol 14, No 1 (2018): March Vol 13, No 2 (2017): September Vol 13, No 1 (2017): March Vol 13, No 1 (2017): Maret Vol 12, No 2 (2016): September Vol 12, No 1 (2016): March Vol 11, No 2 (2015): September Vol 11, No 1 (2015): March Vol 10, No 2 (2014): September Vol 10, No 1 (2014): March More Issue