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Farmasains : Jurnal Ilmiah Ilmu Kefarmasian
Published by Universitas Muhammadiyah Prof. Dr. Hamka
ISSN : 20866968     EISSN : 26219816     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is an national journal published by Faculty of Pharmacy and Science University of Muhammadiyah Prof. DR. HAMKA. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is aimed at being a medium for research results dissemination and scientific paper exchanges on the pharmaceutical field among academics, practitioners, regulators, and public. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian is issued two times annually, i.e., in April, and October.The Editor receives rigorous research manuscripts that have not been offered for publication elsewhere. Since its first issue published in 2010. Farmasains: Jurnal Ilmiah Ilmu Kefarmasian has become a CrossRef Member since 2019. Therefore, all articles published by Farmasains: Jurnal Ilmiah Ilmu Kefarmasian will have unique DOI number with p-ISSN 2086-6968 dan e-ISSN 2621-9816
Arjuna Subject : -
Articles 154 Documents
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PENGHAMBATAN AKTIVITAS ENZIM α-GLUKOSIDASE DARI EKSTRAK AIR TANAMAN RARU (Vatica pauciflora) SECARA IN VITRO eris septiana; wiwi winarti; partomuan simanjuntak
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 4 No. 1 (2017)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (558.706 KB) | DOI: 10.22236/farmasains.v4i1.96

Abstract

Diabetes mellitus is a metabolic disorder that leading the blood sugar levels become higher than normal. In Indonesia, one of the plants that traditionally used to cure hyperglycemic is raru plant (Vatica pauciflora). The objectives of this research was to investigate α-glucosidase inhibitory activity from stem bark, root, and leaf of raru plant. Extraction of stem bark, root, and leaf was conducted with reflux at 70 °C by using water as a solvent. In vitro anti-diabetic activity was tested using the method of α-glucosidase inhibition. The results show that water extracts of raru’s stem bark, root, and leaf have α-glucosidase inhibitory activity. The stem bark water extract has the highest activity than leaf and root with IC50 values were 13.53, 16.96, and 41.91 ppm respectively. All extracts is categorized as active in inhibiting the activity of α-glucosidase enzyme by having IC50≤100 ppm. The results obtain in this research clearly indicate a promising potential as anti-diabetic properties of raru plant.
ANALISIS PENGGUNAAN OBAT ANTI TUBERKULOSIS PADA PASIEN TUBERKULOSIS PARU KASUS BARU RAWAT JALAN DI RUMAH SAKIT ATMA JAYA Yelfi Anwar; Fitri Ayuni
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Abstract

ABSTRACT Tuberculosis (TB) is a contagious infectious disease caused by Mycobacterium tuberculosis. The prevalence of pulmonary tuberculosis incident was included in the top 10 highest disease at Atma Jaya Hospital. Therefore, the study of the analysis of the use of anti-tuberculosis drugs in patients with new cases of lung rational at Atma Jaya Hospital indispensable. The purpose of this study was to determine the profile and analyze the rationality of the use of anti-tuberculosis drugs used in outpatients suffering from pulmonary tuberculosis new cases over the period July 2013 - June 2014.
EVALUASI IMPLEMENTASI PELAYANAN KONSELING OBAT DI APOTEK KOTA YOGYAKARTA farida baroroh; endang darmawan
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Abstract

Therefore, it is important to give counseling for patients and their family. This study is to evaluate the counseling service implementation at several pharmacy in Yogyakarta Indonesia. This study was a cross-sectional design. The result showed that the implementation counseling service at pharmacy was 59,00% of 96,00% patients who required counseling service. The several pharmacy patient were out-patient who responsible to their therapeutical management. There was 55,93% patients experienced that the room for counseling service was comfortable. So, the communication aspects of counseling service at pharmacy in Yogyakarta had been well conducted. Based on the communication technique, the pharmacist communicated with body language such as practicing how to use the drug in counseling services was 64.41%. In conlusion, the implementation counseling service at pharmacy in Yogyakarta Indonesia was 59,00% of 96,00% patients who required counseling service. A number of 94.83% of patients stated that pharmacists use an understandable language in counseling services. It can be concluded that although only 58.59% of respondents who had received counseling but the desire to get counseling services of pharmacy in Yogyakarta is very high, reaching 95.96% of respondents
GAMBARAN EFEK SAMPING ANTIPSIKOTIK PADA PASIEN SKIZOFRENIA RAWAT INAP DI RS. GRHASIA YOGYAKARTA julaeha jualeha; vitarani ananda; dimas pradana
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Abstract

This study aimed to profile the use of antipsychotics, the prevalence of DRPs events, and to compare the prevalence of DRPs use of antipsychotics in patients with schizophrenia in Grhasia hospital. This study is an observational study with cross sectional descriptive. Patients who were included in this study were patients with schizophrenia in the period 2007-2009 Grhasia Hospital who met the inclusion criteria, number of patients who were taken in this research are as many as 300 patients with a stratified sampling method. Data collection was performed retrospectively through medical records included patient characteristics, drug use data, and side effect event. From the data were collected regarding the percentage of use of antipsychotics. The results showed that administration of combination klorpromazin and haloperidol, an antipsychotic of the most widely used for the treatment of schizophrenia with a percentage over the period 2007, 2008, and 2009 are 60%, 70%, and 47%. Percentage side effect event over the period 2007, 2008, and 2009 are 31%, 28 % dan 14 %.
EVALUASI KETEPATAN PENGGUNAAN OBAT PASIEN IBU HAMIL DI DEPARTEMEN OBSTETRI DAN GINEKOLOGI RUMAH SAKIT “X” Muhammad Fikri Abdushshofi; Ridha Elvina; Yetti Hersunaryati
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Abstract

In the period of pregnancy, a woman requires drug therapy due to the disturbance suffered, whether related or unrelated to the pregnancy process. Drugs taken by pregnants  is noteworthy, because the drug is taken can affect the fetus. This study aimes to evaluate the accuracy of the indication, patient, and doses of drug use in pregnants in accordance with the guidelines used. The type of research is descriptive, data collection is do retrospectively. Sampling was done by purposive sampling in pregnants from the medical records of the Obstetric and Gynecology Department “X” Hospital Jakarta period from January to December, 2014. The results showed that meets the appropriate category indication as much as 99.30% and the category is not appropriate indication as much as  0.70%. Meets the appropriate category of patients as much as 99.30% and the category is not appropriate patients as much as 0.70%. Whereas, meet the appropriate category doses as much as 98.60% and the category is not appropriate doses of as much as 1.40%.
OPTIMASI TABLET FLOATING TEOFILIN MENGGUNAKAN METODE DESAIN FAKTORIAL agus siswanto; Indri Hapsari; yusni ulfiani zulaikha; eva rosmawati
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Abstract

ABSTRACTTheophylline is a drug used in the management of asthma. It has relatively short half-life and narrow therapeutic index with 5-20 μg/mL serum concentration. Thus, Floating tablet formulations that can increase the bioavailability of the drug. The aims of this study were to determine the effect of the excipient (HPMC K4M CR and NaHCO3) to the quality of tablets and determine the optimum formula of theophylline floating tablet. A 22 randomized factorial design was used in development of theophylline floating tablet with HPMC K4M CR (A) and NaHCO3 (B) as independent variables.The flowability of mass tablet, floating character, and dissolution profile were chosen as dependent variables.The results showed that NaHCO3 was the most important factor on increasing flowability of mass tablet. HPMC K4M CR was the dominant factor in lowering the Flag time, improving integrity of the tablet, and decreasing the release of drug. The composition of HPMC K4M CR 40.00 mg and NaHCO3 35.39 mg produced the optimum formula of theophylline floating tablet with desirability value of 0.978.
UJI SITOTOKSIK EKSTRAK ETANOL 50% DAUN KITOLOD (Isotoma longiflora (L.) Presl.) TERHADAP SEL KANKER SERVIKS (Ca Ski Cell Line) SECARA IN- VITRO Aprilita rina yanti
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Abstract

Kitolod (Isotoma longiflora (L.) Presl.) Is a traditional medicinal plant which is efficacious as anticancer. Empirically kitolod had been used  by Indonesian people for the treatment of cancer, but this remains to be proven scientifically through research. The objective of this research was to determine the cytotoxic activity of 50% Ethanol Extract of Kitolod leaves (Isotoma longiflora (L.) Presl) at a concentration of 25 mg / mL, 50 mg / mL, 75 mg / mL, and 125 mg / mL against cervical cancer cells (Ca Ski Cell Line) in vitro assay using red natural methods.Results of Cytotoxic assay  shows that  IC50 values 50% Ethanol Extract of Kitolod leaves (Isotoma longiflora (L.) Presl) in Ca Ski Cell Line  is  55.78 ug / mL. Ethanol extract  at  concentration of 25 mg / mL, 50 mg / mL, 75 mg / mL, and 125 mg / mL have cytotoxic effecst against cervical cancer cells (Ca Ski Cell Line) and extract at a concentration of 125 ug / mL indicates the largest percentage of cell death.
FORMULATIONS GEL OF TUNA BONE COLLAGEN (Thunnus albacares) WITH HPMC AS A GELLING AGENT ari widayanti; Desti Ayu Fauziah; Naniek Setiadi Radjab
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

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Abstract

Tuna’s collagen may be applied to burns at 2%. To provide convenience in use it was made in drug form gel. HPMC is used as a gelling agent because it can form a gel that is clear and netral and has a viscosity that is stable in a long periode. This study aims to determine the effect of increase in the concentration of HPMC as a gelling agent in the gel formula. at a concentration of 3%, 4%, 5%, 6%, 7%. The resulting gel is then evaluated by the organoleptic test, homogeneity test, pH test, viscosity test, centrifugation test, and freeze thaw test. Result of statistical analysis ANOVA one way to test the viscosity of the significant difference in each formula. Based on the result of this study concluded that the increased concentration of HPMC as a gelling agent can increase the viscosity of bone collagen gel tuna.
PENGARUH PEMBERIAN JERUK NIPIS (CITRUS AURANTIFOLIA (Chrism.) SWING) TERHADAP KADAR TRIGLISERIDA DAN BERAT BADAN TIKUS PUTIH (RATTUS NORVEGICUS) JANTAN GALUR WISTAR Meiriza Djohari; Yuni Rahmi
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 4 No. 1 (2017)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (569.996 KB) | DOI: 10.22236/farmasains.v4i1.152

Abstract

The research about the effect of lime (Citrus aurantifolia (chrism.) Swing) to levels of triglycerides and body weight of male rats (Rattus norvegicus) wistar strain at a doses of 1.5, 3 and 4.5 ml/kg body weight has done. This study conducted on five groups consisted of norml control , negative control (-), dose of 1.5; 3 and 4 ml/kg body weight, each group consisted of 5 rats , The normal control group were given regular feed, control (-) was given 2 ml cow's brain and regular feed then the test group were given lime each with a dose of 1.5, 3 and 4.5 ml / kg body weight was added with 2 ml of cow's brain and regular feed. The method of measurement used is Enzymatic Colorimetric Test GPO (Glycerol-3-Phosphate Oxidase) at a wavelength of 546 nm. The results showed that administration of lime doses of 3 and 4.5 ml/kg body weight have a significant difference (p <0,05) to the control (-). However, at a dose of 4.5 ml/kg body weight more effectively and more quickly lowering triglyceride levels because the first measurement time of the second measurement time already showed a significant difference (p<0,05) .
HOMOLOGY MODELING EPITOP ISOCITRATE DEHYDROGENASE TIPE 1 (R132H) MENGGUNAKAN MODELLER, I-TASSER DAN (PS)2 UNTUK VAKSIN GLIOMA Yeni Yeni; Daryono Hadi Tjahjono
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 4 No. 1 (2017)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1031.61 KB) | DOI: 10.22236/farmasains.v4i1.189

Abstract

Glioma is a type of primary malignant brain tumor. The presence of gliomas can be characterized by a mutation R132H of isocitrate dehydrogenase type 1 (IDH1). IDH1 (R132H) contains specific immunogenic epitopes to the tumor. It is appropriate to be used as a gliomas vaccine. Therefore, it was necessary to do homology modeling for IDH1 (R132H) epitopes. TMHMM, MEMSAT-SVM and MEMSAT3 were used to predict transmembrane topology of IDH1 (R132H). Analysis of IDH1 (R132H) epitopes was performed using NetMHCII and IEDB®. The antigenicity of epitopes were predicted using VaxiJen to obtained 91 epitopes. Homology modeling using Modeller, I-TASSER and (PS)2 was established for the epitopes that have probability as tumor antigen. The results of homology modeling of IDH1 (R132H) epitopes were validated by MolProbity, ProSA-web dan QMEAN. A 3D stucture model of the epitopes was selected from three models from the homology modeling based on the validation results. Refinement was established on the epitopes using GalaxyRefine and GROMACS for energy minimization.

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