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Majalah Farmaseutik

majalahfarmaseutik
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Published by Universitas Gadjah Mada

ISSN : 1410590x EISSN : 26140063 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Majalah Farmaseutic accepts submission concerning in particular fields such as pharmaceutics, pharmaceutical biology, pharmaceutical chemistry, pharmacology, and social pharmacy.

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Articles 488 Documents

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Optimation of Avicel PH 102 with Cab-O-Sil M-5P Ratio and Crospovidone Concentration on Liquisolid System Piroxicam Tablet T.N. Saifullah Sulaiman; Rani Puspita; Mutmainah Mutmainah
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Piroxicam is slightly soluble, so it should be developed in a liquisolid system of tablet dosage form to increase its solubility in gastrointestinal tract. Factorial design was applied to optimize the formula of liquisolid system piroxicam tablet by using four formulas: run I (18%A-2%B), run II (45%A-2%B), run III (18%A-5%B), and run IV (45%A-5%B). Component A is the ratio of Avicel PH 102 with Cab-O-Sil M-5P whether B is the concentration of crospovidone. Optimum formula was determined by superimposed contour plot from various parameters: hardness, friability, disintegrating time, and dissolution concentration (C45) using Design Expert software. Based on superimposed contour plot, optimum formula area was obtained in the range of 18-45 of Avicel PH 102 with Cab-O-Sil M-5P ratio and 2-5% of crospovidone concentration.

The Effect of Particle Size Reduction from Ibuprofen Tablet to Ibuprofen Pulveres on Its Dissolution Rate, Dissolution Profile, and Drug Stability Angi Nadya Bestari; T.N. Saifullah Sulaiman; Dita Ayu Purnamasari
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

A factor that influences the release of active ingredient from its dosage form is total particle surface area of drugs that contact with medium. The smaller size of particle can increase the particle surface area which can influence its dissolution and stability. This study aimed to determine the effect of tablet particle size reduction to its organoleptic properties, dissolution rate, dissolution profile, and stability after storage periods of 1, 2, 3, and 4 weeks. Ibuprofen tablet was changed its form by crushing into pulveres dosage form. The pulveres dissolution was conducted by USP type II dissolution tester (paddle method) with phosphate buffer pH 7,2 as the medium. The results of dissolution testing included the value of Q30, DE45, and dissolution rate constant (k). The similarity of dissolution profiles for each preparation could be known by the calculation of similarity factor (f2). Dissolution results showed that changed in particle sizes from the tablet to pulveres could increase dissolution rate constant from 0,063/minute to 0,347/minute and 0,298/minute (p = 0,029) and the DE45 value from 66,52% to 96,76% and 96,17% (p = 0). Pulveres were stable for 4 weeks of storage which were shown by there were not any changes in organoleptic properties. Furthermore, the value of DE45 (%), dissolution rate constants (k) and levels of active substances were not significantly different (p> 0,05) after 4 weeks of storage. The f2 value of ibuprofen tablet and ibuprofen pulveres was under 50 that meant the dissolution profil among them was not similar.

Formulation and Physical Stability Test of Lotion O/W Potato Starch (Solanum tuberosum L.) and the Activities as Sunscreen Abdul Karim Zulkarnain; Luky Oktaviasari
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Potato starch has an opaque characteristic that cannot be penetrated by light but can reflect light, therefore it is useful to prevent the penetration of ultraviolet radiation on the skin. This study aims to obtain a sunscreen product from natural material namely potato starch in lotion form. The experiment uses potato starch made into lotion in oil in water form with the concentrations of potato starch 10; 12.5; 15; 17.5 and 20% w/w. Physical evaluations of lotion formulation were done during storage with physical quality controlling, homogeneity, pH, viscosity, dispersive test, adhesion test, and product stability with a freeze-thaw cycle. Sunscreen activity is done by finding the value of sun protection factor (SPF) of potato starch lotion which determined by in vivo method using albino rabbit that induction by 8-MOP or methoxsalen previously, and irradiated by UV lamp. The 15% concentration variation of potato starch provides the most stable lotion based on the organoleptic parameter, homogeneity, pH, viscosity, dispersive test, adhesion test, and product stability accelerated. The increasing of potato starch concentration gives effect to the physical stability of the lotion during the storage time. Oil in water potato starch lotion with 15% has activity as a sunscreen with SPF value 15.

The Study of Medicinal Plant Diversity at Opak Watershed, Special Region Yogyakarta Djoko Santosa; Subagus Wahyuono; Sugeng Riyanto; S M Widyastuti
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Research on the diversity of medicinal plant at Opak watershed has been done. The purpose of this study is to determine the composition of medicinal plants, distribution and development potential as herbs raw materials. The study area is divided into 6 locations, namely Cangkringan subdistrict (CNK), Ngemplak (NPL), Prambanan (PRB), Kalasan (KLS), Imogiri (IMO), and Pundong (PDO). Each location is placed 30 plots by squares measuring 2x1 m. In the plot is calculated the number of species and individual of each species. The results showed there were 79 speies of plants are grouped into 27 families. Based on the type contribution in the environment and the literature study of Eupatorium riparium, Andrographis paniculata, and Scoparia dulcis are potential plants to be developed as raw materials of herbs medicine.

Effect of Extract Combination Tithonia diversifolia (Hemsley) A.Gray and Curcuma domestica Val. In Function of Heart and Kidney Rats of Cancer Model Angga Anugerah; Woro Rukmi Pratiwi; Mae Sri Hartati Wahyuningsih
Majalah Farmaseutik Vol 14, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Both Tithonia diversifolia (Hemsley) A. Gray leaves and (Curcuma domestica Val.) rhizome have bioactive compound which are an anticancer drug candidate. However, in vivo study about the effect of those to liver function and kidney function has never been carried out. The aim to determine the effect of ethanol extract T. diversifolia (Td) and C.domestica (Cd) combination to Sprague Dawley female rats liver and kidney function which have been induced with DMBA. This research used a quasi experimental study design. There were 31 female rats divided into 6 groups; healthy group; doxorubicin group; breast cancer model; extract combination I (n=5), extract combination II (n=5), extract combination III (n=5). DMBA used to initiate breast cancer was given twice a week for 5 weeks. After palpable breast cancer was showed up, the combination extract groups were given ethanol extract combination of kembang bulan leave and turmeric rhizome twice a day for 4 weeks orally with dosage ratio 40:150 mg/kgBW, 80:150 mg/kgBW, 160:150 mg/kgBW, respectively. Doxorubicin group was given 0,032mg/20gBW intraperitoneally once a day for 4 weeks. Liver and kidney function test were conducted on day 0 and the last day with SGOT, SGPT, Ureum and Creatinine level as the parameters measured. Comparison of liver and kidney function test results between extract combination groups and control groups showed no significant difference. The parameters measured were SGOT (p=0,847), SGPT (p=0,237), Creatinine (p=0,671), Ureum (p=459). Extract combination groups compared to control groups have no significant effect to liver and kidney function.

Evaluation of Empiric Antibiotic Therapy Toward Clinical Outcome in Children Patients with Bacterial Meningitis in Dr. Sardjito General Hospital Yogyakarta 2010-2015 Wihda Yanuar; Ika Puspita Sari; Titik Nuryastuti
Majalah Farmaseutik Vol 14, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Cases of bacterial meningitis in Indonesia reach 158/100,000. Bacterial meningitis attacks children less than 2 years old. Patients with bacterial meningitis who survive are at risk for complications such as brain damage. Therefore, patients with bacterial meningitis, especially in children, need to get optimal therapy. This study aims to determine the pattern of empirical antibiotic use on clinical outcome of pediatric patients with bacterial meningitis in the inpatient ward of Sardjito General Hospital. The study was conducted in an observational descriptive design by collecting data retrospectively on the medical records of patients who met the inclusion criteria. There were 25 patients who met the inclusion criteria. The results showed that 26% use of empiric antibiotics was in accordance with the guidelines for the treatment of bacterial meningitis. Empiric therapy increased clinical outcomes of 40% patients.

In Vitro Antiplasmodial Activity and Cytotoxicity of Isolates of Pasak Bumi (Eurycoma longifolia Jack) Root Eti Nurwening Sholikhah; Mahardika Agus Wijayanti; Laela Hayu Nurani; Mustofa Mustofa
Majalah Farmaseutik Vol 14, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Previous study showed that methanol soluble fractions of Eurycoma longifolia Jack showed a high in vitro antiplasmodial activity, however there is no explanation which isolate is active as antiplasmodial. This study was conducted to evaluate the in vitro antiplasmodial activity and cytotoxicity of 5 isolates of E. longifolia root isolated from methanol soluble fractions. The in vitro antiplasmodial activity was tested on two strains of P. falciparum, FCR-3 and D10 while their cytotoxicity was tested on normal Vero cell line. The antiplasmodial activity and the cytotoxicity were presented as the Inhibitory Concentration 50% (IC50) which showed the concentration of isolate which inhibit the Plasmodium or Vero cell line growth 50%. The IC50 value was determined by probit analysis. The selectivity of isolate was determined by calculating the ratio of the cytotoxicity (IC50 on Vero cell line) with the antiplasmodial activity (IC50 on Plasmodium). The results showed that isolate 4 and 5 showed high antiplasmodial activity with IC50 value 2.21-19.02, 13.54-64.73 µg/mL respectively. The cytotoxic/antiplasmodial ratio indicates that isolate 4 and 5 have also high selectivity with value 11.74-68.75 for isolate 4, and 66.01-316.51 for isolate 5. For conclusion, the isolate 4 and 4 showed the high aniplasmodial activity with the high selectivity

Formula Optimization of o/w Cream Combination Oxybenzone and Titanium Dioxide and Its In Vivo Activity Testing Ribka Elcistia; Abdul Karim Zulkarnain
Majalah Farmaseutik Vol 14, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The downside effects from sunlight exposure can be reduced by using sunscreen. Emulsifier optimization of triethanolamine (TEA) stearate and cetyl alcohol in sunscreen cream containing combination of oxybenzone and titanium dioxide is expected to produce the desired cream optimum formula with good physical stability. This study aimed to determine the optimum TEA sterate and cetyl alcohol proportion and figure out the SPF value of o/w cream containing combination of oxybenzone and titanium dioxide. The optimum formula was obtained based on cream physical characteristics testing with Simplex Lattice Design method using software Design Expert version 9.0.4. One sample t-test was used to determine the difference of optimum formula value between research and software Design Expert version 9.0.4 analysis. The comparison between optimum formula o/w cream combination oxybenzone and titanium dioxide during 4 weeks storage was analyzed using ANOVA test. The SPF value testing through in vivo was conducted against female rabbits strain New Zealand White induced by 8-methoxyprosalen. The result showed that proportion TEA stearate and cetyl alcohol which produced the optimum formula of o/w cream combination oxybenzone and titanium dioxide were 8.93% and 2.07%. The viscosity and adhesiveness were not siginifically different, while cream spreadability was significally different during 4 weeks storage. Testing activity in vivo sunscreen cream o / w combination of oxybenzone and titanium dioxide produced SPF 12.

Antibacterial Activities of Red Flow Oil (Piper Crocatum Ruiz & Pav.) in The Form of Emulsion and Microemulsi Elsa Putri Kartika; Marchaban Marchaban; Sudarsono Sudarsono
Majalah Farmaseutik Vol 14, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The red sirih essential oil (RSEO) known has antibacterial activity and can be obtained by water and steam distillation of red betel leaf (Piper crocatum Ruiz & Pav.). The aim of this study is to compare its bacterial activity if the RSEO is formulated in different dosage forms (i.e. emulsion and microemulsion). The RSEO in emulsion dosage form was prepared by stirring 0.875 g of liquid paraffin, 0.125 g RSEO, 0.125 g of tween-80, 0.375 g of span-80 (HLB 7), and 3.500 g of water. The RSEO in microemulsion dosage form was prepared by stirring 0.125 g of liquid paraffin, 0.125 g RSEO, 0.417 g Tween 80, 0.833 g of PEG-400 and 3.500 g of water. Antibacterial activity against Escherichia coli ATCC 25922 was done by using microdilution method at 1% of w/w concentration using the ELISA reader at 570 nm. The data was then to be analysed to compare the percentage of inhibition of the bacterial growth. The results showed that the bacterial inhibition of RSEO in emulsion dosage form was 17.45±5.9% while in microemulsion dosage form was 49.58±3.27%. It is concluded that the RSEO had a better antibacterial activity in the forms of microemulsion than emulsion.

Gel Formulation of Lemongrass Essential Oil with HPMC and Carbopol Bases Suryani Tambunan; Teuku Nanda Saifullah Sulaiman
Majalah Farmaseutik Vol 14, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Lemongrass (Cymbopogon citratus) essential oil is proven to have efficacy as an antibacterial against pathogenic bacteria, such as Staphylococcus aureus. Essential oils was formulate into gel dosage forms with a base combination of HPMC and carbopol. The use of this combination is known to produce a gel with physical properties better than a single use. This research aimed to investigate the effect of variations of HPMC and carbopol to the physical properties of the gel, the concentration of HPMC and carbopol to produce the optimum formula, and the physical stability of essential oil gel of lemongrass during storage. Gel was made by lemongrass essential oil at a concentration of 6% with base of HPMC and carbopol. Each formula were made and tested the physical properties that include organoleptic, homogenity, pH, viscosity, spreadability and adhesiveness. HPMC and carbopol composition were determined through the process of screening and optimization Simplex Lattice Design methods by Design Expert 7.1.5 software. Experimental results and predictions of SLD were verified by testing one sample t-test with a 95% confidence level. The optimum formula gel of lemongrass essential oil consisting of 4.00% HPMC and 1.00% carbopol. The results test of physical properties of lemongrass essential oil gel obtained homogeneous gel with a pH value of 6.00 ± 0.00, viscosity of 280.00 ± 26.46 dPa.S, spreadability of 9.36 ± 0.47 cm2, and adhesiveness of 2.36 ± 0.10 seconds. Lemongrass essential oil gel was stable for 3 cycles of testing include organoleptic, homogeneity, syneresis, pH, adhesion, and the viscosity of the gel. Spreadability of gel was not stable.

Page 9 of 49 | Total Record : 488

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