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INDONESIA
Indonesian Journal of Chemistry
Published by Universitas Gadjah Mada
ISSN : 14119420     EISSN : 24601578     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
Arjuna Subject : -
Articles 1,956 Documents
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Studies on the Loading and Release of Metformin HCl Using Hydrogels with EGDMA and MBA as Crosslinkers Ariyaldi, Ariyaldi; Nizardo, Noverra Mardhatillah; Lestari, Maria Lucia Ardhani Dwi
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.95826

Abstract

Hydrogel poly(N-vinylcaprolactam-co-2-(dimethylamino)ethylmethacrylate) or (P(NVCL-co-DMAEMA)) containing the active drug metformin HCl were synthesized using the free radical polymerization method in the presence of DMAEMA and NVCL monomers by using two different crosslinkers: ethylene glycol dimethacrylate (EGDMA) and methylene bisacrylamide (MBA). FTIR spectra confirmed the successful formation of hydrogel and its loading with metformin HCl. SEM analysis revealed the physical shape and surface features. Regarding physical appearance, the texture of the hydrogel is sticky and elastic. When the hydrogel was immersed in a solution, it swelled, and returned to its original shape after drying. Additionally, the chemical degradation temperature is thermally stable at 329.75 °C. The loading test results showed that the active drug in EGDMA was 18.38 (% w/w) and 26.19 (% w/w) in MBA as crosslinkers, loaded within 24 h. The drug-loaded hydrogel containing EGDMA as crosslinkers in pH 7.4 had the highest drug release in 24 h compared to MBA. Then, the drug released from hydrogel with EGDMA in pH 2 had the highest drug release than MBA within 30 min. The P(NVCL-co-DMAEMA) hydrogel has the potential for a drug delivery system. However, additional optimizations are necessary to improve the efficiency of the hydrogels as a carrier.
Sulfasalazine as a Corrosion Inhibitor on Carbon Steel Metal Surfaces in Acidic Media Using the Hydrogen Evolution Method: Experimental and Theoretical Studies Obaid, Hadi Thamer; Mutar, Muthanna Mahmood; Ali, Safaa Hussein
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.95852

Abstract

Current study designed to explore the anti-corrosion effect of 2-hydroxy-5-{(E)-[4-(pyridin-2ylsulfamoyl)phenyl]diazenyl} benzoic acid (sulfasalazine, SSZ) on carbon steel. 1 M of HCl solution used as an aggressive medium. The corrosion process was significantly inhibited by SSZ using simple, direct and accurate method (hydrogen evolution) to measure corrosion inhibition process. The results showed that the corrosion inhibition efficiency increased with increasing the inhibitor SSZ concentration. Three different concentrations of the inhibitor SSZ (0.1 × 10−3, 0.5 × 10−3, and 1.0 × 10−3 M) were used in the corrosion experiment. Results showed a maximum inhibition efficiency (89.74%) achieved at the concentration of 1 × 10−3 M and the temperature of 308 K. The calculations of the hydrogen evolution method showed that the investigated SSZ acted as a mixed-type inhibitor. Adsorption of SSZ on the carbon steel surface obeys the Langmuir adsorption isotherm. The quantitative chemical parameters were calculated using density functional theory (DFT). In addition, full geometry optimizations were performed using DFT with B3LYP. The correlation between the theoretical and experimental results is discussed. The theoretical and experimental studies showed that SSZ is a good inhibitor as the maximum anti-corrosion activity was achieved at the highest concentration of the SSZ (1 × 10−3 M), and the lowest temperature used in the experiment.
Enhanced Optical Properties of ZnO-TiO2 Films Through Co-Sensitization with Multiple Natural Dyes Musyarofah, Musyarofah; Nuraini, Inas; Prayitno, Budi; Ernawati, Lusi; Ismail, Andi Idhil; Triwikantoro, Triwikantoro
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.96154

Abstract

The ZnO-TiO2 films were co-sensitized with single, double, and triple natural dyes, leading to distinct effects on the optical properties. ZnO (wurtzite) and TiO2 (anatase) were prepared from commercial powders and the XRD results revealed that the crystallite size is 158 and 443 nm, respectively. The UV absorbance of ZnO powder shows significant peaks at wavelengths of 255 and 345 nm, with a band gap energy of 3.07 eV. Meanwhile, TiO2 powder exhibits a maximum peak at 325 nm and possesses a band gap energy of 3.16 eV. The extraction of natural dyes (Moringa oleifera, Biancaea sappan, Matricaria chamomilla, Rosa, and Chrysanthemum) was carried out using a cost-effective and simple method involving immersion in ethanol for 2 × 24 h followed by filtration. FTIR test results show the presence of O–H, C–H, C=C, and C–O functional groups. The results of coating the ZnO-TiO2 film with natural dyes show that the UV spectrum peaks are higher than the visible light wavelength. Co-sensitization of double natural dyes demonstrated different effects on the ZnO-TiO2 film, i.e., achieved panchromatic absorption mainly in the UV wavelength spectrum.
The Utilization of Gracilaria sp. as Raw Material for Cellulose in Cellulose Acetate-Nickel Oxide (CA-NiO) as Electrode for Energy Storage Technology Karim, Abdul; Ahmad, Ahyar; Arfah, Rugaiyah Andi; Ermawar, Riksfardini Annisa; Karim, Harningsih; Putra, Andi Erwin Eka; Putri, Suriati Eka; Negara, Satria Putra Jaya; Larekeng, Siti Halimah
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.96533

Abstract

In the modern era, electrical energy has become a significant need that drives the large consumption of fossil fuels and their environmental impacts. Supercapacitors can reduce this large consumption of natural polymers such as cellulose acetate (CA), which can be synthesized from Gracilaria sp. Composites with CA can be an environmentally friendly alternative electrode with low toxicity. The results show that the cellulose has been successfully synthesized from the algae Gracilaria sp., which was proven by FTIR spectra analysis. The results also show that supercapacitor electrodes have been successfully made where the manufactured electrodes form a composite between CA and nickel oxide (NiO), with the highest specific capacitance and specific energy values of 15.5 × 102 F/g and 13.3 × 102 Wh/kg, respectively, on the CA-NiO2 electrode, but when the NiO concentration is higher than the CA concentration the specific capacitance and specific energy decrease as shown on the CA-NiO electrode with NiO mass of 0.6 g. Thus, the materials results of this study can be applied to electric vehicles and technology that requires electricity storage in the future.
Chemical Profiling Ethyl Acetate Extract of Basilicum polystachyon Leaves and Exploration of Anticancer SIRT1 Inhibitors Using In Silico Approach Tukiran, Tukiran; Raihan, Muhammad
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.96606

Abstract

Cancer significantly increases prevalence and mortality rate making it a serious health concern currently, including breast cancer. The development of new drugs is a major effort to solve the cancer problems. Natural products are the primary source of medicinal compounds believed to have lower toxicity and side effects than synthetic drugs. This research aimed to reveal the chemical profile of the ethyl acetate extract of Basilicum polystachyon leaves. Through an in silico approach, this research studied the anticancer mechanism against the sirtuin1 (SIRT1) at the molecular level. Molecular docking simulations were performed to understand the interaction behavior of potential compounds as SIRT1 inhibitors. Based on these results, 117 individual compounds were successfully identified in the ethyl acetate extract. Molecular docking simulation revealed that ten compounds could inhibit SIRT1 better than the control inhibitor, indicating that these compounds have potential as anticancer agents. The prediction of these compounds' physicochemical properties and pharmacokinetics showed promising results and fulfilled the medicinal compound's criteria. These findings can be the basis for the application of phytochemical compounds as anticancer drugs, specifically potential compounds in B. polystachyon leaves.
Iron-Binding Capacity and Antidiabetic Activity of Baby Clam (Corbiculidae sp.) Meat Protein Hydrolysate Vo, Tam Dinh Le; Huynh, Thu; Le, Thuy Thi; Tran, An Thi Tuong; Vo, Bao Chi
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.98947

Abstract

Baby clam (Corbiculidae sp.) meat is served as a traditional dish in Vietnam, and the antioxidant activity of its protein extract has been discovered. This study evaluates baby clam meat protein hydrolysate's iron-binding capacity (IBC) and antidiabetic activity. Initially, an analysis of the basic chemical composition of the meat was conducted. Subsequently, Alcalase was employed for hydrolysis. The highest IBC and α-amylase inhibition activity were targets for obtaining the best hydrolysis condition, including the clam meat-to-water ratio, enzyme-to-substrate (E:S) ratio, and time. Under the best condition, the hydrolysates demonstrated the IBC of 1246.20 ± 44.00 µg Fe2+/g protein and α-amylase inhibition activity of 48.33 ± 1.44%, approaching three-quarters of the activity of ethylenediaminetetraacetic acid (EDTA) sodium salt and acarbose, respectively. These results served as preliminary data for the development of the protein hydrolysates as a natural iron chelator or α-amylase inhibitor, which could support the treatment of iron deficiency and diabetes.
Optimization of Protein Hydrolysate from Earthworms (Perionyx excavatus) of Angiotensin-I-Converting Enzyme Inhibitory Activity by One Variable at a Time Bui, Phong Thanh; Hoang, Truc Anh; Pham, My Thi Thuy; Tran, Linh Le Phuong; Nguyen, Oanh Kim
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.99059

Abstract

Hypertension, characterized by elevated blood pressure, is commonly treated with angiotensin-I-converting enzyme (ACE) inhibitors. This study evaluated the ACE inhibitory activity (ACEIA) of protein hydrolysate from earthworms (Perionyx excavatus) by commercial proteases. The results showed that the protein hydrolysate of earthworms gave the highest ACEIA of 85.38 ± 2.31% (at the protein concentration of 2 mg/mL) and IC50 value of 844.64 μg/mL when the earthworms were hydrolyzed with Flavourzyme® 500 MG under optimized conditions such as earthworm:phosphate buffer ratio of 1:6 (w/v), hydrolysis temperature of 50 °C, pH 7, enzyme:substrate ratio of 600 U/g protein and hydrolysis time of 2 h. The membrane further fractionated the hydrolysate, and the < 1 kDa fraction had the highest ACEIA with an IC50 value of 261.94 μg/mL. The stability of ACEIA was assessed under various conditions, including in vitro digestion, heat treatment at 100 °C for 180 min, and pH adjustments from pH 1 to 11. The < 1 kDa fraction maintained ACEIA activity at 133.34, 76.25, and 84.95%, respectively, after these treatments. These results suggest that earthworm protein hydrolysates, particularly the <1 kDa fraction, exhibit strong stability and could be promising candidates for the development of functional foods or pharmaceuticals targeting hypertension.
Bioadsorption of Copper(II) Using Halmahera Specific Marine Algae (Sargassum turbinarioides) Encapsulated Calcium Alginate Sanawi, Dede Ardiansyah Takdir Abubakar; Rumhayati, Barlah; Fardiyah, Qonitah
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.99090

Abstract

This study investigated the conditions for bioadsorption of copper(II) using Halmahera marine algae (Sargassum turbinarioides) encapsulated with calcium alginate by batch method. Physicochemical parameters of biosorption, including contact time, biosorbent mass, pH, and copper(II) concentration, were studied to determine the percentage of copper(II) adsorbed. The maximum percentage of copper(II) bioadsorption was 96.4% under the optimum bioadsorption conditions with a contact time of 90 min, a biosorbent mass of 2 g, a solution pH of 5, and a copper(II) concentration of 60 mg/L. The bioadsorption isotherm study showed that the Langmuir model is more suitable for modeling copper(II) bioadsorption, while the bioadsorption kinetics study showed a pseudo-second-order kinetic model. Characterization of the biosorbent using FTIR showed that the biosorbent has active functional groups such as O–H, C–H, S–H, C=O, S=O, and C–O–C, which act as metal ligands, and SEM characterization showed morphological changes in the biosorbent before and after the copper(II) bioadsorption process.
Sesquiterpenoids from Dysoxylum amooroides Stem Bark: Isolation, Structure Determination, and Cytotoxicity Against MCF-7 Breast Cancer Cells Gunawan, Latifah; Mustofa, Hidayat Nurul; Naini, Al Arofatus; Harneti, Desi; Hidayat, Ace Tatang; Nurlelasari, Nurlelasari; Maharani, Rani; Mayanti, Tri; Fajriah, Sofa; Awang, Khalijah; Azmi, Mohamad Nurul; Supratman, Unang
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.99121

Abstract

Three sesquiterpenoids, guaianediol (1), alismol (2), and spathulenol (3), were isolated from the n-hexane and ethyl acetate extracts of the stem bark of Dysoxylum amooroides. The three compounds were found in D. amooroides species for the first time. The structures of the isolated compounds were identified and established based on an extensive spectroscopic analysis involving HR-TOF-ESI-MS, IR, and NMR data, as well as a comparison with the previously reported works of literature. Compounds 1-3 were further assessed for cytotoxic effects against MCF-7 breast cancer cells. Guaianediol (1) showed inactive activity with IC50 > 100 µM, alismol (2) showed weak activity with IC50 value of 82.1 µM and spathulenol (3) showed considerable activity with an IC50 value of 15.2 µM. A brief structure-activity relationship and comparison with the previous works were also discussed to understand better the role of guaiane- and aromadendrane-type sesquiterpenoids in the biological activity perspective.
Dual-Functional Fe3O4@SiO2/Ag/AgCl Nanocomposites as Photocatalyst for Degrading Methylene Blue Dye Under Natural Light Irradiation Nguyen, Kha Minh; Pham, Nga Ngan; Tran, Hien Thi-Thu; Nguyen, Son Truong
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.99129

Abstract

The textile dyeing industry not only plays a crucial economic role in many nations but also significantly contributes to environmental pollution, particularly in aquatic environments. To mitigate this impact, various materials have been explored for their ability to remove dyes from wastewater. Among these, visible-light-responsive photocatalysts based on Ag nanomaterials have attracted considerable attention. However, challenges remain, including the degradation efficiency and the recoverability of photocatalysts. In this study, Fe3O4@SiO2/Ag/AgCl (FSAC) nanocomposites were synthesized and evaluated for methylene blue (MB) dye degradation under natural light irradiation. The magnetic properties of FSAC remained those of the core Fe3O4 nanoparticles, with a band gap energy of approximately 1.8 eV. Results showed that the photocatalytic decomposition of MB under 25 W natural light was significantly enhanced in the presence of the FSAC nanocomposites, compared to Fe3O4, Fe3O4@SiO2, and Fe3O4@SiO2/Ag nanoparticles. With its dual-functional magnetic and plasmonic properties, enabling both efficient recovery and superior catalytic performance, the FSAC composite holds excellent promise as a photocatalyst for the degradation of organic pollutants in water.

Page 185 of 196 | Total Record : 1956

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