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INDONESIA
Indonesian Journal of Chemistry
Published by Universitas Gadjah Mada
ISSN : 14119420     EISSN : 24601578     DOI : -
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology and Higher Education (RISTEKDIKTI) No : 21/E/KPT/2018 (in First Rank) and indexed in Scopus since 2012. Since 2018 (Volume 18), Indonesian Journal of Chemistry publish four issues (numbers) annually (February, May, August and November).
Arjuna Subject : -
Articles 1,956 Documents
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Synthesis, Characterization, Biological, and Antioxidant Activity of New Metal Ion Complexes with Schiff Base Derived from 2-Hydroxybenzohydrazide Kadhim, Ayyat Jawad; Shaalan, Naser
Indonesian Journal of Chemistry Vol 24, No 6 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.98292

Abstract

The study involved the synthesis of new complexes with tetradentate ligand (LH). The general formula of complexes was [M(LH)(H2O)2] with M of Ni2+, Co2+, Cu2+, and Zn+. The ligand was synthesized by treating the 2-hydroxybenzohydrazide with salicylaldehyde. The structural characteristics of ligands and complexes were analyzed using various techniques, including elemental analyses, magnetic susceptibility, molar conductivity, infrared, ultraviolet absorption, mass, and NMR spectroscopy studies. The physical measurements indicated that the prepared complexes are non-electrolyte and showed that the ligand is tetradentate when coordinated with metal ions through the nitrogen of azomethine (–C=N–), two oxygen atoms of O–H phenolic, and an oxygen atom of carbonyl (C=O) for benzohydrazide. It was found that Co2+, Cu2+, and Zn2+ complexes are octahedral, while Ni2+ complexes are square planar. The biological screening of the complexes demonstrates that the Schiff base metal complexes exhibit remarkable efficacy in combating microorganisms by utilizing Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli) bacteria, as well as Candida albicans fungi. Hence, their results were good in inhibition. Then, the potential of these prepared compounds as antioxidants was determined by inhibiting free radicals.
Synthesis and Characterization of Nickel Nanoparticles: Biological and Photocatalytic Properties Fadliah, Fadliah; Raya, Indah; Ahmad, Ahyar; Taba, Paulina; Burhanuddinnur, Muhammad; Gaffar, Maming; Putri, Tri Widayati; Nur, Arfiani; Abubakar, Andi Nur Fitriani; Munadi, Rachmin; Majid, Ahmad Fudhail; Pratama, Irham; Yasser, M.; Jarre, Sulistiani; Karim, Harningsih
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.90034

Abstract

The potential uses of ecologically benign nickel nanoparticle manufacturing in various sectors, such as biomedicine, energy storage, and catalysis, have garnered much interest. This paper covers green approaches to nickel nanoparticle manufacturing, which integrate natural substances as stabilizing and reducing agents with eco-friendly processes. Phytochemicals derived from bacteria, microorganisms, and plant leaf extracts can convert nickel ions (Ni2+) into nickel nanoparticles. Room temperature is used for the synthesis procedure, and neither dangerous compounds nor unusual reaction conditions are used. Using a variety of analytical methods, the resultant nickel nanoparticles were characterized. We also investigate the possibility of using the generated nickel nanoparticles as a cytotoxic, photocatalytic, antioxidant, and antibacterial agents. The antimicrobial activity of nickel nanoparticles demonstrates their potent antibacterial properties, while their antioxidant activity demonstrates their capacity to combat free radicals effectively. Furthermore, nickel nanoparticles' cytotoxic activity demonstrates their capacity to kill cancer cells, and their photocatalytic activity demonstrates their efficiency in breaking down organic contaminants. This review highlights the value of ecologically benign synthetic methods and creates new avenues for developing nickel nanoparticle applications in health and the environment.
A Review of Marine Bacterial Intracellular and Extracellular Bioactive Compounds as Novel Antibacterial and Anti-Inflammation Agents Karim, Harningsih; Azis, Arief; Ramadani, Ananda; Anita, Anita; Ahmad, Ahyar; Natsir, Hasnah; Taba, Paulina; Putri, Suriati Eka; Sarlan, Sarlan; Larekeng, Siti Halimah; Irfandi, Rizal
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.90039

Abstract

Unique and varied bioactive compounds produced by the ocean have drawn attention and served as a focus for creating antibacterial and anti-inflammatory agents. As part of the approach for locating these research sources, databases such as PubMed, Science Direct, MDPI, Google Scholar, Springer Link, Web of Science, Scopus, and Wiley Online Library were used to identify completed studies. Numerous intriguing bioactive compounds have so far been isolated from marine bacteria. A crucial resource in the ongoing search for novel peptides, proteins, lipids, nucleosides, enzymes, alkaloids, polyketides, and terpenoids is the diversity of marine bacterium strains. This review summarizes several bacterial intracellular and extracellular bioactive compounds that have been applied as antibacterial and anti-inflammatory agents in 2016–2024, which we present in the form of structures, species sources, and evaluations of these compounds' antibacterial and anti-inflammatory activities. Therefore, this review article can be used as a recommendation for utilizing biomaterials from marine bacteria that are promising in the future for industrial-scale production of antibacterial and anti-inflammatory agents.
Antioxidant and Antimicrobial Activity of New Amide Compounds Containing Azo Group Using Dicyclohexylcarbodiimide (DCC) as Coupling Agent Saleh, Dania Mohammed; Al-Salami, Bushra Kamel
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.92305

Abstract

A series of amide compounds (A2D1-A2D6) were synthesized based on sulfathiazole by converting it to diazonium salt using NaNO2 and concentrated HCl via diazotization reaction. This reaction was followed by coupling reaction with vanillic acid in alkaline medium to generated azo compound 4-hydroxy-3-methoxy-5-((4-(N-(thiazol-2-yl)sulfamoyl)phenyl)diazenyl)-benzoic acid (A2). Compound A2 was reacted with substituted aromatic amines such as 2-amino-4,6-dimethylpyridine, sulfamerazine, sulfadiazine, sulfanilamide, sulfathiazole, and sulfanilic acid to form corresponding amides using DCC as coupling reagent to be promoted condensation reaction. The structures of synthesized compounds have been diagnosed with elemental analysis, FTIR, 1H-NMR, 13C-NMR, and mass spectrometry. The antibacterial activities for all new synthetic compounds was estimated accurately depending on selected bacteria such as Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) using different concentrations to calculate minimum inhibition concentration. The effectiveness of inhibiting fungi was also studied against Candida albicans by agar diffusion method. Finally, the antioxidant capacities of the prepared compounds were determined by using DPPH radical scavenging method. The results of potential radical scavenging activity were given as IC50. The compounds showed strong biological activity and good antioxidant activity compared with the standard substance Vitamin C.
Study of Structural, Dielectric, and Phase Transition of Strontium Doped BaTiO3 Zouitine, Asmaa; Ghandouri, Abdelhak El; Elbasset, Abdelhalim; Abdi, Farid; Lamcharfi, Taj-dine; Laribou, Hicham; Mrharrab, Lamiae; Mohammed, Zouhairi
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.93659

Abstract

In this paper, we studied the effect of strontium doping on the structural, microstructural, dielectric, and electrical properties of Ba1-xSrxTiO3 (BSxT) ceramics prepared via the sol-gel method, with x = 0.00 to 0.15. The results obtained from the X-ray diffraction spectrum confirmed the creation of the pure perovskite structure, with the diffraction peaks of the BSxT shifting toward the bigger 2θ with increasing Sr content. Scanning electron microscopy images show that the grain size of the BSxT ceramics decreases with increasing Sr content. An increase in Sr content appears to lower the activation energy by the factor of 0.16 meV/mol% and to decrease Curie temperature by the factor of 3.34 °C/mol%. Furthermore, in case of 15 mol% of Sr addition, the dielectric constant value is increased about twice. Moreover, the relationship between grain sizes and dielectric properties was also investigated. Using the frequency measurement method (up to 2 MHz in a step of 1 kHz), we are able to determine the temperature of transition without using the conventional method.
Effect of Temperature on Synthesis of Hydroxyapatite/Chitosan Composite Using the In-Situ Method as a Heavy Metal Adsorbent Jamarun, Novesar; Amirullah, Tri Yupi; Syukri, Syukri; Prasejati, Arika; Wulandari, Wulandari; Caniago, Sintia; Tricahyani, Nabiila Ayyu
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.93816

Abstract

Removing hazardous non-organic waste containing heavy metals like copper and lead is crucial for environmental protection. Adsorption offers a promising solution, with hydroxyapatite (HAp) serving as a biocompatible adsorbent due to its active surface area. However, its mechanical limitations necessitate enhancement through compositing with chitosan (CTS), a natural biopolymer. This study synthesized hydroxyapatite from cuttlefish bone as a calcium source, while chitosan was extracted from shrimp shells. The hydroxyapatite/chitosan (HAp/CTS) composites were prepared in situ at varying temperatures (55, 60, 65, 70, and 75 °C). The composites were characterized using FTIR, XRD, SEM, and SAA. The result indicated successful integration of HAp and CTS, with a crystallite size of 13.82 nm in the 65 °C composite. Based on SEM-EDS analysis, the HAp/CTS 65 °C morphology was agglomerated chunk particles with a Ca/P ratio of 1.61. The highest adsorption capacity value is found in the HAp/CTS 65 °C composite for both ions, 1.9979 mg/g for Cu2+ ions and 0.9965 for Pb2+ ions. The reusability test results of the HAp/CTS 65 °C composite succeeded up to two cycles. This research proves that the adsorption of Cu2+ and Pb2+ ions by HAp/CTS composite adsorbent has been successfully carried out.
Semiconductor Gas Sensors: Metal Oxides, Synthesis Methods, Applications as Gas Sensors, and Oxidation and Reduction Mechanisms Hammod, Inam Abed; Ridha, Noor Jawad; Tahir, Khawla Jemeel; Alosfur, Firas Kamel Mohamad; Yasir, Asaad Sabbar; Majeed, Luma Ahmed
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.95018

Abstract

Over the last several decades, advancements in industry have facilitated the absorption of harmful gases into the bloodstream or lungs via dermal absorption or inhalation. This process may elicit diverse cellular responses, potentially leading to adverse health effects. Consequently, air pollution has emerged as a significant worldwide issue. Hence, developing a device capable of monitoring air pollution and detecting these chemicals in the surrounding environment became imperative. Gas sensors are instruments used for regulating industrial emissions, surveillance of environmental contaminants, and identification of pollutants and hazardous gases. Semiconductor gas sensors have garnered significant recognition owing to their several advantageous characteristics, including simplified production processes, compact dimensions, and low-cost. Some of its drawbacks include limited selectivity and high operating temperatures. This review discusses the most often used semiconducting materials in gas sensing, as well as the methods used to synthesize them, and the reduction and oxidation processes that happen between metal oxides and analyte gas. Furthermore, the various strategies employed to increase the gas-sensing response are explored, such as doping with noble metals and the formation of heterostructures.
Freeze-Drying Microencapsulation of Ruellia tuberosa L. Extracts: A Comparative Study Using Different Polymers as Encapsulants Gunawan, Firza Rajasa; Ulfa, Siti Mariyah; Safitri, Anna
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.95246

Abstract

Ruellia tuberosa L. leaf and root extracts have been investigated for their biological activity and potential health advantages, including their antidiabetic, antioxidant, and antidiuretic qualities. This research evaluates the freeze-drying microencapsulation of R. tuberosa L. extracts using gum Arabic, maltodextrin, and their combination as coating materials. The resulting microcapsules were tested for encapsulation efficiency, biological activity, and controlled release. Characterization techniques included scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, and particle size analysis (PSA). The choice of encapsulant significantly influenced encapsulation efficiency, morphology, and biological activity. Microcapsules using a combination of gum Arabic and maltodextrin exhibited more spherical shapes and smaller particle sizes than those using either material alone. Alpha-amylase inhibition tests showed that microcapsules effectively inhibit the enzyme, with the coating combination performing best, followed by gum Arabic and then maltodextrin. All microcapsules exhibit moderate antioxidant activity, again in the same order. The active compound release was greater at pH 7.4 compared to pH 2.2 from 0 to 120 min. Therefore, freeze-drying microencapsulation with biodegradable polymers is a viable method for delivering the health benefits of R. tuberosa L. extracts, yielding a convenient powder form suitable for drug delivery systems.
Synthesis of CuO Nanoparticles from Copper(II) Schiff Base Complex: Evaluation via Thermal Decomposition Al-Khazraji, Ali Mudher Abdulkareem; Waheed, Enass Jasim; Ahmed, Awf Abdul Rahman
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.95427

Abstract

Copper oxide (CuO) nanoparticles were synthesized through the thermal decomposition of a copper(II) Schiff-base complex. The complex was formed by reacting cupric acetate with a Schiff base in a 2:1 metal-to-ligand ratio. The Schiff base itself was synthesized via the condensation of benzidine and 2-hydroxybenzaldehyde in the presence of glacial acetic acid. This newly synthesized symmetric Schiff base served as the ligand for the Cu(II) metal ion complex. The ligand and its complex were characterized using several spectroscopic methods, including FTIR, UV-vis, 1H-NMR, 13C-NMR, CHNS, and AAS, along with TGA, molar conductivity and magnetic susceptibility measurements. The CuO nanoparticles were produced by thermally decomposing the complex at 800 °C. These nanoparticles and other metal oxides are highly valued in various industries for their optical, magnetic, and electrical properties. The experiment highlighted the synthesis of CuO nanoparticles through the thermal breakdown of copper(II) ions, starting with copper acetate, which reacted with the ligand to form the complex. The characterization results of CuO nanoparticles reveal a highly pure crystalline structure with an average size of 70–90 nm.
Synthesis of Some Metal Complexes with New Heterocyclic Ligand (5-(((2-(3-(1H-indol-3-yl)acryloyl)phenyl)amino)methylene)-2-thiooxodihydropyrimidine-4,6(1H,5H)-dione) and Their Biological Effectiveness as Antioxidant and Anti-Cancer Hilal, Thanaa Abdul Ameer; Kareem, Ibtihal Kadhim
Indonesian Journal of Chemistry Vol 25, No 1 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.95731

Abstract

A novel ligand 5-(((2-(3-(1H-indol-3-yl)acryloyl)phenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione) (L1) which contains two groups of carbonyl synthesized in one pot and three-component reaction with thiobarbituric acid as starting material, and its complexes with Co(II), Ni(II), Cu(II), Zn(II) and Au(III) have been synthesized. The results of spectrophotometry, nuclear magnetic resonance of proton (H-NMR), infrared spectroscopy (FTIR), ultraviolet and visible (UV-vis) spectroscopy, X-ray diffraction (XRD), elemental analysis (CHNS) and molar conductivity measurements were used to suggest the proposed structures. These data have been utilized to propose appropriate geometric configurations for all complexes. The L1 coordinates toward the metal ions Co(II), Ni(II), Cu(II), and Zn(II), giving an octahedral geometry, while it has a square planar shape with the Au(III) ion. Scanning microscopy (FE-SEM) was used to determine the size of nanoparticles. The present investigation employs a comprehensive molecular docking analysis to assess the binding energies of anti-cancer drugs, thereby elucidating their binding affinity towards the receptor. This indicates that the [Au(L1)Cl]Cl2 complex has a strong affinity for the protein kinase (1HK7). Significant antiproliferative activity was seen in it against human breast cancer (MCF-7) and normal cell lines (MCF-10), as evidenced by the IC50 and selective indices (SI) values. This study could contribute to the development of pharmaceutical preparations.

Page 184 of 196 | Total Record : 1956

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