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Ajuk Sapar
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Department of Chemistry, Faculty of Mathematics and Natural Sciences, Tanjungpura University Jl. Prof. Dr. Hadari Nawawi, Pontianak, Kalimantan Barat, Indonesia
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INDONESIA
Indonesian Journal of Pure and Applied Chemistry
Published by Universitas Tanjungpura
ISSN : 26208571     EISSN : 2620858X     DOI : -
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology Chemistry
Indonesian Journal of Pure and Applied Chemistry (IJoPAC) was first established in 2018 as a scientific journal that accommodates researchers and education practitioners to publish scientific work and research results which are the results of experiments or literature studies in the field of chemistry. Publications are carried out periodically with three issues (January-April, May-August, September-December) in one volume per year. Published scientific work can be in the form of original articles, short communications and review results covering the fields of Physical chemistry, Organic chemistry, Analytical chemistry, Inorganic chemistry, Biochemistry / Biological Chemistry, Applied Chemistry. Focus and Scope of Indonesian Journal of Pure and Applied Chemistry covering the fields : Physical chemistry Organic chemistry Analytical chemistry Inorganic chemistry Biochemistry/Biological Chemistry Applied Chemistry
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol 7, No 2 (2024)" : 5 Documents clear
AKTIVITAS ANTIBAKTERI KURKUMIN DAN KOMPLEKS TEMBAGA (II) KURKUMIN TERHADAP S.AUREUS DAN E.COLI Firdaus, Giska Ristianty; Silalahi, Imelda Hotmarisi; Ardiningsih, Puji
Indonesian Journal of Pure and Applied Chemistry Vol 7, No 2 (2024)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v7i2.77806

Abstract

Copper (II) complex of curcumin was prepared from the reaction between curcumin and a metal precursor (CuCl2.2H2O) in ethanol with a mole ratio curcumin to metal 2:1. The FTIR spectrum of Cu2+-curcumin shows a change in the absorption band and a shift in the wave number, especially in the absorption band of the phenolic "“OH group 3510.45 cm-1 which is a stretching vibration that becomes wider and shifts to a larger wave number, namely 3514.30 cm-1. Compared with free curcumin spectrum the absorption band of the C=O functional group shows a change where in free curcumin is at 1627.92 cm-1 while in the Cu2+-curcumin complex the is at 1735.93 cm-1 this indicate the coordination of metal ions with curcumin. The IR spectrum shows a typical absorption band for the metal oxygen group, Cu-O 480.28 cm-1 in the Cu2+-curcumin complex. The UV-Vis spectrum of the Cu2+-curcumin complex show a shift towards a larger wavelength (red shift/batochromic) of (~2 nm). Antibacterial activity of Cu2+-curcumin complex compound is active in inhibiting S.aureus and E.coli. After complexation, the activity against the tested microorganisms generally increased and the complex showed higher activity than free curcumin.
PENGARUH LAMA PEMANASAN TERHADAP SIFAT FISIKOKIMIA DAN AKTIVITAS ANTIOKSIDAN EKSTRAK VCO DARI CAMPURAN KUNYIT, JAHE GAJAH, BAWANG PUTIH DAN DAUN SIRIH (THE INFLUENCE OF HEATING DURATION ON THE PHYSICOCHEMICAL PROPERTIES AND ANTIOXIDANT ACTIVITY OF VCO EXTRACT FROM A MIXTURE OF TURMERIC, GINGER, GARLIC, AND BETEL LEAF) Wibowo, Muhamad Agus; Pitri, Sela Rahma; Ardiningsih, Puji; Jayuska, Afghani
Indonesian Journal of Pure and Applied Chemistry Vol 7, No 2 (2024)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v7i2.77401

Abstract

The addition of spices to herbal oil increases bioactivity and physicochemical properties. Turmeric, ginger, garlic, and betel leaf are herbal plants that have the potential to enhance the antioxidant activity and physicochemical properties of herbal oil. This study aims to evaluate the effect of heating temperature on the phytochemical content, physicochemical properties, and antioxidant activity of VCO-based herbal oil with the addition of these spices. The research methods include phytochemical analysis, physicochemical analysis, and antioxidant activity testing using the DPPH method. The herbal oil was prepared at 100 °C with a ratio of herbal plants to VCO of 4:30, and heating durations of 15, 30, 60, and 120 minutes were varied. The results show the presence of flavonoids, terpenoids, saponins, phenolics, and alkaloids in the herbal oil, while VCO contains flavonoids, terpenoids, saponins, and alkaloids, with the addition of herbal plants providing additional phenolic compounds. Physicochemical testing of the herbal oil formulations with heating durations of 15; 30; 60; and 120 minutes respectively shows water content of 0.0923; 0.0189; 0.0165; and 0.0123%, density of 0.98522; 1.02854; 1.55110; and 1.1227 g/mL, acidity level of 4.12; 4.80; 4.28; and 4.38, free fatty acid content of 0.0018; 0.0021; 0.00162, and 0.0029%, and peroxide value of 0.0021; 0.0035; 0.0035; and 0.0042 meq/kg. The IC50 value obtained from the antioxidant activity testing of the herbal oil formulation with a heating duration of 60 minutes is 577.3 ppm, while for VCO, the IC50 obtained is 1029.6 ppm. This indicates that the addition of spices and herbal plants can enhance the bioactivity of VCO-based herbal oil formulations. The addition of spices and herbal plants increases phytochemical content and antioxidant activity, but longer heating durations may decrease the physicochemical properties of herbal oil formulations
UJI AKTIVITAS ANTIOKSIDAN CESSA STERA WEDANG HERBAL TANPA GULA (ANTIOXIDANT ACTIVITY TEST OF CESSA STERA AS HERBAL DRINK WITHOUT SUGAR) Marsandah, Marsandah; Musfira, Ainun; Agustina, Ayu Safitri; Karneng, Syahdam
Indonesian Journal of Pure and Applied Chemistry Vol 7, No 2 (2024)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v7i2.82578

Abstract

This study aims to evaluate the antioxidant content and organoleptic properties of herbal tea using a mixture of secang wood and stevia leaves. The sample preparation method involves separation based on wetness level, washing, drying, and grinding to powder. Phytochemical tests showed the presence of flavonoids, saponins, alkaloids, tannins, terpenoids and steroids in both samples. The water content test shows the value is in accordance with the quality standards for packaged dry tea. Antioxidant activity was tested using the DPPH method, and the herbal wedang formulation with a proportion of 1:1 (FIII) showed the highest antioxidant activity of 76%. Organoleptic tests showed that the panelists really liked the color, aroma and taste of the FIII formulation. The overall results show that the FIII formulation is the best choice with high antioxidant content and good acceptance from consumers.
PROFIL GC-MS DAN BIOAKTIVITAS EKSTRAK MINYAK DAUN CENGKEH (Syzygium aromaticum) TERHADAP ULAT GRAYAK Spodoptera frugiperda (GC-MS PROFILING AND BIOACTIVITY OF EXTRACTS CLOVE LEAF OIL (Syzygium aromaticum) AGAINST FALL ARMYWORMS Spodoptera frugiperda) Sitohang, Mikael; Jayuska, Afghani; Hernowo, Kukuh; Alimuddin, Andi Hairil; Aritonang, Anthoni Batahan
Indonesian Journal of Pure and Applied Chemistry Vol 7, No 2 (2024)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v7i2.77091

Abstract

Clove leaf essential oil can be used as a natural insecticide to control pests. Essential oil obtained by steam distillation produces essential oil with a yield of 1.03%. The essential oil obtained was then analyzed using a GC-MS tool where the aim was to separate the mixture of compounds and identify the compounds contained in clove leaf essential oil. The results of GC-MS analysis of clove leaf essential oil shoved 6 compounds whose similarity was above 84%, where the main compounds were eugenol (74.28%), β-Caryophellene (20.49%), α-Caryophellene (2.32%), Caryophellene oxide (2.26%). The essential oils were then tested for mortality and antifeedant activity against 3rd larva S. frugiperda. Concentrations of 0.1%, 0.3%, 0.5%, 0.7% and 0.9% v/v the essential oil caused 43.44%, 56.66%, 70%, 76.77%, and 86.66% mortality on to tested larva. The probit analysis data the mortality resulted LC50 value of 0.58%. Antifeedant concentrations of 0.37% and 0.58% v/v or equivalent to LC25 and LC50 can reduce 42.41-71.96% of the preferred method and 66.46-86.59% of the non-optioned method.
STUDI IN SILICO METABOLIT SEKUNDER DALAM TANAMAN TAHONGAI (Kleinhovia hospita L.) SEBAGAI KANDIDAT AGEN TERAPI KARSINOMA HEPATOSELULER TERTARGET RESEPTOR c-MET (IN SILICO STUDY OF SECONDARY METABOLITES IN TAHONGAI PLANT(Kleinhovia hospita L.) AS A CANDIDATEFOR HEPATOCELLULER CARCINOMA THERAPEUTIC AGENT TARGETING c-MET RECEPTOR) Cahyaningrum, Lydia; Rubianti, Retno; Mahira, Tsania; Gabriel, Kevin; Rusdin, Agus; Novitasari, Dhania
Indonesian Journal of Pure and Applied Chemistry Vol 7, No 2 (2024)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v7i2.82567

Abstract

Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality in the world, mainly caused by chronic disease or virus. Prior studies have documented that the upregulation of c-MET can trigger the cancer progression, hence c-MET has been widely explored as target therapy for HCC. Tahongai plant (Kleinhovia hospita L.) has known to possess several biological effects, including anticancer activity. However, the molecular mechanism in this plant has not been studied yet. In this study, the bioactive constituents from Tahongai were evaluated based on the physicochemical features and molecular interaction in c-MET through in silico approaches. The druglikeness of each compound was checked through SwissADME, while the pharmacokinetic profile was predicted through preADMET webtool. The pharmacophore screening and molecular docking against c-MET were assessed using LigandScout and Autodock, respectively. Out of 14 selected compounds, only one (astragalin) did not pass the Lipinski rule, and most of the compounds demonstrated good ADMET profile. Eleutherol was choosen as the hit compound based on pharmacophore studies, and stibostemin G was potential to inhibit c-MET based on similar molecular interaction compared to its native ligand through molecular docking analysis. Further confirmation is urged to prove its anticancer effect from Tahongai against HCC, particulary targeting on c-MET

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