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Yan Hendrika
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JOPS (Journal Of Pharmacy and Science)
Published by Universitas Abdurrab
ISSN : 26229919     EISSN : 26151006     DOI : https://doi.org/10.36341/jops
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
JOPS is Journal Of Pharmacy and Science with Scopes of Science : 1) Pharmacy 2) Food Chemistry 3) Biotechnology 4) Pharmacology 5) Microbiology 6) Food Analysis JOPS adalah Jurnal Farmasi dan Sains dengan Ruang Lingkup keilmuan : 1) Farmasi 2) Kimia makanan 3) Bioteknologi 4) Farmakologi 5) Mikrobiologi 6) Analisa Makanan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 220 Documents
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Ultra-High Performance Liquid Chromatography (UHPLC) untuk Kuantifikasi Gabapentin dalam Granul dan Kapsul rahmayati rusnedy
JURNAL FARMASI DAN MAKANAN Vol 6 No 1 (2022): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i1.3013

Abstract

Ultra-High Performance Liquid Chromatography (UHPLC) has become the modern standard HPLC platform in recent years. UHPLC as an ideal separation tool for the analysis of complex mixtures with a shorter analysis time is very suitable to be used as a fast and precise method. This study aims to determine the quantitative determination of gabapentin in the form of intermediate products, namely granules and finished products, namely capsules from 1 production batch using the UHPLC method. The results of the quantitative examination of the average content (% recovery) of gabapentin in granule and capsule samples quantified by the UHPLC method met the compendial requirements and internal specifications compared to the standard gabapentin recovery values. The % recovery obtained is 98.254% for gabapentin granules and 97.784% for gabapentin capsules, which means it is still in the 95%-105% range. While the %RSD value is 0.735 for granules and 0.839 for capsules, which means it has an RSD value of <2%. % precision of gabapentin granules was 99.558% with %RSD 0.407, and % intermediate precision gabapentin capsules was obtained 98.845% with %RSD 0.678. In conclusion, based on the quantitative results obtained meet the expected specifications, so it can be considered for use for routine analysis and quality control of medicinal ingredients, in the inspection of intermediate products and other finished drug products in the pharmaceutical industry quickly and accurately.
Penetapan Kadar Total Flavonoid Ekstrak Kulit Buah Limpasu (Baccaurea lanceolata) dengan Metode Spektrofotometri Uv-Vis Risa Ahdyani
JURNAL FARMASI DAN MAKANAN Vol 6 No 1 (2022): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i1.3014

Abstract

Limpasu (Baccaurea lanceolata) is a native plant of Borneo which is used empirically to protect the skin from sun exposure. Limpasu contains flavonoid compounds which generally act as antioxidants. This study aims to determine the total flavonoid content of limpasu pericarp extract by using UV-Vis spectrophotometry method. Limpasu pericarp was extracted by using the stratification maceration method. This extraction was carried out by immersing the simplicia into three types of solvents with different polarities, respectively, namely n-hexane (nonpolar), ethyl acetate (semi-polar), and methanol (polar). The concentration of n-hexane, ethyl acetate, and methanol extracts was determined using a UV-Vis spectrophotometer at a maximum wavelength of 510 nm with quercetin as standard. Based on the test, it was found that the total flavonoid content of pericarp extracts, hexane, ethyl acetate, and methanol, respectively, was 44.1552 g/ml; 155.8506 g/ml; and 25.8506 g/ml. The highest total flavonoid content was found in the ethyl acetate extract.
Uji Aktivitas Antioksidan dari Formulasi Spray Gel Kombinasi Fraksi Etil Asetat Rimpang Kunyit dan Kolagen dari Ikan Patin Denia Pratiwi; Yan Hendrika
JURNAL FARMASI DAN MAKANAN Vol 6 No 1 (2022): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i1.3015

Abstract

Premature aging is the process of aging skin that it faster than time because there is oxidative damage caused by free radicals. This study aims to determine the antioxidant activity of the cosmeceuticals spray gel combination of turmeric rhizome fraction with catfish skin collagen. Curcumin compounds in turmeric are known to have high antioxidant activity to inhibit free radicals and the addition of collagen is intended to be able to provide intake in improving skin structure due to premature aging. The preparations are made into 8 formulas with various concentration. The preparations formed will be evaluated and tested for their antioxidant activity. The result obtained were the extraction of catfish skin collagen the yield of 12.466% collagen. Examination of the ash content, moisture content, fat and protein contain were obtained respectively 0.0105; 0.0525; 5.98; 85.76%. In the evaluation of spray gel preparations, it was found that the preparations F1-F8 met quality standards on the test of spreadability, adhesion resistance, dry time, pH, spray conditions, except for the viscosity value at F4 and F5. The highest % inhibition value was obtained at F8 (0.5% ethyl acetate fractions of turmeric rhizome and 2% collagen of catfish skin) amounted to 48.82%. In statistical t-test showed sig 0.001, indicates there are significant differences in each formula.
Luaran Klinik Terapi Antivirus pada Pasien Komorbid dan non-Komorbid T2-DM COVID-19 di RSUD Rasidin Muslim Suardi
JURNAL FARMASI DAN MAKANAN Vol 6 No 1 (2022): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i1.3016

Abstract

Patients with comorbidity is vulnerable to being attacked by COVID-19. Diabetes mellitus comorbid patients have experience of higher severity viral infections than those without diabetes mellitus. The objective of the research was to evaluate the impact of Type 2 Diabetes Mellitus (T2-DM) comorbidity and antiviral therapy on the clinical outcome of COVID-19 patients. The study was performed following a cross sectional design from April 2020 to March 2021 at Hospital dr Rasidin Padang. Data were collected retrospectively from the patient's medical record. Treatment and clinical outcomes of patients were analyzed using the Kruskal Wallis, Mann-Withney U Test, Repeated Measured ANOVA, and Friedman Test. Results showed that the respiratory rate on T2-DM comorbid and non-comorbid patients were 20.58±0.25 and 20.15±0.08 times/minutes, respectively (p<0.05). While, oxygen saturation was 97.95±0.16 and 98.38±0.06%, respectively (p<0.05). Patient’s length of stay after the treatment of oseltamivir and favipiravir on non-comorbid COVID-19 patients were 14.76±0.861 and 9.96±0.488 days, respectively (p<0.01). While on comorbid patients were 16.00 ±3.17 and 10.47±0.77, respectively (p<0.01). Comorbidity had a significantly impacted on the patient's respiratory rate and oxygen saturation. The use of oseltamivir and favipiravir had a highly significant different on the LOS of comorbid and non-comorbid patients.
Formulasi dan Uji Efek Lilin Aromaterapi Minyak Atsiri Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) terhadap Immobility time Mencit (Mus musculus) Jantan yang Dibuat Stres: Aromatherapy Assay of Scented candles of Aromatic Pandan Leaf (Pandanus amaryllifolius Roxb.) Essential Oil against Stressed Male Mice (Mus musculus) Chikita Inaku; Muhammad Yusuf; Sinar Praktisi
JURNAL FARMASI DAN MAKANAN Vol 6 No 2 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i2.3363

Abstract

Fragrant Pandan is a plant that has been used in traditional medicine, this leaf contains linalool compounds which are efficacious as a sedative so that it can increase a sense of comfort, and suppress aggression and anxiety. This study aimed to determine the physical stability of the aromatherapy wax formula of fragrant pandan leaf essential oil (Pandanus amaryllifolius Roxb.) and its antistress effect on male mice (Mus musculus). The design of this study was a post-test only control group design, using 25 male mice divided into 5 groups, each group consisting of 5 animals exposed to the aromatherapy wax formula of pandan leaves essential oil for 1 hour with various concentratioins of essential oils, where the group I have given 1%, group II was given 2%, group III was given 3%, group IV was given negative control, and group V was given positive control. The results of the research on the physical stability test of the aroma therapy wax formula of pandan fragrant leaf essential oil showed that the formula was organoleptically stable with white color and characteristic odor, the melting point test was stable at temperatures of FI 54O, FII 53OC, and FIII 52OC, time test FI burning shows 4 hours 28 minutes, FII 2 hours 52 minutes and FIII 3 hours 34 minutes, the preference test before and aftrer burning shows the higher the concentration of essential oils the panelists prefer. The results of the antistress effect test showed that the immobility time of mice at KI at 291 seconds, KII at 182 seconds, KIII at 88 seconds, and KIV as a negative control was higher at 334 seconds, which means that at concentrations of 1%, 2%, 3% had an antistress effect with sig analysis values Post-Hoc Tukey Statistics FIII 1,00, F IV 0,00, and FV 1,00
Analisis Senyawa Kafein pada Bubuk Kopi Jenis Arabika di Kota Takengon Menggunakan Analisis Kualitatif dan Kuatitatif: Analysis of Caffeine Compounds in Arabica Ground Coffee in Takengon City Using Qualitative and Quantitative Analysis Ernoviya Ernoviya; Afriadi Afriadi; Hesti Nadila Silfania
JURNAL FARMASI DAN MAKANAN Vol 6 No 2 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i2.3371

Abstract

Background:Coffee is a type of plant that contains caffeine and can be made into a delicious drink. Currently, coffee is the world's most popular drink after water and tea. The stuay aimed was to determine the caffeine content in Arabica ground coffee circulating in the Takengon market according to Indonesian national standards (SNI 01-7152-2006).This research was experimental by taking samples purposively. The research method used was phytochemical screening, qualitative analysis, and ultraviolet spectrophotometry at a wavelength of 273nm. The specified validation parameters were precision, linearity, LOD and LOQ.The results of the phytochemical screening of sample A in the Meyer test treatment obtained negative results but the others were positive. And in sample B, all tests were positive. In the three qualitative analyses tests on samples A and B, the results were positive. The average yield of quantitative analysis in sample A was 11.632 mg once and the daily concentration was 34.897mg. while in sample B the level was 6.663 mg once and drank 19.989mg per day. Validation test results obtained linearity r2 = 0.998, LOD and LOQ namely 0.882µg/ml and 2.94µg/ml, RSD value of 1.11%.Based on the conclusion, sample A and sample B met the requirements according to SNI 2006 (50mg once and 150mg daily) and also met the requirements according to the Pharmacopoeia Edition III, namely a maximum dose of 500 mg once and 1.5g daily to future researchers to determine levels other than caffeine found in Arabica coffee in Takengon.
Pengaruh Booklet Terhadap Pengetahuan Pasien Hipertensi di Puskesmas Rasimah Ahmad Kota Bukittinggi: The Influence Booklet on Knowledge of Hypertension Patient at Rasimah Ahmad Health Center Bukittinggi City Rizqa Hasanah; Yelly Oktavia Sari; Fatma Sri Wahyuni; Miming Andika
JURNAL FARMASI DAN MAKANAN Vol 6 No 2 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i2.3384

Abstract

Hypertension is a chronic disease that requires long-term therapy. The prevalence of hypertension continues to increase every year, but patient knowledge of treatment is still low. Better knowledge will increase patient compliance in treatment so that blood pressure is better controlled and the risk of complications is avoided. This study aims to determine the effect of booklets on the knowledge of hypertensive prolanis patients at the Rasimah Ahmad Health Center, Bukittinggi City. The type of research used was an experimental pretest – posttest control group design with 40 respondents who were randomly divided into two groups (control and intervention). The intervention medium used in this study was a booklet. The instrument used was the HK-LS questionnaire to assess knowledge. The results of the study showed an increase in the compliance of hypertensive patients. The statistical analysis used was the Wilcoxon Signed Ranks test, to determine the effect of the intervention on the patient's level of knowledge. From the results of the study, it showed that giving booklets obtained a significant value (p-value = 0.000), so it could be concluded that giving booklets had an effect on increasing the knowledge of hypertensive prolanis patients at the Rasimah Ahmad Health Center, Bukittinggi City.
Efektivitas Penggunaan Analgetik dan Antibiotik pada Pasien Pasca Operasi Fraktur Tertutup di Instalasi Rawat Inap Bedah RSUD Arifin Achmad Provinsi Riau: Effectiveness of Usage Analgetics and Antibiotics in post Surgical Patients with Closed Fractures in Surgical Department of Arifin Achmad Tertiary Hospital in Riau Province Fridelly Mairani Apt; Fatma Sri Wahyuni; Hansen Nasif
JURNAL FARMASI DAN MAKANAN Vol 6 No 2 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i2.3393

Abstract

The aim of this study was to examine sociodemographic features, visual analogue scale (VAS) scores before and after administration of analgesics, the effectiveness of the use of analgesics and antibiotics. This research uses descriptive analysis method with prospective cross sectional design. Data collection was carried out prospectively with direct observation of the pain felt by the patient using a VAS card at the 24th hour after surgery and after administration of analgesics. Observations were made on the patient's surgical wound on days 3-7 to 30 days postoperatively to observe the presence or absence of ILO. Of the 40 patients studied, the most age was 26 to 35 years (27.77%), the least were 45 to 55 years (11.11%) and 56 to 65 years (11.11%) ). Based on gender, 27 people (67.50%) were male and 13 people (32.50%) were female. Out of 40 patients, 39 patients (97.5%) did not have ILO and 1 patient (2.5%) had ILO. Before administration of analgesics all patients experienced pain. After administration of paracetamol infusion in 8 patients, ketorolac injection in 31 patients, and tramadol injection in 1 patient, the pain scale decreased. Data analysis using the Wilcoxon test showed the effectiveness of the use of analgesics on changes in the pain scale in patients (p <0.05) and descriptive analysis showed that there was effectiveness in the use of antibiotics in postoperative closed fracture patients.
Aktivitas Antibakteri dari Kulit Buah Mundar (Garcinia forbesii) Hayatun Izma; Muhammad Ikhwan Rizki; Khoerul Anwar; Dyah Anggraeni; Satrio Wibowo Rahmatullah; Aditya Maulana Perdana Putra; Dita Ayulia Dwi Sandi
JURNAL FARMASI DAN MAKANAN Vol 6 No 2 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i2.3417

Abstract

Garcinia forbesii is traditionally used as medicine and cosmetics. The aimed was to determine antibacterial activity of ethanolic extract and fraction of Garcinia forbesii pericarp against Staphylococcus aureus and Propionibacterium acne based on the diameter of inhibition zone, the minimum inhibitory concentration (MIC) and the minimum killing concentration (MBC). The results showed that the largest inhibition zone diameter against Staphylococcus aureus and Propionibacterium acne was indicated by ethyl acetate fraction of 5.08±1.020 mm and 14.33±3.326 mm. The MIC value of ethanol extract against Staphylococcus aureus and Propionibacterium acne bacteria was >1.5%, n-hexane and ethyl acetate fraction had the same results, namely against Staphylococcus aureus >1.5% and Propionibacterium acne at 1.5%. The MBC value was only obtained for fraction samples of Propionibacterium acne at concentration of 1.5%. It was concluded that ethyl acetate had strong antibacterial activity against Propionibacterium acne based on the value of inhibition zone diameter, MIC, and MBC.
Gambaran Kejadian Berpotensi Medication Errors Fase Prescribing Resep Pasien Rawat Jalan RSUD Arifin Achmad Riau: Description Event Potentially Medication Errors Phase Prescribing Outpatient Prescription Regional General Hospital Arifin Achmad Riau Wardatul Jannah; Septi Muharni
JURNAL FARMASI DAN MAKANAN Vol 6 No 2 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i2.3425

Abstract

This study aims to look at the percentage of occurrence of potentially overview phase prescribing medication errors in the outpatient prescription Regional General Hospital Arifin Achmad Riau province. This study is an observational study / survey descriptive. Sampling was done by accidental sampling method, the sample obtained in this study as many as 300 sheets of prescription outpatient entrance at the time of the research conducted at Arifin Achmad. The results showed that the highest percentage of incidence of medication errors that could potentially prescribing phase of outpatient prescription Arifin Achmadbased on the payment status is the highest percentage in the general patient prescription that is equal to 27.78%. Based on the origin prescribers percentage gained is a general practitioner in the amount of 26.32%. Based on the number of prescription drugs in the percentage of the highest incidence ≥5 is the amount of drug that is equal to 29.44%. Based on the patient's weight recipe completeness 96.67%, height pasien96,67% and this study was not found prescription that can not be read, and there is no drug name abbreviation unusual. These results indicate that the phase of prescribing medication errors in the outpatient prescription Arifin Achmad still high.

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