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Yan Hendrika
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JOPS (Journal Of Pharmacy and Science)
Published by Universitas Abdurrab
ISSN : 26229919     EISSN : 26151006     DOI : https://doi.org/10.36341/jops
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
JOPS is Journal Of Pharmacy and Science with Scopes of Science : 1) Pharmacy 2) Food Chemistry 3) Biotechnology 4) Pharmacology 5) Microbiology 6) Food Analysis JOPS adalah Jurnal Farmasi dan Sains dengan Ruang Lingkup keilmuan : 1) Farmasi 2) Kimia makanan 3) Bioteknologi 4) Farmakologi 5) Mikrobiologi 6) Analisa Makanan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 130 Documents
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Hypertension Efek Bisoprolol Terhadap Penurunan Tekanan Arteri Rata-rata dan Laju jantung Pada Tikus Putih Jantan Hipertensi Dan Hipertensi komplikasi Hiperkolesterolemia Miming Andika
JURNAL FARMASI DAN MAKANAN Vol 5 No 2 (2022): Journal Of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v5i2.2445

Abstract

Hipertensi merupakan penyakit kardiovaskular yang banyak terjadi di Indonesia. Hal ini merupakan masalah kesehatan dengan prevalensi yang tinggi, yaitu sebesar 25,8 %, sesuai dengan data Riskesdas 2013. Orang dengan Hipertensi juga sering mengalami komplikasi dengan penyakit kardiovaskuler yang lainnya seperti hiperkolesterolemia. Anti-hipertensi golongan beta-blocker umumnya digunakan oleh orang untuk mengobati tekanan darah tinggi dan detak jantung yang berlebihan. Uji efek farmakologis dari bisoprolol terhadap penurunan tekanan darah dalam keadaan hipertensi telah dilakukan beberapa peneliti sebelumnya baik secara preklinis maupun klinis, namun pengaruh patologi hiperkolesterolemia terhadap efek penurunan tekanan arteri rata-rata danlaju jantung belum ada. Oleh karena itu peneliti tertarik untuk meneliti efek penurunan tekanan arteri rata-rata dan laju jantung pada tikus hipertensi dan hipertensi dengan penyakit penyerta hiperkelesterolemia. Maka peneliti tertarik untuk melakukan penelitian tentang efek bisoprolol terhadap penurunan tekanan arteri rata-rata dan laju jantung pada tikus putih jantan hipertensi dan hipertensi komplikasi hiperkolesterolemia pada tikus putih jantan. pada penelitian ini hewan percobaan dihipertensikan semuanya terlebih dahulu kemudian kelompok yang komplikasi hiperkolesterolemia diinduksi dengan PTU dan pemberian makanan lemak tinggi, kemudian diukur menggunakan fotometer v5­+ 5010. Sedangkan tekanan arteri rata-rata dan laju jantung diukur dengan menggunakan pengukur tekanan darah adinstrument NIBP (Non invasive blood pressure) merk CODA (kent scientific). Data hasil penelitian ini dianalisis dengan ANOVA dua arah. Didapatkan hasil bahwa pemberian bisoprolol dengan dosis 2,5 mg, 5 mg dan 10 mg berpengaruh terhadap penurunan tekanan arteri rata-rata dan laju jantung secara signifikan (p ˂ 0,05). Dan dosis 10 mg yang paling efektif dalam menurunkan tekanan arteri rata-rata dan laju jantung pada tikus putih jantan hipertensi dan hipertensi komplikasi hiperkolesterolemia. Dan adanya perbedaan penurunan tekanan arteri rata-rata dan laju jantung pada tikus putih jantan yang hipertensi penurunan nya lebih besar dibandingkan dengan tikus putih jantan yang hipertensi komplikasi hiperkolesterolemia.
Formulasi Dan Evaluasi Granul Effervescent Kombinasi Ekstrak Kering Rimpang Jahe Merah, Temulawak Dan Kayu Manis Wahyu Margi Sidoretno
JURNAL FARMASI DAN MAKANAN Vol 5 No 2 (2022): Journal Of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v5i2.2461

Abstract

Granul effervescent merupakan serbuk kasar sampai kasar sekali mengandung unsur obat dalam campuran yang kering, biasanya terdiri dari natrium bikarbonat, asam sitrat, dan asam tartrat bila ditambah dengan air, asam dan basanya bereaksi membebaskan karbondioksida sehingga menghasilkan buih. Sediaan dalam bentuk Effervescent dapat menghasilkan rasa yang enak yang disebabkan adanya karbonat yang mana dapat membantu memperbaiki rasa dari beberapa obat tertentu. Penelitian ini bertujuan untuk mengetahui kombinasi ekstrak kering rimpang jahe merah, temulawak dan kayu manis yang di formulasi menjadi granul effervescent dan memenuhi kriteria granul effervescent yang baik. Metode yang digunakan adalah granulasi basah dengan empat variasi formula yaitu F1 merupakan granul biasa, F2 granul effervescent tanpa zat aktif, F3 dan F4 granul effervescent dengan variasi asam dan basa. Evaluasi mutu fisik granul meliputi uji kadar air, uji kompresibilitas, uji waktu alir, sudut istirahat, uji daya penyerapan cairan, Scanning Electron Microscope (SEM), waktu dispersi dan pH. Berdasarkan hasil yang diperoleh kombinasi ekstrak kering rimpang jahe merah, temulawak dan kayu manis dapat diformulasi menjadi granul effervescent. Sediaan granul effervescent kombinasi ekstrak kering rimpang jahe merah, temulawak dan kayu manis belum memenuhi kriteria granul effervescent yang baik yaitu pada pengujian kadar air granul F2, F3, F4 masing masing diperoleh 6,47±0,07, 6,61±0,03, dan 5,82±0,04% dimana rentang kadar air granul yang baik 2-5%
Literature Study: Efficacious Indonesian Herbs for Lowering Cholesterol Levels Wahyudi Wahyudi
JURNAL FARMASI DAN MAKANAN Vol 5 No 2 (2022): Journal Of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v5i2.2464

Abstract

High cholesterol is generally suffered by obese people, but it is possible that thin people can also experience it, especially by consuming foods that are low in fiber but high in fat. Cholesterol can settle on artery walls, so blood flow to the heart, brain, and other body parts can be blocked. There are several herbal ways that can reduce cholesterol levels in the blood, namely by administering avocado leaf extract and avocado fruit, soursop leaf extract, red dragon fruit, rambutan leaf extract and chayote stew as alternative therapy so as not to depend on synthetic drugs. The method used in writing this journal uses a literature review approach. The process of collecting journals is done by searching for literature sources based on specified criteria. The inclusion criteria taken include: journals published in the last 10 years. And the research sample used was obtained from Google Scholar. The results of previous studies explained that cholesterol can not only be treated by using synthetic drugs that come from a doctor's prescription but can also use herbal medicines such as avocado, red dragon fruit, and soursop leaf water extract.
Penetapan Kadar Vitamin C Buah Nanas Segar (Ananas comocus L.) Hasil Budidaya di Kecamatan Teluk Meranti, Kabupaten Pelalawan dengan Metode Spektrofotometri UV-Vis Annisa Fauzana
JURNAL FARMASI DAN MAKANAN Vol 5 No 2 (2022): Journal Of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v5i2.2483

Abstract

Vitamin C is a water-soluble antioxidant that affect the body immune system. Vitamin C deficiency is related to the high risk of infection disease manifestation. Consuming vitamin C of 100-200 mg/day is effective to optimize physiological functions of tissues and cells. Fruits are a natural source of vitamin C that can be consume to achieve vitamin C requirement intake, such as Ananas comocus. However, the vitamin C content in Ananas comocus can be varied depending on some factors, such as their varieties, growth environment, and preparation. This research aims to determine vitamin C content in some fresh Ananas comocus fruits from three plantations in Teluk Meranti area, Pelalawan using Spectrophotometry UV-Vis method, that is a suitable method for vitamin C content determination. The result shows that the calibration curve of vitamin C giving a good linearity, with r value of 0,9943. Vitamin C content in the three plantation was varied. The content from the plantation 1, 2, and 3 was 51,1889; 48,3320; dan 144,200 mg/100 g. Keywords: fresh fruit, spectrophotometer, vitamin C content determination, Teluk Meranti, Ananas comocus
Pola Penggunaan Obat Antipsikotik pada Pasien Skizofrenia di Puskesmas Rawat Jalan Alah Air Kabupaten Kepulauan Meranti Husnawati - Husnawati
JURNAL FARMASI DAN MAKANAN Vol 6 No 1 (2022): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i1.2755

Abstract

Tingginya jumlah pasien skizofrenia di Puskesmas Alah Air perlu mendapatkan perhatian salah satunya tentang pola pengobatannya. Penelitian ini bertujuan untuk mengetahui pola penggunaan obat antipsikotik di Puskesmas Alah Air Kecamatan Tebing Tinggi Kabupaten Kepulauan Meranti. Penelitian ini merupakan penelitian observasional dengan rancangan deskriptif. Sumber data pada penelitian ini adalah data rekam medik pasien selama bulan Januari sampai Desember 2021 di Puskesmas Alah Air Kabupaten Kepulauan Meranti. Sampel penelitian berjumlah 81 pasien yang memenuhi kriteria inklusi. Hasil penelitian menunjukkan bahwa mayoritas pasien skizofrenia berjenis kelamin laki-laki (74,1 %), dengan rentang usia dewasa awal (18 – 40) tahun yakni sebanyak 60,5 %. Berdasarkan obat antipsikotik yang paling banyak digunakan adalah golongan antipsikotik tipikal dengan obat halloperidol yakni sebanyak 71,6 %. Berdasarkan rute pemberian obat 100% diberikan secara oral. Berdasarkan nama generik dan nama dagang, obat digunakan yaitu generik sebanyak 100%. Berdasarkan terapi tunggal dan kombinasi hasil yang didapatkan terapi kombinasi yaitu 90,1 % dan kombinasi yang paling banyak adalah antipsikotik tipikal dengan tipikal. Kesimpulan penelitian ini menunjukkan bahwa pola penggunaan obat antipsikotik adalah penggunaan antipsikotik tipikal gerik secara oral dalam bentuk kombinasi
Addition of Catfish (Pangasius hypophthalmus) Bone Meal as a Source of Calcium in Catfish Nugget Azlaini Yus Nasution
JURNAL FARMASI DAN MAKANAN Vol 6 No 1 (2022): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i1.2836

Abstract

Tulang ikan mengandung kalsium yang dapat dimanfaatkan sebagai sumber kalsium yang diperlukan tubuh. Kalsium berfungsi sebagai pembentukan dan pemeliharaan tulang dan gigi. Tujuan penelitian ini untuk menetapkan kadar kalsium pada nugget ikan patin setelah dilakukan penambahan tepung tulang yang berasal dari ikan patin. Formula yang dibuat terdiri dari F1 (nugget tanpa penambahan tepung tulang maupun kalsium karbonat), F2 (nugget dengan penambahan tepung tulang ikan patin), dan F3 (nugget dengan penambahan kalsium karbonat). Analisis kandungan kalsium menggunakan metode Spektrofotometri serapan atom. Kandungan kalsium pada nugget ikan patin masing-masing adalah pada F1=350,010 mg/100 gram, F2=1025,335 mg/100 gram, dan F3=1498,058 mg/100 gram. Tepung tulang dari ikan patin yang ditambahkan dapat meningkatkan kandungan kalsium pada nugget ikan patin.
Profil Penggunaan Obat Antidiabetes Tipe II Di RSUD Dr. Husni Thamrin Natal Medan, Sumatera Utara Robiatun - Rambe
JURNAL FARMASI DAN MAKANAN Vol 6 No 1 (2022): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i1.2971

Abstract

The pancreas does not produce enough insulin or the body cannot use the insulin it produces effectively. Insulin is a hormone that regulates the balance of blood sugar levels. (hyperglycemia). This research was conducted with a non-experimental descriptive method with a cross-sectional design that was carried out every month. Sampling was carried out in the internal medicine section of RSUD by Dr. Husni Thamrin Natal. Samples were taken retrospectively every month using secondary data, namely medical records of patients using oral antidiabetics (drugs) in the period from January to June 2019. The data obtained was presented in the form of table proportions and graphs. The results showed that the largest percentage of use of antidiabetic drugs was male, as many as 67 people (57.26%), over 50 years old, as many as 97 people (82.91%), and the type of work was self-employed for as many as 47 people (40, 17%). The most widely used antidiabetic drug groups are the biguanide groups (75.17%), the combination type of drug with a combination of metformin and glimepiride (93.33%), and the frequency of use of the drug metformin (74.15%). Based on the results of the study, it can be concluded that the highest prevalence is in the male sex, and the average age is over 50 years. The pattern of prescribing antidiabetic drugs based on the most widely used drug class is the biguanide group, which is a combination of metformin and glimepiride types of drugs, and the frequency of drug use is metformin.
Analisis Asam Salisilat pada Krim Wajah yang Beredar di Pasar Besar Kota Malang Lukky Jayadi
JURNAL FARMASI DAN MAKANAN Vol 6 No 1 (2022): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i1.2972

Abstract

Salicylic acid is a skin remedy that is used to treat various skin problems such as acne. Salicylic acid is safe to use and contains Beta Hydroxy Acid (BHA), which is an ingredient used to reduce wrinkles and acne. Although it has benefits for removing acne, salicylic acid is a dangerous chemical if used in excess of the prescribed limits. To determine the levels of salicylic acid in anti acne creams circulating in Pasar Besar Malang City, qualitatively with color test using FeCl3 and quantitatively using UV-Vis spectrophotometry to analyze levels of salicylic acid in anti-acne cream. Qualitative research using FeCl3 showed that from four samples, one sample was declared negative, while three positive samples contained salicylic acid, while testing using UV-Vis spectrophotometry found all samples containing salicylic acid. The levels of salicylic acid in all samples were within the safe limits set by BPOM with the highest level contained in skin surface products, including substances harmful to the skin, should not be more than 2%.
Hubungan Tingkat Pengetahuan Terhadap Perilaku Vaksinasi Covid-19 Pada Masyarakat Kota Samarinda Sinta Ratna Dewi
JURNAL FARMASI DAN MAKANAN Vol 6 No 1 (2022): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i1.3011

Abstract

Outbreak is corona virus disease or what is often called COVID-19 is a problem in the world and also in Indonesia. In addition to the implementation of a good understanding and knowledge of all elements including society, in addition, one of the factors that influence a person's behavior is the level of knowledge. This study aims to determine the relationship between the level of knowledge and covid-19 vaccination behavior in the people of Samarinda City. This study used quantitative research with a cross-sectional design where the number of samples in this study was 130 samples obtained from direct interviews and filling out questionnaires. The data analysis in this study was to use the Pearson correlation test. Based on the results obtained, it shows that out of a total of 130 respondents, a sig value (2-tailed) of 0.000 <0.05 is known so that it can be said that there is a significant relationship between 2 variables, namely knowledge and perception, besides that, a correlation coefficient of 0.346 is obtained, which means that the level of strength or correlation of the relationship between 2 variables is weak. Knowledge is one of the factors that influence a person's behavior, so the higher the knowledge about vaccines, the higher the public's desire to vaccinate against COVID-19.
Aktivitas Antiinflamasi Gel Cabai Rawit (Capsicum frutescens L.) pada Tikus Putih (Rattus norvegicus) Rahmat Ismail; Abulkhair Abdullah; Ahlan Sangkal; Randi R. Toboleu
JURNAL FARMASI DAN MAKANAN Vol 6 No 1 (2022): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v6i1.3012

Abstract

Cayenne pepper (Capsicum frutescens L.) is a plant that has many benefits, one of which is as an anti-inflammatory. The anti-inflammatory effect of cayenne pepper was tested on white rats in the form of a gel. Two gel formulas were used with different concentrations of propylene glycol as additive, 25% and 30%, respectively. White rats were grouped into 4 groups, negative control group (gel base), positive control group (Voltaren® Emulgel), gel formula 1 group (enhancer 25%), and gel formula 2 (enhancer 30%). Albumen was induced on the backs of white rats then samples were given. Skinfold thickness measurements were taken every 1 hour for 6 hours. The data obtained in the form of skin thickness values ​​(mm). The % Inflammation Inhibition (% PI) was calculated for each sample. Formula 1 and Formula 2 gave %PI of 32.58 ± 1.80 and 40.75 ± 5.71, respectively. Both formulas had an anti-inflammatory effect against edema on the back of rats although not better than Voltaren® Emulgel. Based on One Way ANOVA test, Formula 2 has a better anti-inflammatory effect than Formula 1. LSD test results show that %PI Formula 2 is similar to %PI Voltaren® Emulgel with a significance value of 0.117 (>0.05).

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