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INDONESIA
Indonesian Journal of Medicine
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
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Articles 10 Documents
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Search results for , issue " Vol 1, No 1 (2016)" : 10 Documents clear
miR-21 Expression in Grade I, II, and III Breast Cancer -, Juwita; Ompusunggu, Henny E.S.; Nauphar, Donny; Pardede, Sumondang M.; Lim, Hadyanto; Siregar, Yahwardiah
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Breast cancer is the second largest cancer in the world.The gold standard for breast cancer diagnosis and prognosis is grade assessment (mitotic, nuclear pleiomorphism, tubular formation), based on breast tissue histopathology. However, this assessment has limitation in that it is subjective and semi quantitative. A genetic biomarker known as  microRNA (miRNA) may regulate human gene expression by targetting mRNA. One of the miRNA, i.e. miR-21, is able to suppress tumor suppressor mRNA, resulting in increased cellular proliferation andneoplastic transformation, and decreased apoptosis. This study aimed to investigate the expression of miR-21in breast cancer with histopathologic grade I, II, and III.Subjects and Method: This was a descriptive study with cross-sectional design involving paraffin block (FFPE) samples of ductal-type breast cancer tissue. Sixty four samples were obtained from the department of Anatomical Pathology, Haji Adam Malik Hospital, Medan. Patients history were obtained through medical records followed by sample processing (Total RNA Isolation, cDNA Synthesis, and Examination of miR-21 Expression using Real-Time qPCR). MiR-21 expression from every hystopathologic grade was obtained using Fold Change Calculation.Results: Breast cancer occurred more frequently in age group of 30-49 years old. Based on the histopathologic grade, most breast cancer was found in grade II. Analysis of miR-21 expression showed that miR-21 expression was higher in grade III compared to other grade.Conclusion: Breast cancer occured more frequently in the productive age group.Most breast cancer were found in grade II. Increased miR-21 expression in grade III may suggest that miR-21 is an oncomiR, which plays an important role in the development of malignant breast cancer.Keywords: breast cancer, histopathology grade, miRNA, miR-21.Correspondence: Juwita. Masters Program in Biomedical Sciences, Faculty of Medicine, North SumateraUniversity, Medan. Mobile: 08125262339.Indonesian Journal of Medicine (2016), 1(1): 26-33https://doi.org/10.26911/theijmed.2016.01.01.04
Comparison of β-Hydroxylase Enzyme 11 Serum in Obese, Overweight, and Normoweight Young Men Sitepu, Jenny Novina; Sari, Mutiara Indah; Tann, Gino
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Previous studies showed that cardiovascular risk factor was increased in obese and overweight subjects. Obesity and cardiovascular risk factor are associated with hypothalamic-pituitary-adrenal (HPA) axis hyperactivity that causes hypercortisolism, cortisol level is associated with cardiovascular risk factor on obesity. 11 β-hydroxylase is an enzyme that involved in cortisol synthesis. The aim of this study was to investigate 11 β-Hydroxylase concentration in obesity, overweight, and normal weight young men.Subjects and Method: This was analytic-observational study using cross-sectional design. The study was conducted at HKBP Nommensen University, Medan. The study subjects included by 76 young men aged 18-28 years old, consisting of 25 obese subjects, 25 overweight, and 25 normoweight. The concentration of 11 β-Hydroxylase was evaluated in blood sample after 10 hours fasting. The data was analyzed bivariately.Results: Mean of 11 β-Hydroxylase concentration was 52.76 ± 44.27 in obese subjects, 70.16 ± 46.83 in overweight subjects, and 43.42 ± 27.75 in normoweight subjects. The 11 β-Hydroxylase concentration in overweight subjects was statistically higher than normoweight subjects (p = 0.007), but the 11 β-Hydroxylase concentration on obese subjects statistically was not different from normoweight subjects (p = 0.362).Conclusion: The 11 β-Hydroxylase concentration on overweight subject is higher than normoweight subject. There is no difference of 11 β-Hydroxylase concentration on obese and normoweight subject. Mitochondrial stress and mitochondrial failure mechanism on overweight and obesity merit further investigation.Keywords: 11 β-Hydroxylase, cortisol, obesity, overweightCorrespondence: Jenny Novina Sitepu. Faculty of Medicine, HKBP Nommensen Medan University, Medan.Indonesian Journal of Medicine (2016), 1(1): 71-75https://doi.org/10.26911/theijmed.2016.01.01.09
Precision and Accuracy of Thyroid Dysfunction Questionnaire (TDQ) for Hyperthyroidism Screening in Childbearing Age Women -, Mutalazimah; Mulyono, Budi; Murti, Bhisma; Azwar, Saifuddin
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Community-based case finding efforts of hyperthyroidism rather not to do, but constrained because accurate markers measurements using hormones.  TDQ as a screening in­strument which meets several criteria for diagnostic tests, provide more convenience for the patient, cheaper, easier and simpler. This study aimed to determine the precision and accuracy of the diagnostic test of hyperthyroidism screening in childbearing age women.Subjects and Method: The study was a diagnostic study with the cross-sectional design. It conducted in Prambanan, Sleman, Yogyakarta. The sample consisted of 112 randomly selected of childbearing age women. Clinical symptoms of hyperthyroidism were measured using the TDQ, thyroid status measured by thyroid stimulating hormone (TSH) and free thyroxin (FT4). TDQ diagnostic precision and accuracy were tested using the percent agreement (PA), Kappa coefficient, sensitivity (Se), specificity (Sp), LR (+), LR (-), Youden’s index, the area under the curve (AUC) in the receiver operating curve (ROC) and diagnostic odds ratio (DOR).Results: The best value in diagnostic precision is TDQ score with the cutoff point score of 40, with PA 81.2 % and Kappa coefficient 0.62. Similarly, the best accuracy value Se 90%, Sp 76%, LR(+) 3.75, LR(-) 0.13, Youden’s index 0.66, AUC 0.831 and DOR 28.8.Conclusion: The values and the optimal accuracy obtained from the best score of 40 and this cut off point of the score is sufficient to be used as a threshold determination of a diagnosis of hyperthyroidism by TDQ scores. Keywords: diagnostic tests, thyroid dysfunction questionnaire (TDQ), hyperthyroidism, child­bearing age women.Correspondence: Mutalazimah. Department of Nutritional, Muhammadiyah University of SurakartaIndonesian Journal of Medicine (2016), 1(1): 34-43https://doi.org/10.26911/theijmed.2016.01.01.05
Effect of Purple Sweet Potato (Ipomoea Batatas L.) on Reducing Renal Tissue Damage of House Mice (Mus Musculus L.) After Excessive Physical Exercise Sinaga, Rika Nailuvar; Rusmarilin, Herla; Mardiani, T.Helvi; Elvana, Ayu
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Heavy physical exercise can reduce blood flow and metabolism in kidney that eventually release free radicals. The free radicals can form oxydative stress and damage renal tissue. Exogenous antioxydant administration is usually recommended to minimize the renal tissue damage. This study aimed to examined the effect of purple sweet potato (Ipomoiea batatas L.) extract on renal tissue damage  in mice  (mus musculus L.) after heavy physical exercise.Subjects and Method: This was a randomized controlled trial with post test only control design. The study subjects included twenty four male white mice with DD Webster strain. These mice were divided into six groups. After undergoing excessive swimming exercises that lasted forteen days, purple sweet potato extract was given to the experimental group. There were three experimental groups receiving three different doses of purple sweet potato. The mice kidney was taken as sample for microscopic examination to determine the extent of tissue damage. Difference in renal tissue damage was tested by Kruskal-Wallis.Results: Microscopic examination showed statistically significant difference in tissue damage both in right (p=0.001) and left (p=0.036) kidneys, between study groups. The experimental groups showed less damaged than control group.Conclusion: Purple sweet potato (Ipomoiea batatas L) can lessen renal damage in male white mice (Mus musculus L) undergoing excessive physical exercise.Keywords: purple sweet potato (Ipomoiea batatas L), renal tissue damage miceCorespondance: Rika Nailuvar Sinaga. Faculty of Sport Science, Medan University. Email: rikanailuvar890@gmail.comIndonesian Journal of Medicine (2016), 1(1): 76-83https://doi.org/10.26911/theijmed.2016.01.01.10
Association Between Hormonal Contraception and Blood Glucose Level Among Women of Childbearing Age in Sangkrah Community Health Center, Surakarta Sabania, Brillian Ferika; Murti, Bhisma; Hanim, Diffah
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Hormonal contraceptive contains estrogen and progesterone hormones. These hormones are hypothesized to affect blood glucose level. This study aimed to determine the association between hormonal contraception and blood glucose level among childbearing aged women.Subjects and Method: This was an analytic observational study with cross-sectional design. The study subjects were childbearing aged women who used and did not use hormonal contraceptive in Sangkrah community health center, Surakarta. A total sample of 47 people consisting of 32 hormonal contraceptive users and 15 non users were selected for study by fixed exposure sampling. The data were collected by questionnaire, interview, anthropometric measurement, and direct measurement of blood glucose level. The data were analyzed using a multiple linear regression with SPSS for Windows.Results: Women of childbearing age who used hormonal contraceptive had an average blood glucose 26 mg / dL higher than the non-users of hormonal contraceptive (b = 26.18; 95% CI 15.03 to 37.33; p <0.001). These estimates had controlled for the effect of confounding variables (i.e. Body Mass Index and diabetes mellitus risk factors).Conclusion: There is a positive and statistically significant association between the use of hormonal contraceptive and blood glucose level among women of childbearing age.Keywords: hormonal contraception, blood glucose level.Correspondence: Brillian Ferika Sabania. Faculty of Medicine, Sebelas Maret University, Surakarta.Indonesian Journal of Medicine (2016), 1(1): 1-11https://doi.org/10.26911/theijmed.2016.01.01.01
Effect of Ethanol Extract of Chayote (Sechiumedule.Jacq.Swartz) on the Activity of Glutathione Peroxide (GPx) in House Mice (Musmusculus L) Strain DD Webster Hyperglycemia Induced by Streptozotocin (STZ) Siahaan, Jekson Martiar; Harahap, Urip; Loesnihari, Ricke
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Streptozotocin can cause hyperglycemia in guinea pig through the mechanism of oxidative stress which damages pancreatic b cells. Ethanol extract of chayote can decrease oxidative stress.  This study aimed to determine the effect of Ethanol Extract of Chayote ((EEBLS) Ekstrak Etanol Buah Labu Siam) on decreasing blood sugar content and increasing the activity of glutathione peroxide enzyme. Subjects and Method: This was an experimental study. The samples were using random sampling technique. The control group was using male white mice (Musmusculus L.) Strain DD Webster which randomized into four groups: negative control group, positive control group, group which got EEBLS of 100 mg/kgBB, and group which got EEBLS of 200 mg/kgBB.Results: The result of the research showed that there was significant decrease in blood sugar, compared with the control group. There was insignificant decrease in the activity of glutathione peroxide enzyme, compared with the control group.Conclusion: The conclusion of the research was that EEBLS of 200 mg/kgBB decreased blood sugar content of mice significantly, but there was no significant change in the activity of glutathione peroxide enzyme when EEBLS was given to the mice.   Keywords: streptozotocin, oxidative stress, antioxidant, flavonoidCorrespondence: Jekson Martiar Siahaan. Biomedical Science, Faculty of Medicine, North Sumatera University.Indonesian Journal of Medicine (2016), 1(1): 44-49https://doi.org/10.26911/theijmed.2016.01.01.06
Factors Associated with Adherence to Blood Glucose Test among Diabetes Mellitus Patients at Prof. Dr. W. Z. Johannes Hospital, Kupang Timuneno, Dessy Nelciani; Tira, Deviarbi Sakke; Manurung, Imelda F.E
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Blood glucose level test for the Diabetes Mellitus patients is a procedure to monitor blood glucose level control and early detect complication of the disease. This study aimed to investigate the factors associated with adherence to blood glucose test among diabetes mellitus patientsat Prof. dr. W. Z. Johannes Hospital, Kupang.Subjects and Method: This was an analytic study withcross sectional study. A total of 93 Diabetes Mellitus patientswho had attended Internal Medicine Clinic at Prof. dr. W. Z. Johannes Hospital, Kupang, for at least 10 years, were sampled for this study. This sample consisted of 45 patients who adhered and 48 patients did not adhere to blood glucose test. Association of variables under study was analyze by chi square test.Results: There is a positive but weak relationship between adherence to blood glucose test and distance to health care facility (C=0.28; p=0.005), as well as family support(C=0.21; p=0.043).Conclusion: the health care authority should consider providing health care service for diabetes mellitus patients as close as possible to their home. In addition families of the patient are suggested to support their family members with diabetes mellitus in controlling blood glucose regularly.Keywords: adherence, blood – glucose level, diabetes mellitus.Correspondence: Dessy Nelciani Timuneno. Epidemiology and Biostatistics, School of Public Health, Nusa Cendana University, Kupang.Indonesian Journal of Medicine (2016), 1(1): 1-11https://doi.org/10.26911/theijmed.2016.01.01.02
Risk Factors Associated with Prostate Hyperplasia at Prof. Dr. W.Z. Johannes Hospital Misnadin, Indri W.; Adu, Apris A.; Hinga, Indriati A. Tedju
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The increase of Indonesia’s population life expectancy causes the increase of advanced age people. This issue resulted in increasing of degenerative diseases such as Hyperplasia Prostate which is the second biggest disease in urology clinic in Indonesia. This study aimed to determine the risk factors in the form of age, smoking, alcoholic consumption, physical exercise, cholesterol, and diabetes mellitus associated to hyperplasia prostate cases at Prof.Dr. W. Z. Johannes, Hospital Kupang.Subjects and Method: This was an observational analytic study with case-control design. A total of the samples were 68 men were collected by random sampling technique. Dependent variable was prostate hyperplasia. Independent variables were age, smoking, phisycal exercise, alcohol consumption and diabetes mellitus. The data were analyzed by Chi-Square.Results: This research showed that risk associated the risk factors were age (OR=12.63; 95% CI= 2.60 to 61.37; p<0.001), smoking (OR=3.52; 95% CI=1.27 to 9.7; p=0.026), physical exercise (OR=3.38; 95%CI=1.25 to 9.16; p=0.014), and cholesterol level (OR=3.88; 95%CI= 1.41 to 10.66; p=0.007). There was no association on alcohol consumption (OR= 1.33; 95% CI= 0.47 to 3.78; p=0.595) and diabetes mellitus (OR=0.88; 95% CI=0.32 to 2.39; p=0.798).  Conclusion: Increase prevention efforts such as screening prostate-specific antigen socialization and non-communicable diseases as a prevention in the future.Keywords: prostate hyperplasia, risk factorsCorrespondence: Indri W. Misnadin, Apris A. Adu, Indriati A. Tedju Hinga. Epidemiology and Biostatistics, School of  Public Health, Universitas Nusa Cendana, KupangIndonesian Journal of Medicine (2016), 1(1): 50-57https://doi.org/10.26911/theijmed.2016.01.01.07
MicroRNA-155 Tissue Expression in Patients with Breast Cancer at Dr Haji Adam Malik Hospital, Medan Ompusunggu, Henny Erina Saurmauli; -, Juwita; Nauphar, Donny; Pardede, Sumondang M.; Lim, Hadyanto; Siregar, Yahwardiah
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: MicroRNA (miRNA) is noncoding-RNA that comprises 18-22 nucleotides. miRNA binds its gene targets in the 3-untranslated region (3-UTR), causing direct degradation of mRNA and repressed translation of RNA. MicroRNA regulates various biological processes, including cell proliferation, apoptosis, cell growth, cell differentiation, and metabolism. Various changes have been identified miRNA expression in different types of cancers. This study aimed to describe the expression of miR-155 in patients with breast cancer tissue in Haji Adam Malik Hospital in Medan.Subjects and Method: This was a descriptive study. A total sample was 64 paraffin tissue blocks was taken from female patients with breast cancer at the surgical oncology unit, Haji Adam Malik Hospital in 2013-2014. RNA sample were isolated and checked using a spectrophotometer followed by cDNA synthesis. Then this sample was analyzed for miR-155 expression by using Real Time qPCR. Histopathological grade data were obtained from the medical record.Results: The miR-155 expression in the breast cancer patients is higher than that in the UniSp6 RNA Spike-in (internal controls). miR-155 expression was 29.64, 28.44, 29.22, in grade-I, grade-II, grade-III breast cancer, respectively. UniSp6 RNA Spike-in was 22.30, 22.89, 23.10, respectively in the control groups. Thus, increased of miR-155 expression was the highest in grade I breast cancer patients.Conclusion: Increased miR-155 expression can be used as a biomarker for early diagnosis and prognosis of breast cancer.Keywords: miRNA, miR-155, breast cancer.Correspondence: Henny Erina Saurmauli Ompusunggu. Department of Cellular and Molecular Biology, Faculty of Medicine, HKBP Nommensen University, Medan. Email: ompusunggu.henny@gmail.comIndonesian Journal of Medicine (2016), 1(1): 20-25https://doi.org/10.26911/theijmed.2016.01.01.03
Association between hsCRP Levels, Glycemic Control and Total Interatrial Conduction Time in Patients with Type 2 Diabetes Mellitus K, Isyana Miranti; Wasyanto, Trisulo; Murti, Bhisma
Indonesian Journal of Medicine Vol 1, No 1 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Type 2 Diabetes Mellitus (T2DM) represents one of the most important risk factors for atrial fibrillation (AF). Numerous studies have shown that T2DM and poor glycemic control reflected by glycated hemoglobin A1c (HbA1c) levels are independently associated with new onset AF. Recent experimental studies reported that the increased susceptibility to AF in the diabetic patients was presumably due to the slowing of conduction associated with increased interstitial fibrosis. Systemic inflammation cam play role in the development of atrial fibrillation. High-sensitivity C-reactive protein (hsCRP) is an inflammatory biomarker that independently predicts the cardiovascular risk. This study aimed to determine the association between hsCRP level and glycemic control with total interatrial conduction time in T2DM patients.Subjects and Methods: This was an analytic study with cross-sectional design. A total of samples were 41 patients with T2DM. Peripheral venous blood samples to measure hsCRP and HbA1c were drawn in all study population. The total interatrial conduction time was measured by tissue Doppler echocardiography. Multivariate analysis was performed using multiple regression analysis. P < 0,050 was considered to indicate a statistically significant difference. Results: The high-sensitivity C-reactive protein level was higher in the T2DM patients with HbA1c≥7% than in the T2DM patients with HbA1c<7%, but not statistically significant (0,44±0,30 vs 0,32±0,22; p = 0,183). The total atrial conduction time was longer in the T2DM patients with HbA1c≥7% than in T2DM patients with HbA1c<7%, but not statistically significant (100,29±28,53 vs 94,88±16,50; p = 0,449). Multiple regression analysis showed that hsCRP levels and glycemic control had significant positive correlation with total interatrial conduction time in T2DM patients (r = 0,51; p = 0,004).Conclusions: The hsCRP levels and glycemic control were significant positively correlated with total interatrium conduction time in patients with type 2 diabetes.Keywords: hsCRP, glycemic control, HbA1c, total interatrial conduction time.Correspondence: Isyana Miranti K. Biomedic, Family Medicine Program, Sebelas Maret University, Surakarta. Indonesian Journal of Medicine (2016), 1(1): 58-70https://doi.org/10.26911/theijmed.2016.01.01.08

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