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INDONESIA
Indonesian Journal of Medicine
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
Arjuna Subject : -
Articles 6 Documents
 1 
Search results for , issue "Vol. 10 No. 4 (2025)" : 6 Documents clear
Impact of Dental Restoration and Extraction Treatments on Oral Health–Related Quality of Life (OHRQoL) Sulistyawati, Tri; Novika, Revi Gama Hatta; Murti, Bhisma; Cahyanto, Erindra Budi; Demartoto, Argyo
Indonesian Journal of Medicine Vol. 10 No. 4 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.2.843

Abstract

Background: Cavities or dental caries is one of the most common diseases as the main cause of pain in the oral cavity which can have a significant impact on quality of life. Cavities have several treatment modalities available such as restoration and tooth extraction. These treatment options not only affect the patient's clinical condition, but can also affect the psychological, social, and functional aspects reflected in the Oral Health Related Quality of Life (OHRQoL). The study aimed to determine the effect of restoration treatment and tooth extraction on Oral Health Related Quality of Life (OHRQoL). Subjects and Method: This research was conducted in December 2024 with a total of 200 samples in Surakarta, This study uses a quantitative design with a cross-sectional approach. Data were collected from patients who had undergone restoration treatment and/or tooth extraction on cavities. Dependent variables are in the form of Oral Health Related Quality of Life (OHRQoL) and independent variables in the form of restorative treatments, tooth extraction, age and gender. Data were analyzed by double linear regression. Results: Multiple linear regression analysis showed a significant negative association between the type of dental treatment and OHRQoL. Patients who underwent tooth extraction had OHRQoL scores that were 26.89 units lower than those who received restorative treatment (b = -26.89; 95% CI = -29.39 to -24.39; p < 0.001). No significant association was found between age or sex and OHRQoL. Conclusion: Dental restoration treatments have a significant influence on improving Oral Health Related Quality of Life (OHRQoL), while tooth extraction shows a positive but insignificant relationship. Age and sex variables had no statistical effect on OHRQoL.
Ultrasonography Findings of Rare Form Deep Vulvar Hemangioma: A Case Report Purmata, Andrew Theo William Chris; Ubaid, Angling Febriani Ariqoh; Sandy, Emy Noviana; Adiwinoto, Ronald Pratama
Indonesian Journal of Medicine Vol. 10 No. 4 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.4.839

Abstract

Background: Hemangiomas are the most common vascular tumors in infants and children, they typically appear after birth, grow rapidly, and then gradually involute. Early diagnosis is crucial, but the clinical presentation of hemangiomas can resemble other vascular anomalies, necessi­tating the use of imaging studies like ultrasonography (US) in order to establish accurate diag­nosis. This study aims to present the ultrasonographic characteristics of a rare case of vulvar hemangioma, with the objective of aiding in its differentiation from other vulvar vascular malformations. Case Presentation: A 9-year-old girl presented with a painless vulvar mass that had been enlarging over 3 months. Physical examination revealed a 3 x 2.5 x 1.5 cm, well-defined, skin-colored, non-tender, and immobile mass. Greyscale ultrasonography showed a septated cystic lesion with internal echoes. Doppler ultrasonography showed low flow vascular patterns, suggestive of a hemangioma.  Surgical excision was performed, and histopathology confirmed the diagnosis of a  hemangioma Results: Although vulvar hemangioma is rare, it can mimic other vascular anomalies, making imaging essential for accurate diagnosis and management. Ultrasonography, as a inexpensive and non-invasive imaging modality, plays a crucial role in differentiating hemangiomas from other vascular malformations. Conclusion: Hemangioma is a form of vascular mass and the most common one, at early phase the clinical presentation might resemble other vascular anomalies. Thereby diagnostic modalities such as ultrasonography might be able to help to establish the diagnosis
Effect of Hydroxypropyl Methylcellulose Concentration Variations as a Gelling Agent on the Physical Quality of Hydrogel Formulations Containing Ethanol Extract of Impatiens balsamina L. Herb Buana, Komang Dirga Mega; Pebriani, Ni Luh Gede Wiwin; Suryani, Ade Irma; Mendra, Ni Nyoman Yudianti; Candraningrat, I Dewa Agung Ayu Diva; Sasadara, Maria Malida Vernandes
Indonesian Journal of Medicine Vol. 10 No. 4 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.4.872

Abstract

Background: Impatiens balsamina L. herb is known to possess anti-inflammatory and antioxidant activities, making it a promising candidate for development as an active ingredient in topical formulations. Hydrogels are considered an ideal delivery system for topical wound treat­ment due to their ability to provide controlled drug release, with hydroxypropyl methyl­cellulose (HPMC) commonly employed as a stable gelling agent. This study aimed to evaluate the effect of varying HPMC concentrations on the physical quality of hydrogel formulations containing ethanol extract of Impatiens balsamina L. herb. Subjects and Method: This was an experimental study. Hydrogel formulations were prepared with varying concentrations of hydroxypropyl methylcellulose (HPMC) at 1%, 2%, and 3% as the gelling agent. Each formulation was evaluated for physical quality parameters, including organo­leptic properties, homogeneity, spreadability, adhesiveness, and pH value, following standard topical formulation testing procedures. Results: The evaluation results showed that all formulations exhibited good homogeneity and pH values within the safe range for skin application. Increasing HPMC concentration did not visually affect the color of the formulations; however, it influenced the formulation consistency, decreased spreadability, and increased adhesiveness. Conclusion: Variations in HPMC concentration in hydrogel formulations containing ethanol extract of Impatiens balsamina L. herb significantly affected the physical quality parameters, particularly consistency, spreadability, and adhesiveness. The formulation with 2% HPMC concen­tration demonstrated the most optimal physical characteristics for topical application.
Older Adults Exhibit a Nine-Fold Increased Risk of Type 2 Diabetes Mellitus: Evidence from a Hospital-Based Cross-Sectional Analysis Ni Putu Widyanti Suastiari; Andiani
Indonesian Journal of Medicine Vol. 10 No. 4 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.4.873

Abstract

Background: Type 2 diabetes mellitus represents a significant global health burden with increasing prevalence worldwide. Age and gender are recognized as important demographic risk factors influencing diabetes incidence. This study aimed to determine the relationship between age and gender with the incidence rate of type 2 diabetes mellitus at Bhayangkara Pusdik Brimob Watukosek Hospital. Subjects and Method: This cross-sectional study conducted at internal medicine polyclinic, Bhayangkara Pusdik Brimob Watukosek Hospital, Pasuruan, East Java, Indonesia, from October 2020 to May 2021. Study subjects of 250 patients were selected using total sampling technique. Secondary data from medical records were analyzed using odds ratio calculations to determine associations between age (categorized as high-risk ≥45 years vs low-risk <45 years) and gender with type 2 diabetes mellitus incidence. Data were analyzed using a multiple logistic regression. Results: Among 250 respondents, 140 (56.00%) were diagnosed with type 2 diabetes mellitus. High-risk age group comprised 136 respondents (54.40%), with 107 (76.40%) having diabetes. Female respondents totaled 148 (59.20%), with 80 (57.10%) having diabetes. Age demonstrated significant association with diabetes incidence (OR= 9.06; 95% CI= 5.15 to 15.93; p<0.001), indicating that high-risk age individuals were nine times more likely to develop diabetes compared to low-risk age individuals. Gender showed no significant association with diabetes incidence (OR= 0.82; 95% CI= 0.48 to 1.41; p=0.475). Conclusion: Age has a significant relationship with type 2 diabetes mellitus, while gender shows no significant association.
Guttate Psoriasis Flare Following the Third Dose of mRNA COVID-19 Vaccine in a 36-Year-Old Male: A Case Report Samodra, Velia Maya; Hendrawan, I Wayan; Medikawati, I Gusti Agung Ayu Ratna; Anulus, Ayu
Indonesian Journal of Medicine Vol. 10 No. 4 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.4.879

Abstract

Background: Psoriasis is a chronic, immune-mediated skin disease known to flare in response to various environmental and immunologic triggers, including infections, stress, medications, and vaccinations. With the global rollout of COVID-19 vaccines, rare instances of psoriatic eruptions have been reported. This study aimed to report the case of guttate psoriasis flare following the third dose of mRNA COVID-19 vaccine in a 36-year-old male. Case Presentation: We report the case of a 36-year-old male with a history of guttate psoriasis that occurred seven years prior, which resolved spontaneously without recurrence. The patient had remained disease-free until five days after receiving a third (booster) dose of an mRNA COVID-19 vaccine, when he developed a sudden, widespread eruption of erythematous, drop-like papules and small plaques, predominantly involving the trunk and extremities. Initial management with topical corticosteroids yielded minimal response. Skin biopsy revealed histopathological features consistent with psoriasis. The patient was subsequently started on low-dose methotrexate, result­ing in significant clinical improvement within four weeks. Conclusion: This case highlights the possibility that mRNA COVID-19 vaccination may, in rare cases, trigger guttate psoriasis even in individuals with a remote history of the disease and prolonged remission. While vaccination remains a crucial public health intervention, healthcare providers should remain aware of potential cutaneous adverse events and provide prompt, individualized management to maintain both optimal patient care and public vaccine confidence.
Anti-inflammatory and Anti-infertility Effects of Ethanol Extract of Turmeric (Curcuma longa) in Male Wistar Rats with Type 2 Diabetes Mellitus Induced by Streptozotocin-Nicotinamide-High Fat Diet Vivian, Vivian; Lim, Hadyanto; Siahaan, Jekson Martiar; Anto, Endy Juli; Ilyas, Syaffrudin; Ardinata, Dedi
Indonesian Journal of Medicine Vol. 10 No. 4 (2025)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2025.10.4.891

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder associated with chronic inflammation and male reproductive dysfunction. The ethanol extract of turmeric (Curcuma longa) has demonstrated potential as an alternative therapeutic agent due to its anti-inflammatory and reproductive restorative properties. This study aims to analyze the anti-inflammatory and anti-infertility effects of the ethanol extract of Curcuma longa in male Wistar rats with T2DM induced by a streptozotocin-nicotinamide-high fat diet (STZ-NA-HFD). Subjects and Method: Thirty male Wistar rats were randomized into six groups (n=5): normal control (K1), diabetic control (K2), positive control (T2DM + metformin 45 mg/kgBW, K3), and three treatment groups receiving Curcuma longa extract at doses of 50 mg/kgBW (K4), 100 mg/kgBW (K5), and 150 mg/kgBW (K6). Diabetes was induced with STZ (55 mg/kgBW) and nicotinamide (120 mg/kgBW). Blood glucose, IL-6, testosterone levels, sperm count, and sperm motility were evaluated after 21 days of treatment. Results: The turmeric extract significantly reduced blood glucose levels (p<0.001) and IL-6 concentrations from 574.06±68.99 to 214.06±78.71 ng/mL at a dose of 150 mg/kgBW (p<0.001). Normal sperm motility increased significantly at 150 mg/kgBW (20.0±2.55%) compared to the diabetic control (8.40±2.07%) (p=0.008). Conclusion: The ethanol extract of Curcuma longa demonstrated significant anti-inflammatory activity by reducing IL-6 levels and improving glycemic control. Its anti-infertility effect was reflected by enhanced sperm motility, particularly at the 150 mg/kgBW dose. These findings indicate that Curcuma longa possesses potential as an adjuvant therapy for the management of T2DM and its associated complications.

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