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Global Health Management Journal
Published by Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)
ISSN : -     EISSN : 25809296     DOI : 10.35898/ghmj
Core Subject : Health, Education,
Education Health Professions Medicine & Pharmacology Nursing Public Health
GLOBAL HEALTH MANAGEMENT JOURNAL (GHMJ) focuses on health field with strong preference (but not limited) on public health in general, maternal and child health, nursing, midwifery, sexual and reproductive health, public health nutrition, environmental health, occupational health and safety, health promotion, health economics in South East Asia and other regions. Applied science in health also becomes one of our priority, especially in the field of health information and technology, innovation in health, and development of devices, medicines, vaccines, procedures and systems developed to solve a health problem and improve quality of lives.
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Articles 282 Documents
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Exploring the Antioxidant and Anti-proliferative Effects of Murraya koenigii (L.) Leaves Methanol Extract on T47D Breast Cancer Cell Lines Nisa, Mutia Khoirun; Salamah, Rohmi; Wijayanti, Nastiti
GHMJ (Global Health Management Journal) Vol. 8 No. 1 (2025)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-811204

Abstract

Background: Murraya koenigii (Curry) leaves are herbal plants that have bioactive compounds such as phenolics, flavonoids, and alkaloids that function as antioxidants and anti-cancers. Aims: This study aimed to quantitatively determine the bioactive compounds in curry leaves by calculating phenolic, flavonoid, and alkaloid content. Its potential as an antioxidant and anti-proliferative compound in T47D breast cancer cell lines was also analyzed. Methods: Murraya koenigii leaves extract was obtained by maceration using 80% methanol (1:5 w/v), then the antioxidant and anti-proliferative test was carried out using the 1,1-Diphenyl-2-Pycrylhidracyl (DPPH) and MTT (-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay, respectively, followed by flow cytometry to determine the apoptotic activity of the extract on T47D breast cancer cell lines. Results: The results for the bioactive compounds in the methanol extract of Murraya koenigii leaves were 156.62±1.49 mg/g phenolics, 99.19±0.25 mg/g flavonoids, and 2.90±0.01 mg/g alkaloids. The IC50 value for antioxidant activity was 25.058±2.2 μg/ml and showed an anti-proliferative effect on T47D cells in a dose-dependent manner with IC50 74.71±5.45 μg/ml for cytotoxicity. Furthermore, flow cytometry showed that a concentration of 1/16 IC50 has the best results for apoptosis. Conclusion: The methanol extract of Murraya koenigii leaves has the potential as an antioxidant and anti-proliferative agent and can induce apoptosis of T47D cells.
Reviewer Acknowledgements: GHMJ (Global Health Management Journal), Volume 8, Number 1, 2025 GHMJ (Global Health Management Journal)
GHMJ (Global Health Management Journal) Vol. 8 No. 1 (2025)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-811211

Abstract

As GHMJ (Global Health Management Journal) celebrates its 8th anniversary, we take this opportunity to express our deepest gratitude to the dedicated reviewers whose expertise and insights have significantly contributed to the quality and integrity of this edition. This edition of the Global Health Management Journal (Vol. 8, No. 1, 2025) presents a diverse range of research addressing critical health challenges. The editorial underscores the urgency of global health strategies in mitigating the adverse impacts of climate change on human health (Macnab, 2025). A perspective piece examines Thailand’s policies on PM 2.5 air pollution, revealing hidden gaps in environmental health governance (Wongtongtair, 2025). The best practice article highlights the economic and nutritional potential of Crab Abon as a sustainable fishery product in Balikpapan, Indonesia (Haqiqiansyah, et al., 2025). In the research section, studies explore the psychosocial effects of Indonesian soap operas on Malaysian millennials (Perdana, et al., 2025), the role of HIV education in Indonesian schools (Astuti, et al., 2025), and the quality of life in heart failure patients within the obesity paradox framework (Rachmawan, et al, 2025). Other articles analyze personal hygiene among traditional jamu handlers (Suryani, et al., 2025), the transmission risks of tuberculosis in children (Pratiwi, et al., 2025), and the antioxidant and anti-proliferative properties of Murraya koenigii (L.) leaves on breast cancer cells (Nisa, et al., 2025). This collection of articles reflects our ongoing commitment to advancing global health knowledge and solutions. Link to download: https://publications.inschool.id/index.php/ghmj/issue/view/GHMJ.08.01 Each article in this edition has undergone a rigorous double-blind peer review process, ensuring high standards of academic excellence. We extend our heartfelt appreciation to the reviewers who have played a crucial role in refining and enhancing these works. Editor-in-chief Prof. Andrew John Macnab Managing Editors Doni Marisi Sinaga, M.Sc. Kukuh Madyaningrana, M.Biotech. Journal Managers Suyitno, M.PHM Maretalinia, M.A  External Reviewers Prof. Dr. Solikhah S.KM., M.Kes. (Universitas Ahmad Dahlan, Indonesia) Dr. Tulus Handra Kadir, M.Pd. (Universitas Negeri Padang, Indonesia) dr. Hawani Sasmaya Prameswari, SpJP. (Universitas Padjajaran, Indonesia) dr. Raymond Pranata (Universitas Pelita Harapan, Indonesia) dr. Tiar Masykuroh Pratamawati, M.M., M.Biomed. (Universitas Swadaya Gunung Jati, Indonesia) Fanisya Dwiyani, S.T, M.Eng. (Sekolah Tinggi Teknologi Cipasung, Indonesia) Fataa Kusumattaqiin, M.Sc. Ph.D (Politeknik Negeri Samarinda, Indonesia) Musparlin Halid, S.Pd., MPH. (Politeknik Medica Farma Husada Mataram) Sari Hastuti, S.SiT., MPH. (Poltekkes Kemenkes Yogyakarta, Indonesia) Siti Rahmah, SKM., MPH. (Poltekes Kemenkes Mamuju, Indonesia) GHMJ (Global Health Management Journal) welcomes scholars and professionals to contribute to the advancement of global health research by joining our team of reviewers. If you are passionate about supporting high-quality publications, we invite you to be part of our review process. Simply register on our website and select the "Reviewer" option during sign-up. Why Join as a Reviewer? Recognition – Your contributions will be acknowledged in each edition you review. Professional Growth – Eligible reviewers may be considered for future roles on our Editorial Board. Exclusive Publishing Opportunity – Enjoy the chance to publish Guest Editorial Papers at no cost.   Acceptance Rate                           : 44% Days to First Editorial Decision : 21 days Days to accept                                : 28 days   Published: 28 February 2025 
Medical Students’ Perception on the Ideal Lecturer Attributes in Problem-Based Learning on the Onion Model Theory Erlangga, M. Ramses; Meidianawaty, Vivi; Permatasari, Tissa Octavira
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1118

Abstract

Background: The success of Problem-Based Learning (PBL) is closely related to an effective discussion process. A good PBL will affect the success of the learning process. In addition, an effective teaching process from lecturers to students is very influential in producing a qualified doctor. Korthagen's Onion Model is a theory that emphasizes layered aspects in communication and can provide an in-depth view of the relationship between lecturers and students in the context of learning, such as PBL. Aims: To identify what is the ideal lecturer attributes in Problem Based Learning based on the onion model theory according to medical faculty students. Methods: This study uses a descriptive method. Respondents were selected using stratified random sampling techniques, resulting in 98 respondents. This study uses primary data with univariate analysis. Results: From the 98 analyzed samples, it was found that level 1 students gave the highest average score on the identity aspect, with the following average scores: Level 1 (14.4167), Level 2 (13.1111), Level 3 (12, 6667), and Level 4 (12.7826). The behavioral aspect also showed similar results, with the highest score at Level 1 (14.0417) followed by Level 2 (13.5926), Level 3 (13.2083), and Level 4 (13.1739). Conclusion: Most students of the Faculty of Medicine, Universitas Swadaya Gunung Jati, have a good perception of the attributes of ideal lecturers in Problem-Based Learning based on the Onion Model Theory.
Phytochemical Screening and Potency of Mango Peel Extract (Mangifera indica L.) var. Gedong Gincu in Inhibiting the Growth of Staphylococcus aureus ‘Adawiyah, Robi’atul; Apriyanto, Dadan Ramadhan; Brajawikalpa, Rama Samara
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1156

Abstract

Background: Staphylococcus aureus is a pathogen most of which develop into Methicillin-resistant Staphylococcus aureus. To prevent bacterial resistance, herbal medicine is needed. Mango plants have secondary metabolite compounds that can inhibit bacterial growth. Gedong gincu mango is a specific mango variety that grows widely in Cirebon district. There has been no research that knows the secondary metabolite content and its potential as an antibacterial, especially the peel part which only becomes waste. Aims: To find out the chemical compounds contained and determine the potential of mango peel extract (Mangifera indica L.) var. gedong gincu in inhibiting the growth of Staphylococcus aureus. Methods: This research is an experimental with a posttest only control group design. Phytochemical screening test employed a qualitative method. The extract was made using the maceration method with 70% ethanol solvent. Antibacterial testing with well diffusion method, and given four treatment concentrations (W/V), namely 25%, 50%, 75%, 100%. The measurement on the inhibitory zone after 24 hours at temperature of 370C. Results: Gedong gincu mango peel extract contains secondary metabolite compounds flavonoids, tannins, saponins, and steroids. The inhibitory activity of gedong gincu mango peel extract with a concentration of 25% gedong gincu mango peel extract has an average inhibition zone of 11,55 mm, 50% average inhibition zone 13,55 mm, 75% average inhibition zone 14,88 mm, and 100% average inhibition zone 16,22 mm in inhibiting the growth of Staphylococcus aureus p(<0.05). Conclusion: Mango peel extract var. gedong gincu with a concentration of 25% has the potential to inhibit the growth of Staphylococcus aureus bacteria.
Profile of Psoriasis Vulgaris in Waled General Hospital, Cirebon, Indonesia: A Retrospective Study (January 2020-December 2023) Putra, Fadhlan Adiguna; Rahayu, Frista Martha; Wahdini, Maya
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1157

Abstract

Background: Psoriasis is a chronic skin disease that significantly impacts the quality of life. In Indonesia, it affects 2.5% of the population, with increasing cases observed in major hospitals. This study aimed to profile psoriasis vulgaris at Waled General Hospital, Cirebon, from January 2020 to December 2023. Aims: To understand the profile of psoriasis vulgaris in the Dermatology and Venereology Clinic of Waled General Hospital, Cirebon Regency, for the period January 2020 to December 2023. Methods: This study employed a descriptive, cross-sectional design with a retrospective approach to analyze secondary data sourced from medical records of patients treated at Waled General Hospital. The inclusion criteria focused on individuals diagnosed with psoriasis vulgaris who received treatment or consultation between January 2020 and December 2023, provided their medical records were complete. Conversely, the exclusion criteria removed patients diagnosed with other forms of psoriasis, such as guttate psoriasis, as well as those with incomplete records. The final sample size consisted of 56 patients, ensuring a focused and manageable dataset for analysis. By applying these criteria, the study aimed to provide a clear and accurate understanding of psoriasis vulgaris cases, ensuring the findings were both scientifically robust and clinically relevant. Results: From January 2020 to December 2023, psoriasis vulgaris was most prevalent among the age group of 15-49 years, with a mean age of 42.3 ± 14.7 years comprising 53.57% of the cases. The female sex predominated over the male sex, with 53.57% versus 46.42%. The major clinical presentation in all cases was red plaques, 100%. Hypertension was the most common comorbid condition, affecting 17.85% of the patients. The universal systemic antihistamine used was 100%, while the topical corticosteroid used was performed for 80.35% of the cases. Conclusion: These findings put into perspective the need for early recognition of symptoms, standardized treatment, and integrated care for comorbidities such as hypertension in a regional hospital setting. This study thus provides important lessons that could be used to improve psoriasis management by proactively identifying specific strategies to address demographic and clinical characteristics of affected populations and ultimately improve patient outcomes and resource use.
TNF-α -308 G/A Gene Polymorphism as a Risk Factor for Pulmonary Tuberculosis in Cirebon, Indonesia Oktaviyati, Nurfithria; Pratamawati, Tiar Masykuroh; Nauphar, Donny
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1159

Abstract

Background: Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis, spreads via droplets. The TNF-α-308 G/A gene polymorphism is one of the host genetic variables that may affect an individual's vulnerability to the disease. However, this polymorphism has not been studied in Cirebon. Aims: To analyze the TNF-α -308 G/A gene polymorphism as a risk factor for the occurrence of pulmonary tuberculosis in Cirebon. Methods: A total of 64 participants joined part in an analytical observational study using a case-control design at the Biomolecular and Genetics Laboratory, Faculty of Medicine, Universitas Swadaya Gunung Jati, Indonesia. DNA extraction from blood samples, ARMS-PCR genotyping, and 1.5% electrophoresis gel visualization were all part of the data gathering process. The chi-square test was used to analyze the data. This study including inclusion criteria, exclusion criteria, and sample control for the research. Results: According to the study, there is no link between Cirebon's risk of pulmonary tuberculosis and the polymorphism in the TNF-α-308 G/A gene (OR = 0.462; P > 0.05). However, the study shown a protective factors which means that individuals with the TNF-α -308 G/A gene polymorphism have a lower risk of developing pulmonary tuberculosis compared to those without the polymorphism. Conclusion: The TNF-α-308 G/A gene variant is not associated with an increased risk of pulmonary tuberculosis in the Cirebon community.
Potassium Inwardly Rectifying Channel Subfamily J Member 11 (KCNJ11) RS5219 Gene Polymorphism as a Risk Factor for Type 2 Diabetes Mellitus in Indonesia: A Case Control Study Putri, Annisa Septiani Putri; Pratamawati, Tiar Masykuroh; Nauphar, Donny
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1160

Abstract

Background: Diabetes Mellitus (DM) is a chronic metabolic disease caused by the failure of the pancreas to produce the hormone insulin or ineffective use of the hormone insulin. It is estimated that 537 million adults aged 20-79 years worldwide suffer from DM. Genetics is one of the risk factors involved in the pathophysiology of type 2 DM. The KCNJ11 gene encodes the Kir6.2 protein that is responsible for adenosine triphosphate-sensitive potassium ion channels (kATP) synthesis in pancreatic beta cells plasma membrane. Aims: This study aims to examine the KCNJ11 rs5219 gene polymorphism as a risk factor for type 2 diabetes mellitus in Cirebon population. Methods: This case control study involved 29 cases of type 2 diabetes mellitus and 29 healthy controls with purposive sampling technique. Sample data was obtained through the examination of blood sugar, DNA extraction, PCR-RFLP with Eco24I restriction enzyme, then visualization of the results with Gel Electrophoresis. Results: The frequency of G allele was found more in the case group (70%) while the frequency of A allele was found more in the control group (38%). The frequency of heterozygous GA genotype was found more in the control group (48.3%) and the frequency of homozygous mutant AA genotype was more in the case group (17.2%) compared to the control group (13.8%). Chi-Square Test results obtained p-value 0.115, OR value 2.318. Conclusion: This study showed no significant association between Potassium Inwardly Rectifying Channel Subfamily J Member 11 (KCNJ11) rs5219 gene polymorphism and the incidence of Type 2 Diabetes Mellitus in Cirebon population.
Changes in Corneal Curvature Value Before and After Phacoemulsification in Senile Cataract Patients: A case from Waled Regional Public Hospital, Cirebon Nuruzzahrah, Naufarah; Piscaloka, Viora Rianda; Sisprihattono, Boyke
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1165

Abstract

Background: Cataract is the main cause of visual impairment and reversible blindness in the worldwide, especially in people over 50 years old. Cataract could be treated through cataract surgery, which one of the methods is phacoemulsification. Phacoemulsification has the advantage of reducing the risk of post-operative astigmatism due to its smaller incision compared to other techniques. Astigmatism was assessed by the curvature of the cornea, which measured using keratometry. Aims: To describe the differences in curvature cornea value pre and post phacoemulsification surgery in senile cataract patients at Waled Regional Public Hospital, Cirebon. Methods: This is a descriptive observational study. Sampling was obtained from medical records at Waled Regional Public Hospital. Data analysis using univariate analysis. Results: Subjects with preoperative keratometry difference (K1 and K2) of < 1 diopter (D) were 39 subjects (73.6%), and > 1 diopter (D) were 14 subjects (26.4%). Subjects with postoperative keratometry difference (K1 and K2) of < 1 diopter (D) were 38 subjects (71.7%), and > 1 diopter (D) were 15 subjects (28.3%). Subject who had reduction in corneal astigmatism were 21 subjects (39.6%), subject who did not have any change in corneal astigmatism were 14 subjects (26.5%), and subject who had increment in corneal astigmatism were 18 subjects (34%). Statistical analysis showed a p-value of 0.033, indicating a statistically significant change in corneal curvature value between before and after surgery (p-value = < 0.05). Conclusion: The results showed that out of 53 samples, most subjects had preoperative and postoperative astigmatism with a keratometry value difference (K1 and K2) of < 1 diopter (D). One month after phacoemulsification surgery, most samples showed a decrement in astigmatism compared to those who showed an increment in astigmatism.
Correlation between Types of Bleeding Brain Lesion with Glasgow Coma Scale in Head Injury Patients at Gunung Jati Regional Hospital, Cirebon, Indonesia Tantowijaya, Bibit; Debyanti, Merliana; Kusnandang, Agus
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1166

Abstract

Background: Head injuries were a leading cause of morbidity and mortality worldwide, often resulting in bleeding brain lesions such as epidural hematoma, subdural hematoma, subarachnoid hemorrhage, and intracerebral hematoma. The Glasgow Coma Scale (GCS) was a widely used tool to assess the level of consciousness in head injury patients. Understanding this relationship was essential for guiding clinical management and predicting patient outcomes, especially in regions with high incidences of traumatic brain injuries, such as Cirebon, Indonesia. Aims: To analyze the relationship between bleeding brain lesions and the Glasgow Coma Scale in head injuries at Gunung Jati Regional Hospital, Cirebon, Indonesia. Methods: This study used an analytical observational method with a cross-sectional approach. Data collection was conducted using total sampling with a sample size of 28. The inclusion criteria were patients with CT-confirmed brain hemorrhages (epidural, subdural, subarachnoid, or intracerebral hematomas).  Data were obtained from medical records in 2023 at Gunung Jati Regional Hospital. The analysis was performed using the Spearman rank correlation test to evaluate the relationship between the type of brain hemorrhage and GCS scores. Results: The total sample of 28 included 21 patients (75%) with Intracerebral Hematoma, 3 patients (10.7%) with Subdural Hematoma, 2 patients (7.1%) with Epidural Hematoma, and 2 patients (7.1%) with Subarachnoid Hematoma. The level of consciousness in these patients was as follows: 15 patients (53.6%) with mild injuries, 8 patients (28.6%) with moderate injuries, and 5 patients (17.9%) with severe injuries. Spearman correlation analysis showed no significant relationship between Bleeding Brain Lesions and Glasgow Coma Scale in head injuries (p =0.645). The absence of correlation might have been due to unaccounted factors in this study, such as hemorrhage volume, lesion location, midline shift, and injury mechanism. Conclusion: There is no significant relationship between types of bleeding brain lesions and Glasgow Coma Scale in head injury patients. The study's limitations included a small sample size and the exclusion of variables such as hemorrhage volume and location, which could affect the level of consciousness. Future research was recommended to involve larger sample sizes and additional clinical factors to better understand the dynamics between types of brain hemorrhages and patients' levels of consciousness, potentially improving clinical management strategies.
Factors Influencing Quality of Life among Patients with Type 2 Diabetes Mellitus (T2DM) at Waled General Hospital, Cirebon, Indonesia Hidayat, Abimanyu; Zein, Ahmad Fariz Malvi Zamzam; Suwarno, Hermansyah
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1171

Abstract

Background: Diabetes Mellitus (DM) is a chronic disease that requires long-term management and carries the risk of leading to other health conditions, which can result in decrease of quality of life. Aims: To find the quality of life of patients with Type 2 Diabetes Mellitus (T2DM) and the factors affecting it at Waled General Hospital (RSUD Waled), Cirebon, Indonesia. Methods: It was an analytic observational study with a cross-sectional approach. The study took place at RSUD Waled, Cirebon Regency, and used 96 (T2DM) patients as research samples that were chosen with simple random sampling. The source of data was primary through a questionnaire and secondary from the patient’s medical record. The questionnaire used for the quality of life’s variable in this research was WHOQOL-BREF. The analytical statistics used were Spearman’s correlation test for the bivariate analytics, and binary logistics regression for the multivariate analytic. Results: There were 54.2% of T2DM patients that fell into bad quality of life category and 45.8% of T2DM patients had good quality of life. Analytic statistics showed a significant relationship between glycemic control (p = 0.003 and r = 0.304), family support (p = 0.000 and r = 0.502), and self-acceptance with quality of life of T2DM patients (p = 0.000 and r = 0.606). Meanwhile types of therapy, comorbidities, and complication didn’t show a significant correlation with quality of life of T2DM patients. Multivariate analysis showed the most correlated factor for quality of life of patients T2DM was self-acceptance (OR=30). Conclusion: There were some factors that had significant correlation with quality of life of T2DM patients. Self-acceptance was the most correlated factor with quality of life of T2DM patients. Healthcare providers can incorporate educational intervention programs into routine diabetes care, emphasizing patients' psychological health, especially with regard to self-acceptance and family support techniques. In order to improve knowledge, motivation, and efficient self-management, this program may incorporate counselling, education, and the creation of support groups.

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