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INDONESIA
Jurnal Kartika Kimia
Published by Universitas Jenderal Achmad Yani
ISSN : 26551322     EISSN : 26550938     DOI : -
Core Subject : Science, Education, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education
Jurnal Kartika Kimia is National Journal that publish all research article/ review/ short communication related to progres of chemistry researchs. Scope of this journal are: 1) Analytical Chemistry ; 2) Inorganic Chemistry ; 3) Physical Chemistry ; 4) Organic Chemistry ; 5) Biochemistry also applied chemistry such as Material Chemistry, Environmental Chemistry, Catalyst, Food Chemistry, Natural Products Chemistry, and Computational Chemistry. Jurnal Kartika Kimia published by Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University. Jurnal Kartika Kimia publish 2 issues per year at May and November. Jurnal Kartika Kimia can be accessed via print (ISSN 2655-1322) and online (ISSN 2655-0938)
Arjuna Subject : -
Articles 134 Documents
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Docking and Dynamics Studies: Identifying the Binding Ability of Quercetin Analogs to the ADP-Ribose Phosphatase of SARS CoV-2 Arfan, Arfan; Muliadi, Rahmat; Malina, Rachma; Trinovitasari, Nita; Asnawi, Aiyi
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.143

Abstract

The SARS-CoV-2 coronavirus outbreak has resulted in severe pneumonia, even death (COVID-19). ADP-Ribose phosphatase (ADPR), a highly conserved macrodomain of this virus, was appropriate for viral RNA replication and transcription. According to studies, quercetin suppresses the main protease and 3-chymotrypsin and papain-like proteases, exhibiting antiviral efficacy against SARS CoV-2. However, quercetin analogs to ADPR have yet to be investigated. This study aims to obtain candidate compounds for ADPR based on binding energy, interaction mode, and binding stability using docking and molecular dynamics (MD) studies.The native ligand (AMP) has estimated binding energy based on docking results of -7.35 kcal/mol. Quercetin analogs, lig_C00013871 (Quercetin 3-(2''-galoylrutinoside), lig_C00006532 ([5',5']-Bisdihydroquercetin), and lig_C00013874 (Quercetin 3-(2G-(E)-p-coumaroylrutinoside) has more negative binding energy, with estimates of -9.43, -9.26, and -8.98 kcal/mol, respectively. These results align with binding energy estimates based on MM-GBSA of -14.76, -29.39, -34.90, and -42.79 kcal/mol for AMP, lig_C00006532, lig_C00013871, and lig_C00013874, respectively. According to the MD simulation, lig_C00006532 and lig_C00013874 will be more effective in stabilizing the ADPR complex. Finally, these two analogs are potential candidate compounds as ADPR inhibitors of SARS CoV-2.
Synthesis Study of Amylum-Carboxymethyl and Amylum-Sulfonate to Increase their Solubility in Water Khusna Widhyahrini
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.156

Abstract

Modified starch is synthesized to change the physical and chemical properties, one of which is solubility. Two new things were produced in the starch substitution process, namely modifications in the final stage (workup) of the reaction of each substituent, namely changes in the neutralization stage/carboxymethyl starch solids using 30% CH3COOH and the use of methanol pro-analyst in the starch sulfonate deposition process. The results of the solubility test showed that at room temperature and a concentration of 1.5% g/L, carboxymethyl substituted starch was completely soluble in water, while starch with the same concentration was completely soluble at 30°C. The viscosity test at room temperature resulted in a flow time of 25.02 seconds for starch-carboxymethyl and 10.15 seconds for starch-sulphonate. The a-amylase test was identified by thin layer chromatography (TLC) with the presence of reducing sugar stains on the starch-carboxymethyl hydrolysis product but not on the starch-sulphonate hydrolysis product. The Dinitrosalicylate (DNS) test showed that the amount of reducing sugar of starch sulfonate was much smaller than that of starch-carboxymethyl.
Alkilamida dari Buah Zanthoxyllum acanthopodium (Andaliman) Musthapa, Iqbal; Nuraini, Vidia Afina; Gumilar, Gun Gun; Humairo, Ristvi
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.163

Abstract

An unsaturated alkylamide namely ZP-amida F, was isolated from the fruit of Zanthoxyllum acanthopodium. Discovery of this compound is first time in this plant. Determination of the structure using 1H-NMR and comparison with standard.
Pungut Ulang Perak dari Limbah Elektronik Baterai Koin Perak Oksida Menggunakan Pelarut Deep Eutectic Oksalin Fatimah, Soja Siti; Nugraha, Agung Slamet; Mora, Abraham
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.165

Abstract

Silver is a metal that has the highest electrical conductivity, thermal conductivity and reflectivity among all metals and by 2021 the world's silver demand will reach 32,627 tons. To meet the world's silver demand, apart from mining from nature, silver can also be obtained through re-collection of electronic waste using environmentally friendly Deep Eutectic Solvent (DES). The aim of this study was to recover metallic silver from electronic waste of silver oxide coin batteries using oxalin DES leaching method. The research methodology consisted of the steps of synthesizing the eutectic solvent oxalin, characterizing it, and its application to the leaching of silver from the cathode of a silver oxide battery. Silver leaching was carried out by dissolving 0.2 grams of sample with 1:1 oxaline solvent by direct heating for 3 × 8 hours at 500 rpm. The leaching temperature variations were 50, 60, 70, and 80oC and the volume variations of the DES oxalin used were 20, 40, 60, 80, 100, and 125 mL/g. The concentration of leached silver was measured using AAS instrumentation. The results of the synthesis were characterized by FTIR indicating the formation of a new intermolecular interaction, namely the COOH••••Cl interaction. DES oxalin has a density of about 1.2095 g/mL. Based on the results of the optimization of the leaching temperature using 20 mL/g of solvent, the optimum temperature for leaching was found at 60oC with a leaching efficiency of 88.35%. While the results of the volume optimization of the solvent carried out at the optimum temperature, it was found that the optimum volume of the solvent used was 80 mL/g of sample with a leaching efficiency of 94.23%. Based on these results, it can be seen that oxaline has the potential to be used as a solvent in the treatment of used silver oxide battery waste.
Potential of Corn Stalk Biomass as Biosorbent in Adsorption of Mercury (Hg) Metal Contaminants Fathurrahman, Muhammad; Sutanto, Sutanto; Sukresna, Yobi
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.167

Abstract

Corn stalks are an agricultural waste that is commonly found in Indonesia. Corn stalks have a high enough cellulose content which has functional groups that can be used as biosorbents. This study aims to optimize the adsorption of corn stalk waste to mercury metal ions and then determine the adsorption capacity and adsorption constant of the Langmuir and Freundlich isotherm model. This research begins with corn stalk preparation, delignification, characterization using FTIR and SEM, determination of optimization of biosorbent weight, pH of Hg solution, contact time, and concentration of Hg solution, then applied to mercury metal contamination waste. Optimization of the weight of biosorbent in the range 0.4-1.2 grams, pH of the Hg solution is 2-4, contact time is 60-120 minutes, and concentration of the Hg solution of 30-100 g/L with a solution volume of 50 mL. Furthermore, determination of mercury levels, manufacture of standard series, and testing using ICP-OES. Followed by the determination of Langmuir and Freundlich's adsorption isothermal model. The results of this study indicate that the optimum conditions for the adsorption process occur at the weight of the biosorbent 1.2 grams, pH of the Hg 3 solution, contact time of 90 minutes, and concentration of Hg solution of 40 ppb with a solution volume of 50 mL. The application of biosorbent to metal contamination waste with adsorbed Hg concentration obtained 27.5772 ppb in 50 mL of waste solution with an adsorption efficiency of 88.44%. In the determination of Langmuir and Freundlich isotherms, a match was found for Langmuir adsorption isothermals with an adsorption capacity of 0.00333 mg Hg/g biosorbent and b = 176.8256.
Aktivitas Antioksidan dari Ekstrak Daun Kedondong (Spondias dulcis) Melalui Penangkal Radikal Superoksida Somantri, Ucu Wandi; Rudiana, Tarso; Kuncoroyekti, Prasetyo Alfaridzi
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.168

Abstract

Ambarella (Spondias dulcis) is a tropical plant which is known to have antioxidant activity. This study aims to determine the antioxidant activity of the n-hexane, ethyl acetate and methanol extracts of S. dulcis leaves through superoxide radical scavenging and to characterize the phytochemical compounds in the extract using LCMS/MS. S. dulcis leaf powder was macerated with n-hexane, ethyl acetate and methanol. Antioxidant activity was tested through superoxide radical scavengers. The n-hexane extract of S. dulcis leaves had the best antioxidant activity with an IC50 value of 2080 µg/mL. Based on LCMS/MS, 6 compounds were detected in the n-hexane extract at retention time (Rt) 3.23-9.89 minutes. Compounds Ajmalin, Scopoletin, scoparone, 3-methyl-6-[[2-(2-methylbut-3-en-2-yl)-1H-indole-3-yl] methyldene]piperazine-2,5-dione, [3-hydroxy-3-methylbut-1-enyl]-5,7-dimethoxy-2-phenyl-2,3-dihydrochromene-4-one, and 4-hydroxy-3-(3-methylbut-2-enyl)phenyl ]ethanone.
Valorisasi Bonggol Pisang dengan Polyol dan Kitosan Sebagai Bahan Baku Bioplastik Berghuis, Nila Tanyela; Shelly, Rafkita; Ajipratama, Stanislaus Axel; Ar-Raihan, M. Hasbi; Wulandari, Oktaviani; Fitri, Ayu Silvia
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.171

Abstract

Banana stumps, which are plentiful yet still underutilized, are one of the waste products of the banana harvesting process. Recent research indicates that banana stumps contain up to 76 percent starch. To address environmental issues brought on by the use of disposable plastics, we used starch from banana stumps as bioplastics feedstock. To enhance the performance of bioplastics, experiments with the addition of glycerol, sorbitol, and chitosan were conducted. FTIR spectra of the two bioplastic films indicate that additives do not alter the functional groups of bioplastics because they give equal absorption areas with just varying intensities. The result of the thermogravimetric analysis showed glycerol bioplastics disintegrated more quickly (231.85oC) than sorbitol bioplastics (278.75oC). The water absorption test reveals that glycerol bioplastics are more water-resistant than sorbitol bioplastics. According to the results of the biodegradation test, sorbitol bioplastics break down more quickly than glycerol bioplastics. The tensile strength test of sorbitol-based bioplastics yielded a value of 2.233 N/m2, which is greater than the glycerol-based bioplastics' value of 1.830 N/m2. These results show the banana stump's potential as a feedstock for the manufacturing of bioplastics.
Pengaruh Tempat Tumbuh Tanaman Daun Gaharu (Aquilaria malaccensis Lam) dari Dua Daerah yang Berbeda terhadap Aktivitas Antioksidan Aris Suhardiman; Wempi Budiana
Jurnal Kartika Kimia Vol 6 No 1 (2023): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v6i1.172

Abstract

Where it grows can affect the content of its compounds, this will also affect the activity test being studied. This study used gaharu leaves from two different regions, namely from Palembang and Bogor. The aim of the study was to determine the antioxidant activity of Palembang and Bogor gaharu leaves and to determine the total flavonoid content. The research method began with sample preparation, simplicia characterization then extracted by maceration using 96% ethanol, then fractionated by liquid – liquid extraction using n-hexane, ethyl acetate, methanol:water solvents. Extracts and fractions were monitored using TLC and tested for antioxidant activity using the DPPH (1,1-Diphenyl-2-Pikrihidrazil) method using a UV-Vis spectrophotometer where the intensity of antioxidant activity was determined by the IC50 value and the determination of total flavonoid content. IC50 results of Palembang gaharu leaves ethanol extract, methanol:water fraction, ethyl acetate fraction, n-hexane fraction respectively 47.44, 71.98, 84.30 and 138.81 µg/ml while Bogor gaharu leaves extract ethanol, methanol fraction : water, ethyl acetate fraction, n-hexane fraction respectively 45.57, 66.39, 81.12, and 140.09 µg/ml. The total flavonoid content of Palembang gaharu leaves was 13.452 QE/g and that of Bogor gaharu leaves was 11.254 QE/g. In conclusion, the ethanol extract of Palembang gaharu leaves is stronger in antioxidants than Bogor gaharu leaves. Directly proportional to the total flavonoid content, this is thought to be due to the influence of the place where it grows, such as soil nutrient content, temperature, climate, and sunlight intensity.
Molecular Docking Studies of Phoenix dactylifera L. Against SARS-CoV-2 ACE-2 Receptor Warnasih, Siti; Mulyati, Ade Heri; Kholisoh, Siti
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.177

Abstract

Dates (Phoenix dactylifera L.) are one of the most useful plants. According to previous research, those dates contain bioactive compounds with antioxidant, antimicrobial, and anti-inflammatory properties. Furthermore, dates can be used as an antiviral, but the potential of dates as an antiviral, particularly the SARS-CoV-2 antiviral, has received little attention. As a result, the goal of this study was to see if date palm bioactive compounds could be used as SARS-CoV-2 antivirals with molecular docking against the Angiotensin-Converting Enzyme-2 (ACE-2) receptor. The study was carried out using molecular docking methods with Autodock Vina, where 21 chemical compounds found in date palms as ligands were attached to the ACE-2 receptor, and four chemical compounds used as SARS-CoV-2 antiviral medicines, namely chloroquine, favipiravir, plitidepsin, and remdesivir, were used as a control ligand. The results showed that proanthocyanidin B1, B2, and quercetin ligands had the highest interaction and stability with Gibbs free energy values of -9.20 kcal/mol, -9.10 kcal/mol, and -8.20 kcal/mol, respectively. This value is known to be higher than control ligands plitidepsin -9.02 kcal/mol, remdesivir -7.88 kcal/mol, chloroquine -5.65 kcal/mol, and favipiravir -5.38 kcal/mol. As a result, dates can be used as a SARS-CoV-2 antiviral candidate.
Thermodynamics Theoretical Investigation for Synthesis of Pyridine from Pyrylium Salt using Density Functional Theory Khoiriah, Selmi F.; Aprianto, Agil; Kania, Putri; Fauzi, Rafi N.; Nurhayati, Mita
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.178

Abstract

Pyridine is a heterocyclic compound that is widely used as an ingredient in medicines, vitamins, food flavors, pesticides, dyes, adhesives, and others. Currently, pyridine synthesis is carried out with coal tar as a raw material, which is a non-renewable natural resource. In this research, a theoretical study was carried out to evaluate the synthesis process of pyridine using pyrylium salt as an alternative raw material to displace coal tar. This study also aims to simulate the pyridine synthesis and the energy required or released in the process. Density Functional Theory (DFT) method was employed to calculate some thermodynamic properties of the species involved in the reaction such as enthalpy, entropy, and Gibbs free energy in a vacuum and solvated model in order to study the progress of the reaction and mechanism. Based on the calculation results, the lowest value of enthalpy, entropy, and free energy Gibbs is obtained when the reaction takes place in a vacuum. The change of entropy and free Gibbs energy of the reaction was not predominantly affected by the degree of polarity of the solvent. Meanwhile, the enthalpy of reaction simulated in water solvent is higher than in the ethanol solvent. The synthesis reaction of pyridine from pyrylium salt is exothermic and exergonic because it has a negative value of enthalpy change and Gibbs free energy at 298.15 K, which is potential to be done at room temperature without extreme condition control.

Page 8 of 14 | Total Record : 134

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