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Jurnal Kartika Kimia
Published by Universitas Jenderal Achmad Yani
ISSN : 26551322     EISSN : 26550938     DOI : -
Core Subject : Science, Education, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education
Jurnal Kartika Kimia is National Journal that publish all research article/ review/ short communication related to progres of chemistry researchs. Scope of this journal are: 1) Analytical Chemistry ; 2) Inorganic Chemistry ; 3) Physical Chemistry ; 4) Organic Chemistry ; 5) Biochemistry also applied chemistry such as Material Chemistry, Environmental Chemistry, Catalyst, Food Chemistry, Natural Products Chemistry, and Computational Chemistry. Jurnal Kartika Kimia published by Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University. Jurnal Kartika Kimia publish 2 issues per year at May and November. Jurnal Kartika Kimia can be accessed via print (ISSN 2655-1322) and online (ISSN 2655-0938)
Arjuna Subject : -
Articles 134 Documents
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Perbandingan Metode Sonikasi dan Radiasi Gelombang Mikro dalam Sintesis Isoeugenol dengan Katalis Rutenium(III) klorida Mardatillah, Athina; Suryasaputra, Dadan; Anugrah, Rina; Kartika, Tyara; Widiastia, Estu
Jurnal Kartika Kimia Vol 6 No 2 (2023): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v6i2.212

Abstract

Transformasi eugenol menjadi isoeugenol diperoleh melalui reaksi isomerisasi, reaksi ini umumnya dipengaruhi oleh katalis dan suhu. Salah satu upaya untuk mempercepat laju reaksi dapat menggunakan bantuan energi agar dapat menghasilkan metode sintesis yang efisien. Metode yang umum digunakan dalam mempercepat laju reaksi diantaranya dengan energi ultrasonik dan energi dari gelombang mikro. Sebanyak 0,24% (b/b) katalis direaksikan dengan eugenol kemudian dilakukan sonikasi serta radiasi gelombang mikro. Analisis karakterisasi pada larutan produk sintesis dengan menggunakan kedua metode menunjukkan adanya perubahan struktur pada ikatan rangkap gugus alkenil eugenol menjadi isoeugenol, yang dibuktikan dengan nilai indeks bias, profil KLT, spektrum IR, dan 1H-NMR. Nilai indeks bias pada larutan produk sintesis dengan menggunakan sonikasi dan radiasi gelombang mikro masing-masing adalah 1,579 dan 1,574. Hasil analisis spektroskopi inframerah terhadap produk-produk sintesis kedua metode terdapat gugus (C=C) alkena pada 1602,25 cm-1 dan gugus metil (–CH3) pada 2938,83 cm-1. Begitu pula hasil analisis spektroskopi 1H–NMR terhadap produk sintesis menghasilkan 12 proton, dan pada geseran kimia δH 1,85 ppm dan δH 1,87 ppm menunjukkan terbentuknya gugus –CH3. Sehingga berdasarkan nilai persen rendemen produk sintesis yang dihasilkan dengan menggunakan metode sonikasi dan radiasi gelombang mikro yang masing-masing sebesar 97,87% dan 82,97%, menunjukkan metode sonikasi lebih efisien.
Pembuatan Sabun Padat dengan Penambahan Ekstrak Etanol Daun Binahong (Anredera Cordifolia (Ten.) Steenis) Sebagai Agen Antibakteri Sujono, Hernandi; Ai Nurohmah, Gina; Jasmansyah, Jasmansyah
Jurnal Kartika Kimia Vol 6 No 2 (2023): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v6i2.213

Abstract

Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dari ekstrak etanol daun binahong dan formulasi sabun padatnya. Maserasi menggunakan pelarut etanol 70% digunakan untuk mendapatkan ekstrak etanol daun binahong. Metabolit sekunder dari daun binahong diperoleh dari maserasi menggunakan pelarut etanol 70%. Ekstrak yang diperoleh kemudian dilakukan uji fitokimia, formulasi sabun padat, uji antibakteri, dan uji hedonik. Ekstrak etanol daun binahong mengandung metabolit sekunder golongan flavonoid, saponin, kuinon, dan fenol. Pengujian terhadap sabun padat ekstrak etanol daun binahong mengacu pada SNI 3532-2016. Berdasarkan uji SNI terhadap sabun padat binahong, kadar air berkisar 26 - 28% (SNI <15%); rata-rata pH yaitu 9 (pH SNI 9 – 11), %FFA atau % asam lemak bebas yaitu 0,7896 – 0,9137% (SNI < 2,5%), dan %bahan tak larut dalam etanol yaitu 3,9% dan 4,4% (SNI <5%). Berdasarkan hasil uji sensitivitas, seluruh panelis (n=30) tidak mengalami iritasi. metode kertas digunakan untuk pengujian antibakteri pada ekstrak etanol daun binahong dan sabun padatnya. Hasil pengujian antibakteri menunjukkan bahwa ekstrak etanol daun binahong dan sabun padatnya memiliki daya hambat dengan kategori sedang untuk bakteri Staphylococcusaureus dan Pseudomonas aeruginosa.
Standardisasi Ekstrak Buah Ceremai (Phyllanthus Acidus L. Skeels) dan Aktivitas Inhibisi Enzim Elastase Ernawati, Eneng Elda; Suryani, Nani; Nuramalia, Sifa; Anisah, Anisah; Yustika, Rd. Widya
Jurnal Kartika Kimia Vol 6 No 2 (2023): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v6i2.225

Abstract

One way to ensure that efficacy and quality are guaranteed is that a product/medicinal ingredient quality standard needs to be met by standardizing the extract. Ceremai fruit (Phyllantus acidus) is thought to have elastase enzyme inhibitor activity because it contains vitamin C and flavonoids. The elastase enzyme functions in skin elasticity. This research aims to determine the standardization of ceremai fruit extract (P. acidus) and the inhibitory activity of the elastase enzyme. The sample was extracted using the maceration method using 70% solvent. Parameters in determining extract standardization are specific and non-specific. The inhibitory activity of the elastase enzyme was analyzed using the ELISA method. The results of determining the standardization of extract-specific parameters, the water-soluble essence content was 65.57%, and the ethanol-soluble essence content was 27.875. Non-specific parameters for determining water content 9.17%, determining total ash content 5.68%, determining acid insoluble ash content 1.5%, determining residual solvent 0.01%, determining microbial contamination ALT and AKK 10-1, heavy metal examination with undetectable results. Ceremai fruit extract (EBC) is positive for containing flavonoids, tannins, saponins, alkaloids, steroids, and phenolic compounds. The elastase enzyme inhibitory activity of ceremai fruit extract (EBC) resulted in an average IC50 value of 281.09 ± 11,3µg/mL and retinol with an average IC50 value of 23.81 ± 0,4 µg/mL. This research concludes that based on standardization testing of specific and non-specific parameters, ceremai fruit extract meets raw material quality standards and ceremai fruit extract (EBC) has weak category elastase enzyme inhibitory activity.
Adsorben Karbon Aktif dari Kulit Durian untuk Menurunkan Kadar COD pada Limbah Cair Laboratorium Sains Ruspita, Roza; Agipa, Ade Irmadiki; Kurnia, Siti Khoirunisatul
Jurnal Kartika Kimia Vol 7 No 1 (2024): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v7i1.226

Abstract

In this research, the preparation and characterization of durian peel activated carbon with acid and base activators has been carried out, as well as testing its performance in reducing COD levels in Sains Laboratory wastewater. Synthesis of durian peel activated carbon was carried out using the wet impregnation method followed by calcination at a temperature of 700⁰C for 3 hours. Characterization was carried out using FTIR and SEM-EDX. FTIR spectra results show changes in functional groups in activated carbon after activation with absorption at a wave number of 1691 cm-1 which shows a stretched C=C group. SEM micrograph results show that the pore size of activated carbon increases after activation. The activity test was carried out by comparing the reduction in COD levels in laboratory waste using activated carbon adsorbents activated by HCl and NaOH. COD levels in laboratory liquid waste were 29493 mg/L. An HCl concentration of 0.4 M was the optimum concentration to reduce the COD concentration in laboratory waste by 20.69%. These results show that activated carbon from durian peel could reduce COD levels and can be used as an alternative wastewater treatment in laboratory.
Fotodegradasi Metilen Biru oleh Metal Organic Framework (MOF) Fe-PTC dengan Penambahan H2O2 dan Dioptimasi Menggunakan Desain Box Behnken Fathurrahman, Muhammad; Zulys, Agustino; Gunlazuardi, Jarnuzi
Jurnal Kartika Kimia Vol 6 No 2 (2023): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v6i2.228

Abstract

Metal-organic framework (MOF) is a group of materials that can act as a photocatalyst to degrade dyes under visible light. This research aims to synthesize a new MOF material using iron metal (Fe) and the organic linker perylene-3,4,9,10-tetracarboxylate (PTC) via the solvothermal method, then characterize it using FTIR, XRD, DRS, and SEM-EDS, as well as its application in photodegradation of methylene blue dye by MOF Fe-PTC with the addition of H2O2 using a Box Behnken design. FTIR spectrum with absorption at a wave number of 572 cm-1 which identifies the presence of bonds between Fe and O. Solubility tests show that the material was difficult to dissolve in polar, semipolar, and nonpolar solvents. EDS Mapping which shows the presence of the Fe element with a weight percentage of 21.6%. The synthesized MOF Fe-PTC has a degree of crystallinity of 46.56% and an average crystal size of 50.9 nm with the highest diffraction peak at 2θ = 33.16°. DRS analysis shows that the MOF Fe-PTC has a bandgap energy of 1.93 eV with a maximum wavelength (lmax) of 638 nm. Characterization using SEM shows that the MOF Fe-PTC has a shape like a cylindrical tube. The optimum conditions obtained from photodegradation of methylene blue by MOF Fe-PTC with the addition of H2O2 under visible light irradiation of 250 W statistically are 1.35 mg for photocatalyst weight, 0.22 M for H2O2concentration, and 135 minutes for contact time.
Komposisi Proksimat dari Gracilia Sp, Sargassum Sp, dan Ulva Lactuca di Pantai Sayang Heulang, Garut Selatan, Jawa Barat, Indonesia Rusli, Handajaya; Lestari, Sri Dewi; Iqbal, Muhammad; Rusnadi, Rusnadi
Jurnal Kartika Kimia Vol 6 No 2 (2023): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v6i2.229

Abstract

Carbohydrate protein, fat, and minerals are the main ingredients of seaweed besides water. These main contents can vary depending on environmental conditions and the type of seaweed. Gracilaria sp, Sargassum sp, and Ulva lactuca grow widely and have been used on Sayang Heulang beach, South Garut, West Java, Indonesia. Unfortunately, no information was found for its main content that can indicate the seaweed quality. This research aims to conduct a proximate analysis of the three seaweeds, representing brown seaweed, red seaweed, and green seaweed, respectively. Carbohydrate total analysis was done using Luff Schoorl method and gave 11.2 %w/w, 25.3 %w/w, and 20.4 %w/w for Gracilaria sp, Sargassum sp, and U. lactuca, respectively. Determination of total protein using the Kjeldahl-Nessler method gives 6.5 %w/w for Gracilaria sp, 7.8 %w/w for Sargassum sp, and 8.7 %w/w for U. lactuca. The methods for fat analysis are Soxhlet extraction, which gives 0.3 %w/w for Gracilaria sp, 1.6 %w/w for Sargassum sp, and 1.1 %w/w for U.lactuca. The study also showed Gracilaria sp, Sargassum sp, and U. lactuca contain 26.9 %w/w, 23.6 %w/w, and 32.5 %w/w mineral content, respectively. These results indicate that different types of seaweed provide different chemical compositions.
QSAR, ADMET, and Molecular Docking of Pyrazole Carboxamide Derivatives as Potential Antifungals Against the Fungus Rhizoctonia solani Aziz, Hafiz Aji; Sari, Adani Ghina Puspita; Al-Ghani, Ranggaweny; Novianti, Tria Nurwina
Jurnal Kartika Kimia Vol 7 No 1 (2024): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v7i1.234

Abstract

Sheath blight is generally caused by the fungus R. solani. The emergence of this fungus causes losses for farmers due to reduction of grain crops (cerelia) production such as rice. Thus, the use of antifungal compounds containing succinate dehydrogenase inhibitors is an effort to control sheath blight of the fungus R. solani. This research examines a new pyrazole carboxamide derivative designed as a succinate dehydrogenase inhibitor. Antifungal activity value prediction was determined using the Quantitative Structure-Activity Relationship (QSAR) equation and visualization of the interaction of pyrazole carboxamide derivatives with succinate dehydrogenase inhibitors was determined using molecular docking. A total of 29 pyrazole carboxamide derivatives and activities (EC50) were used in this study for QSAR modelling and molecular docking. The structure was optimized using the DFT/B3LYP/LanL2DZ method as an electronic descriptor calculation and QSAR modelling using the Multiple Linear Regression (MLR) method. The MLR test shows a valid QSAR equation model with good modelling accuracy and produces an equation logEC50 = 2.3936( 0.9447)[C13] + 9.1367 ( 3.0682)[C10] + 2.2473( 0.6055)[HOMO] - 48.1289( 14.1289)[C4] + 1.3937( 0.9465)[C14] + 28.3750( 6.6731) with R2tr = 0.8911; Q2 = 0.793; F = 28.079; R2val = 0.9908; and RMSE = 0.3450. ADMET analysis using ADMETlab indicated that the new pyrazole carboxamide derivative complies with Lipinski's rules, is moderately carcinogenic, and includes inhibiting the activity of hERG blockers. The new pyrazole carboxamide derivatives that have potential as succinate dehydrogenase inhibitors were determined based on the interaction of the docking results, namely compound A1, A5, and A7 -4.9, -5.1, and -5.3 kcal/mol, respectively.
Karakteristik Fisik dan Laju Difusi In Vitro Sediaan Transdermal Patch Domperidon Menggunakan Polimer Turunan Metil Metakrilat-Asam Metakrilat Purnamasari, Nira; Sutarna, Titta Hartyana; Angraeni, Wulan; Karin, Amada; Qotrunnada, Daffa; Alatas, Fikri
Jurnal Kartika Kimia Vol 6 No 2 (2023): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v6i2.235

Abstract

Sediaan patch transdermal merupakan pilihan yang tepat untuk menghindari proses metabolisme lintas pertama pada zat aktif domperidon. Tujuan penelitian ini adalah untuk mengetahui karakteristik fisik dan laju difusi in vitro sediaan transdermal patchdomperidon yang dibuat dengan menggunakan dua matriks polimer turunan metil metakrilat-asam metakrilat, yaitu Eudragit E100 dan Eudragit L 100-55. Sediaan patch transdermal domperidon dipreparasi dengan metode penguapan pelarut menggunakan variasi konsentrasi Eudragit E100 dan Eudragit L100-55 5-20%. Evaluasi karakteristik fisik patch meliputi organoleptis, ketebalan, kandungan lembab, keseragaman bobot, dan ketahanan lipat, dan uji kekuatan mekanik. Uji difusi in vitro dilakukan menggunakan metode flow-through menggunakan sel difusi Franz yang dimodifikasi. Transdermal patch dengan polimer Eudragit E100 menunjukkan homogenitas baik tanpa adanya kristalisasi domperidon diperoleh pada konsentrasi 10% (F2) dan 20% (F3), sementara transdermal patch dengan polimer Eudragit L100-55 menunjukkan homogenitas baik hanya di konsentrasi 20% (F6). Ketahanan lipat dan kandungan lembab seluruh formula menunjukkan hasil yang memenuhi persyaratan ketahanan lipat dan kandungan lembab yang baik. Persentase elongasi dan tensile strength transdermal patch dengan polimer Eudragit E100 cenderung meningkat dengan kenaikan konsentrasi polimer, sementara transdermal patch dengan polimer Eudragit L100-55 menunjukkan penurunan persentase elongasi dan kenaikan tensile strength dengan meningkatnya konsentrasi polimer. Penurunan Laju difusi in vitro transdermal patchterjadi ketika konsentrasi polimer ditingkatkan, baik pada transdermal patch yang menggunakan Eudragit E100 maupun Eudragit L100-55.
Kandungan Metabolit Sekunder dan Aktivitas Antioksidan Batang Tanaman Selasih Ungu (Ocimum basilicum Linn.) Paulina, Erni; Shofiyani, Anis; Rudiyansyah, Rudiyansyah
Jurnal Kartika Kimia Vol 7 No 1 (2024): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v7i1.242

Abstract

Selasih ungu (Ocimum basilicum Linn.) merupakan salah satu tanaman endemik Kalimantan Barat yang berpotensi sebagai antioksidan alami. Penelitian kandungan kimia dan bioaktifitas pada tanaman selasih ungu telah banyak dilakukan khususnya pada bagian daun, akan tetapi informasi ilmiah pada bagian batang tanaman ini masih sangat terbatas. Penelitian dilakukan untuk mengidentifikasi golongan senyawa metabolit sekunder dengan uji fitokimia dan menentukan aktivitas antioksidan menggunakan metode DPPH terhadap ekstrak dan fraksi-fraksi batang tanaman selasih ungu. Hasil penelitian menunjukkan bahwa crude ekstrak metanol dan semua fraksi mengandung alkaloid dan tanin. Selain itu, crude ekstrak metanol juga mengandung flavonoid dan fenolik, fraksi diklorometana (DCM) mengandung flavonoid, dan pada fraksi metanol terkandung senyawa golongan fenolik. Nilai aktivitas antioksidan (IC50) berturut-turut untuk crudeekstrak metanol, fraksi n-heksana, fraksi DCM, dan fraksi metanol adalah 65,52 ppm, 98,11 ppm, 2,89 ppm, dan 67,11 ppm, sedangkan asam askorbat sebagai standar positif memiliki nilai IC50 11,75 ppm. Berdasarkan nilai-nilai aktivitas antioksidan tersebut diketahui fraksi DCM batang tanaman selasih ungu memiliki aktivitas antioksidan lebih kuat dibandingkan asam askorbat.
Analisis Kandungan Logam Berat Fe, Ni, Pb, dan Cr di Kawasan Muara, Mangrove, dan Green Canyon Sungai Cijulang di Pangandaran Putri, Rizkya Dwiananda; Rofilah, Salsazahra; Susetyo, Eprafoditus Kristiadi; Ma’ruf, Nardyawan Arifi; Kevin, Kevin; Solikah, Al Milatus; Pinandita, Aria; Putra, Mochamad Resya; Azis, Muhammad Yudhistira
Jurnal Kartika Kimia Vol 7 No 1 (2024): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v7i1.245

Abstract

One of the main natural resources of living things is water. Water quality is a parameter that determines the function of water. This gives urgency in conducting research related to water quality analysis. Water with good qualities has many essential functions for life. However, water contamination due to anthropogenic activities and natural phenomena is unavoidable. The most common contaminants are heavy metals. Analysis of the content of heavy metals such as Fe, Ni, Cr, and Pb was carried out in samples of Cijulang River water in three zones, namely estuaries, mangroves, and green canyons using the Atomic Absorption Spectrophotometry (AAS) method. Data acquisition was further analyzed with statistical visualization tests in the form of boxplots and bar charts, as well as non-parameter tests in the form of the Kruskal-Wallis test and the Friedman test. Analysis with boxplots shows that the results of the data have a high distribution. Analysis using bar charts shows that most of the data exceeds the Class I quality standard. Analysis using the Kruskal-Wallis test and Friedman test obtains a p-value of 0.3916 for the Kruskal-Wallis test and 0.7788 for the Friedman test. This value indicates that the median of the three data is assumed to be the same. Based on the Regulation of the Minister of Health Number: 416 / MENKES / PER / IX / 1990 concerning Requirements and Quality Control, the quality standard for Cijulang River water samples is classified as Class II.

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