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Jurnal Farmasi Indonesia

farmasi-indonesia
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Published by Universitas Setia Budi

ISSN : 16938615 EISSN : 23024291 DOI : -

Core Subject : Health, Science, Engineering,

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.

Arjuna Subject : -

Articles 271 Documents

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Analisis Pengelolaan Obat Pada Tahap Pengadaan Di Instalasi Farmasi RSUD Gambiran Kota Kediri Tahun 2016 Tri Suyanti
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Drug management is an important aspect in pharmaceutical services. Drug procurement is one stage in the hospital drug management. The purpose of this study is to obtain an overview and analyze drug procurement in pharmacy department of RSUD Gambiran Kota Kediri period 2016. This research is a descriptive study with data collection by retrospective based on period 2016 for primary data and for secondary data interview with relevant department drug management on procurement analyzed by Depkes RI and research results before. The result showed that the drug procurement in RSUD Gambiran Kota Kediri using the financial resources BLUD, DAU and DBHCT with direct method and E-procurement. The results analysis drug procurement shows: percentage of the funds available at the overral required 99,12%, percentage of the allocation drug procurement 16,53%, frequency of the procurement of each drug items 4 times/ year by 94,96%, 16 times/ year by 7,73% and 32 times/ year by 3,22%, and long delays payment to the specified time 22 day.

Faktor yang Mempengaruhi Biaya Terapi Pada Pasien Fraktur Radius Ulna Dengan Pembedahan Orif dan Kesesuaian Dengan Tarif INA-CBG’S Di RSUD Kabupaten Sukoharjo Mayang Aditya Ayuning Siwi; Tri Murti Andayani; Rina Herowati
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ASSAY OF METAMIZOLE, THIAMINE AND PYRIDOXINE IN TABLET Vevi Maritha
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

The aim of the present study was develop and validate HPLC method for the simultaneous assay of metamizole, thiamine and pyridoxine in tablet. Metamizole is a substance that is easily hydrolyzed in the presence of water and oxygen. To inhibit the hydrolysis of metamizole during sample preparation prior to HPLC analysis. Sodium sulfite is added and its optimum concentration was investigated. The chromatographic system includes a RP C8(2) column (150x4.6 mm, 5 µm particle size) in conjunction with Photo Diode Array (PDA) detector. The optimal chromatographic condition was obtained using a mobile phase consisting of phosphate buffer 35mM pH 3.0: methanol (80:20), flowrate 1.0 mL/min, and 10 µl injection volume. The metamizole, thiamine and pyridoxine were detected at 275 nm. The hydrolysis of metamizole was successfully inhibited by adding solution containing 1.5 mg/mL sodium sulfite to solvent and 0.5 mg/mL sodium sulfite to mobile phase. The validation results indicate a good specificity and a linear detector responses with r>0.999. The accuracy (% recovery) for metamizole, thiamine and piridoxine were 100.26%; 99.09%; and 100.03%, respectively. The method yields good precision with RSD of metamizole, thiamine and pyridoxine were 2.0912%; 1.4489%; and 0.8418%, respectively. The validated method was successfully applied for simultaneous assay of metamizole, thiamine and pyridoxine in tablet.

Pharmacophore Optimization Of Berberine As HER2 Inhibitor Mohammad Rizki Fadhil Pratama; Guntur Satrio Pratomo
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Previous research has shown that berberine, an alkaloid found in several plants such as akar kuning (Arcangelisia flava) shows the potential for inhibition of Human epidermal receptor-2 (HER2). Pharmacophore modification on the berberine was predicted could increase the affinity of berberine derivatives against HER2. The present study aims to determine the main pharmacophore of berberine with the highest influence towards berberine affinity against HER2. Molecular docking was performed on several modified pharmacophore of berberine against HER2. The docking results show that O atom at position number 23 has the most important influence on the berberine affinity towards HER2, where modification of O atom resulting in a decrease of berberine affinity. The highest affinity showed by derivate berberine-6 with the free energy of binding score and dissociation constant -10.80 kcal/mol and 12.17 nM, respectively. In contrast with other berberine derivatives, the berberine-6 derivate does not interact with the amino acid threonine at position 862. It provides a prediction that interaction of that amino acid potentially decrease the berberine activity towards active site of HER2. Further, derivate berberine-6 could be developed into HER2 inhibitor and should be potential to be developed as HER2-positive breast cancer therapy.

UJI AKTIVITAS ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN KETAPANG (Terminalia catappa L) PADA MENCIT PUTIH YANG DIINDUKSI ALOKSAN Jena Hayu Widyasti; Dian Marlina; Avianti Eka Dewi A.P Eka Dewi A.P
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Diabetes mellitus is a chronic disease that caused of decreasing insulin production at Pancreatic β cell or insulin production which not effective. The purpose of this research was proving catappa’s leaves extract (Terminalia catappa L) have an activity to decrease blood glucose levels trough diabetics on effective doses. The prominent goal may achieved was obtaining efficacious natural medicine of anti-diabetes and knowing the effective doses of catappa’s leaves extract (Terminalia catappa L) as anti-diabetes. This Anti-hyperglycemic research is using mice as many as 30 mice. The activity experiment of anti-diabetes was executed to 6 treatment groups, there are Group I (normal control), Group II negative control (alloxan induced 180 mg/kgBW and aquadest), Group III (alloxan induced and catappa’s leaves extract 75 mg/kgBW), Group IV (alloxan induced and catappa’s leaves extract 150 mg / kgBW), Group V (alloxan induced and catappa’s leaves extract 300 mg/kgBW), and Group VI (positive control that given by alloxan induced and glibenclamide 10mg/kgBW). All of the treatment group was given with that treatment for 14 days and were carried measurement of blood glucose levels on days 0, 3, 10, 17. The leaf extract anti-diabetes activities shown by calculating hypoglycemic capacity of each treatment. The result of this research showed that the ethanol extract of catappa’s leaves have anti-hyperglycemic activities on mice that alloxan induced. At the doses of ethanol extract of leaves of catappa 300 mg/kgBW have effectively anti-hyperglycemic activities than doses of 150 mg/kgBW and 75 mg/kgBW that was comparable with positive control group

Analisis Kesesuaian Biaya Riil Terhadap Tarif INA-CBGS Pada Pengobatan Stroke Non Hemoragik Pasien JKN Rawat Inap RSUD Dr. Soehadi Prijonegoro Sragen Tahun 2015 Ari Dwidayati; Tri Murti Andayani; Chairun Wiedyaningsih
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Stroke is one of the degenerative diseases and is also the number one cause of death in Indonesia. Enforcement INA-CBGs (Indonesia Case Based Groups) on the financing of the hospital for stroke patients in need of treatment planning and cost analysis for a costly stroke so that the hospital can make cost savings and is expected to be a solution in controlling health care costs. The purpose of this study was to determine treatment pattern of non-hemorrhagic stroke, correlation between real cost to INA-CBG's cost, and factors affecting the real cost. This study was an observational research, the data was taken retrospectively from the document of national health insurance claim in January-June 2015 period. The descriptive analysis is used for patient characteristic and real cost, the data analysis was conducted using one sample t-test to compare the real cost and INA-CBG’s tariff, correlational test to find out the factors affecting the real cost. The results showned that treatment pattern were citicoline (35,31 %), clopidogrel (26,02 %), amlodipin (7,06 %), simvastatin (5,20 %). Analysis using one sample t-test obtained severity I treatment class 3 Rp. 1.066.143,-, severity II treatment class 3 Rp. 766.848,-, dan severity III treatment class 3 Rp. 931.119,-. Factors that affect were secondary diagnosis, severity, treatment class and LOS.

Gambaran Biaya dan Lama Rawat Inap Pada Pasien Diare Akut Anak Yang Menggunakan Kombinasi Suplemen Zink-Probiotik Nurmainah Nurmainah; Ressi Susanti; Esy Nansy
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Diarrhea is an endemic disease that has the potential for extraordinary events, which can lead to death. Treatment of diarrhea quickly and appropriately needs to be done, especially in pediatric patients. Giving supplements zinc and probiotics singly known to accelerate healing diarrhea in pediatric. The purpose of this study is to describe the cost and lenght of stay in patients with acute diarrhea of children who use a combination of zinc-probiotics supplements during their admission in the hospital. This is an observational research method with cross sectional study design that is descriptive. The data collection is done retrospectively database of pediatric patients hospitalized for acute diarrhea in RSUD Sultan Syarif Mohamad Alkadri Pontianak during September 2014-June 2015. The results of this study were all patient with acute diarrhea in hospitalized using combination of supplements zinc-probiotic (100%). The average length of stay in patients with acute diarrhea with mild dehydration for 2.42 days, while the average length of hospitalization in patients with acute diarrhea with mild dehydration is accompanied by infection during 4.26 days. Meanwhile, the average cost of hospitalization in patients with acute diarrhea with mild dehydration Rp. 560,248.48±198,127.01 whereas patients with mild dehydration from acute diarrhea accompanied infections spend an average cost of hospitalization by Rp.930.542,10 ± 346,312.35. The conclusion of this research was the combination of zinc and probiotics supplements for the treatment of acute diarrhea provides a brief hospitalization. It adversely affects the average cost of hospitalization in pediatric patient with acute diarrhea.

HUBUNGAN PELAKSANAAN CLINICAL PATHWAY TERHADAP LAMA RAWAT INAP DAN KEJADIAN FATAL PASIEN SINDROMA KORONER AKUT NOVI AYUWARDANI
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Acute Coronary Syndrome (ACS) is a cardiovascular disease that become a major cause of death until 2020. Standard strategy which summarize the treatment of therapy known as clinical pathways is required caused by the high rate of morbidity and mortality of patients with ACS. This study aimed to determine the relationship of the clinical pathways implementation based on the clinical pathway assessment sheet to the length of stay and number of fatal events in patients with acute coronary syndrome (ACS). This study was a cross sectional study in patients with ACS (NSTEMI/STEMI) treated in ICCU Hospital Dr. Sardjito. The materials used were ACS patient medical records. The tool used is a data collection sheet and clinical pathways assessment sheet. Making retrospective (February - July 2014) and prospective (August - September 2014). The research subjects are 102 patients were divided into 2 groups (49 patients without variation and 53 patients with variations) based on clinical pathways assessment sheet. Variations obtained from the discrepancy amounted to one/more of the therapeutic management of clinical pathways assessment sheet in the first 24 hours of treatment in ICCU. Data analysis includes analysis of long hospitalization relationship to the implementation of clinical pathways in the two groups using the chi-square test and analysis of the relationship number of fatal events (death, heart failure, stroke, and reinfarction) on the implementation of clinical pathways in the two groups using Fisher's exact test. The results of this study indicate that the implementation of clinical pathways based on clinical pathways assessment sheet there is no relationship to the length of stay and the number of fatal events in patients with ACS (p>0,05) in ICCU Dr. Sardjito due ACS assessment sheet clinical pathways are less informative and general management of therapy within the first 24 hours in accordance with the patient's clinical pathways for ACS.

Evaluasi Uji Hedonik dan Uji Iritasi Sediaan Lotion Minyak Atsiri Daun Cengkeh (Eugenia Aromatic L.) Fitri Kurniasari
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Clove (Eugenia aromatic L.) is one of the natural subtances that can be used to natural repelan with the biggest metabolite compound eugenol. This study was to determine the quality standardization of clove leaf essential oil compounds and their components. This study aimed to evaluated the lotions hedonic test and lotions irritation test. Essential oil was obtained by water and steam destillation then analyzed the levels of compounds clofe leaf with GCMS method. Essential oils are used in the preparation obtained lotion with a concentration of 1% (F1), 3% (F2), 5% (F3) and 7% (F4). Observations were done on the organoleptic test, i.e. color, smell, homogeneity, irritation, pH, viscosity, protection ability and hedonist test of formulas Test repelan activity of essential oil. Test data in statistical analysis by one-way ANOVA with a level of 95%. The research shows that standardization in the clove leaf essential with hedonic test of the clofe leaf essential oil concentration of 7% (F4), with and no irritation reported.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN SURUHAN (Peperomia pellucida L. Kunth) TERHADAP BAKTERI Shigella dysentriae Destik Wulandari; Desi Purwaningsih
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Shigella dysentriae is a bacteria that causes bacillary dysentery. This disease cause the patient to experience severe diarrhea. The efforts to overcome this disease is with using of antibiotics, but if the antibiotic is used for a long time can also to provide negative effects for humans. Therefore, needs a new antimicrobials that don't have negative effects for human, that is used of antimicrobial from plants. One of the plants that become candidate is suruhan (Peperomia pellucida L. Kunth). The purpose of this research is to know the antibacterial activity from the etanolic extract of the suruhan leaf (Peperomia pellucida L. Kunth) to against Shigella dysentriae bacteria by using dilution method. The method of this research is begins with the making of ethanol extract from suruhan leaf by maseration technique. The extracts then tested with concentrations of 100%, 80%, 60%, 40% and 20%. The antibacterial test using dilution method to find out Minimum Inhibition Concentration (MIC) and Minimum Kill Concentration (MKC). The results is show that MIC values can’t be determined because the mixture between the leaf extract and the Shigella dysentriae bacteria is very turbid. The value of MKC obtained by antibacterial activity from etanolic extract of the suruhan leaf on Shigella dysentriae bacteria was 40%.

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