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Jurnal Farmasi Indonesia

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Published by Universitas Setia Budi

ISSN : 16938615 EISSN : 23024291 DOI : -

Core Subject : Health, Science, Engineering,

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.

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Articles 271 Documents

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PENGARUH METIL SELULOSA 4000 DAN PROPILEN GLIKOL TERHADAP STABILITAS FISIK GEL VITAMIN C Anita Nilawati; Tn. Saifullah Sulaiman; Ediati Sasmita
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Vitamin C is an antioxidant and itâ€™s usefull to prevent skin from free radicals damage. Vitamin C gel is preferably because it is not sticky, easy to spread, and not leaving oily texture on skin. Methyl cellulose 4000 can influence viscosity and propylene glycol is a cosolvent with dielectrict constant lower than water, this 2 factors can increase the stability of vitamin C gel. This study aimed to optimize and evaluate the influence of methyl cellulose 4000 and propylene glycol to physical stability and antioxidant activity of vitamin C gel. A 22 factorial design was applied to optimize the vitamin C gel using methyl cellulose 4000 and propylene glycol as independent variables. Each factor had 2 levels i.e 2% and 3% for methyl cellulose 4000, 10% and 20% for propylene glycol. The results showed that methyl cellulose 4000 and propylene glycol influence the physical stability and antioxidant activity of vitamin C gel. Increasing concentration methyl cellulose 4000 had increase the viscosity and stickability, and at the other hand decrease spreadability and viscosity changes. Increasing propylene glycol concentration had increase viscosity.

COST - MINIMIZATION ANALYSIS KAPTOPRIL DIBANDINGKAN LISINOPRIL PADA PASIEN HIPERTENSI RAWAT JALAN Diesty Anita Nugraheni; Tri Murti Andayani
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Cost minimal of hypertension can saving money because cardiovascular morbidity and mortality. This study intend to know cost minimal among captopril versus lisinopril of outpatients with hypertension, based on hospital aspect. This study was epidemiology survey, with descriptive analysis and retrospective. The subject was outpatients hypertension in RSUP Dr. Sardjito and RS PKU Muhammadiyah Yogyakarta using captopril or lisinopril as new therapy, addition therapy, or replacement therapy, observed in two months therapy. Samples were selected non-randomly with purpose. Number of samples are 50 patients. The cost was direct medical cost of outpatients with hypertension. The analysis of data describe the use of antihypertensive, sum of direct medical cost, and cost-minimization analysis. The results showed that the clinical outcome of captopril and lisinopril was equivalent. The mean direct medical cost in hypentension without compelling indications for captopril was Rp 134.715,41, and lisinopril was Rp 315.093,16. In hypentension with compelling indications diabetes mellitus, mean direct medical cost for captopril was Rp 242.430 and lisinopril was Rp 492.270. Captopril was cost minimal among two diagnosis.

AKTIVITAS ANTIBAKTERI DAN ANTIJAMUR KULIT BATANG KRANGEAN(Litsea cubeba Pers.) Mamik Ponco Rahayu; Ismi Rahmawati; Wahyu Listiantoro; Wayndy Chrisantoso
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Litsea cubeba Pers or Krangean is a traditional medicinal plant widely used as an antidiarrheal, skin diseases, as well as antiseptic agent. In addition to essential oils, this herb also contains various components such as tannins, saponins, flavonoids and alkaloids. The purpose of the study was to determine the activities of n-hexane fraction, ethyl acetate, and water from the ethanolic extract of the Krangean stem bark as antibacterial and antifungal properties against E. coli ATCC 25922, S. aureus ATCC 25923 and C. albicans ATCC 1023. Krangean stem bark extraction was conducted by maceration method using 70% ethanol as solvent, followed by fractionation with n-hexane, ethyl acetate, and water as solvent. Antibacterial and antifungal activities were determined by diffusion and dilution method. Diffusion method was used to measure the diameter of the inhibitory area against bacteria colonies with concentrations used were 50%, 25%, as well as 12.5%. Dilution method (dilution tubes), was conducted in serial dilutions of various concentrations, 50%, 25%; 12.5%, 6.25%; 3.12%; 1.56%; 0.78%; 0.39%; and 0.195%. The results showed that n-hexane fraction of the ethanolic extract of the Krangeanâ€™ stem bark had the highest activity against E. coli ATCC 25922 and C. albicans ATCC 10231 compared to other fractions, based on the average of diameter inhibition values. The diffusion method showed that nhexane fraction at concentration of 50% had inhibitory activity against E. coli ATCC 25922, and C. albicans ATCC 10231 with the average inhibitory power were 30 Â± 0,00 mm and 20,4 Â± 0,58 mm, respectively. n-Hexane fraction could kill E. coli ATCC 25922, and C. albicans ATCC 10231 with the Minimum Killing Inhibitory Concentration (MKC) value were 1.56%, and 0.39%, respectively.The presence of essential oils and triterpenoid in n-hexane fraction were detected in the preliminary phytochemical tests.

Penggunaan Obat Off Label di Instalasi Rawat Inap Rumah Sakit Kahyangan Happy Elda Murdiana
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Off label drug use is defined as prescriptions for indications or dosage form that did not pass the approval process asociations Food and Drug Administration (FDA). The main reason the off label use of the drug in pregnant women is to avoid complications such as premature birth problems womb, labor, pre-eclampsia and eclampsia or increase the capacity of postnatal adaptation that may occur for example, sepsis or respiratory distress. The purpose of this studywas to determine the type and percentage of drugs used off label installed hospital inpatient heavenly. The research method using the cross section for the retrieval of data from medical records and descriptive analysis. The results obtained was 9.8% lidocaine for perineal sewing anestesi therapy, 5.6% misoprostol for induction of labor and 8.5% issue of abortion, ondancetron 59.1% for the prophylaxis of nausea and vomiting due anestesi cesarean section, bupivacaine 59.1 % The FDA does not approve the use of spinal anestesia, analgesic ketorolax 59.1% cesarean surgery, dexamethasone 1.4% for fetal lung maturation has not been quite the month. So there were six kinds of off label drug used that all off label indications already mentioned above.

Pengaruh Pemberian Ekstrak Etanolik Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) Terhadap Kadar Enzim Alp Pada Tikus Putih Yang Diinduksi Isoniazid Dan Rifampisin Angga Adi Rahmawan; Supriyadi Supriyadi; Tri Wijayanti
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Pandan leaves are medicinal plants that contain alkaloids, saponins, flavonoids, tanins and poliphenols compounds that have high antioxidant activity and potential as hepatoprotective. This research was conducted to determine the effect of ethanol extract pandan leaves (Pandanus amaryllifolius Roxb.) on the rate of ALP in to determine potency extract ethanol pandan leave inhibit necrosis cell of liver in white rats isoniazid and rifampisin induced. This research was used thirty rats were divided in 6 groups. Group I as a normal group. Group II as a hepatotoxic group. Group III as a drug group was given Curcuma 3,6 mg/200 g BW. Group IV, V, and VI as the treatment group given test solution ethanol extract pandan leaves 8,64 mg/200 g BW, 17,28 mg/200 g BW and 25,92 mg/200 g BW for 28 days. All groups except group I were induced by isoniazid and rifampisin 10,8 mg/200 g BW. All groups on day 0, 14th and 28th set ALP rate. Results obtained were analyzed by One Way ANOVA test. The results showed that ethanol extract pandan leaves at a dose of 8,64 mg/200 g BW, 17,18 mg/200 g BW, and 25,92 mg/200 g BW can inhibit ALP in to determine potency ethanol extract pandan leave inhibit necrosis cell of liver in white rats isoniazid and rifampisin induced. Dose of the ethanol extract pandan leaves was the most effective is 25,92 mg/200 g BW.

Efek Antihiperkolesterolemia Ekstrak Etanol Herba Alfafa (Medicago sativa) Pada Tikus Putih Jantan Ika Puspitaningrum; Lia Kusmita; Wahyuning Setyani
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Hypercholesterolemia is a disorder characterized by an increased concentration of cholesterol in the blood. Alfalfa (Medicago sativa) is one of the plants that are believed to control blood cholesterol. This study aims to determine antihypercholesterolemia effect of herb alfafa ethanol extract and the effective dose. Test antihypercholesterolemia ethanol extract of herb alfalfa using male Wistar rats as many as 30 individuals were divided into 6 groups. Group 1 (normal control) was given standard feed. Group 2 (negative control) was given CMC Na 0,5%. Group 3 (positive control) was given Simvastatin. Groups 4, 5 and 6 was given herb alfafa ethanol extract 270, 540 and 1080 mg/kg rat. All treatments are given 7 days orally. Induction hypercholesterolemia with high-fat feed a mixture of standard rat food with lard and egg yolk duck (3:1), as well as fructose 1.8 g/kg rat. Induction was given to all groups for 50 days, except for the normal control. Measurement of total blood cholesterol levels was done on days 0, 51 and 58. Cholesterol levels were obtained calculated % decline further tested with SPSS statistical release 16. The test results showed a statistically significant difference between the negative control group with the ethanol extract of herb Alfalfa three doses. While the comparison between the positive control with the ethanol extract of the herb alfalfa three doses showed no significant differences. It was provided that the ethanol extract of the herb alfalfa could affected antihypercholesterolemia, but not comparable to Simvastatin. The effective dose of ethanol extract of alfalfa as antihypercholesterolemia was 270 mg/kg rat.

Pengembangan dan Evaluasi Formulasi dari Tablet Kunyah Nanopartikel Mebendazol Muhammad Dzakwan; Widodo Priyanto
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Mebendazole is a benzimidazole derivative with broad spectrum anthelminthic activity and excellent tolerability. Orally it is rapidly absorbed and metabolized to sulfoxide and sulfone, which may be responsible for its anthelminthic action. This research aimed to formulate mebendazole nanoparticle chewable tablet to increase its dissolution velocity and impact saturation solubility. Mebendazole nanoparticle chewable tablets (300 mg) were prepared by direct compression. The tablets prepared by this method were evaluated by different parameters such as average weight, hardness, friability, disintegration, drug content and in vitro dissolution etc. All the parameters were found within the specifications. The study on the dissolution profile revealed that F1 had better dissolution rate while compared to F2, F3 and mebendazole microparticle, respectively. Assay values were within the limits of 90% to 110%.

Optimasi Proporsi Polisorbat 80 dan Sorbitan 80 dalam Formulasi Krim Ekstrak Etil Asetat Daun Jengkol (Pithecollobium lobatum Benth) Sebagai Antibakteri dengan Metode Desain Faktorial Ghani Nurfiana Fadma Sari; Ilham Kuncahyo; Mamik Ponco Rahayu
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Jengkol leaves ethyl acetate extract shows to have antibacterial activity because it contains saponins, flavonoids and tannins. The use of jengkol leaves ethyl acetateextract directly assessed less well, so that it made cream preparations to make it more convenient to use. This study aimed to obtain the optimum formula of cream of jengkol leavesethyl acetate extract using additional materials polysorbate 80 and sorbitan 80 by Factorial Design method. The Jengkol leaves extract obtained by soxhletation using n-hexane solvent followed by ethyl acetate was then evaporated to obtain a viscous extract. Jengkol leaves extract ethyl asetat cream was made four made in four formulas based on factorial design method. The resulting cream conducted stability tests including organoleptic test, viscosity, adhesiveness, and dispersive power. Optimum formulation parameters based on physical properties, namely: viscosity, viscosity shift, and dispersive power, using Design EaseÂ® Software version 7.1.6. Optimum formula was determined the physical properties and the data were analyzed using t-test. Antibacterial activity was tested by diffusion method. Optimum formula cream of jengkol leaves ethyl acetate extract obtained from proportion polysorbate 80 of 0.44 g and sorbitan 80 of 1.15 g with the physical properties of the response of the optimum formula predictions and experimental result showed no significant difference. Optimum cream showed antibacterial activity presented as inhibition diameter of 14 mm after one day incubation, more potential than formulation 1 (12.8 mm), formulation A (13,8 mm), formulation B (13,2 mm), and formulation AB (13 mm) against Staphylococcus aureus bacteria.

Optimasi Formula Gel Ekstrak Buah Mengkudu (Morinda Citrifolia L.) Sebagai Antioksidan Dengan Metode Simplex Lattice Design Dewi Ekowati; Evie Yuliaswari; Endang Sri Rejeki
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Noni Fruit (Morinda citrifolia L.) contains polyphenols, flavonoids, saponins, which plays a role as an antioxidant. Noni fruit extract is formulated in gel dosage form for the comfortness and convenience of topical use. This research aims to obtain the optimum formula noni fruit gel which effective as an antioxidant. Gel formula was optimazed by method of Simplex Lattice Design (SLD). design-expert 8.0.6.1. Gel formula was preparated using CMC-Na base (A) and (B) Carbopol 940 so it was obtained 3 formula, i.e. F1 (100% A:0% B), F2 (50% A:50% B), F3 (0% A:100% B) and then was optimized based on physical properties of viscosity, adhesivity, power spread and the shift of viscosity. The SLD's equation was used to make the gel with the response a total of physical prop erties of the gel the most optimum. Optimum gel tested antioxidant activity by using DPPHmethod. Antioxidant activity the ï¬ maximum and operating time so the IC50 values were obtained through analysis of probit with the use of vitamin C as a comparison. The optimum formula of noni fruit extract gel obtained by SLD method was the formula contained CMC-Na 78,92% : carbopol 940 21,08% with the desirability value of 0,511. The t-test results of viscosity, power latched onto, power spread and the shift of viscosity shows no significant difference. The results demonstrated the optimum gel fruit noni had antioxidant activity with IC50 value of 92,875 ppm.

Analisis Stabilitas Senyawa Aktif Antioksidan Kelopak Bunga Rosella (Hibiscus sabdariffaL.) Pada Penggunaannya Sebagai Bahan Tambahan Pangan Alami Vivin Nopiyanti; Reslely Harjanti
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Penggunaan pewarna alami sebagai bahan tambahan pangan merupakan langkah yang lebih baik untuk mencegah penggunaan bahan tambahan pangan sintetik yang berbahaya. Banyak tanaman yang berpotensi sebagai sumber bahan tambahan pangan alami. Salah satunya adalah kelopak bunga rosella. Kepraktisan penggunaannya mendorong masyarakat beralih pada penggunaan bahan tambahan pangan alami tersebut, tetapi terkendala dengan daya simpannya yang tidak tahan lama. Kelopak bunga rosella mengandung pigmen antosianin dengan kadar yang relatif tinggi, sehingga mempunyai potensi untuk dimanfaatkan sebagai sumber bahan tambahan pangan terutama sebagai zat pewarna yang bermanfaat bagi kesehatan karena kandungan giziserta zat aktif yang mempunyai aktivitas farmakologis di antaranya antioksidan. Etanol adalah pelarut yang diperbolehkan digunakan dalam bahan makanan (food grade) dalam batas tertentu. Etanol dapat berfungsi sebagai pengawet sehingga bahan makanan tidak mudah rusak. Penelitian ini bertujuan untuk menganalisis stabilitas kandungan senyawa aktif kelopak bunga rosella yang dibuat dalam bentuk sediaan ekstrak etanol supaya dapat digunakan masyarakat sebagai bahan tambahan pangan dengan daya simpan lama. Penelitian ini dilakukan dengan cara membuat sediaan ekstrak etanol kelopak bunga rosella dengan metode maserasi dibandingkan dengan penggunaannya di masyarakat berupa rebusan. Senyawa aktif antioksidannya diidentifikasi dan ditetapkan aktivitas antioksidannya dengan metode penangkapan radikal bebas DPPH. Stabilitas senyawa aktifnya dipantau dengan pengujian aktivitas antioksidan setelah digunakan dalam produk makanan. Hasil Penelitian menunjukkan bahwa ekstrak etanol bunga rosella sebagai bahan tambahan pangan yang masih mempunyai aktivitas antioksidan dengan nilai IC50 33,79 Î¼g/ml dibandingkan dengan nilai IC50 dari ekstrak etanol bunga rosella yaitu sebesar 8,416 Î¼g/ml. Ekstrak etanol mempunyai aktivitas antioksidan lebih baik jika dibandingkan dengan rebusan dengan nilai IC5019,74 Î¼g/ml

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