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Jurnal Farmasi Indonesia

farmasi-indonesia
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Published by Universitas Setia Budi

ISSN : 16938615 EISSN : 23024291 DOI : -

Core Subject : Health, Science, Engineering,

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.

Arjuna Subject : -

Articles 271 Documents

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Optimasi Kombinasi Asam Stearat dan Trietanolamin dalam Formula Krim Ekstrak Daun Legetan (Spilanthes acmella L.) sebagai Antioksidan secara Simplex Lattice Design Astiti Noer Cahyati; Dewi Ekowati; Reslely Harjanti
Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Legetan leaves extract has been shown to have antioxidant activity because it contains flavonoids and polyphenols. The use of legetan leaves extract directly assessed less well, so that it made cream preparations to make it more convenient to use. This study aimed to obtain the optimum formula of cream of legetan leaves extract using additional materials stearic acid and triethanolamine by Simplex Lattice Design method. The legetan leaves extract obtained by maceration using ethanol 96% solvent was then evaporated to obtain a viscous extract. Legetan leaves extract cream were made three formulas based on the Simplex Lattice Design. Cream were tested physical properties include organoleptic test, viscosity, viscosity shift, dispersive power, pH, and antioxidant activity. Optimum formulation parameters based on physical properties, namely: viscosity, viscosity shift, dispersive power, using Design Expert software version 8.0.6.1. Optimum formula was made and the physical properties of the cream was analyzed using t-test. Antioxidant activity was tested by DPPH methode. Optimum formula cream of legetan leaves extract obtained from composition stearic acid 1,824% and triethanolamine 2,176% with the physical properties of the response of the optimum formula predictions and experimental results showed no significant difference. Cream optimum was 10% extract with antioxidant activity of 443,232 ppm after two day and 1233,3 ppm after one month.

Uji Aktivitas Ekstrak Etanol Herba Sambiloto (Andrographis paniculata Nees) dan Biji Jinten Hitam (Nigella sativa L.) terhadap Reaksi Anafilaksis Kutan Aktif pada Tikus Putih Wistar Jantan yang Diinduksi Ovalbumin Yeli Trimayanti; Gunawan Pamudji Widodo; Yul Mariyah
Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Development of medical plants for the allergic reaction is continuing with the extrac of the bitter (Andrographis paniculata Nees) and black seed (Nigella sativa L.) as an example. This reseachâ€™s purpose is studying inhibition of anaphylaxis reactions effect from ethanol extracts of the bitter herbs and black seed for active anaphylaxis reaction inducted by ovalbumin in male Wistar rats. Research used active anaphylaxis reaction method with 5 test groups, i.e. negative control group, positive control group and 3 tread group. The rats were subcutaneously sensitized by ovalbumin two act time with an interval of seven days. Back rats shavered and intravenaosly injected with evans blue in rats tail. Diameter area of pigmentation measured every hour, up to 8 hours. Obtained data then tested statistically using ANOVA. Results showed that the extract of bitter herbs (120 mg/kg BB), black seed (30 mg/kg BB) and combination of both (60 mg/kg BB : 15 mg/kg BB) could inhibit pigmentation in the back rats skin area. Percent inhibition respectively is 12.39 %; 14.51 %; 22.36 %. Nevertheless, the inhibitory effect was still lower compared with cromolyn sodium as an mast cell stabilizer drug. It can be concluded that the combination of bitter herbs ethanol extracts with black seed ethanol extracts more effectively inhibit active cutaneous anaphylaxis reaction of ovalbumin induced in male Wistar rats.

Uji Aktivitas Diuretik Ekstrak Daun Matoa (Pometia pinnata) pada Tikus Jantan Galur Wistar Ika Purwidyaningrum; Muhammad Dzakwan
Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Matoa leaves (Pometia pinnata) empirically were used as antihypertensive. Diuretic medicine correlated with antihypertensive drugs so this study aims to determine the effect of diuretics matoa leaves extract. Matoa leaves ethanol extract was tested on male rats wistar strain. Animal tests used as many as 25 tails were divided into 5 groups, namely: negative control CMC 0.5%, furosemide 3.6 mg/kg, matoa leaves ethanol extract 50 mg/kg, matoa leaves ethanol extract 100 mg/kg BB, matoa leaves ethanol extract 150 mg/kg. Then the hour urine volume is recorded at 1, 2, 3, 4, 5 and 24 hours. Diuretic effect can be seen from the analysis of data obtained diuretic percent of the volume of urine each time of observation. Results of this research was conducted matoa leaves extract diuretic test. Based on data and ANOVA test can be concluded that the ethanol extract of the matoa leaves can efficacious as a diuretic and its effective dose is 100 mg/kg.

Pengaruh Edukasi Farmasis terhadap Tingkat Kontrol Asma Sunarti Sunarti; Tri Murti Andayani
Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

One effort to achieve therapeutic success is to improve the control of asthma patients, so that the patient's quality of life is enhanced. The provision of appropriate education and useful by pharmacists is expected to improve asthma control and quality of life better. The purpose of this study was to determine the effect of pharmacist education on the level of asthma control and quality of life of patients with asthma, as well as to determine the correlation level of asthma control and quality of life of asthma patients in the outpatient Center for Public Health Pulmonary Surakarta. Research used experimental design with a control group design with pretest post test. Patients received therapy for asthma were divided into two groups: patients who received education from the researcher (treatment group) and patients without the benefit of education (control group). Data was collected by conducting interviews and questionaires ACT (Asthma Control Test). The amount of test subjects were 77 patients, consisting of 39 treatment group and 38 control group. Analysis of statistical tests used Wilcoxon to see the change in the average scores on the level of asthma control before and after the education of each group, p = 0.000 (Î± <0.05). Mann Whitney test was conducted to determine differences in mean score changes in the level of asthma control in the control group and counselingp = 0.000 (Î± <0.05). This study concluded that education could affect the level of asthma control and quality of life of patients in the education group compared to the control group.

Aktivitas Antihiperglikemik Ekstrak Air Daun Sukun (Artocarpus altilis (Park.) Fosberg) terhadap Tikus Diabetes yang Diinduksi Aloksan Apriyani Evalina Lema; Dwi Ningsih; Vivin Nopiyanti
Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Sukun leaves is one plant that used for the treatment of diabetic. This study was aimed to determine antihyperglycemic activity of aqueous extract of sukun leaves, determine the extract dose which affect on blood glucose level, and determine the effect increased in dose of antihyperglycemic activity rats by alloxan induction. The method was used alloxan diabetic. Test animal were divided into five groups, consists of five male white rats: group I was diabetic control (CMC 0,5%), group II was comparative control (glibenclamide) at a dose of 0,09 mg/200 g BB rats, and group III, IV, V were given doses of aqueous extract of sukun leaves of 7 mg/200 g BB rats, 14 mg/200 g BB rats, 28 mg/200 g BB rats. Alloxan were induced on day 0 (after fasting 16 hours) intraperitoneally. Blood sugar levels were determined on days 4, 8 and 12 after administration of the test preparation. The results showed that aqueous extract of sukun leaves has antihyperglycemic activity. The aqueous extract sukun leaves affect by lowers blood glucose level with an effective dose of 7 mg/200 g BB. The greater the dose of aqueous extract of sukun leaves (7 mg/200 g BB rats, 14 mg/200 g BB rats, 28 mg/200 g BB rats) nothing with increased antihyperglycemic effect in significantly.

UJI AKTIVITAS SITOTOKSIK EKSTRAK KULIT BATANG KAYU MANIS (Cinnamomum burmannii) TERHADAP KULTUR SEL T47D Wiwin Herdwiani; Endang Sri Rejeki
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Cinnamon is plant commonly used as an aroma enhancer in cooking. Cinnamon can be used as an alternative cancer treatment. The content of cinnamon bark essential oil including, safrole, cinnamaldehyde, eugenol, tannins, flavonoids, saponins. This study aimed to examine the cytotoxic activity of ethanol extract skin cinnamon to inhibit T47D breast cancer cell activity. Ethanol extract skin cinnamon was obtained through maceration method by 96% ethanol. The content of flavonoids and cinnamaldehyde was detected by Thin Layer Chromatography (TLC). Cytotoxic test on breast cancer cells T47D used 3-[4,5-dimetilthiazol-2yl]-2,5-difeniltetrazolium bromide (MTT) method and the absorbance was read at ELISA reader. Parameter single cytotoxic test is IC50.and its cytotoxic activity was compared with doxorubicin. The result showed that ethanol extract skin cinnamon had cytotoxic effect on breast cancer T47D with IC50 71,157 Î¼g/ml. The ethanol extract skin cinnamon has the potential to be developed as a cemoprefentive agency.

RESPON RASA CAMPURAN EKSTRAK SELEDRI (Apium graveolens L.) DAN EKSTRAK ASAM JAWA (Tamarindus indica L.) DALAM SEDIAAN SERBUK EFFERVESCENT Nutrisia Aquariushinta Sayuti
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

The research aimed to determine effervescent powder formula with concentration variation of Celery extract and Tamarind extracts to the taste aspects of the best. The research was a quasi-experimental design with one shot case study. The evaluation was done to three formula with combination of celery extract and tamarind extract 50%:50% (formula A), 75%:25% (formula B), and 25%:75% (formula C). Physical test was conducted on the organoleptic, moisture content, flow rate, angle of repose and time dispersion of formula. Hedonic test performed to assess the response of the resulting flavor. Respondents of hedonic test was 54 students of Jamu Department, Health Polytechnic Surakarta. The results showed that the different combinations of extract affected to color, aroma and taste parameter of organoleptic results and time dispersion. 61% of respondents liked the flavor of formula C. The flavor of formula A and B was favored by 45% of respondents for each formula. The conclusion was there were no differences of taste respons in the hedonic test results because of differences in theconcentration of combination of celery extract and tamarind extract in effervescent powder formula with p = 0.423 (p> 0.05)

AKTIVITAS ANTIJAMUR KRIM EKSTRAK ETANOL DAUN SIRIH MERAH (Piper betle L. var Rubrum) PADA KELINCI BETINA YANG DIINFEKSI Candida albicansATCCÂ® 10231 Dwi Ningsih; Aneng Ardiya Sukmawanti; Gunawan Pamudji Widodo
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Piper betle L. var Rubrumbe one of herbal that have historically been used as an antifungal. Flavonoid, alkaloid, saponin, tannin, and essential oils that consisting in it was expectedhave antifungal activity. Thestudy aimto determine theantifungal activity ofPiper betle l. var Rubrumleaves ethanol extract creamon female rabbit infectedCandida albicans ATCCÂ® 10231. The antifungal experiment of Piper betle L. var Rubrumdone by infecting vagina New Zealand White rabbits with Candida albicans ATCCÂ® 10231. Forty-eight hours after infection, vaginal smeared with 96% ethanol extract of Piper betel leaf concentration of 2.5%, 5%, 10%, and ketoconazole 2% as a positive control. Clinical symptoms that arise in the rabbit vagina during healing were observed and the number of fungal colonies of rabbit vagina calculated. The data obtained were analyzed with Anova methods with significant level of 95%, followed by SNK test. The results showed that 96% ethanol extract cream Piper betel leaf concentration of 2.5%, 5%, and 10% have antifungal effect. Cream with a 10% concentration was the most effective as an antifungal.

PENGARUH EKSTRAK ETANOL KULIT BUAH MANGGIS DAN DAUN PEPAYA TERHADAP KADAR BILIRUBIN PADA TIKUS PUTIH YANG DIINDUKSI ISONIAZID DAN RIFAMPISIN Meta Kartika Untari; Yane Dila Keswara; Nur Aini Dewi Purnamasari
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Tuberculosis (TB) is a disease with a very high prevalence in Indonesia. Clinical trials of drugs isoniazid and rifampicin have known most active in combating tuberculosis in the lungs. Side effects caused by administration of OAD (anti-tuberculosis drugs) one of them is a liver function disorders characterized by elevated levels of serum bilirubin. This study aimed to determine the activity of a decrease in serum bilirubin levels in rats induced after administration of isoniazid and rifampin combination of ethanol extract of mangosteen peel and papaya leaf. Serum bilirubin measurement method using a spectrophotometer, the bilirubin level is expressed in mg / dl. Data were analyzed using Kruskal-Wallis method shows that there was a significant difference between the treatment groups (p <0.05), while between the time measurements showed no significant difference. A combination of ethanol extract of papaya dose of 120 mg / 200 g BW rat, and the ethanol extract of mangosteen peel dose of 160 mg / 200 g rat BW the most effective of all treatment groups in lowering levels of bilirubin in isoniazid and rifampicin induced rat.

HUBUNGAN EDUKASI FARMASIS TERHADAP PENINGKATAN KUALITAS HIDUP PASIEN ASMA Sunarti Sunarti
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Asthma is a respiratory disease an dis often found to be a problem in the community and require the selection and use of appropriate medications to reducethe frequency of asthma attacks.The provision of appropriate education and useful by pharmacists is expected to improv equality of life better. The purpose of this study wast on determine the effect of pharmacist education on the qualityof life of patients with asthma,as well as to determine the correlation quality of life of asthma patients in the out patient Center for Public Health Pulmonary Surakarta. Research methods using experimental design with a control group design with pretest post test. Patients who received therapy for asthma were divided into two groups,treatment group and control group. Data was collected by conducting interviews and quality of life using the SGRQ questionnaire (St.George's Respiratory Questionnaire). Analysis of statistical tests showed that the quality of life was used paired t test analysis and t independent test results p = -0.000 (Î± <0.05), whereas the mean score of quality of life, p = 0.000 (Î± <0.05) there are differences meaningful before and after education between the control group and the treatment group. This study concludes that education can affect the quality of life of patients in the education group compared to the control group.

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