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Jurnal Farmasi Indonesia

farmasi-indonesia
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Published by Universitas Setia Budi

ISSN : 16938615 EISSN : 23024291 DOI : -

Core Subject : Health, Science, Engineering,

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.

Arjuna Subject : -

Articles 271 Documents

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EVALUASI PERENCANAAN KEBUTUHAN OBAT PUBLIK SERTA KETERSEDIAAN OBAT DI TINGKAT PUSKESMAS SE-WILAYAH KERJADINKES KOTA SURAKARTATAHUN 2015 Eko Yudha Prasetyo; Satibi .; Gunawan Pamudji Widodo
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Drug planning is an important aspect of drug management. Planning is aimed at determining the type and amount of drug in accordance with the needs of community helth center. Although the regulatory guideline of public drug management have been made, but still found the incidence of overstock and stockout. With these considerations it’s necessary to evaluate related planning processes and drug availability. The purpose of this study to know the planning process, the problems encountered and the level of drug availability in community health center throughout the whole working area of Surakarta Department of Health. This research is observational and evaluative study with qualitative approach, supported by quantitative data. Secondary data were obtained from the search document of drug plan for 2015, the usage and demand report of drug. The secondary data is processed to determine the accuracy of planning, the availability and suitability of drug demand. To strengthen information were conducted triangulation and interviews with drug manager related. The results showing the drug plan has not been efficient seen from an average accuracy of drug planning in treatment primary health centers is 440.5% and 389.98% at non-treatment primary health centers. The problems in planning isn’t optimal use of information management system based on electronically in providing data for drug planning, the procurement with e-purchasing requires time and administration are too long, the plan of medicine isn’t fully realized, the community health center received drug beyond the plan so that the use of drugs less effective, The average availability of drugs in the category of excess which amounted to 31.13 months in treatment health centers and 33.95 months in non-treatment.

EFFECT OF KNOWLEDGE LEVEL TO QUALITY OF LIFE WITH DRUG USE COMPLIANCE AS INTERMEDIATE VARIABLE AT RHEUMATOID ARTHRITIS PATIENTS IN OUTPATIENT PHARMACY DEPO Dr. MOEWARDI HOSPITAL SURAKARTA Rahmadani .; Chairun Wiedyaningsih; Gunawan Pamudji Widodo
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Prevalensi rheumatoid arthritis di berbagai negara termasuk Indonesia meningkat sejalan dengan perubahan gaya hidup seperti asupan makanan, obesitas, kurangnya aktivitas fisik, dan obat-obatan. Peningkatan pengetahuan dan kepatuhan penggunaan obat diharapkan dapat mempengaruhi peningkatan kualitas hidup pasien rheumatoid arthritis. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh tingkat pengetahuan terhadap kualitas hidup dengan kepatuhan penggunaan obat sebagai variabel antara. Penelitian menggunakan metode cross sectional, dengan survey untuk melihat pengaruh tingkat pengetahuan terhadap kualitas hidup dan kepatuhan penggunaan obat sebagai variabel antara. Penilaian pengetahuan menggunakan ACREU RAKQ, penilaian kepatuhan menggunakan MMAS-8 dan penilaian kualitas hidup menggunakan The AIMS2-SF. Data yang diambil adalah data tingkat pengetahuan, kepatuhan penggunaan obat dan kualitas hidup dengan menggunakan kuesioner dan data dianalisis menggunakan path analysis. Subyek yang diperoleh dalam penelitian sejumlah 30 pasien rheumatoid arthritis. Hasil kuesioner tingkat pengetahuan yaitu didapatkan 13 responden (43,33%) yang memiliki pengetahuan tinggi. Hasil kuesioner kepatuhan penggunaan obat yaitu didapatkan 14 responden (46,67%) yang memiliki kepatuhan sedang. Hasil kuesioner kualitas hidup yaitu didapatkan 16 responden (53,33%) yang memiliki kualitas hidup sedang. Pengaruh signifikan antara tingkat pengetahuan terhadap kualitas hidup dengan kepatuhan penggunaan obat sebagai variabel antara dengan nilai estimasi atau besaran persentase pengaruh 79%, artinya kepatuhan penggunaan obat berpengaruh signifikan.

COMPARISON OF ESSENTIAL OILS QUALITY FROM PARTS OF NUTMEG BASED ON MYRISTICINE LEVELS Hery Muhamad Ansory; Hardjono Sastrohamidjojo; Bambang Purwono; Nurrohmah Dwi Mahesti
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Telah dilakukan isolasi minyak atsiri dari daging buah, fuli dan biji buah pala denganmenggunakan metode distilasi uap. Analisis kadar senyawa miristisin sebagai indikator darikualitas minyak pala dilakukan dengan menggunakan kromatografi gas dan spektrometer massa.Isolasi senyawa miristisin dilakukan dengan metode distilasi fraksinasi pengurangan tekanan.Analisis kemurnian miristisin dari hasil isolasi dilakukan dengan menggunakan kromatografi gas.Analisis struktur miristisin hasil isolasi dilakukan dengan menggunakan spektrofotometer inframerah dan 1H NMR.Hasil isolasi minyak pala dengan metode distilasi uap dari daging buah pala didapatkan0,75% dengan kadar miristisin 10,54%, fuli pala didapatkan 4,77% dengan kadar miristisin 38,45%dan biji pala didapatkan 6,62% dengan kadar miristisin 9,24%. Hasil isolasi senyawa miristisin dariminyak pala dengan metode distilasi fraksinasi pengurangan tekanan didapatkan dengan kadar92,13%.Kualitas minyak atsiri dari bagian fuli pala memiliki kualitas yang lebih baik dengankandungan miristisin sebesar 38,45%.

Penentuan Kadar Vitamin C dan Aktivitas Antioksidan Buah Carica (Vasconcellea cundinamarcensis) Wonosobo Hery Muhamad Ansory; Rinda Binugraheni; Argo Khoirul Anas
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

The content of vitamin C information in carica fruit is very important because it can improvethe marketability of this fruit. The potential of Carica fruit as antioxidants agent hasn’t beenstudied by the researchers. It’s made Carica fruit are interesting to be studied, so theresearchers conducted this study to determine the vitamin C contain and the antioxidant activityof Carica fruit that grows in Wonosobo.This study was started by the preparation of the Carica fruit to obatined Carica fruitsolution. So that the total content of organic acids, ascorbic acid, and antioxidant activity ofCarica fruit solution could be analyzed. The organic acid content analysis of Carica fruit solutionwas performed by alkalimetric method. The ascorbic acid content analyses were performed byUV-Vis Spectrophotometry, and analysis of antioxidant activity were performed with DPPHmethod.The organic acids total concentration of Carica fruit solution was equal to 0,4 N. Theascorbic acid concentration of Carica fruit solution was 1560 ppm and The C50 value of Caricafruit obtained from sample solution by 118x dilution or equivalent to 17 gram of Carica fruit.

Pengembangan Dan Optimasi Formula Self Mikroemulsi Drug Delivery System (SMEDDS) Kurkumin Untuk Meningkatkan Bioavaibilitas Ilham kuncahyo; Pudiastuti RSP
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Curcumin has been shown to have activity as an anti-tumor, anti-inflammatory, anti-viral, anti-oxidizing and anti-HIV. The use of curcumin in a long-term treatment process provides a low toxicity so it is clinically very beneficial to develop. The active ingredient of curcumin derived from curcuma longa plant extract has a very low bioavaiblity. This is due to the poor solubility of curcumin in water (11 ng / ml, pH 5.0) so that it is slightly absorbed in the gastrointestinal tract. This problem can be overcome by making the preparation of curcumin in the form of Self Microemulsion Drug Delivery System (SMEDDS). Initial studies were screened for the solubility of curcumin with carriers of various types of oils, surfactants and cosurfactants. The screening results continued with the selection of optimum formula SMEDDS kurkumin using Simpelx Lattice Design (SLD) method. Three variables will give 14 SMEDDS curcumin formulas each of which the formula is tested for its characteristics as a critical point include:% transmittance, emulsification time and drug loading. The results of each test were analyzed with Exspert version 7 and continued validation of optimum formula with T test with 95% confidence level. The results showed that the initial screening of curcumin was found to be the highest solubility in olive oil, Tween 80 surfactant and PEG 400 cosurfactant. The three types of materials were optimized with SLD giving optimum formula of SMEDDS curcumin composition with 0,026 olive oil composition; 0.0913 Tween 80 and 0.061 PEG 400.

Aktivitas Antitusif Dan Ekspektoran Ekstrak Etanol, Fraksi Polar-Semi Polar Herba Meniran (Phyllanthus niruri L.) Pada Marmut (Cavia porcellus) Fakhruddin Fakhruddin; Arief Nurrochmad; Gunawan Pamudji Widodo
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Phyllantus niruri L., is wild plants, has wide applications in traditional medicine. The purpose of this study is to evaluated antitussive, expectorant activity, and description antitussive mechanism of phyllantus herbs. Test animal male guniea pigs as many as 36 divided into 9 groups each consisting of 4 guinea pigs. The antitussive activity of ethanol extract and polar-semi-polar fraction be observed on percentage cough suppression by giving a citric acid 7.5% for 5 days. The Expectorant activity was evaluated with phenol red concentration in guinea trachea on 7 days. The mechanism description is evaluated by looking at the comparison of phyllantus herbs and combination ethanol extract phyllantus herbs and codeine modulated by the opioid receptor and glibenclamide modulated by the ATP sensitiv.e K+ channel. The research showed ethanol extract and polar-semi-polar fraction increased the suppression of citric acid induced by citric acid 7.5% and decreased the a supprssant of mucus secretion on evaluation of expectorant. Polar-semi-polar fraction 160 mg/kgBB showed the effective activity antitussive 63,57%. Polar-semi-polar fraction 80 mg/kgBB showed decreased phenol red secretion by 56,91%. This study provides evidence that phyllantus herbs can be used as an antitussive and a suppressant of mucus secretion. Phyllantus herbs not description on mechanism antitussive modulated by the opioid receptor and ATP sensitiv.e K+ channel. The antitussive mechanism may be modulated by other systemic nerves and peripheral nerves

Uji Aktivitas Analgetika Fraksi-Fraksi Ekstrak Etanol Daun Gandarusa (Justicia gendarussaBurm. f) dengan Metode Tail Flick Rosa Juwita Hesturini; Rina Herowati; Gunawan Pamudji Widodo
Jurnal Farmasi Indonesia Vol 15 No 1 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

ABSTRACTGandarusa (Justicia gendarussa Burm. f) is a potential plant as analgetic activities.The aim of the present research was to investigate the analgetic activity with tail flick method onrat models of ethanol extract and the fractions of gandarusa leaf.Partitioned fractinations isolated from ethanolic extract of gandarusaleaves with nheksana,etil asetat and water. Dosage extracts and fractions gandarusa leaf, respectively, are250 mg/kg bw, 500 mg/kg bw, n-hexane fraction of 314 mg/kg bw, the fraction of 41,05 mg/kgbw and water fractions 144,8 mg/kg bw, the negative control group CMC and aspirin 360 mg/kgbw. The results showed the n-heksana fraction has optimal analgesic activity withantinociceptive percentage 94,58% comparable to aspirin.The preliminary phytochemical analisys showed the presence of active phytochemicalsuch as flavonoids, alkaloids, saponins, steroids dan tannins and these compound might beresponsible for analgetic mechanism. The possibility analgetic mechanism of the gandarussa itsstimulate lipomodulin protein biosynthesis which inhibit the action of phospolipase enzimaticthat affecting the enzyme activity arachidonic acid but there is also has gastroprotective activitywith increased mucus production and prevents the release of histamine.

Evaluasi Ketidaktepatan Pemilihan Obat Berdasarkan Kriteria STOPP Pada Pasien Geriatri Santi Dwi Astuti; Nila Darmayanti Lubis; Fitri Kurniasari
Jurnal Farmasi Indonesia Vol 14 No 2 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

ABSTRACTOlder patients have various comorbidities with a variety of prescribed treatments, therefore the Adverse Drug Events rate increases. This is due to physiological changes associated with age and body composition of the impact of aging processes that are universal in the form of decreased cell, tissue and organ functions that are progressive and gradual affecting the condition and response of drugs in the body of elderly patients. The STOPP criteria contains inappropriate medications given to elderly patients.The study was a retrospective analytics, consisting of two study groups: the right group of patients undergoing treatment and an inappropriate group of patients undergoing treatment. Research data taken is geriatric patient data.Treatment based on STOPP criteria from 70 geriatric patients consisted of 33 male patients (47%) and 37 female patients (53%). A total of 51 patients (73%) received appropriate treatment, while 19 patients (27%) received inappropriate treatment. Treatments include cardiovascular, antiplatelet and anticoagulant medications, central nervous system and psychotropic drugs, renal system, gastrointestinal system, respiratory system, muscle and skeletal system, endocrine system, analgesic drug. The group who received inappropriate treatment had an occurrence of Side Effects Drugs include heart palpitations, nausea, vomiting and constipation.

Aktivitas Sitotoksik Ekstrak Etanol Kulit Buah Pinang (Areca catechu) dan Daun Kayu Manis (Cinnamomum burmanni) Wiwin Herdwiani; Soemardji AA; Elfahmi .; Tan MI; Nabila K; Anita K
Jurnal Farmasi Indonesia Vol 15 No 1 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

The areca plant (Areca cathecu) and cinnamon (Cinnamomum burmannii) haveanticancer properties. The aim of this research is to know the cytotoxic effect of Areca catechuof ethanol extract on T47D breast cancer cell culture and Cinnamomum burmannii leaves ofethanol extract on WiDr colon cancer cell culture.The obtained simplicia macerated to obtain ethanol extract of pinang peel and cinnamonleaves. The method used in testing cytotoxic activity was MTT (3- [4,5-dimethylthiazol-2yl] -2, 5-diphenyltetrazolium bromide) to obtain IC50 values.The results showed that ethanol extract of pinang peel and cinnamon leaf did not havecytotoxic effect on T47D culture with IC50 467,34 μg/mL and on WiDr culture with IC50 405,69μg/ml.

Deteksi Molekuler Ekson 2 Gen Beta Globin pada Pasien Beta Talasemia Mayor di RSUD DR. Soeroto Ngawi menggunakan Metode Polymerase Chain Reaction- Single Strand Conformation Polimorfism Yahya Febrianto; Ana Indrayati; Elfahmi .
Jurnal Farmasi Indonesia Vol 15 No 1 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Beta thalassemia is a hereditary blood disorder that caused by genetic disorder ofglobin gene.The condition leads to red blood cell damage so regular blood transfusion isneeded.This study was aimed to determine the presence of mutations in exon 2 gene beta frombeta globin thalassemia patients using PCR-SSCP method. The DNA was isolated from 5samples and amplified using PCR. The amplified product was characterizaed usingelectrophoresis. Region 2 of beta globin was product of primer forward 4 and primer reverse 5with 350 bp of target size. The PCR products of each region then futher analyzed using SSCPmethod. There was indication of mutation in 1,2,3,and 6 samples whereas no mutation insample 5.Based on the results of research can be concluded that PCR-SSCP method can beused to determine the type and location of mutations in exon 2 genes β globin from βthalassemia.

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