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INDONESIA
Jurnal Farmasi Indonesia
Published by Universitas Setia Budi
ISSN : 16938615     EISSN : 23024291     DOI : -
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.
Arjuna Subject : -
Articles 271 Documents
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Efektivitas Terapi dan Kejadian Tidak Dikehendaki Penggunaan Regimen Pengobatan Jangka Pendek pada MultiDrug-Resistant Tuberculosis: a Scoping Review Yunilistianingsih - Yunilistianingsih; Vitarani Dwi Ananda Ningrum
Jurnal Farmasi Indonesia Vol 20 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i2.1970

Abstract

The increase in Multidrug-resistant Tuberculosis (MDR-TB) is a global problem that must be addressed immediately. Duration of treatment, adverse events (ADRs) and medical costs can affect adherence and treatment success. This literature review was conducted to review the effectiveness and ADRs of short-term regimens (STR) in MDR-TB patients. We used PubMed, ScienceDirect, and Google Scholar to retrieve the relevant original articles on MDR-TB treatment with STR in English-language, published from 2018 through 2022. The keywords used in the search for articles are "multi-drug-resistant tuberculosis", "short regimens" or "short-term regimens", effectiveness, safety" or "adverse events". Of the 13 articles obtained, the all-oral regimen proved promising for implementation in the treatment of MDR-TB. Based on sputum conversion, cure rate, and percentage of patients who completed treatment, the regimen with the highest therapeutic effectiveness was 6KmMfxPtoCfzHEZ/5MfxCfzEZ at 92.9%, and the lowest was 4KmMfxPtoCfzHEZ/5MfxCfzEZ at 63.6%. The all-oral regimen with or without Bedaquilin showed a better average therapeutic effectiveness (87.04%) than regimen containing injection (78.43%). Meanwhile, the serious ADRs that emerged were death, cardiotoxicity, hepatotoxicity and ototoxicity. Apart from monitoring the safety, research needs to be expanded to a larger population and wider sites, to find more effective regimens because Mycobacterium tuberculosis are easily resistant.
Gambaran Tingkat Kualitas Hidup pada Usia Produktif dengan Kelebihan Berat Badan di Kota Palu Muhamad Rinaldhi Tandah; Almira Azahriantika; Afriani Kusumawati; Khusnul Diana
Jurnal Farmasi Indonesia Vol 21 No 1 (2024): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v21i1.1989

Abstract

Quality of life is a self-view of an individual in the aspect of assessing one's life. Being overweight to obese of productive age is a factor that can influence the level of assessment of the quality of life. The purpose of this study was to determine the picture of the level of quality of life at a productive age with overweight using pharmacological and non-pharmacological therapies, and to find out whether there was a significant difference between the level of quality of life and overweight using pharmacological and non-pharmacological therapies. This study used a non-experimental method that is descriptive with cross-sectional data collection. Respondent data will be retrieved using a questionnaire (WHOQOL-BREF) and will be analyzed using t-test. The determination of samples in this study using the Yamane and Isaac formulas from a total population of 649 people obtained a sample of 155 respondents. The results of this study can interpret from the data of respondents who use pharmacological therapy, the highest average score is found in the psychological with a value of 71.65, where these results in general in the good category. The highest average score with non-pharmacological therapy is 75.7 with a good category. The significance value obtained from the Independent sample t-test was 0.75 which can interpret that this data did not have a significant difference, due to factors of therapy consumed by respondents by combining pharmacological therapy with the use of other medicines such as herbal medicine or traditional medicine, and supported by a poor lifestyle.
Kajian Drug Related Problems pada Pasien Diabetes Melitus Tipe 2 yang Terinfeksi Covid-19 Pande Made Desy Ratnasari
Jurnal Farmasi Indonesia Vol 21 No 1 (2024): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v21i1.2026

Abstract

Type 2 Diabetes Mellitus (T2DM) is one of several factors exacerbating Covid-19. Previous studies showed that polypharmacy might lead to Drug Related Problems (DRPs) due to some drugs administered during the management of both conditions. This study aimed to analyze DRPs in T2DM patients with Covid-19 at a private hospital in Denpasar, Bali. This study was designed as cross-sectional research in June-July 2022. Data was collected from patient medical records based on inclusion and exclusion criteria. The inclusion criteria were patients T2DM with Covid-19, aged ³18 years, hospitalized between July 2020-July 2021, received Covid-19 and antidiabetic therapy. Patients who transferred to other hospitals during treatment were excluded. The DRPs included 6 aspects, namely indications without therapy, therapy without indications, inappropriate drugs, insufficient drug doses, high drug doses, and drug interactions which were analyzed by reffering to therapeutic guidelines. Majority of 106 respondents is male (66.98%), aged 46-65 years (70.75%), had a fever (30.72%), oxygen saturation 91-95% (55.66%), blood glucose 228.38 mg/dL, temperature 36.68°C, degree of high severity (49.06%), length of stay ≥10 days (52.83%), and final status as discharge (80.19%). Patients received an average of 10.89±3.46 number of drugs. The highest number of antidiabetic use was rapid-acting insulin group (38.97%) then insulin aspart (20.00%). A number of 86.00% of the prescribed patients had experienced at least 1 type of DRPs (61.54%). The top three DRPs events found in this study were drug interactions (87,75%), inappropriate drugs (7,28%), and therapy without indications (4,97%). Role of pharmacists is required for preventing and minimizing DRPs events in the practice.
Kajian Interaksi Obat Pada Pasien Demam Tifoid di Rumah Sakit X di Surakarta Eersta Zusvita Widyastuti; Adhi Wardhana Amrullah; Agnes Prawistya Sari; Avianti Eka Dewi Aditya Purwaningsih
Jurnal Farmasi Indonesia Vol 21 No 1 (2024): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v21i1.2140

Abstract

Salmonella typhi bacteria reside in the human body and cause an infection known as typhoid fever. The number of cases of typhoid fever in Indonesia reaches 81% per 100,000 people. The use of various drugs in the treatment of typhoid fever will increase the possibility of drug interactions. This research is a descriptive observational cross-sectional study. Data from medical records of typhoid fever patients at "X" Hospital in Surakarta from January to December 2021 were used in this study. Potential drug interactions were analyzed using the Drug Interaction Checker application and Stockley's Drug Interaction Guidebook. The data were then statistically analyzed using SPSS 25. The results showed that out of 96 patients with typhoid fever, 29 experienced potential drug interactions. Of the 29 patients, 68 cases occurred, consisting of 41 non-antibiotic-non-antibiotic cases (60.3%) and 27 antibiotic-non-antibiotic cases (39.7%). The highest potential drug interactions were levofloxacin and ondasetron in 8 cases, dexamethasone-omeprazole in 7 cases, ceftriaxone-lansoprazole in 5 cases and sucralfate-lansoprazole in 5 cases. Based on the level of severity, the potential drug interactions that are minor are 26 cases (38.235%), moderate drug interactions are 26 cases (38.235%) and major interactions are 16 cases (23.53%). Based on the mechanism, the most potential drug interactions in pharmacokinetics occurred, namely 52 cases (72.47%) compared to pharmacodynamics as many as 16 cases (23.53%).
Docking Molekuler Senyawa Bioaktif Andrographis paniculata sebagai Kandidat Antimalaria Rizky Resvita R. Bahi; Moh Rivaldi Mappa; Alia Afrilia Gobel; Tarisya Pobela
Jurnal Farmasi Indonesia Vol 20 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i2.2145

Abstract

Efforts to eradicate malaria have been severely hampered by the growing resistance of Plasmodium falciparum to currently available antimalarial drugs. Therefore, efforts should be made to find and develop new effective antimalarial drugs for the treatment of malaria. One of the plants reported to have antimalarial activity is sambiloto. This study aims to carry out molecular docking of the bioactive compounds contained in sambiloto to obtain potential compounds that have antimalarial activity. In this study, 18 bioactive compounds of sambiloto were docked to 3 target proteins involved in the malaria pathway, namely P. falciparum Plasmepsin II (PDB: 1LEE), PfENR (PDB: 1NHG), and PfDHFR-TS (PDB: 7F3Z) using Autodock 4.0. Based on the docking results, the bioactive compounds with the best activity were analyzed using SwissADME webtool for their pharmacokinetic parameters and drug-likeness. The results showed that the bioactive compound with the best activity against the molecular targets involved in malaria was bisandrographolide C, andrographiside, ninandrographolide, 14-acetylandrographolide, daucosterol, andrographic acid and neoandrographolide. These compounds have the lowest binding energy and interact with important amino acid residues present in the target protein. The bioactive compounds contained in sambiloto have the potential to become candidates for antimalarial drugs and have the opportunity to become oral drugs based on Lipinski’s filter except for andrographiside.
The Relationship Between Knowledge and The Use of Health Supplements During The Pandemic Towards Non-Medical Students of Sanata Dharma University Yosef Wijoyo
Jurnal Farmasi Indonesia Vol 21 No 1 (2024): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v21i1.2153

Abstract

The World Health Organization (WHO) declared COVID-19 as a pandemic on 11 March 2020. Based on the data on the distribution of the development of Covid-19, the pandemic in Indonesia itself is still high. One of the efforts to prevent the spread of COVID-19 cases is by increasing the body's immune system. Consuming health supplements is one of the efforts to increase endurance because it has the function to maintain, improving and/or repairing health. This study aims to determine whether there is a relationship between knowledge and actions to use health supplements among non-health students at Sanata Dharma University. This study is a type of Analytical Observational research with a cross-sectional approach. The research instrument is a questionnaire that was distributed online through the Google Form platform. The sample in this study was 368 respondents. The Data analysis in this study uses descriptive statistical tests, normality tests, chi-square tests and simple linear regression tests. In respondents' knowledge of health supplements, 85.9% of 316 respondents fell into the "GOOD" category, and 14.1% of 52 respondents fell into the "BAD" category. While the respondents that use health supplements is 42.4% of 156 respondents, 34.5% of 127 respondents fall into the category of "GOOD", and 23.1% of 85 respondents fall into the category of "GOOD" and there are no respondents who fall into the category of "BAD" and "VERY BAD". This study concludes that there is a relationship between knowledge and actions to use health supplements during a pandemic among non-health students at Sanata Dharma University Yogyakarta, with a strength level, namely "STRONG" with a correlation coefficient value of 0.610
Analisis Farmakokinetik dan Toksisitas pada Bunga Telang (Clitoria Ternatea): In Silico Study Erna Yovi Kurniawati; Noor Pramono; Syarief Thaufik Hidayat; Endang Mahati
Jurnal Farmasi Indonesia Vol 20 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i2.2190

Abstract

This study explores the pharmacokinetic and toxicity aspects of Clitoria ternatea, which is well-known in traditional medicine for its promising pharmacological potential. Using computational methods, research seeks to unravel the interaction of active compounds in the human body, predicting not only pharmacokinetic properties but also exploring the correlation between chemical structure and parameters such as lipophilicity and P-glycoprotein substrate status, which improves our understanding of the compound's behaviour. The urgency of this research stems from the need for a safe source of therapeutics. Through in-depth in silico toxicity assessments, potential side effects of compounds are carefully identified, ensuring a comprehensive safety evaluation. This important step lays the foundation for responsible pharmacological development. This research introduces a new perspective on exploring traditional medicinal plants, emphasising the importance of safe therapeutic alternatives. The ultimate goal is to establish a solid foundation to further develop C. ternatea as a valuable resource for pharmacological applications and advance natural medicine. The results revealed many compounds with significant pharmacological potential, which show promise for future natural medicine applications. However, the imperative for additional research and experimental validation underscores our commitment to understanding the pharmacological and toxicological aspects of these compounds.
Inovasi Fermentasi: Meningkatkan Kandungan Antioksidan pada Bekatul Menggunakan Aspergillus Oryzae Hafidh Al Azzhar; Mardiyono Mardiyono; Hery Muhamad Ansory
Jurnal Farmasi Indonesia Vol 20 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i2.2234

Abstract

This study aims to assess the antioxidant activity of fermented rice bran extract as an innovative approach to enhance the content of bioactive compounds. Although rice bran is known for its richness in phenolic compounds and γ-oryzanol, the use of enzymatic fermentation to increase its bioactivity remains limited. The research explores the antioxidant activity of fermented rice bran extract, providing fresh insights into harnessing the untapped potential of natural antioxidants. Rice bran was fermented with Aspergillus oryzae for 7, 14, and 21 days. The fermented product was then extracted using 70% ethanol, and its antioxidant activity was determined in vitro using the DPPH method. The results indicated that a 14-day fermentation exhibited the highest antioxidant activity (AAI 1.47), categorized as strong antioxidant activity. For non-fermented rice bran and 7-day fermentation, AAI values were 1.09 and 1.05, respectively. Fermentation for 21 days showed the lowest antioxidant activity (AAI 0.55), which was categorized as moderate. These findings contribute to understanding the impact of fermentation duration on the antioxidant activity of rice bran, supporting its potential as a valuable source of antioxidants.
Pengujian Toksisitas Akut Minyak Atsiri Biji Pala pada Mencit Jantan (Mus musculus) Ghani Abhi Majid; Yane Dila Keswara; Hery Muhamad Ansory
Jurnal Farmasi Indonesia Vol 20 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i2.2263

Abstract

Nutmeg seed essential oil works as an antibacterial, antioxidant, antifungal and anti-inflammatory. It is not yet known the safety of using nutmeg seed essential oil as a medicine so it is necessary to carry out safety tests, namely acute toxicity tests. The purpose of this study was to determine the safety of nutmeg seed essential oil and determine the LD50 value, influence on body weight, behavioral changes and macropathology of mouse organs. Isolation of nutmeg seed essential oil using the steam distillation method. Nutmeg seed essential oil was analyzed using GS-MS. Acute toxicity test in this study used fixed dose method. The test animals used 30 male white mice were divided into 6 test groups, namely the placebo control group and the treatment group given nutmeg essential oil doses of 5, 50, 300, 2000 and 5000 mg / KgBB. The observation parameters of test animals include toxic symptoms, body weight, and organ macropathology. The analysis method used is one way ANOVA followed by Tukey's Post-Hoc test. The results showed that after giving nutmeg seed essential oil there were no significant toxic effects but could affect the body weight of mice. Macropathological observation of mouse organs in all groups looked normal and no damage to mouse organs resulted from the administration of test preparations. Thus, the LD50 essential oil of nutmeg seeds is pseudo ≥ 5000 mg/KgBB, including the classification of practically non-toxic.
Evaluasi Rasionalitas Penggunaan Antibiotik Pada Pasien dengan Demam Tifoid di Rumah Sakit X di Surakarta Adhi W. Amrullah; Rolando Rahardjoputro; Atiek Murharyati; Avianti Eka Dewi Aditya Purwaningsih
Jurnal Farmasi Indonesia Vol 21 No 2 (2024): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v21i2.478

Abstract

The bacterium Salmonella typhi is the cause of a systemic infection known as typhoid fever. These bacteria usually enter through contaminated food or drink. To treat typhoid fever, antibiotics must be given as rationally as possible to achieve ideal therapeutic goals. An understanding of various aspects of an infectious disease should be used to plan the use of antibiotics. This understanding must also consider the pharmacokinetics and pharmacodynamics of the antibiotic to be used as well as individual resistance, virulence and microorganisms. The development of antibiotic-resistant bacteria is the worst effect of irrational use of antibiotics. In this study, the Gyssens method was used to analyze the rationality of antibiotics. This observational descriptive study also uses a cross-sectional approach. Data was collected through a retrospective search of medical records in the medical records section of "X" Hospital in Surakarta from January to December 2021. The data collected consisted of analytic and descriptive data, which consisted of patient characteristics and the patient's pattern of prescribing antibiotics. The SPSS computer program is used to process the data. The results of rationality analysis showed that in 84 prescriptions in typhoid fever patients who were included in category 0 (zero) or rational as many as 25 prescriptions (29.76%) and irrational as many as 59 prescriptions (70.24%) consisting of category IV A as many as 18 prescriptions (21.43%), IV B as many as 8 prescriptions (9.52%), III A as many as 3 prescriptions (3.57%), category III B as many as 47 prescriptions (55.95%), II A as many as 34 prescriptions (40.47%) and II B as many as 27 prescriptions (32.14%).

Page 26 of 28 | Total Record : 271

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