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INDONESIA
Jurnal Farmasi Indonesia
Published by Universitas Setia Budi
ISSN : 16938615     EISSN : 23024291     DOI : -
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.
Arjuna Subject : -
Articles 271 Documents
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Pengaruh Variasi Konsentrasi Gelling Agent Terhadap Sifat Fisik Dan Efek Antibakteri Sediaan Gel Handsanitizer Ekstrak Bawang Dayak faizal Mustamin; Irma Novrianti
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1541

Abstract

Currently, there are many alcohol-based hand sanitizers on the market. Alcohol-based products when used in the long term can cause irritation, so it is necessary to develop Handsanitizer preparations that use active substances other than alcohol. Onion Dayak (Eleutherine palmifolia (L.) Merr.) is a typical Kalimantan plant that has antibacterial properties. The purpose of this study was to examine the effect of variations in the concentration of gelling agent in the hand sanitizer gel preparation of Dayak onion extract on the physical properties and antibacterial effects of S. aureus and E. coli bacteria. Gel Handsanitizer preparations were made using the gelling agent carbopol with 3 variations in concentration, namely FI (carbopol 0.3%), FII (carbopol 0.4%), and FIII (carbopol 0.5%). The finished preparation will be tested for physical properties such as organoleptic, pH, viscosity and homogeneity. To see the antibacterial effect of the hand sanitizer, Dayak onion extract was tested on S. aureus and E. Coli bacteria. The hand sanitizer preparation of Dayak onion extract produced has a maroon color, has a distinctive odor, and is homogeneous. The results of the physical properties test showed that the viscosity and pH would increase with increasing gelling agent concentration, while the dispersion decreased with p < 0.05. The results of the test on S. aureus bacteria for FI, FII, FIII, and positive control showed a weak category, while the E. Coli bacteria showed a moderate category for FI, and a strong category for FII, FIII, and positive control with p value > 0, 05. The negative control did not form an inhibition zone. Variations in the concentration of geling agent (carbopol) had an effect on the physical properties of the hand sanitizer gel preparation of Dayak onion extract, but did not affect its effectiveness against S. aureus and E. coli bacteria.
Formulasi dan Uji Antibakteri Masker Peel-Off Ekstrak Daun Gulma Siam (Chromolaena odorata L.) Terhadap Propionibacterium Acnes Sari Wijayanti
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1554

Abstract

Leaves of gulma siam (Choromolaena odorata L.) contain tannins, phenols, flavonoids, saponins, and steroids which are effective for killing acne-causing bacteria. Applied as anti-acne, the extract of gulma siam is formulated as a preparation of a peel-off gel mask. This research produces formulas of peel-off masks made from the extract of gulma siam leaves and perpetrates an antibacterial test on the peel-off masks against propionibacterium acnes. Four formulas of peel-off masks were made using different concentrations of the extract of gulma siam leaves. The concentrations were 3.25% (FI), 7.5% (FII), 15% (FIII), and 20% (FIV). The preparations of the peel-off masks were physically evaluated for organoleptic, spreadability, homogeneity, pH, viscosity, and dry time. A well diffusion method was implemented to test antibacterial potencies against propionibacterium acnes. The potency measurement was based on the resistance around wells in the form of a clear zone. Predicated on the evaluation results of the physical properties of gulma siam leave extracts during storage, organoleptically, the extracts were homogenous, had a pH of 4.5-6.5, and had a dry time of 15-21 minutes. Concerning spreadability, FIII and FIV lived up to the criteria. Meanwhile, for viscosity, all formulas of peel-off masks were unstable during storage. FI and FII presented weak and medium antibacterial activities, respectively. Moreover, FII and FIV showed strong ones. The ANOVA analysis showcased differences in antibacterial activities among the four formulas (p < 0.05). In conclusion, the extract of gulma siam leaves in the form of a peel-off mask preparation was a potential actibacterial ingredient for dealing with propionibacterium acnes.
Gambaran Efek Samping Kontrasepsi Hormonal pada Akseptor Keluarga Berencana di Wilayah Puskesmas X Kabupaten Karanganyar Lucia Vita Inandha Dewi; Eunike Yuvita Purbosari; Inaratul Rizkhy Hanifah
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1556

Abstract

Hormonal contraception use in the Family Planning (KB) program can cause side effects that interfere with health, reduce comfort, and cause the program to stop, in several previous studies, weight gain and menstrual disorders have been reported as the most side effects, but it is suspected that there are still side effects. For others that have not been reported, a complete description of the incidence of side effects is needed to consider the selection of a safe and suitable type of contraception for the acceptor. The purpose of the study was to describe the incidence of side effects and the percentage of events based on the type of hormonal contraception. This research is an observational descriptive study involving 327 respondents according to the inclusion criteria, using a questionnaire that has been tested for validity and reliability. The study was conducted on family planning acceptors who are in the working area of ​​Puskesmas X Surakarta. Analysis of the results was carried out univariately by the percentage of the number of adverse events based on the type and type of hormonal family planning used. The results showed that the incidence of side effects in the form of weight gain was 51.8%,, menstrual disorders 38.8%, dizziness 9.1%, nausea 7%, acne 6,1%, and anxiety was 3%. Based on the type of hormonal contraception, the incidence of side effects experienced by acceptors of 3-month injections was 74,3 %, 1-month injections 38,8%, pills 29,9%, and implants was 6,4%.
Pengaruh Ekstrak Etanol Tangkai Begonia multangula Blume Terhadap Biofilm Bakteri Aggregatibacter actinomycetemcomitans Haidy Lailatun Nabila
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1617

Abstract

Aggressive periodontitis is a type of peridontitis with rapid disease progression and destruction. One of the causes of aggressive periodontitis is the presence of Aggregatibacter actinomycetemcomitans biofilm. Prevention of biofilm formation is one way to prevent aggressive periodontitis. The stalk of B. multangula Blume has antibacterial activity and has the potential to be used as an antibiofilm. This research aimed to determined antibiofilm activity of etanol extract of the stalk B. multangula Blume against A. actinomycetemcomitans.. This research used 5 concentration of extract (6,25%, 12,5%, 25%, 50% and 100%), Negative Control (Aquades sterile) and Positive Control (CHX 0,2%). Inhibition biofilm test using microtitter plate biofilm assay with crystal violet staining at anaerobic incubation for 24 hours and using microplate reader at 620 nm. One way ANOVA and post hoc LSD were used to analyze the differences in antibiofilm activity. The result showed inhibition biofilm activity of A. actinomycetemcomitans by the extract increased as increasing of the concentration. The highest biofilm inhibition was at 100% (74,92%) of the extract concentration and Minimum Biofilm Inhibition Concentration 50 (MBIC50) against A. actinomycetemcomitans was found at 25% (54,42%) of the extract concentration. There were significant difference (p≤0,05) between treatment group of etanol extract (concentration 6,25%, 12,5%, 25%, 50%, and 100%) with negative control and there were no significant difference (p≥0,05) in the positive control with 50% and 100% of the extract concentration. This study concluded that there was an antibacterial activity etanol extract of the stalk B. multangula Blume against inhibition biofilm of A. actinomycetemcomitans.
Hubungan Kepatuhan Penggunaan Obat terhadap Tekanan darah dan Kualitas Hidup Peserta Prolanis Hipertensi di Kabupaten Demak Galih Kurniawan; Ika Purwidyaningrum; Wiwin Herdwiani
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1704

Abstract

Optimal quality of life for people with hypertension is very important so as not to reduce patient productivity. Adherence drug use is one of the factors thought to be associated with blood pressure and quality of life. This study aims to determine the relationship between adherence to medication use on blood pressure and quality of life of patients with hypertension in Prolanis . participants at the First Level Health Facility of the Klinik Pratama. This study used a cross sectional design involving hypertensive patients participating in Prolanis who met the inclusion and exclusion criteria at seven Primary Clinics in Demak Regency. Data on medication adherence were obtained using the MARS-5 questionnaire, quality of life data using the EQ-5D-5L questionnaire, and blood pressure data using a digital sphygmomanometer. The relationship between the level of compliance with blood pressure and the relationship between the level of compliance with quality of life was tested using Spearman rho analysis. The results of the study with a total of 87 respondents showed that most of them had moderate levels of adherence (52%), systolic blood pressure (64%) and diastolic blood pressure (57%) were not controlled and the average utility score was 0.845. There is a relationship between drug use adherence to systolic and diastolic blood pressure (P = 0.009), (P = 0.032) with a weak correlation level (r = 0.27), (r = 0.23) and there is a relationship between drug use adherence on quality of life (P = 0.000) with a moderate level of correlation (r = 0.42).
Hubungan Efek Samping Obat Dengan Length Of Stay (LOS) Pasien Jantung Koroner Di Rumah Sakit “X” Inaratul Rizkhy Hanifah; Asa Puspagiri Setiyasih; Lucia Vita Inandha Dewi
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1790

Abstract

Coronary heart disease (CHD) is caused by the narrowing and blockage of blood vessels that carry blood to the heart. CHD is listed as the highest deadly disease by WHO. CHD treatment is carried out long-term and uses a combination of several drugs, so there is a risk of drug side effects. Length of stay (LOS) is one indicator of successful therapy for CHD patients. However, no correlation studies of LOS with the incidence of drug side effects in CHD patients. Therefore, the purpose of the study was to analyze the potential side effects that occur in CHD therapy and to find the relationship with LOS in the "X" Hospital in Surakarta in 2021. This research uses a descriptive observational method by retrospectively taking patient medical record data that match the inclusion criteria. The sample in this study was 81 patients whose results were tabulated and analyzed univariately by describing the results based on the percentage of events. The reference in this study was Meyler's Side Effects of Drugs guidelines and several supporting journals. To find the relationship between the incidence of drug side effects with LOS using SPSS with the chi-square test. The result show that 23 patients (28%) had the incidence of side effects from CHD treatment. Potential side effects arising in patients include muscle pain; weakness; fever; diarrhea; dizziness; constipation; and nausea-vomiting; are 43.48%, 26.09%, 13.04%, 4.35%, 4.35%, 4.35%, 4.35%, respectively. There was no correlation between side effects and LOS (p=0.803; OR=1,132).
Pengembangan Kuesioner Pengetahuan Masyarakat tentang Penyakit Ginjal Kronik Irwan Nuryana Kurniawan; Mursidha Rakhmi Salicha; Rahma Yuantari; Vitarani Dwi Ananda Ningrum
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1849

Abstract

To reduce the prevalence of chronic kidney disease, a pillar of health paradigms through community empowerment has been introduced. Society with profound knowledge of such disease has proved to be able to raise awareness of kidney disease early detection. Meanwhile, limited data on public knowledge of chronic kidney disease make the education programs in health promotion seem ineffective. This study therefore aims to develop a questionnaire with high validity and reliability to assess public knowledge of this disease. The development included five stages of conceptualisation, instrument construction, a trial with Study 1 of 240 medical and non-medical students and Study 2 of 300 participants from Sleman Regency in Yogyakarta, a test of the revision, and an analysis using the Cronbach’s alpha reliability test. A validity test compared this questionnaire with another reliable questionnaire. Both studies yielded a knowledge scale with two variables comprising kidney disease knowledge (risk factors, causes, symptoms, management) and kidney disease prevention knowledge with Cronbach’s alpha of 0.623 and 0.703 (Study 1) and 0.361 and 0.545 (Study 2). This has proved that the preliminary psychometric evidence (factor structure, reliability, convergent validity) satisfied the requirements for an instrument used to measure public knowledge of chronic kidney disease.
Uji Aktivitas Antihipertensi Ekstrak Dan Fraksi-Fraksi Daun Matoa Pada Tikus Jantan yang Diinduksi Angiotensin II dengan Parameter Kadar Renin dan Angiotensin II Iyem Shahira; Jason Merari; Ika Purwidyaningrum
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.926

Abstract

ABSTRACT Matoa leaves (Pometia pinnata) is a plant thought to have hypertensive activity because it contains kuersetin. Research conducted by (Purwidyaningrum, 2017) extracts and fractions of matoa leaves has antihypertensive activity with an effective dose of 150 mg/kg. Other studies conducted by (Elisa, 2019) effects that can reduce blood pressure are extract doses of 300 mg and 30 mg of ethyl acetate fraction induced by angiotensin II can reduce systolic and diastolic blood pressure. This study aims to determine extracts and fractions of matoa leaves in decreasing renin levels and angiotensin II levels. The extraction method was maseration with 96% ethanol solvent and fractionated by liquids method using n-hexane solvent, ethyl acetate water. In this study used 21 male wistar strain rats divided into 7 groups, namely group I (normal), group II as negative control (CMC 1%), group III as positive control (Irbesartan), group IV (matoa leaves extract 60 mg/200g), Group V (fraction n-hexane 2,34 mg/200g), Group VI (ethyl acetate fraction 9,54 mg/200g), Group VII (water fraction 7,98 mg/200g). The results showed ethanol extract and matoa leaves fractions were not significantly difference in meaning with the positive control group different in reducing blood pressure, renin levels and angiotensin II induced by angiotensin II and were significantly from the normal and negative group. The water fraction (7,98 mg/200g) showed a decrease in systolic blood pressure of 9.0% and diastolic 7.1%, the ethyl acetate fraction showed a decrease in renin level 0f 23.6 %. EDM showed a decrease in 17.2% angiotensin II levels. Keyword : Pometia pinnata; renin levels; angiotensin II levels; induced angiotensin II
Analisis Pengendalian Persediaan Obat Kategori Av Dengan Metode Abc, Ven Dan Eoq Di Instalasi Farmasi Rumah Sakit Aura Syifa Kediri Chandra Arifin; Tri Wijayanti; Gunawan Pamudji Widodo
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.1086

Abstract

ABSTRACT Inventory Control Analysis Of AVMedicine CategoriesbyABC, VEN and EOQ Method In Pharmacy Installation at Aura Syifa Hospital Kediri.Pharmaceutical logistics management and pharmaceutical services aim to identify, prevent and resolve drug-related problems. Broadness of services and Aura Syifa Hospital Kediri participation in Jaminan Kesehatan Nasional (JKN) requires an efficient pharmaceutical supplies management. Regulations changes in Badan Penyelenggara Jaminan Sosial (BPJS) regarding tiered referral also change the pattern of drug consumption. In addition, arrears of BPJS patient claim payment at Aura Syifa Hospital Kediri during the last few months caused hospital to be slightly constrained in terms of operations and services, especially related to the procurement of medicines. Purpose of this study was to analyze control system and improve the efficiency of managing AV classification medicine using ABC, VEN and EOQ methods inpharmacy installation at Aura Syifa Hospital Kediri.This study wasdescriptive with retrospective data collected, data used in the period January 2018 - December 2018. Medicine analyzed were oral drugs, injections and infusions that were included in group A from the results of ABC analysis, group V from the results of VEN analysis so it was obtained BPJS medicine AV categories. Result of this study were combination of ABC and VEN analysis methods could identify drugs that require strict inventory control and prioritize 12 BPJS medicine in AV category. Pharmacy installation at Aura Syifa Hospital Kediri in 2018 did not meet cost efficiency that is: procurement frequency was higher than the EOQ method. Calculation of ABC, VEN and EOQ methods may improve efficiency in controlling AV classification medicine supplies in BPJS patients at IFRS Aura Syifa Kediri.
Studi Mekanisme Molekuler Antibakteri dari Daun Telang (Clitoria ternatea L.) Mario Hendrik Refwalu; Ana Indrayati; Ika Purwidyaningrum
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.1193

Abstract

The bacterium is one of the infectious pathogens that cause infectious diseases. A problem currently developing in the treatment of infectious diseases is antimicrobial resistance. Antimicrobial resistance is the inability of an antibiotic to cure infectious diseases so that new antimicrobial compounds are needed that can kill infectious pathogens (by bacteria, fungi, viruses, and multi-cellular parasites). The butterfly pea plant (Clitoria ternatea L.) has been identified as a potential antibacterial plant. This literature study aims to determine the antibacterial activity and identify molecular mechanisms based on the chemical content of telang leaves that have not been done before. This literature study uses the systematic literature review (SLR) method to determine the activity and antibacterial mechanisms based on the bioactive compounds contained by using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyzes) as the review protocol. Data search strategy using search engines: science direct, google scholar, and Pubmed. The keyword search uses a combination of words in the problem statement and uses the Boolean "OR" and "AND". The finding shows that the relevant literature obtained 22 articles that met the criteria consisting of articles on chemical compounds, antibacterial activities and mechanisms. The SLR results showed that telang leaf has potential as an antibacterial and has a molecular mechanism, namely, interfering with the permeability of cell membranes, inhibiting nucleic acid and protein synthesis and inhibiting the formation of biofilms. Chemical compounds that have the potential as antibacterial agents are kaempferol, quercetin, cyclotide, b-sitosterol alkaloids and tannins.

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