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INDONESIA
Jurnal Farmasi Indonesia
Published by Universitas Setia Budi
ISSN : 16938615     EISSN : 23024291     DOI : -
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Indonesia (e-ISSN : 2302-4291 dan ISSN : 1693-8615) merupakan jurnal yang dikelola oleh Fakultas Farmasi, Universitas Setia Budi yang terbit sejak Februari 2004 dan terbit 2 kali dalam setahun yaitu periode bulan Maret dan November. Jurnal Farmasi Indonesia menerima naskah tentang hasil penelitian laboratorium, lapangan, studi kasus, telaah pustaka yang erat kaitannya dengan bidang kefarmasian, kesehatan dan lingkungan hidup.
Arjuna Subject : -
Articles 271 Documents
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Formulasi Nanoemulgel Ekstrak Biji Kopi Robusta (Coffea canephora Pierre) Dengan Variasi Gelling Agent Sebagai Antioksidan Raden Roro Karina Pambudi; reni ariastuti; Ahwan Ahwan
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.1518

Abstract

Antioxidants are compounds that are significant in the body's mechanism against free radicals, namely inhibiting oxidative reactions by binding to free radicals or preventing oxidative damage that can lead to oxidative stress conditions. One of the natural ingredients that have antioxidant activity is robusta coffee beans. Robusta coffee beans contain polyphenol compounds have antioxidant activity. Nanoemulgel s a gel preparation that is incorporated in a basic gel and has nano-sized particles. This study aims to 1) determine the stable formula of robusta coffee bean extract nanoemulgel with a variation of gelling agent 2) determine whether the robusta coffee bean extract nanoemulgel has antioxidant activity. The methods used include 1) extraction with maceration 2) nanoemulsions are made using a low-performance technique (magnetic stirrer) and a high performance technique (sonicator) 3) particle size test used dynamic light scattering 4) stability parameters include pH, dispersibility, adhesion, and viscosity 5) antioxidant activity was analyzed using the DPPH method (1,1-diphenyl-2- picrylhydrazyl) 6) statistical analysis used SPSS 21 software using Paired T-test and One Way Anova. The results nanoemulsion particle size of robusta coffee bean extract was 12.3 nm and the polydisperse index was 0.274 nm, the most stable nanoemulgel was formula 3 with varying concentrations of gelling agent (1 gram HPMC: 0.5 gram Carbopol) had an average value of pH 5, average adhesion 1.59 seconds ± 0.01, average dispersion 6.7 cm ± 0.1, and the average viscosity value of 2500 cPs. The formula with the strongest antioxidant activity is formula 1 (0.5- gram carbopol) with an average IC50 value of 10.678 ± 0.0346 ppm.
Kombinasi nanoemulsi Minyak Kemiri (Aleurites mollucana L.) dan Serbuk Daun seledri (Apium graveolens L.) pada Model Penyakit Alopesia Yonathan Tri Atmodjo Reubun; Anggelina Aprilia Pangalila
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.1856

Abstract

Candlenut oil and celery leaves have been widely used by people in the world as a treatment for hair loss problems as well as strengthening hair roots and blackening hair. Hair loss disease or in the medical world called alopecia is a disease where the amount of hair loss is more than hair growth in general. The main cause pf alopecia generally occurs due to inflammation in the hair follicles. The purpose of this experimental animals used, namely male rabbits of the New Zealand White type. The study began by testing the phytochemical screening on each of the materials used. Furthermore, a combination of candlenut oil and celery powder was carried out to form a nanoemulsion preparation. After that, tests were carried out including pH, emulsion type, hair growth including hair weight and thickness of the shaving area. The results showed that the co,bination of candlenut oil and celery powder had a pH value of 6.30 with an emulsion type, namely oil in water (O/W) and had hair growth activity from test animals for 28 days with the average weight and thickness of hair 0.2458 and 1,15 cm. this result is better than average positive control product X with an average weight and thickness of 0.2076 and 1 cm. in addition, compared with the negative control, the results of weight and hair thickness were 0.0305 and 0.5 cm. based on these results, it was concluded that the combination of candlenut oil and celery powder had good hair growth activity in experimental animals so that it could be used as treatment therapy for alopecia patients.
Peningkatan Aktivitas Antioksidan pada Ekstrak Daun Kelor (Moringa oleifera) melalui Fermentasi: Studi Perbandingan Kandungan Fenolik dan Aktivitas Antioksidan Hery Muhamad Ansory; Nuraini Harmastuti; Windia Wulantika; Afif Meilana Sindani Putri
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.1652

Abstract

This study aimed to investigate the effect of fermentation on the antioxidant activity and phenolic content of 96% ethanol extract from Moringa oleifera leaves. While the antioxidant potential of Moringa leaves has been recognized, this research introduces a novel concept of utilizing fermentation to enhance the levels of active compounds. The state of the art in antioxidant activity and fermentation is used to validate the significant improvement in antioxidant activity. The findings provide new insights into utilizing Moringa leaves as a natural antioxidant source obtained through fermentation. The research methodology involved fermenting the 96% ethanol extract from Moringa leaves using Lactobacillus B bacteria for 24, 48, and 72 hours. The phenolic content was measured using the Folin-Ciocalteu method, while the antioxidant activity was evaluated using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The results demonstrated a significant increase in phenolic content after the fermentation process. The phenolic content of the fermented Moringa leaf extract was 86.133±5.925 mgGAE/gram after 24 hours, increased to 91.244±7.374 mgGAE/gram at 48 hours, and reached 122.578±9.576 mgGAE/gram at 72 hours. Additionally, the antioxidant activity also increased with fermentation time. The IC50 values for samples fermented for 24, 48, and 72 hours were 60.887 µg/ml, 58.742 µg/ml, and 53.169 µg/ml, respectively. These results indicate that fermentation of Moringa leaf extract can significantly enhance phenolic content and antioxidant activity.
a Kajian Naratif Pengukuran Kualitas Peresepan Pasien Diabetes Mellitus Lanjut Usia Fisia Niti Admadja; Yosi Irawati Wibowo; Karina Kumaladewi Widjaja; Adji Prayitno Setiadi
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.1468

Abstract

The aging populations has increased worldwide, resulting in higher prevalences of non-communicable diseases, including Diabetes Mellitus (DM). Elderly with DM requires long-term prescribing which warrants special considerations. Hence, this narrative review aims to identify quality measurement tools and quality prescribing in elderly patients with DM. This review included literature searching in three databases [i.e., Pubmed (MEDLINE), Science Direct, and CINAHL] with combination of keywords: (Diabetes) AND (Elderly OR older OR geriatric) AND (“Potentially inappropriate medication” OR “potentially inappropriate prescribing” OR “inappropriate prescribing” OR “quality prescription” OR “rational prescribing”). The searching resulted in 1059 articles; and after the selection process, 10 articles were included in this study. The extracted data indicated that tools with explicit criteria (such as Beer's Criteria) were more commonly used to measure quality prescribing in elderly patients with DM compared to those with implicit criteria (i.e., Prescribing Quality Assessment Checklist) (9 articles versus 1 article, respectively). Varying quality prescribing were reported dependent on the tools used. The percentage of Potentially Inappropriate Medication (PIM) measured using explicit tools ranged from 22,7% to 68,1%; glibenclamide or glyburide were among the most common PIM. Whereas, 83.2% of precriptions measured with the implicit criteria in one article indicated poor quality. This finding demonstrated the needs of strategy to improve the quality of prescribing in elderly patients with DM.
Elimination of the Ultraviolet Spectrophotometric-Based Limitation on the Quantification of Metformin HCl in Acid-Stage Medium for a Comparative Dissolution Testing Syaiful Choiri; Dwi Larasati; Ilham Kuncahyo
Jurnal Farmasi Indonesia Vol 20 No 1 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i1.2150

Abstract

Herein, this work aimed to develop an ultraviolet spectrophotometric assay for metformin HCl in comparative dissolution testing along with the acid stage medium due to low molar absorptivity. Metformin HCl was incorporated into the immediate tablet formulation to mimic the analytical matrix system. The dissolution validation procedure was carried out by linearity, accuracy, precision, the limit of quantification, filter compatibility, and aliquot stability that fulfil the USP method for validation of dissolution procedure, particularly assay of the analyte.The results revealed that metformin HCl had difficulty quantifying in acid pH due to the absence UV-band peak. The addition of pH-shifting agents promoted better performance for metformin quantification. Therefore, the method was successfully developed along with R2, predicted R2, accuracy, and precision of 0.9999, 0,9998, 100.57%, and 1.27%, respectively. In addition, it had the minimum placebo interference (0.47%) and was stable for long-term storage under determined conditions.
Analisis Pengelolaan Obat Dan Strategi Perbaikan Dengan Metode Hanlon Di Instalasi Farmasi RSU Budi Setia Kabupaten Minahasa Provinsi Sulawesi Utara Hanna Mariana Rumagit; Titik Sunarni; Ika Purwidyaningrum
Jurnal Farmasi Indonesia Vol 21 No 2 (2024): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v21i2.825

Abstract

Pharmaceutical installation is a part in the hospital responsible carry out the management of a drug that covers the, selection , procurement distribution and use of medicine.The problem of managing a drug can affect the availability of medicines. This study aims to analyse the efficiency of drug management in IFRSU Budi Setia Minahasa regency. The study design was descriptive for the data that is retrospective and concurrent. Data obtained from IFRSU Budi Setia stage drug management in, analyzed the efficiency of using indicators, then compared to the standard or the results of other studies. The results show the results not according to standards: Selection, compliance with Fornas (65,28%), procurement, allocation of available funds (14,74%), the frequency of each item procurement of drugs (6,02 times a year), and EOQ (8,16 times/year), the distribution, the medicinal value of the damaged/expired (1,16%), the stock is dead (0,6%), the use, the number of items per strip of prescription drugs (3,22 sheet). The results according to the standard are: procurement, capital funds available to the overall funds needed (100%), incomplete SP/Invoices (0 times), the number of drug items held as planned (100%), the distribution, the accuracy of the amount of drug on card stock (100%), TOR (12,28 times), the rate of drug availability (12 months), stage of use, the number of items cents ( 3,22 ) prescription drugs, prescribing generic name (90,25%), the average time spent on prescriptions of non concoction (2,8 min) compounded prescription (3,5 minutes). Priority problem handling method hanlon: (1) percentage of stock dead, (2) percentage of and medicinal value expired and or damaged, (3) the number of items cents a prescription drug, (4) conformity items a drug that is available with fornas, (5) the frequency of procurement every items drug per year, (6) allocation percentage funds procurement drug 2019.
Potensi Ekstrak Terpurifikasi Daun Umbi Bit (Beta vulgaris) sebagai Antioksidan dan Penetapan Kadar Flavonoid Totanya Diah Pratimasari; Dian Puspitasari; Noor Anisa
Jurnal Farmasi Indonesia Vol 20 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i2.1430

Abstract

The ethanol extract of beetroot leaves contains high levels of phenolic and flavonoid compounds, making it potentially beneficial as an antioxidant. However, the ethanol extract of beetroot leaves has a disadvantage as it is still mixed with other components that are not necessary, limiting its formulation development. In relation to this, the purpose of this research is to eliminate unwanted compounds as antioxidants and to observe the impact of purification on the antioxidant activity and total flavonoid content of the extract. The production of purified extract involves fractionating the suspension of beetroot leaf extract using solvents with different polarities, namely n-hexane and ethyl acetate, in sequence. Antioxidant activity tests are conducted on Ethanol Extract of Beetroot Leaves (EEDUB), Purified Extract of Beetroot Leaves (ETDUB), and quercetin as a positive control. Antioxidant activity is assessed using 2,2-Diphenyl-1-Picrylhydrazyl (DPPH). The total flavonoid content of EEDUB and ETDUB is determined with a spectrophotometer using AlCl3. The antioxidant activity of EEDUB is indicated by an IC50 value of 157.87 µg/mL, while ETDUB has an IC50 value of 129.60 µg/mL. The total flavonoid content of EEDUB is 2.82% ± 0.85 QE, and for ETDUB, it is 2.90% ± 1.16 QE. The research results show that ETDUB has a higher flavonoid content and antioxidant activity compared to EEDUB. This also indicates that the purification process of the beetroot leaf extract has not reached its maximum effectiveness.
Pengetahuan dan Perilaku Pelajar SMP dan SMA di Jawa Timur terhadap Protokol Kesehatan 6M Natasha Vine Angelique; Syahrani Madiha Putri; Rika Putri Septiawati; Sagita Putri Ramadhina; Yussi Ananda; Syeila Rahmadina; Nadea Kalila Yasmin; Melisa Ramadhaniar; Hana Ameli Widyasari; Indiarto Lukman Susetiya; Dika Herian Saputra; Allisya Fathatul Fauziyah; Zenita Dwi Rahmaudina; Alfionita Isnaini; Elida Zairina
Jurnal Farmasi Indonesia Vol 20 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i2.1532

Abstract

Since 2019, the infectious disease Covid-19 has spread throughout the world. Schools have begun to hold limited face-to-face meetings. This study sought to identify a knowledge profile and behavior profile of middle and high school students in East Java toward 6M health protocols, as well as the relationship between age, knowledge score, and practice score, as well as a comparison of knowledge and behavior profile based on gender, education level, and class. This study used a cross-sectional study with accidental sampling and questionnaires to collect data from 743 respondents in 8 districts or cities in East Java. The Spearman, Mann-Whitney, and Kruskal-Wallis tests were used for statistical analysis. The results show that 80,5% of respondents have good knowledge, and more than 90% had positive behavior towards 6M health protocols. There was a significant correlation between age and knowledge score (p<0,05), age and behavior score (p<0,05), and knowledge score and behavior score (p<0,05). The study also discovered differences in knowledge and behavior scores based on gender, education level, and class.
Kontribusi Karakteristik Pasien Gagal Ginjak Kronik dengan Hemodialisis pada Pengetahuan dan Kepatuhan Pengobatan Agustina Nila Yuliawati; Pande Made Desy Ratnasari; Ni Ketut Kristina Dewi; I Gusti Ayu Putu Priyanti
Jurnal Farmasi Indonesia Vol 20 No 2 (2023): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v20i2.1751

Abstract

The knowledge and adherence of end-stage renal disease (ESRD) patients can vary based on their characteristics, then could influence the success of their therapy. This study aimed to determine the contribution of ERSD patients’ characteristics undergoing hemodialysis (HD) to their knowledge and adherence. Data were collected using questionnaires including the CKD-KQ, the ESRD-AQ, and respondent identity sheets sourced from medical records. The relationship between respondent characteristics and their knowledge and adherence was analyzed using bivariate statistical tests. Findings showed that the average respondent had a knowledge score of 18.12±3.40 (max.24) and adherence of 1092.86±135.20 (max.1200). Patient characteristics contribution in adherence was found in the age and suffering from ESRD undergoing HD duration (p<0.05), but not with patient knowledge. Other elements such as providing education from health workers are considered to increase patient knowledge, and the ease of undergoing ESRD therapy has an impact on high patient adherence(p<0.05).
Potensi Lotion Ekstrak Daun Pandan Wangi (Pandanus Amaryllifolius Roxb.) Sebagai Repellent Nyamuk Culex Sp Farida Mutik Istikomah; Suhartinah Suhartinah; Fitri Kurnia sari
Jurnal Farmasi Indonesia Vol 21 No 1 (2024): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v21i1.1933

Abstract

Pandan wangi leaves contain flavonoids and have repellent activity. This study uses fragrant pandanus leaves as a substitute for DEET chemicals as repellent for Culex sp Pandan wangi leaves formulated in lotion with concentrations of 4, 8, and 12%. The physical quality of the lotion was observed organoleptically, as well as homogeneity, viscosity, pH, spreadability, stickiness, emulsion type, and cycling test. The test method for repellent effectivity is inserting a proband hand in a cage containing 50 mosquitoes and observing mosquitoes sticking for 5 minutes every hour with a total observation of 6 hours. The results of the repellent effectiveness test and physical quality test on the lotion formulation obtained with a concentration of 4,8 and12% have not shown effective potential results because it still has a repulsion of<80%, the highest protection power result is obtained from the concentration of 12% extract which has a repulsive power of 54.47% the more significant the concentration of the added extract, the greater the protection power produced, But all formulas used have good quality tests.

Page 25 of 28 | Total Record : 271

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