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Eksakta : Berkala Ilmiah Bidang MIPA
Published by Universitas Negeri Padang
ISSN : -     EISSN : 25497464     DOI : https://doi.org/10.24036/eksakta/
Core Subject : Science, Education, Agriculture, Social, Engineering,
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Energy Engineering Environmental Science Materials Science & Nanotechnology Mathematics Mechanical Engineering
Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) is an open access journal and peer-reviewed that publishes either original article or reviews. The journal is dedicated towards dissemination of knowledge related to the advancement in scientific research. The prestigious interdisciplinary editorial board reflects the diversity of subjects covered in this journal. Under the realm of science and technology, the coverage includes environmental science, pure and applied mathematics, agricultural research and engineering, biology, biotechnology, bioinformatics, Healthcare sciences (including clinical medicine, preventive medicine & public health), physics, biophysics, computer science, chemistry and bioengineering, to name a few. This Journal Is Published at 3 Month intervals on January-Marc, April-June, July-September and October-December
Arjuna Subject : Umum - Umum
Articles 329 Documents
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Phyrochemical Screening and Potential Inhibition of Pacing Extract (Costus speciousus, J.Sm) Against Mycobacterium Tuberculosis H37Rv Puspaningtyas, Ayik Rosita; Rumaikewi, Carolin Enjelin; Sari, Indah Purnama
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 03 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss03/451

Abstract

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb) and can attack various organs of the body. Transmission occurs through sputum splashes when coughing, sneezing or talking. TB treatment using antituberculosis drugs (OAT) can cause side effects that affect health. Therefore, alternative therapies from natural ingredients are needed. This study aims to explore secondary metabolites in extracts and plant fractions of Pacing (Costus speciousus, J.Sm) and determine their effectiveness against Mycobacterium tuberculosis H37Rv. The extraction method used is remaceration with methanol solvent. The concentrations of the samples tested varied with isoniazid positive controls. The results showed that Pacing plant extracts and fractions contained alkaloids, flavonoids, saponins, and tannins. Terpenoid compounds were not detected in the samples tested. The antituberculosis test showed that the n-hexane fraction had the best anti-TB activity, although the IC50 value of the extract and fraction was still lower than isoniazid as a positive control. However, Pacing extract and fraction still have potential as very strong anti-TB agents because their IC50 values ​​are below 50 ppm.
The Potential of Active Compounds from Melinjo Leaves (Gnetum gnemon) as an Antihistamine using Molecular Docking Approach for Acetylcholine Muscarinic M3 Receptor Inhibition Gaspersz, Nelson; Amos, Matthew Adi Honey; Male, Yusthinus T.; Baharudin, Muh. Daswar A.; Leuwol, Dean Y.E.; El, Rahma; Pattiasina, Priska M.; Sohilait, Mario R.; Herland Satriawan
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 24 No. 04 (2023): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol23-iss04/460

Abstract

Melinjo leaves (Gnetum gnemon) have been used traditionally in Maluku to treat spoilage in the fish product. Melinjo leaves contain secondary metabolites with anti-inflammatory and antibacterial biological activities. It has been identified contain gnetumal, callyspinol, cassipuorol, (+)-dehydrovomifoliol, p-coumaric acid, ferulic acid, isovitexin, swersitin, isoswersitin, vicenin 2, swertiajaponin, isoswertiajaponin and ursolic acid. This research aims to predict the potential of the compounds in melinjo leaves as antihistamines by inhibiting the activity of the acetylcholine muscarinic M3 receptor. The research was carried out using an in silico study method using a molecular docking approach. Docking results showed that gnetumal, callyspinol, cassipuorol, (+)-dehydrovomifoliol, p-coumaric acid, ferulic acid, isovitexin, swersitin, isoswersitin, vicenin 2, swertiajaponin, isoswertiajaponin and ursolic acid for the muscarinic acetylcholine receptor M3 had a binding affinity value of -7.4, -8.0, 7.0, 7.0, -6.6, -6.6, -7.4, -5.7, -4.4, -3.7, -6.0, -4.9 and -4.7 kcal/mol, respectively.
Biological Activity of Der p 1 and Der f 1 in Allergic Asthma and Their Contribution in Inflammation and the Role of Anti-inflammation in Allergic Asthma Julian; Rozaliyani, Anna; Wibowo, Heri; Damayanti, Triya
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 24 No. 04 (2023): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol23-iss04/463

Abstract

Asthma is a disease marked by chronic inflammation of the airways, with indications including wheezing, shortness of breath, and/or cough. As reported by GINA, the global prevalence of asthma is 1-18%. One type of asthma is Allergic asthma which is triggered by allergens, like Der p 1 and Der f 1 which upregulate type II immune response to secret IL-4 and IL-13 to upregulate IgE secretion. IgE binds to FcεRI in mast cells to release mediators that cause hypercontraction, this condition leads to asthma. Meanwhile, anti-inflammatory IL-10 manages IgE production by reducing inflammatory cytokine production and changing isotype switching. IgE Production is a crucial step. Therefore, it is essential to explore the cellular and molecular factors that trigger the regulated isotype-switching IgE and its suppressed mechanism, so this review will explore the biological activity of Der p 1 and Der f I and their contribution to inflammation and the role of anti-inflammation in allergic asthma especially isotype switching IgE We used PRISMA approaches, and tools (RSCB PDB, Uniprot, and SMART). The result appeared Der p 1, and Der f 1 activity have impacts on IL-4, IL-13, IL-10, and IgE secretion.
Virtual Screening and Molecular Modelling Anticancer Molecules Targeting Fibroblast Growth Factor Receptor 4 Rosa, Feby Lilia; Fadilah, Fadilah; Erlina, Linda
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 03 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss03/464

Abstract

Cancer, characterized by uncontrolled cell proliferation, is a leading global cause of mortality. Targeting the fibroblast growth factor receptor (FGFR), a receptor tyrosine kinase (RTK), holds promise for anticancer drug development. FGFR4, a specific subtype, regulates various cellular processes, making it a valuable target. In-silico methods were employed to screen 20 compounds against FGFR4 (PDB ID 5JKG) using AutoDock Version 4.2.6. The top three potential inhibitors, based on Gibbs energy (ΔG) and inhibition constant (Ki), were identified: epigallocatechin3-O-pcoumarate (ΔG = -10.46 kcal/mol; Ki = 21.37 nM), 6_deoxoteasterone (ΔG = -10.22 kcal/mol; Ki = 32.35 nM), and epigallocatechin3-O-caffeate (ΔG = -9.78 kcal/mol; Ki = 68.16 nM). ADMETOX analysis confirmed compliance with Lipinski's rules, indicating their safety. These compounds show promise as FGFR4 inhibitors, potentially as standalone therapy or in combination with other anticancer drugs.
The Evolution of Zoonosis-Related Studies in Indonesia, 1977-2023: Bibliometric Analysis Concepts Nurjanah, Diana; Dharmayanti, Indi; Fadilah, Fadilah
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 01 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss01/465

Abstract

Various zoonotic diseases have been reported as epidemics throughout the world, including in Indonesia. Various studies have been conducted related to gaps in knowledge, especially on disease distribution, etiology, pathogens, hosts, vector biology, dynamics, cycle of transmission, predisposing factors, and risk factors. To find out the dynamics of zoonotic disease study and research in Indonesia, a study was conducted to report a literature analysis that focused on bibliometric analysis of the Scopus database and VOSviewer software to create a visualization map that identified how the evolution of zoonotic diseases studies from 1977-2023 in Indonesia. In co-occurrence analysis, two units of analysis are used, namely "author keywords" and "index keywords" in VOSviewer. It showed that studies related to zoonoses in Indonesia tend to increase every year with a significant increase in 2020 and 2022. Document types are dominated by articles (72%) with subjects or research areas related to “medicine” (29%). From the "author keywords" analysis unit, the words "zoonosis" and "Indonesia" were the words that appeared the most. Meanwhile, from “index keywords” six clusters were found with the word "human" "animals", and "zoonosis" being the word that appears the most in the analysis of the studies conducted.
Synthesis and Characterization of ZnO Semiconductor Nanoparticles with Annealing Temperature Variation for Dye Synthesized Solar Cell Application Supu, Idawati; Aulia Fitrah Ramadhani; Bunga Tang; Haerul Ahmadi; Dewa Gede Eka Setiawan
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 03 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss03/467

Abstract

This study aims to make ZnO semiconductor nanoparticles using annealing temperature variations for dye synthesized solar cells, identify the structure and particle size and surface morphology using SEM-EDX and UV-VIS to determine the wavelength and absorbance values. In the gel-combustion method, three samples were made with varying annealing temperatures of 700⁰C, 800⁰C, and 900⁰C, respectively. The annealing temperature variation shows the difference in SEM test results, where the higher the annealing temperature, the smaller the particle size. EDX test results show that ZnO has been formed. In the UV-VIS characterization results for the three samples have different transmittance values and wavelengths from samples without dye, ZnO doping chlorophyll. Based on XRD data, the higher the calcination temperature, the smaller the particle size, and the distribution of particle size at each increase in annealing temperature. Based on the results of SEM analysis obtained that the particle size is getting smaller with increasing annealing temperature.  According to the UV-Vis analysis results obtained that the addition of chlorophyll extract does not have a significant effect about wavelength 370 nm on the transmittance value of each sample, so the best absorbance is owned by the ZnO doping dye sample.
Quota Share Reinsurance and Excess of Loss Reinsurance Calculations Using Ruin's Theory Dwi Susanti; Riaman; Badrulfallah; Dimas Apriliyanto
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 03 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss03/468

Abstract

Ruin theory is commonly used to predict the likelihood of bankruptcy for an insurance company and relates to the rate of surplus of the insurance company for the insurance policy portfolio. Considering the change in the insurance fund from time to time, the timing of the occurrence of a number of claims is highly taken into account. Ruin theory is necessary so that companies can anticipate and detect bankruptcy early. One way to help insurance companies minimize their bankruptcy chances is through reinsurance. In this paper, will discuss about application of ruin theory in computing two methods of reinsurance treaty, that is Quota Share Reinsurance and Excess of Loss Reinsurance to decide more effective method to minimize probability of ruin. Results show that Excess of Loss Reinsurance method more effective than Quota Share Reinsurance method to minimize ruin probability of insurance company.
Testing the Antibacterial Activity of Red Ginger Essential Oil and Red Ginger Methanol Extract Kapelle, Imanuel Berly Delvis; Mauhurry, Mirella Fonda; Neite, Prisca Nelcy
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 01 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss01/469

Abstract

The red ginger plant is a spice plant used in traditional medicine and has the potential to be antibacterial. This research aims to isolate and identify red ginger essential oil, extract red ginger, and test antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria. Red ginger essential oil is obtained by steam distillation, while red ginger extract is obtained using the maceration method with methanol solvent. Red ginger essential oil yielded 0.13%, and red ginger extract was 12%. The phytochemical test results of red ginger essential oil contain tannin and sopinin, while red ginger extract contains flavonoids, tannin and saponin. The results of analysis using GCMS show that there are 31 components of red ginger essential oil, with the main compounds 2-butanone-4-(3-hydroxy-2-methoxyphenyl) (21.51%) and Zingerone (15.10%). The GCMS test results for red ginger methanol extract obtained 31 components, with the main components being citral (24.05%). The results of antibacterial testing of red ginger extract did not provide activity in inhibiting bacteria, whereas red ginger essential oil at a concentration of 100% provided inhibition of the growth of E. coli bacteria (14.00 ± 2.00 mm) and at a concentration of 40% for S. aureus bacteria (22.67 ± 2.31 mm).
Growth Response of Banana Kepok Tanjung (Musa acuminata balbasiana) with the Application of BAP (Benzyl Amino Purine) and Cow’s Milk In Vitro Rozanah Indira Lestari; Susiyanti; Samsu Hilal; Andi Apriany Fatmawaty
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 01 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss01/473

Abstract

Tissue culture is a plant propagation technique using artificial media by adding particular growth regulators (ZPT) to produce plants as expected. Although, the availability of other issues such as browning and contamination can inhibit the process of explant propagation. The addition of cow’s milk to the culture media and BAP is a type of cytokinin is expected to regenerate the growth of banan Kepok Tanjung variety optimally. This study aims to have best concentration of BAP and cow’s milk for the growt Kepok Tanjung explants in vitro. The experimental design used was a randomized with 16 treatment combinations. The result showed a significant of the combination of media treatment of banana Kepok Tanjung variety on the number of leaves (24.2 sheets) and explant height (25.62 cm) starting from 3-12 WAP.
Connecting the Dots: Transcriptomic Approaches and Relationship between Myocardial Infarction and Breast Cancer Miftahul Khair Akbar; Fadilah Fadilah; Arief Aulia Rahman
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 25 No. 01 (2024): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol25-iss01/478

Abstract

Myocardial infarction, resulting from coronary blood vessel blockage, inflicts lasting damage on the heart muscle. Meanwhile, breast cancer ranks among the most diagnosed cancers, causing millions of deaths annually. Mouse model research suggests that myocardial infarction induces systemic changes, fostering cross-disease communication that expedites breast cancer. Using GEO2R for transcriptomic analysis, Cytoscape for protein-protein interaction (PPI), and EnrichR for enrichment analysis, we explored the myocardial infarction-breast cancer relationship with datasets from GEO. We identified 3,300 differentially expressed genes, including 6 commonly upregulated and 18 commonly downregulated genes. PPI and enrichment analyses revealed RAD51 genes associated with homologous recombination pathways (P-value 0.02032). Additionally, 4 genes (RAD51, KIF4A, DTL, and DLGAP5) were linked to CD105+ endothelial cells (P-value 0.00002216), connecting myocardial infarction and breast cancer. Nevertheless, further testing is needed for accurate results and to support this study's transcriptomic analysis.

Page 24 of 33 | Total Record : 329

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