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Eksakta : Berkala Ilmiah Bidang MIPA
Published by Universitas Negeri Padang
ISSN : -     EISSN : 25497464     DOI : https://doi.org/10.24036/eksakta/
Core Subject : Science, Education, Agriculture, Social, Engineering,
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Energy Engineering Environmental Science Materials Science & Nanotechnology Mathematics Mechanical Engineering
Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) is an open access journal and peer-reviewed that publishes either original article or reviews. The journal is dedicated towards dissemination of knowledge related to the advancement in scientific research. The prestigious interdisciplinary editorial board reflects the diversity of subjects covered in this journal. Under the realm of science and technology, the coverage includes environmental science, pure and applied mathematics, agricultural research and engineering, biology, biotechnology, bioinformatics, Healthcare sciences (including clinical medicine, preventive medicine & public health), physics, biophysics, computer science, chemistry and bioengineering, to name a few. This Journal Is Published at 3 Month intervals on January-Marc, April-June, July-September and October-December
Arjuna Subject : Umum - Umum
Articles 327 Documents
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Response of PM2.5 Concentrations at the GAW Bukit Kototabang Station to ENSO Phases Based on Superimposed Epoch Analysis Dodi Saputra; Nofri Yendri Sudiar; Dhiyaul Qalbi; Aditya Prapanca
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 02 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss02/666

Abstract

This study aims to analyze the response of PM2.5 concentrations and rainfall to the El Niño and La Niña phases at the Global Atmosphere Watch Bukit Kototabang station, West Sumatra, using the Superposed Epoch Analysis method. Observational data of PM2.5 from the Beta Attenuation Monitor  1020, rainfall from the Automatic Agroclimate Weather Station, and sea surface temperature in the Niño 3.4 region were analyzed for the period October 2021 to May 2025. A total of 31 extreme rainfall events were identified as reference points (epochs) and classified into El Niño and La Niña periods. The results show that during the La Niña phase, an average rainfall increase of 41.1 mm effectively reduces PM2.5 concentration anomalies by approximately ±3.1 µg/m³. In contrast, during the El Niño phase, although rainfall increases by 33.5 mm, PM2.5 concentrations remain highly variable, with anomaly increases of approximately ±1.3 µg/m³, due to drier air masses and lower rainfall intensity. The combined results of SEA analysis and the Monte Carlo test indicate a 13-day SST lead during the El Niño period and a 9-day lag during the La Niña period. This study reveals that ENSO influences both rainfall and air quality at the GAW Bukit Kototabang station.
Use of Nanoemulsion-Based Merkubung (Macaranga gigantea) Sap Extract Inhibitor to Improve Corrosion Inhibition Efficiency on Steel Naibaho, Adetra Febriani; Putri, Alya Adiningtyas; Natasya, Dian; Sinaga, Grescia Angelita; Fadillah, Wan Nurul; Gusti, Diah Riski
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 02 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss02/471

Abstract

Corrosion frequently affects steel. Although it is an unavoidable natural process, its progression can be managed and its rate reduced. One strategy for mitigating corrosion is the use of corrosion inhibitors. Inhibitors derived from organic sources are widely employed because of their high inhibition efficiency. Sap extract from Merkubung (Macaranga gigantea) can function as a corrosion inhibitor due to the presence of secondary metabolites such as tannins. Tannins are promising corrosion inhibitors since their –OH groups enable them to form complexes with metal surfaces. This study evaluates the performance of a nanoemulsion containing Merkubung sap extract as a steel corrosion inhibitor. The methodology includes extraction, nanoemulsion formulation, and assessment of corrosion rate and inhibition efficiency at various concentrations and temperatures. In this work, nanoemulsion‑based inhibitors were applied to improve corrosion protection of steel. The nanoemulsion demonstrated the lowest corrosion rate (0.902 mg cm⁻² h⁻¹) and the highest inhibition efficiency (66.05 %) at 500 ppm and 30 °C. These results show that the nanoemulsion enhances inhibition performance, making it an effective corrosion inhibitor.
The Spectrum of Severity: Clinical and Hematological Markers in Jakarta’s COVID-19 Patients Listiyaningsih, Erlin; Sari, Shinta Dewi Permata; Martalena, Dewi; Sukarya, Wawang
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 02 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss02/660

Abstract

Jakarta, a densely populated megacity with high hybrid immunity, presents a unique epidemiological landscape for COVID-19. Understanding the clinical and hematological markers in this context is vital for improving clinical management. This study aims to analyze the clinical and hematological profiles of COVID-19 patients in Jakarta to identify markers associated with disease severity. This cross-sectional study analyzed secondary data from 100 confirmed COVID-19 patients (26 mild, 54 moderate, 20 severe) at two Jakarta hospitals. ANOVA and Kruskal-Wallis tests were employed to compare variables across severity groups, while categorical variables were analyzed using Chi-square tests. Significant associations with increasing severity were found for higher HR and RR. Among hematological parameters, basophil levels decreased significantly with higher severity. Although not statistically significant, trends of decreasing lymphocytes and platelets, alongside increasing blood glucose and neutrophils, were observed. Diabetes was the most prevalent comorbidity in severe cases. In conclusion, HR, RR, and basophils roles as significant markers of COVID-19 severity in our population. Trends in lymphocyte, thrombocyte, blood glucose, and diabetes prevalence, align with known patterns of severe disease with insignificant statistically, due to sample size limitations.
In Silico Evaluation of Quinoline Derivatives as PfLDH Inhibitors through Molecular Docking, Lipinski’s Rule, and ADMET Profiling Rijas, Livia Putrima; Zainul, Rahadian; Meksim Rebezov; Vikash Jakhmola; Tarek Elkhooly
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 02 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss02/669

Abstract

 This study aimed to evaluate quinoline-spiro derivatives as potential inhibitors of P. falciparum lactate dehydrogenase (PfLDH), a key enzyme involved in parasite energy metabolism, using an in silico approach. Molecular docking was performed to assess ligand-protein interactions, followed by drug-likeness evaluation based on Lipinski's Rule of Five and pharmacokinetic-toxicity prediction using ADMET analysis. The results showed that all tested compounds exhibited favorable binding interactions with PfLDH, thus demonstrating potential as enzyme inhibitors. Several compounds exhibited stronger binding affinity than reference ligands, suggesting that structural modifications with the spiro framework enhance interaction with the target protein. Most compounds also met drug-likeness criteria, although there were minor deviations. Among the compounds evaluated, one candidate, (Z)-2-((2-(7- chloroquinolin-4 -yl) hydrazinyl) methyl) -4-(3- methylbenzylidene)-2-azaspiro[4.5] decan-3-one showed the most balanced profile, based on results obtained by combining strong binding interactions with favorable pharmacokinetic properties and predicted low toxicity. Quinoline-spiro derivatives may be promising candidates for the development of antimalarial drugs targeting PfLDH. This study describes the integrated in silico evaluation of quinoline-spiro derivatives as PfLDH inhibitors, as drug candidates for further development.
Exploring the Chemopreventive Potential of Soybean Phytochemicals Targeting BRCA1 Protein: A Molecular Docking Study Liviandari, Regina; Estuningtyas, Ari; Kusmardi; Erlina, Linda
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 02 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss02/671

Abstract

Breast cancer remains a significant cause of cancer-related mortality among women globally, highlighting the importance for preventive strategies targeting early molecular events. BRCA1 plays a critical role in maintaining genomic stability through DNA repair mechanisms. However, the potential of soybean phytochemicals to modulate BRCA1 activity at the molecular level, particularly through computational approaches, has not been extensively explored. This study aimed to evaluate the chemopreventive potential of soybean phytochemicals targeting the BRCA1 protein using an in silico approach. A total of 32 compounds were prepared and docked into the BRCA1 binding site using Autodock Tools 1.5.7, followed by interaction analysis and visualization, prediction of pharmacokinetic and toxicity profiles using SwissADME, pkCSM, and ProTox. The results showed that the top compounds exhibited binding energy ranging from -6.04 to -8.07 kcal/mol, which were lower than the reference compound. Interaction analysis revealed stable binding with key amino acid residues, including Met1775, Leu1839, and Lys1702 through hydrogen and hydrophobic interactions. Among the evaluated compounds, daidzin showed the most balanced profile in terms of binding affinity, interaction relevance, and favorable ADMET properties. This study provides a systematic in silico evaluation of soybean phytochemicals targeting BRCA1 and highlights their potential as candidates for breast cancer chemoprevention.
In Silico Evaluation of Cardiac Glycosides from Vernonia amygdalina as EGFR Inhibitors in Triple Negative Breast Cancer Gisela Agustin Habayahan; Denny Satria
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 02 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss02/676

Abstract

Triple-negative breast cancer (TNBC) is an aggressive subtype with limited targeted therapies, emphasizing the urgent need for novel molecular inhibitors. Epidermal growth factor receptor (EGFR) is overexpressed in TNBC, but current inhibitors show limited clinical efficacy, indicating a significant therapeutic gap. This study aims to evaluate cardiac glycosides from Vernonia amygdalina as EGFR inhibitors using an integrated in silico approach. Docking results demonstrated that vernoniosides A3 exhibited the lowest binding energy of -12.2 kcal/mol, outperforming the native ligand (-9.0 kcal/mol) and gefitinib (-8.5 kcal/mol). Molecular dynamics (MD) simulations revealed that EGFR-vernoniosides A3 complex remained stable, with RMSD values within stable range (0.7-3.8 Å), RMSF values (0.4-8.3 Å), radius of gyration (Rg) (6.0-7.0 Å), solvent-accessible surface area (SASA) (830-871 Ų), while forming up to 15 hydrogen bonds. However, MM-PBSA analysis showed that binding free energy of vernoniosides A3 (321.60 ± 5084.43 kcal/mol) was lower than the native ligand (569.25 ± 8997.10 kcal/mol) and gefitinib (623.87 ± 9862.73 kcal/mol), indicating weaker thermodynamic binding strength. This discrepancy arises as docking measures potential binding in a static state, while MM-PBSA reflects dynamic, realistic binding strength. These results suggest that vernoniosides A3 shows promising binding affinity but requires further optimization and validation for TNBC therapy.
In Silico Evaluation of Bisbenzylisoquinoline Compounds from Stephania sp. as EGFR Inhibitors for Triple-Negative Breast Cancer Amanda, Amanda Triastuti; Denny Satria
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 27 No. 02 (2026): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464) In Progress
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol27-iss02/677

Abstract

Triple-negative breast cancer (TNBC) represents a highly aggressive breast malignancy subtype characterized by constrained therapeutic alternatives and poor clinical outcomes. Since Epidermal Growth Factor Receptor (EGFR) is frequently overexpressed in TNBC, it remains a strategic molecular target for anticancer drug innovation. This study evaluates the inhibitory potential of bisbenzylisoquinoline (BBIQ) compounds from Stephania species against EGFR using an in silico framework. Molecular docking analysis revealed that isotrilobine possessed the highest binding affinity toward EGFR, achieving a docking score of -10.5 kcal/mol, indicating potent interactions within the active site. Molecular dynamics simulations over a 100 ns trajectory demonstrated that the EGFR-isotrilobine complex maintained structural stability throughout, as evidenced by RMSD values of 0.193-1.223 Å, RMSF of 1.5 ± 1.1 Å, radius of gyration (Rg) of 4.597-4.918 Å, and a solvent-accessible surface area (SASA) of 772.3 Ų. Hydrogen bond analysis identified an average of four stable interactions, reinforcing persistent ligand binding within the receptor pocket. Furthermore, MM-PBSA calculations yielded a binding free energy of 101.063 ± 127.26 kJ/mol, indicating energetically favorable binding. These findings suggest that isotrilobine and related BBIQ analogues exhibit significant potential as EGFR inhibitors for TNBC therapy, serving as viable candidates for further experimental validation and drug development.

Page 33 of 33 | Total Record : 327

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