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Erina Yatmasari
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Oceana Biomedicina Journal
Published by Universitas Hang Tuah
ISSN : -     EISSN : 26140519     DOI : https://doi.org/10.30649/obj.v5i1.67
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Medicine & Pharmacology Nursing Public Health
Oceana Biomedicina Journal is an open access journal of health and medicine.Specifically, the journal focuses on marine medicine, hyperbaric medicine and health, medicine on ships, harbor health, maritime and coastal health, medicolegal studies related to ships, ports and districts, maritime/coastal communities and fishermen, epidemiological aspects of diseases, disabilities and disorders that occur on ships and affect boat workers, ports and maritime zones, coastal areas, fishermen communities and their families, including pharmacological and non-pharmacological prevention and treatment management policies; and miscellanous.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 110 Documents
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Pengaruh Flavonoid Daun Karamunting (Rhodomyrtus tomentosa (Ait.)Hassk.) terhadap Kadar Glukosa Darah, Serum MDA dan SOD pada Diabetes Melitus Wiranti Anggraini; AM.T. Kamaluddin; Irsan Saleh
Oceana Biomedicina Journal Vol 6 No 2 (2023): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v6i2.89

Abstract

Diabetes melitus (DM) adalah suatu penyakit metabolik yang ditandai dengan hiperglikemia akibat kelainan sekresi insulin atau kerja insulin maupun keduanya. Diabetes melitus dapat dikategorikan menjadi dua jenis yaitu diabetes melitus tipe 1 (DMT1) dan tipe 2 (DMT2). Diabetes melitus tipe 1 (DMT1) merupakan kondisi yang sering disebut dengan DM yang bergantung insulin sedangkan DMT2 merupakan sebaliknya. Diabetes melitus tipe 2 sebagian besar ditandai oleh adanya kondisi hiperglikemia, defisiensi relatif insulin, dan resistensi insulin. Pada kondisi DM, jumlah radikal bebas yang berlebihan akan mengoksidasi dan mendegradasi komponen lipid pada membran sel sehingga terjadi peroksidasi lipid. Akibat dari terjadinya peningkatan radikal bebas, peroksidasi lipid membran sel juga akan diikuti dengan meningkatnya produk akhir yang disebut malondialdehida (MDA) dan penurunan Superoksida Dismutase (SOD). Tujuan literatur riview ini adalah untuk mengumpulkan literatur terkait pengaruh flavonoid sebagai antioksidan terhadap kadar glukosa darah, serum MDA dan SOD pada kondisi diabetes melitus, dalam kurun waktu 2013-2021. Kumpulan referensi yang didapat kemudian ditelaah dan disusun secara sistematis untuk dibahas lebih lanjut. Secara garis besar dapat dikatakan bahwa flavonoid memiliki efek sebagai antioksidan yang berpengaruh terhadap kadar glukosa darah, penurunan kadar MDA, dan peningkatan kadar SOD pada diabetes melitus.
Activities of Tembusu Plants (Cyrtophyllum fragrans (Roxb.) DC.) As Medicinal Plants; Literature Review Article Bunga Anggreini Sari; Eddy Mart Salim; Irsan Saleh
Oceana Biomedicina Journal Vol 6 No 2 (2023): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v6i2.90

Abstract

Tembusu (Cyrtophyllum fragrans (Roxb.) DC.) is a plant belonging to the Gentianaceae family that can be used as medicine for various diseases. This study aims to determine the pharmacological effectiveness of the Tembusu plant. The method used in this study is a literature review article (LRA) approach. The literature search used Pubmed, Google Scholar, Scient Direct and Research Gate as sources of electronic data published from 2010 to 2022. The results found 19 literatures that met the criteria. Based on a review of several literatures, it shows that the Tembusu plant has pharmacological activities including antimicrobial, antioxidant, anti-inflammatory, anticancer and antidiabetic activities.
PREVALENSI DAN KARAKTERISTIK PERDARAHAN ANTEPARTUM DI RUANG RAWAT INAP OBSTETRI DAN GINEKOLOGI DI RSPAL DR. RAMELAN SURABAYA I Ketut Edy Sudiarta
Oceana Biomedicina Journal Vol 6 No 2 (2023): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v6i2.93

Abstract

Background: Bleeding in obstetrics is one of the main causes of maternal mortality. Based on the 2017 World Bank report, in 1 day there are 4 mothers in Indonesia who die due to childbirth. One of the main causes of maternal mortality is antepartum bleeding, as well as preeclampsia and infection. The incidence and characteristics of antepartum bleeding cases are not known with certainty. In this study, we wanted to know the characteristics and prevalence of antepartum bleeding at the Obstetrics and Gynecology Laboratory, RSPAL Surabaya. Methods: A descriptive retrospective study that used a cross-sectional approach to determine the prevalence and characteristics of antepartum bleeding in the Obstetrics-Gynecology Laboratory of the Naval Center Hospital, Dr. Ramelan Surabaya for the period 2019 to 2021. Results and Conclusions: The prevalence of antepartum bleeding in the Obstetrics and Gynecology laboratory during the period January 2019 – December 2021 was 29.9% (91 out of 304 deliveries), with the highest age group being 30-34 years as many as 31 people (34.1%), parity ( P2) mostly 34 patients (37.4%). Based on gestational age, 50 people (54.9%) gestational age <37 weeks, 51 cases (56%) placenta previa and 39 cases (42.8%) placenta accreta/percreta. Case management, 81 cases (89%) were terminated via sesarean section.
REVIEW OF THE ACCURACY OF THE DIAGNOSIS CODE OF DENGUE HAEMORRHAGIC FEVER IN MEDICAL RECORDS IN RSUD dr. RASIDIN PADANG Deni Maisa Putra; Yulia Fitriani; Dian Novita; Anadya Afriyanti; Washi Fadhila
Oceana Biomedicina Journal Vol 6 No 2 (2023): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v6i2.98

Abstract

ABSTRACT The accuracy of the code is needed so that the information resulting from the diagnosis and action is accurate. However, the authors found that at RSUD dr.Rasidin Padang there were still incorrect codes. This is because the diagnosis of Dengue Haemorrhagic Fever is not correct in giving the code according to the ICD-10. The purpose of this study was to determine the accuracy of the diagnostic code for dengue haemorrhagic fever in medical records at dr.racidin. This research method used is quantitative with a descriptive approach. This research was conducted from February to May 2022. The number of samples was 59 medical records using the total sampling method, and the tool used was a checklist table with univariate analysis. The results of this study were obtained from 59 medical records, there were 37 (62.7%) medical records with inappropriate codes, and a small proportion of 10 (16.9%) medical records that were not clearly written, and there were 39 incomplete diagnosis writings. (66.1%) this was due to errors in determining the diagnosis code, doctors' writings that were difficult to read, incomplete completeness, non-specific written diagnoses based on ICD-10, and the use of abbreviations that were not standardized in hospitals. Therefore, researchers suggest that coders should pay attention to the rules and procedures for coding a diagnosis based on ICD-10. Keywords: Coding Accuracy, Clarity, Completeness
Respon Imun Pada Penderita Cacar Monyet Agnes Felicia Lubis
Oceana Biomedicina Journal Vol 6 No 2 (2023): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v6i2.107

Abstract

Monkeypox is a viral infection caused by the orthopoxvirus. Following the global eradication of smallpox in 1977, monkeypox became the leading source of human monkeypox outbreaks, particularly in West and Central African nations where outbreaks typically occur in isolated locations. Monkeypox (monkeypox) displays clinical symptoms comparable to smallpox, such as flu-like symptoms, fever, lethargy, backache, headache, and rash. There is currently no treatment for monkeypox that infects people, however monkeypox may be diagnosed by biomolecular investigation using PCR-RFLP.
SEORANG PENDERITA HEPATITIS B AKUT BERAT, MUTAN “PRECORE”, GENOTIP C, YANG DITERAPI DENGAN ENTECAVIR MENGALAMI KECURIGAAN SINDROMA GIANOTTI-CROSTI Hendrata Erry Andisari
Oceana Biomedicina Journal Vol 6 No 2 (2023): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v6i2.111

Abstract

Introduction: The clinical course of HBV is very dynamic and difficult to predict, it can survive in the liver without causing clinical symptoms, or transform into a mutant form with clinical manifestations of severe acute hepatitis B (HBA) or fulminant hepatitis. Case: Patient Mr. AS, 22 years old, came to a private clinic (West Surabaya) on January 22, 2022. Due to yellow eyes, since 1 week before the patient has complained of weakness, lack of appetite, muscle and joint pain, and body aches. Conclusion: Entecavir therapy in Severe HBA is safe, provides clinical improvement, accompanied by clearing of HBV DNA and rapid anti-HBs seroconversion occurs.
DEDIFFERENTIATED LEIOMYOSARCOMA Anggie Sasmita Kharisma Putri; Diah Prabawati Retnani; Aina Angelina; Harun Al Rasyid; Karyono Mintaroem; Eviana Norahmawati; M Luqman Fadli
Oceana Biomedicina Journal Vol 6 No 2 (2023): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v6i2.130

Abstract

Background: Meningioma is the most common intracranial tumor in adults. Progesterone plays a role in the cell development and proliferation of hormone-associated tumors, such as meningiomas. Significant morbidity and mortality can occur, when the lesion is localized in an area that is difficult to undergo surgical resection or is highly infiltrative in the surrounding tissue. Many studies have been published on the molecular properties associated with meningioma aggressive behavior, including matrix metalloproteinase (MMP), but research on the relationship between PR expression and MMP-9 has not been widely carried out. Methods: This study used a cross-sectional analytic observational study design. The analysis used in this study includes descriptive analysis and bivariate analysis. The data obtained was processed using SPSS software. Results: Spearman's correlation test for PR expression with WHO grading in meningioma, obtained p = 0.492 and correlation coefficient -0.117. This shows a correlation that is not significant. Spearman's correlation test for MMP expression with WHO grading in meningioma, obtained p = 0.16 and a correlation coefficient of 0.236. This shows a correlation that is not significant. Spearman's correlation test between MMP9 expression and WHO grading in meningioma obtained p = 0.008 which indicated that the correlation between PR and MMP9 values ​​was significant with a correlation value of -0.427. Conclusion: There is no significant correlation between PR expression and WHO grading. There was no significant correlation between MMP9 expression and WHO grading. There is a significant correlation between PR expression and MMP9.
Effect of time delay in centrifugation and centrifugation immediately on the stability of triglyceride levels in blood samples Mustika Hutabarat
Oceana Biomedicina Journal Vol 6 No 2 (2023): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v6i2.131

Abstract

Background : Triglyceride examination was carried out in three stages, namely pre-analytical, analytical, and post-analytical stages. The pre-analytical stage of specimen processing is one of the factors that can affect triglyceride levels. However, in the field are often that the processing for triglyceride test specimen examination oftenis not in accordance with applicable regulations. Method : This research is a pre-experimental research design with intact Group Comparison. The research subjects used were 30 TLM students. Blood samples were collected in 2 clot activator tubes, then the first tube was immediately centrifuged and the second tube was left for 30 minutes before being centrifuged. Results : The results showed that the average triglyceride level in the blood that immediately centrifuged was heigher than the blood that was left for 30 minutes before being centrifuged. There for, It is stated that there is a significant difference in the p value = 0.001 (p<0.05). Conclusion : Based on the research, it was concluded that there was a significant difference in the examination of triglyceride levels. Between blood sample that was immediately centrifuged and the blood that was left for 30 minutes before being centrifuged.
PENGARUH SUHU PENGERINGAN TERHADAP KADAR FLAVONOID EKSTRAK ETANOL DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Yuska Noviyanty; Oktri Wardania; Hepiyansori Hepiyansori
Oceana Biomedicina Journal Vol 6 No 2 (2023): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v6i2.133

Abstract

Introduction : Binahong leaf (Anredera cordifolia (Ten.) Steenis) is one of the plants that is empirically used to treat various diseases. And contains many secondary metabolites, one of which is flavonoid compounds. Binahong leaf (Anredera cordifolia (Ten.) Steenis) has bioactivity as an antioxidant, antibacterial, antifungal, antidiabetic, anti-inflammatory, antiseptic, and antibacterial contains many secondary metabolites, one of which is flavonoid compounds. Methodes: The leaves used were processed into simplicia by oven heating method with different temperature variations (35OC, 50OC, 65OC) and extracted using 70% ethanol solvent. Furthermore, the identification of flavonoid compounds with the addition of concentrated Mg and HCl powder which is positive for flavonoids if the color is yellow-orange. The determination of the levels of flavonoid compounds was carried out using the UV-Vis spectrophotometric method. Results: Identification tests that have been carried out with ethanol extract of Binahong (Anredera cordifolia (Ten.) Steenis) leaves at 35OC, 50OC, and 65OC positive contain flavonoids seen from the color produced, which is yellow-orange. And the average levels of flavonoids obtained at a temperature of 35oC: 2.685% 50oC: 2.476% and 65oC: 1.980%. Conclusion : The lower the drying temperature of the simplicia, the higher the levels of flavanoid compounds. Variations in simplicia drying temperature had no effect on the presence of flavanoid compounds.
Differences of Ki-67 Expression in Basal Cell Carcinoma Low-Risk and High-Risk Subtypes associated with Age, Gender, Location of the Lesion and Histologic features Mochamad Sonny Yanuar Akbar; Siti Amarwati; Udadi Sadhana; Ika Pawitra Miranti; Meira Dewi Kusuma Astuti
Oceana Biomedicina Journal Vol 6 No 2 (2023): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v6i2.135

Abstract

Background: An increase in the number of BCC worldwide has also resulted in an increase in the rate of disability, recurrence and increased treatment costs, so additional examinations are needed to support existing standard histological examinations so as to produce a precise and accurate diagnosis. No accurate data on Ki-67 expression in BCC subtypes have been published yet Objective: To evaluate differences of Ki-67 expression in low-risk and high-risk basal cell carcinoma subtypes associated with age, sex, lesion location and histologik features Methods: In 2017-2020 there were 39 samples of paraffin blocks diagnosed as low-risk and high-risk BCC subtypes at Dr. Kariadi Hospital. Consecutive sampling method was used, namely 29 samples of low subtype and 10 samples of high subtype of BCC. Results: All sample are positive for Ki-67 in low risk BCC and high risk subtypes, with differences between subtypes (p = 0.084) indicating no significant difference in Ki-67 expression on both BCC subtypes. Conclusion: Expression of Ki-67 low risk subtype at age > 60 years female gender and high risk subtype age > 60 years male gender.

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