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INDONESIA
Jurnal Respirologi Indonesia
Published by Perhimpunan Dokter Paru Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
Arjuna Subject : -
Articles 378 Documents
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Comparative Analysis of Copeptin, IL-6, and TNF-α as Predictive Biomarkers for Clinical Outcome in Moderate to Severe COVID-19 Patients Harsini, Harsini; Aphridasari, Jatu; Siregar, Sihsusetyaningtyas Tiominar
Jurnal Respirologi Indonesia Vol 46 No 1 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/mbaw4490

Abstract

Abstract Background: This retrospective clinical study aimed to evaluate the correlation of copeptin, IL-6, and TNF-α levels with the clinical outcomes of patients with moderate to severe COVID-19. Methods: The study included patients who met the selection criteria and provided written informed consent. A sample size of 41 was determined via power analysis to achieve 80% power at a 0.05 significance level. Consecutive sampling was employed to select participants. The study utilized medical records of patients with moderate to severe COVID-19 who underwent copeptin, IL-6, and TNF-α testing. Correlation analyses and Bonferroni corrections were performed using SPSS® ver. 21. Results: Results revealed a moderate positive correlation between copeptin levels and patient outcomes (Bonferroni correlation: 0.597; p < 0.001). A weak positive correlation was observed between IL-6 levels and outcomes (Bonferroni correlation: 0.239; p = 0.055), while a negligible positive correlation was found for TNF-α levels (Bonferroni correlation: 0.140; p = 0.177), which was not statistically significant. Conclusion: Copeptin emerged as a more sensitive biomarker for predicting the outcomes of COVID-19 patients compared to IL-6 and TNF-α. Elevated copeptin levels were associated with a poorer prognosis. Copeptin emerged as the strongest biomarker in this study, likely due to its role as a surrogate for vasopressin release, signaling a severe inflammatory response. Furthermore, its stability in serum renders copeptin a more sensitive biomarker than IL-6 and TNF-α.
Diagnostic Performance of Cardiopulmonary Exercise Testing (CPET) in Chronic Obstructive Pulmonary Disease (COPD) at a Tertiary Hospital in Indonesia Musdalifah
Jurnal Respirologi Indonesia Vol 46 No 2 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v46i2.1078

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) remains a major global health burden. Spirometry is the diagnostic gold standard but has limitations for functional assessment. CPET provides a comprehensive evaluation of integrated cardiopulmonary and metabolic responses during exercise and may improve diagnostic and management decisions in COPD. This study aim to determine the diagnostic quality of CPET parameters for COPD. Methods: Observational analytic cross-sectional study using synchronized spirometry and CPET data from medical records at Universitas Sebelas Maret Hospital. Thirty-seven eligible records were analyzed after ethics approval. CPET parameters included VO₂max, respiratory exchange ratio (RER), and VE/VCO₂ slope. Discrimination was assessed with AUC; diagnostic performance used chi-square; correlation with obstruction severity used GOLD classification (p<0.05). Results: Of 37 subjects, 23 had COPD; COPD status was significantly associated with older age and smoking (both p<0.05). VO₂max (sensitivity = 73.9%; specificity = 78.6%), RER (78.3%; 78.6%), and VE/VCO₂ slope (78.3%; 71.4%) showed useful discrimination (AUC = 0.795, 0.846, and 0.742; χ² p = 0.002, 0.001, and 0.003, respectively). Among CPET parameters, RER correlated significantly with obstruction severity by GOLD (p<0.05), while VO₂max and VE/VCO₂ slope did not (p>0.05), though trends were worse with more severe disease. Conclusion: Spirometry and CPET together aid diagnosis, evaluation, and prognostication in COPD; combining them may enhance comprehensive management.
The Agreement Level of Colorimetric Indicator Paper and pH Meter Examination Compared to Urine Analyzer in Measuring Exudative Pleural Effusion Fluid pH Huda, Muttaqin; Subagio Sutanto, Yusup; Aphridasari, Jatu
Jurnal Respirologi Indonesia Vol 46 No 2 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jqq7dj53

Abstract

Background: Pleural effusion is an abnormal accumulation of fluid in the pleural space, commonly associated with pulmonary infections and malignancies. Measurement of pleural fluid pH is important for diagnosis, therapeutic decision-making, and prognostic evaluation. Various methods are used, including pH meters, indicator papers, and urine analyzers; however, their concordance has not been widely studied in Indonesia. This study aimed to evaluate the agreement of pleural fluid pH results measured using pH meters, indicator papers, and urine analyzers to support appropriate selection of diagnostic methods. Methods: This observational analytic study with a cross-sectional design conducted at Dr. Moewardi General Hospital, Surakarta, from March to June 2025. The sample consisted of 55 patients with exudative pleural effusion who met the inclusion criteria. Pleural fluid pH was measured using three methods: colorimetric indicator paper, a pH meter, and a urine analyzer. Data were analyzed using the kappa coefficient and the Intraclass Correlation Coefficient (ICC) to assess the agreement between methods. Results: The mean pH values of pleural fluid measured by the urine analyzer, pH meter, and colorimetric indicator paper were 8.18 ± 0.47, 8.13 ± 0.46, and 8.15 ± 0.59, respectively. Agreement analysis showed a very strong and statistically significant correlation between the pH meter and urine analyzer (ICC = 0.948; p < 0.001), between the pH strip and urine analyzer (ICC = 0.855; p < 0.001), and between the pH meter and pH strip (ICC = 0.916; p < 0.001). A significant positive correlation was also observed between glucose levels and pH measured by both the urine analyzer and the pH meter. Conclusion: There is good agreement among pH measurements obtained using colorimetric indicator paper, urine analyzer, and pH meter in exudative pleural effusion fluid.
A Compounding Challenge: An Evidence-Based Case Report on the Link Between Obesity and Asthma Exacerbations in Pregnancy Muhammad Bimo Ramadhan; Halidza Nursasqia Pasyah; Aurora Serena Ueda; Rafi Akbar Putranto; Fanny Fachrucha
Jurnal Respirologi Indonesia Vol 46 No 2 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/eqb78x22

Abstract

Background: Asthma exacerbations in pregnancy have been found to increase risk of adverse perinatal outcomes. Obesity during pregnancy, a condition of rising prevalence, is hypothesized to worsen asthma control through inflammatory mechanisms. However, the scientific evidence on the association between the two variables remains contradictory. This Evidence-Based Case Report aims to determine the association between early-pregnancy obesity and asthma exacerbation during pregnancy by synthesizing findings from various related studies. Methods: A literature search was conducted using relevant keywords from utilized databases: PubMed, ScienceDirect, Cochrane, and ClinicalTrials.gov. The Oxford Centre for Evidence-Based Medicine (CEBM) framework was used to appraise the literature that met the inclusion and exclusion criteria. Results: This review identified five studies, comprising one systematic review and meta-analysis and four cohort studies. These studies were appraised as valid, important, and applicable. Four of the five studies reported significant increased risk of asthma exacerbation in pregnant women with early-pregnancy obesity. The study by Stevens et al. (2022) reported a decreased risk of exacerbation in pregnant women with obesity compared to the control group, attributing this to differences in perception thresholds between the groups and the possibility of study bias. Conclusion: Pregnant women with obesity in early pregnancy have a higher risk of experiencing asthma exacerbations during pregnancy compared to non-obese groups. Therefore, this condition requires enhanced monitoring and asthma management to prevent maternal and perinatal complications.
The Relationship Between Urinary Bromotyrosine Levels and Eosinophils in Asthma and Non-Asthma Patients at Harum Melati Clinic, Pringsewu, Lampung, Indonesia Dimas Trend Pinaka Baladika
Jurnal Respirologi Indonesia Vol 46 No 2 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/stm24d16

Abstract

Background: In the era of personalized medicine, biomarkers have become an important tool for detecting and predicting asthma episodes over the last decade. Urinary bromotyrosine has several advantages as a potential biomarker for asthma, including its stability and the practicality of non-invasive urine sample collection. Methods: This is an analytical observational study with a cross-sectional design. From May to December 2023, the study involved 82 patients aged 6 to 65 years from the Harum Melati Clinic in Pringsewu. The participants underwent spirometry, differential leukocyte count, urinalysis, and chest X-rays. The severity of asthma obstruction was classified as mild (n = 66) or moderate-severe (n = 6), with non-asthmatic patients (n = 10) served as the control group. Urinary bromotyrosine levels were tested using the 3-BrY ELISA Kit EU3112. Results: Urinary bromotyrosine levels were significantly higher in asthma patients compared to the control group (154.11 ng/mL vs. 11.87 ng/mL, p = 0.000). Furthermore, elevated eosinophil levels in asthma patients showed a strong correlation coefficient (0.307) with higher urinary bromotyrosine levels, indicating statistical significance (p = 0.005). Conclusion: The results of this study showed a significant difference in urinary bromotyrosine levels between asthmatic and non-asthmatic participant. There was a strong correlation between elevated eosinophil levels in asthma patients and increased urinary bromotyrosine levels.. Keywords: asthma, urinary bromotyrosine, eosinophils
KL-6 Serum Elevation among Supit Urang Landfill Workers: Based on Length of Work Duration and Type of Work Anggraeni, Rizki Diah; Astuti, Tri Wahju; Sari, Fitri Indah; Rakhma, Sastia
Jurnal Respirologi Indonesia Vol 46 No 2 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/57wdw018

Abstract

Background: KL-6 serum was a glycoprotein biomarker of lung inflammation and epithelial damage. Waste workers at Supit Urang Landfill, Malang, Indonesia has a risk from occupational inhalation exposure such as bacterial bioaerosol, VOC, CH4, CO, H2S. This study analyzed serum KL-6 serum levels as inflammation biomarker according to length of exposure duration and type of work. Methods: The study design analytic experimental with cross-sectional approached. Total subject was 79 worker who grouped by exposure duration in 24 subjects on 1–5 years; 29 subjects on 5–10 years; 26 subjects on >10 years as. Others groups type of work consisted of 48 scavengers; 20 waste sorters as; 9 waste processors; 2 laboratories technicians. KL-6 levels were measured by ELISA. Anova and spearman-rho analysis was used for KL-6 serum level in each group. Results: KL-6 serum level was significantly (p = 0.000) increased in workers with >10 years of exposure (1170,3 ± 621,4 U/mL) compared to the others group. Scavengers have a significantly (p = 0,002) increased of KL-6 serum level (1049,6 ± 586,6 U/mL) compared to the others groups. Moderate correlation existed between exposure duration and KL-6 serum levels with positive result (r=0.470, p=0.000). Conclusion: The research found higher serum KL-6 levels after 10 years of exposure. Gas product exposure puts scavengers at danger of inhalation.
Comparison Between Imprint Cytology and Histopathology Results in Pleural Effusion Cases Undergoing Pleuroscopy Aniwidyaningsih, Wahju; Dameria, Flora; Rahardjo, Eylin; Beginta, Romi; Sembiring, Ruth Emalian; Rasmin, Menaldi; Reisa, Tina; Arum, Ginanjar; Elhidsi, Mia; Prasenohadi; Fahmi, Muhammad; Soehardiman, Dicky; Utami, Dian Prastiti; Martini, Ni Putu Laksmi Ananda
Jurnal Respirologi Indonesia Vol 46 No 2 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/j57hm670

Abstract

Background: Pleuroscopy is a valuable minimally invasive procedure for evaluating undiagnosed pleural effusion. Rapid diagnosis of malignancy is often needed to reduce procedure time and patient discomfort, particßularly when pleurodesis is planned. Imprint cytology is a quick and simple method, though underutilized in pleuroscopy practice in Indonesia. This study aims to compare the diagnostic yield of imprint cytology and histopathology in pleural effusion cases undergoing pleuroscopy. Methods: This observational cross-sectional study was conducted in September–October 2024, involving patients with pleural effusion who underwent diagnostic pleuroscopy. Pleural biopsies were taken using forceps. Imprint cytology was performed by directly smearing the biopsy tissue onto slides, followed by staining. Histopathology was done using standard tissue processing. Results: Of the 25 patients who underwent pleuroscopy during September–October 2024, 14 met the inclusion criteria. Pleuroscopic findings varied, with the most common being lump of mass (35.7%), followed by multiple nodules (21.4%) and sago nodules (14.3%). Histopathology revealed malignancy in 10 patients (71.4%) and nonspecific inflammation in 4 (28.6%). Imprint cytology detected malignancy in 12 patients (85.7%) and infection in 2 (14.3%).   Conclusion: Imprint cytology offers a rapid, reliable alternative to frozen section analysis during pleuroscopy, especially in resource-limited settings. It may increase diagnostic sensitivity for malignancy and facilitate timely clinical decision-making.
Rapid Onset of Cutaneous Adverse Drug Reaction to 2HPMZ/2HPM: A Case Report Widiarto, Pandu; Azzumar, Farchan; Putriana, Khansa; Burhan, Erlina
Jurnal Respirologi Indonesia Vol 46 No 2 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/2me4aq90

Abstract

Background: The World Health Organization (WHO) has endorsed the 4-month tuberculosis (TB) regimen, 2HPMZ/2HPM (Isoniazid, Rifapentine, Moxifloxacin, Pyrazinamide), as a non-inferior alternative to the standard six-month course, representing a major advancement in global TB control. While large clinical trials established its general safety, real-world data and management on its adverse drug reaction (ADR), particularly cutaneous adverse drug reactions (CADRs), remains limited.  Case Presentation: We present a case of a 19-year-old male initiated on the 2HPMZ/2HPM regimen for pulmonary TB. Within 30 minutes of treatment initiation, the patient developed a maculopapular erythematous rash on both arms and legs. Given the mild degree, the treatment is continued along with Cetirizine and Prednisone administration.  Discussion: CADR is the most common and visible ADR of Anti Tuberculosis Drugs. The clinical severity of ADR extends from mild, severe, to life-threatening, however, most of the CADRs are mild. Grading the CADR is very important to determine proper management. In this case, continuing treatment after mild CADR is demonstrated to be safe and sufficient. Conclusion: Our experience demonstrates the safety and feasibility of maintaining the full 2HPMZ/2HPM regimen despite mild cutaneous manifestations, thus avoiding treatment interruption, the need for complex re-challenge protocols, and potential treatment failure.

Page 38 of 38 | Total Record : 378

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