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INDONESIA
JFIOnline
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.
Arjuna Subject : -
Articles 443 Documents
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Bioaktivitas Ekstrak n-Heksana dan Alkaloida Kasar Kulit Batang Actinodaphne macrophylla (Blume) Nees var angustifolia Koord & Valeton Rachmatiah, Tiah; Subaryanti, .
Jurnal Farmasi Indonesia Vol 6, No 2 (2012)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (337.013 KB) | DOI: 10.35617/jfi.v6i2.127

Abstract

Bioactivies of n-hexane extract and crude alkaloid extract from stem bark of Actinodaphne macrophylla (Blume) Nees var angustifolia Coordinator. & Valeton (Lauraceae) have been investigated. The plants of Lauraceae family are known to contain active compounds such as alkaloids, lactones, fatty acids, terpenes and essential oils. Phytochemical screening of the bark exhibited that it contains triterpenoids, alkaloids and tannins. N-hexane extract was prepared by maceration and the crude alkaloid extract was prepared by maceration in dichloromethane after the powdered bark was previously moistened with 25% NH4OH. The bioactivity assays involved the test of toxicity against brine shrimp larvas (Artemia salina Leach), cytotoxicity against Murine P-388 cells and antimalarial against Plasmodium falciparum. The results indicated that n-hexane extract was active against shrimps larvas with LC50 value of 85.11 ppm, and against P.falciparum with IC50 values of 1.824 ppm, but inactive against Murine P-388 cells with IC50 values of 43.0 ppm, while the crude alkaloid extract was active against shrimp larvas with LC50 value of 36.31 ppm, against Murine P-388 cells with IC50 values of 5.2 m ppm, and against P.falcifarum with IC50 value of 0.1 ppm.Keywords : Lauraceae, Actinodaphne, bioactivity, alkaloids, extract.
Farmakokinetika Rifampisin akibat Praperlakuan Jus Kulit Buah Manggis pada Tikus Wistar Jantan Pradana, Dimas Adhi; Hayati, Farida; Praptiwi, .
Jurnal Farmasi Indonesia Vol 7, No 2 (2014)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v7i2.162

Abstract

Aim of this study was to determine the effect of pre-treatment of mangosteen rind juice on the pharmacokinetics of rifampicin on white male Wistar rats. Rats (10) devided into 2 groups, each group consisted of 5 rats. Group I rats were given a dose of rifampicin 50 mg/kg body weight as the control group. Group II rats were given pre-treatment  mangosteen rind juice 200 mg/kg for 7 days and then on day 8 were given rifampicin 50 mg/kg and ma ngosteen rind juice 200 mg/kg as the treatment group. On the hour of 0,25; 0,5; 1; 1,5; 2; 3; 4; 6; 8; 10; 12 and 24  blood sample was taken and then deter-mined the rifampicin plasma levels by HPLC. The results obtained produced curve rifampicin levels in the blood versus time and pharmacokinetic parame-ters of rifampicin such AUC0-â?? , AUMC0-â??, and MRT and MRT can be determined.The results showed that pre-treatment mangosteen rind juice did not have a signiÏ?icant effect on the pharmacokine tics of rifampicin based parameters AUC0-â??, AUMC0-â??, and MRT.Keywords: pharmacokinetics, mangosteen rind, rifampicin Penelitian ini bertujuan untuk mengetahui pengaruh praper-lakuan jus kulit manggis terhadap proϐil farmakokinetika rifampisin pada ti-kus Wistar jantan. Hewan uji terdiri dari 2 kelompok, tiap kelompok terdiri dari 5 ekor tikus. Kelompok I, tikus diberi rifampisin dengan dosis 50 mg/kg BB sebagai kelompok kontrol. Kelompok II tikus diberi praperlakuan jus kulit manggis 200 mg/kg BB selama 7 hari kemudian pada hari ke-8 diberi rifampisin 50 mg/kg BB sebagai kelompok perlakuan bersama jus kulit mang-gis 200 mg/kg BB. Pada jam ke 0,25; 0,5; 1; 1,5; 2; 3; 4; 6; 8; 10; 12; dan 24 di-ambil sampel darah kemudian ditetapkan kadar rifampisin dalam sampel da-rah dengan HPLC. Hasil yang diperoleh dibuat kurva kadar rifampisin dalam plasma terhadap waktu kemudian ditentukan nilai parameter farmakokinetik rifampisin seperti AUC0-â??, AUMC0-â??, dan MRT. Hasil penelitian menunjukkan bahwa pemberian praperlakuan jus kulit manggis tidak memberikan penga-ruh yang signiϐikan terhadap farmakokinetika rifampisin berdasarkan para-meter AUC0-â??, AUMC0-â??, dan MRT.Kata kunci: farmakokinetika, kulit manggis, rifampisin
PERBANDINGAN EFEK ANTIPIRETIK ANTARA IBUPROFEN DENGAN CAMPURAN IBUPROFEN DAN KAFEIN Juwita, Dian Ayu; Noviza, Deni; Erizal, .
Jurnal Farmasi Indonesia Vol 7, No 4 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.937 KB) | DOI: 10.35617/jfi.v7i4.185

Abstract

ABSTRAK Ibuprofen merupakan kelompok obat anti inflamasi non steroid yang mempunyai efek antiinflamasi, analgetik dan antipiretik. Penggunaannya sebagai antipiretik semakin meningkat di masyarakat. Pada sediaan farmasi, obat-obat antipiretik sering dikombinasikan penggunaannya bersama kafein. Penelitian ini bertujuan untuk mengetahui perbandingan efek antipiretik dari ibuprofen murni dengan campuran ibuprofen dan kafein. Penelitian ini menggunakan 15 ekor tikus putih jantan berumur 2-3 bulan yang dibagi menjadi 3 kelompok uji. Kelompok I diberi Na-CMC 1% dan larutan pepton 5%. Kelompok II diberi Ibuprofen murni dosis 5,4 mg/ 200 gram BB dan larutan pepton 5%. Kelompok III diberi Campuran Ibuprofen : Kafein ; 0,4 : 0,6 dosis 5,4 mg/ 200 gram BB dan larutan pepton 5%. Pengukuran suhu dilakukan sebelum pemberian larutan pepton, 3 jam setelah pemberian larutan pepton, dan tiap 30 menit setelah perlakuan hingga menit ke 150 menggunakan termometer digital. Data penurunan suhu dianalisa secara statistik menggunakan uji ANOVA dan uji lanjut duncan. Hasil penelitian menunjukkan adanya perbedaan secara bermakna (p < 0,05) pada penurunan suhu antara ibuprofen murni dengan campuran ibuprofen dan kafein, ini artinya efek antipiretik campuran ibuprofen dan kafein lebih tinggi dibandingkan dengan ibuprofen murni.   Kata kunci : Efek antipiretik, Ibuprofen, Kafein   ABSTRACT   Ibuprofen is a group of non-steroid anti-inflammatory drugs which have anti-inflammatory, analgesic and antipyretic effect. The using of Antipyretic is increase in society. In pharmaceutical product, antipyretic drugs often combined with caffeine. This research is done to find out the comparation of antipyretic effect between ibuprofen and combination of ibuprofen with caffeine. This research used 15 male white rats which aged between 2-3 months and divided into three groups. Group I received Na-CMC 1 % and peptone solution 5 %. Group II received Ibuprofen with dose 5.4 mg/200 g BW and peptone solution 5 %. Group III received combination of Ibuprofen : Caffeine ; 0.4 : 0.6 with dose 5.4 mg/ 200 g BW and peptone solution 5 %. Temperature measurement was conducted before and 3 hours after giving peptone solution, and every 30 minutes post treatment until 150 minutes using a digital thermometer. The data was analyzed by statistical ANOVA and further duncan test. The results showed significant differences (p< 0.05) in the temperature drop between ibuprofen and combination of ibuprofen with caffeine, it means that the antipyretic effect on the combination of ibuprofen and caffeinn is higher than ibuprofen only.
UJI DIFUSI MIKROEMULSI NITROGLISERIN MENGGUNAKAN TWEEN 80 SEBAGAI SURFAKTAN Yati, Kori; Situmorang, Almawati; Umoro, Ani
Jurnal Farmasi Indonesia Vol 9, No 1 (2017)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (9030.693 KB) | DOI: 10.35617/jfi.v9i1.557

Abstract

ABSTRACT: Nitroglycerine is a drug of choice in the treatment of angina pectoris. Nitroglycerine has low dose, short time of plasma half life and liver metabolizing. This study used the formulation of microemulsion. The advantages of microemulsion transparent form, stable and has better skin penetration due to the smaller size of its droplet. This study aims at determining concentration of Tween 80 as surfactant as penetration in the nitroglycerine microemulsion. Tween 80 concentrations used were 40% (F1), 42,5% (F2) and 45% (F3). Penetration ability was tested by invitro using Franz diffusion cells. The results showed that 42,5% of the concentration of Tween 80 produces good penetration. F2 shows the measurement result of droplet size is 69,0 nm and diffusion test on the minutes of 180 for 86,00% ± 3,65. It can be concluded that the concentration of Tween 80 as surfactant of 42,5% gives microemulsion nitroglycerine with good penetration.
ANALISIS EFEKTIVITAS BIAYA PENGGUNAAN INSULIN DIBANDINGKAN KOMBINASI INSULIN-METFORMIN PADA PASIEN DIABETES MELITUS TIPE 2 Primadiamanti, Annisa; Andayani, Tri Murti
Jurnal Farmasi Indonesia Vol 4, No 3 (2009)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i3.21

Abstract

The use of metformin in insulin therapy hopefully could increase effectiveness of type 2 diabetes treatment equal with the expenditure. Non experimental research was conducted to investigate cost-effectiveness of insulin use and insulin-metormin combination. Data was taken prospectively from baseline until month 3. The measurable cost was direct medical cost which covered cost of antidiabetic drugs, cost of complication drugs, doctorâ??s fee, and cost of laboratory checkup. The measurable effectiveness of therapy was reduction of FPG and HbA1c level. ACER (average cost-effectiveness ratio) was calculated based on cost and effectiveness ratio in both groups. ICER (incremental cost-effectiveness ratio) was calculated based on difference of cost and effectiveness ratio in both groups. Results showed FPG level reduction in insulin group and insulin-metformin combination consecutively was 25,05% and 1,03%. Increase of HbA1c level in insulin group and insulin-metformin combination consecutively was 6,21% and 1,87%. Based on HbA1c level reduction, ACER value in insulin group and insulin-metformin combination consecutively was Rp -37.617,00 and Rp -161.729,00, ICER value was Rp 15.860,00. From the results it can be concluded that insulin-metformin combination was more cost-effective than insulin in maintaining HbA1c level. ABSTRAK Penelitian ini dirancang untuk mengetahui efektivitas biaya pada pasien DM tipe 2 yang menggunakan insulin dan kombinasi insulin-metformin. Data diambil secara prospektif dari baseline hingga bulan ke-3. Analisis efektivitas biaya dilakukan dengan perspektif ASKES. Komponen biaya yang diukur adalah biaya medik langsung, mencakup biaya antidiabetik, biaya komplikasi, biaya kunjungan ke klinik dan biaya pemeriksaan laboratorium. Efektivitas terapi yang diukur adalah penurunan kadar GDP dan HbA1c. ACER (average cost-effectiveness ratio) dihitung berdasarkan rasio biaya dan efektivitas terapi pada kedua kelompok terapi. ICER (incremental cost-effectiveness ratio) dihitung berdasarkan rasio antara selisih biaya dan efektivitas terapi pada kedua kelompok terapi. Hasil penelitian menunjukkan penurunan kadar GDP pada kelompok insulin dan kombinasi insulin-metformin berurutan adalah 25,05% dan 1,03%. Peningkatan kadar HbA1c pada kelompok insulin dan kombinasi insulin-metformin berurutan adalah 6,21% dan 1,87%. Berdasarkan penurunan kadar HbA1c, nilai ACER pada kelompok insulin dan kombinasi insulin-metformin berurutan adalah Rp -37.617,00 dan Rp -161.729,00, nilai ICER adalah Rp15.860,00. Berdasarkan hasil penelitian dapat disimpulkan bahwa kombinasi insulin-metformin lebih cost-effective dalam mempertahankan kadar HbA1c.
PERBANDINGAN RESPON IMUNOLOGI EMPAT KOMBINASI ANTIRETROVIRAL BERDASARKAN KENAIKAN JUMLAH CD4 Mariam, Siti; Radji, Maksum; Budi, Erwanto
Jurnal Farmasi Indonesia Vol 5, No 3 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i3.51

Abstract

This research was conducted to determine the differencies in immunological response of the four first-line antiretroviral combination, that is lamivudin-Zidovudin-Nevirapin, lamivudin-Zidovudin-Evapirenz, lamivudin-Stavudin-Nevirapin and lamivudin Stavudin-Evapirenz, which were based on increase in CD4 of patients and the factors influencing it in patients HIV / AIDS in Dr. H. Mahdi Marzoeki Bogor. The study was conducted retrospectively using data from Medical Record (MR) patients from March 2006 until March 2010 on patients who had CD4 examination every 3-4 months for using antiretroviral. Provided for descriptive analysis and statistical analysis were 335 patients and 73 patients resfectively . The results showed that the increase in the average patient's CD4 count were different for their four combinations of antiretroviral drugs, but on the basis of statistical tests using ANOVA showed that differences in CD4 cell increase were not significant. Factors patient's age, number of opportunistic infections, CD4 early and drugs used to treat opportunistic infections did not affect the increase in CD4 of patients.   ABSTRAK Penelitian ini dilakukan untuk mengetahui perbedaan respon imunologi dari empat kombinasi antiretroviral lini pertama yaitu Lamivudin-Zidovudin-Nevirapin, Lamivudin-Zidovudin-Evapirenz, Lamivudin-Stavudin-Nevirapin dan Lamivudin-Stavudin-Evapirenz berdasarkan peningkatan  CD4 pasien dan faktor-faktor yang mempengaruhinya pada pasien HIV/ AIDS di Rumah Sakit Dr. H. Marzoeki Mahdi Bogor.  Penelitian dilakukan secara retrospektif menggunakan data dari Catatan Medik (MR) pasien dari bulan Maret 2006 sampai Maret 2010 pada pasien yang mempunyai hasil pemeriksaan CD4 setiap 3-4 bulan selama menggunakan antiretroviral. Diperoleh 335 pasien untuk analisis deskriptif dan 73 pasien untuk analisis statistik. Hasil penelitian menunjukkan bahwa kenaikan CD4 rata-rata pasien berbeda dari keempat kombinasi ARV, tetapi berdasarkan uji statistik menggunakan ANOVA menunjukkan bahwa perbedaan kenaikan CD4 tidak bermakna. Faktor-faktor umur pasien, jumlah infeksi oportunistik, CD4 awal dan obat yang digunakan untuk mengobati infeksi oportunistik tidak mempengaruhi kenaikan CD4 pasien.
PENGEMBANGAN FORMULASI TABLET PREDNISON SECARA KEMPA LANGSUNG DENGAN TEKNIK DISPERSI PADAT Syukri, Yandi; Mulyanti, Eka
Jurnal Farmasi Indonesia Vol 3, No 3 (2007)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i3.83

Abstract

Prednison adalah obat yang digunakan untuk menekan sistem imun dan inflamasi yang sukar larut dalam air. Penelitian ini dilakukan dengan tujuan untuk menaikkan kelarutan prednison pada proses formulasi melalui pembentukan dispersi padat menggunakan polivinilpirolidon (PVP). Formulasi tablet prednison secara kempa langsung dengan teknik dispersi padat dibuat dengan 5 variasi konsentrasi PVP 1, 2, 3, 4, dan 5%. Sebagai  pembanding digunakan kontrol negatif yaitu yang mengandung 0% PVP. Serbuk dispersi padat yang diperoleh diuji sifat alirnya meliputi waktu alir dan sudut diam untuk optimasi metode kempa langsung. Tablet yang dihasilkan diuji sifat fisiknya meliputi keseragaman bobot, kekerasan, kerapuhan dan waktu hancur serta sifat kimianya (uji disolusi). Hasil evaluasi sifat fisik tablet menunjukkan bahwa semua formula memenuhi persyaratan yang tercantum dalam Farmakope Indonesia edisi IV dan kepustakaan lainnya. Data yang diperoleh dari uji disolusi dianalisis menggunakan ANAVA dengan taraf kepercayaan 95 %. Hasil dari penelitian ini menunjukkan adanya peningkatan laju disolusi prednison dibanding dengan kontrol negatif yaitu formula I 0,35%; formula II 0,64% ; formula III 0,12% ; formula IV 15,9% dan formula V 27,37%. Hasil perhitungan DE30 dari seluruh  formula yaitu 65,98% untuk formula I; formula II 66,16%; formula III 74,55%; formula IV 80,37%; formula V 91,02%, sedangkan pada kontrol negatif memiliki DE30 63,47% dan kontrol positif 83,94%. ABSTRACT Prednisone is a drug, used to provide relief for inflamed areas of the body which insoluble in water. The aim of this research was to increased the solubility of prednisone to formulation process by solid dispersion system using polyvinnilpyrrolidon(PVP). Direct compression prednisone tablet formulation by solid dispersions teknique was made with 1, 2, 3, 4 and 5 % PVP variation concentration and a compatitor used the formula with 0% PVP (negative control). The mass powder of solid dispersion that have got, tested about the fisical and the chemistry point include  the flowing time and angle of repose to optimate direct compresiion method. Tablet yields was tested its physical characteristics include uniform weigh, hardness, friability, disintegration and dissolution. Dissolution data was analized statistically used ANAVA. The result showed that there were an increased percentage of prdnisone disolution compared with negative control ( 0% PVP), e.a : 0,35% for 1st formula; 0,64% for 2nd formula ; 3rd formula 0,12% ;  4th formula 15,9% dan 5th formula  27,37%. The disolution efficiency from all of the formula are 65,98% for formula I; formula II 66,16%; formula III 74,55%; formula IV 80,37%; formula V 91,02%. DE30 of  negative control 63,47% and for positive control 83,94%.
Koproses Karagenan-Pragelatinasi Pati Singkong Propionat sebagai Eksipien Sediaan Tablet Mengapung Junaedi, .; Iskandarsyah, .; Anwar, Effionora
Jurnal Farmasi Indonesia Vol 6, No 4 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.675 KB) | DOI: 10.35617/jfi.v6i4.140

Abstract

The aim of this study was to prepare floating tablet dosage forms using coprocessed of kappa and iota carrageenan and pregelatinized cassava starch propionate (PPSP) as excipients. In this study, tablets were made by wet granulation method and using famotidine as a model drug. Several formulations of floating tablets were prepared using varying composition of the excipients coprossed carragenan with a certain ratio. The swelling and bupyancy of the floating tablets were evaluated. Furthermore, the drug release from the floating tablets were studied and analyzed using several models of kinetic equations. The result showed that formula A with excipients coprocessed carragenan (1:1) as much as 60% with 10% HPMC produce the best formula with floating lag time 11.42±1.53 minutes and total floating time for 22 hours. The formula also revealed a profile of controlled drug release and approached to Higuchi kinetics model and the non Fickian diffusion mechanism.Keywords : carragenan, PCSP, coprocess exipients, floating tablets.
Identifikasi Interaksi Padat Campuran Parasetamol dan Ibuprofen dengan Metode Thermal Noviza, Deni; Zaini, Erizal
Jurnal Farmasi Indonesia Vol 7, No 3 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (97.432 KB) | DOI: 10.35617/jfi.v7i3.190

Abstract

Solid-state interaction between parasetamol and ibuprofen was studied using thermal and spectroscopic techniques. Parasetamol-Ibuprofen binary mixtures were prepared by rotary ball mill grinding method. Differential scanning calorimetry was used to investigate the stoichiometry and thermal properties of the complex between parasetamol and ibuprofen. Powder X-ray diffraction were used to investigate the type of interaction between the two components. Two endothermic peaks in a binary mixture of paracetamol and ibuprofen was observed in DSC thermograph. X-ray powder diffractogram do not shows shift and formation of new peaks and the position of each peak is a super-imposition of each component without dominates. It can be concluded that the solid interaction between paracetamol and ibuprofen for grinding effect is the formation of mixed crystal system.
Pengaruh pemberian fraksi air kulit buah delima (Punica granatum L) terhadap jumlah duktus payudara tikus yang diovariektomi Sunarmi, Sunarmi; Bahtiar, Anton; Wuyung, Puspita Eka
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (619.422 KB) | DOI: 10.35617/jfi.v8i2.512

Abstract

Pomegranate (Punica granatum L.) is known to have estrogenic activity. Pomegranate peel proven to increase the number of osteoblasts and increases bone density. This study aims to determine the potential of the water fraction of the pomegranate peel as natural Selective Estrogen Receptor Modulators (SERMs) through histological mammary in ovariectomized rats. Ovariectomy method used as a model representing menopause, conducted on 42 rats female Sprague Dawley strain aged 50 days were divided into 7 groups: Sham, OVX, and a group of OVX, each getting estradiol, tamoxifen and fractions water pomegranate peel dose of 50, 100, and 200 mg/kg BW. The results obtained showed water fraction of pomegranate peel did not show any increase in volume and number of mammary ducts.

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