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INDONESIA
JFIOnline
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.
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Articles 443 Documents
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Evaluasi Kuantitatif Penggunaan Antibiotik pada Pasien Caesarean Section di RSUD se-Kabupaten Banyumas Kusuma, Anjar Mahardian; Galistiani, Githa Fungie; Wijayanti, Dwi Nur; Umami, Muzayanatul; Nurdiyanti, .; Utaminingrum, Wahyu; Sudarso, .
Jurnal Farmasi Indonesia Vol 8, No 1 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.912 KB) | DOI: 10.35617/jfi.v8i1.245

Abstract

ABSTRACT : Antibiotics usage in woman having caesarean section is assumed 5-fold greater than woman having normal labor. The aim of the study is to count the antibiotics usage in patient having caesaren section in several hospitals in Banyumas, i.e. RSUD Prof. DR. Margono Soekarjo, RSUD Ajibarang, and RSUD Banyumas. This study use cross sectional study design, retrospective data collection of medical records and data were statistically analyzed with Mann- Whitney and Kruskal-Wallis. Results of the study showed that the greatest quantity of antibiotic use was in RSUD Ajibarang with 110.75 DDD/100 patient- days, followed by RSUD Prof. DR Margono Soekarjo and RSUD Banyumas respectively 76.20 DDD/100 patient-days and 46.07 DDD/100 patient-day. The comparison of DDD for each antibiotic in three hospitals showed a significant difference on antibiotic amoxicillin and cefotaxime usage. Keywords : antibiotics, DDD, caesarean section ABSTRAK : Penggunaan antibiotik pada pasien caesarean section diperkirakan 5 kali lipat lebih banyak dibandingkan pada persalinan normal. Penelitian ini bertujuan untuk menghitung kuantitas penggunaan antibiotik terapi pada pasien caesarean section di beberapa rumah sakit di kabupaten Banyumas, yaitu RSUD Prof. DR. Margono Soekarjo, RSUD Ajibarang, dan RSUD Banyumas. Penelitian ini menggunakan rancangan studi potong lintang (cross sectional), pengambilan data dilakukan secara retrospektif terhadap rekam medik dan data dianalisis dengan analisis statistik Man-Whitney and Kruskal-Wallis. Dari hasil penelitian ini diperoleh data bahwa kuantitas penggunaan antibiotik terbesar terjadi di RSUD Ajibarang yakni 110,75 DDD/100 pasien-hari kemudian diikuti RSUD Prof. DR. Margono Soekarjo dan RSUD Banyumas dengan masing-masing 76,20 DDD/100 pasien-hari dan 46,07 DDD/100 pasien-hari. Hasil perbandingan DDD tiap antibiotik di tiga rumah sakit menunjukkan adanya perbedaan bermakna nilai DDD antibiotik amoksisilin dan sefotaksim di tiga rumah sakit tersebut. Kata kunci: antibiotik, DDD, caesarean section
EFEK EKSTRAK DAUN MENGKUDU (Morinda citrifolia L.) TERHADAP JUMLAH PROTEIN GLUT4 PADA TIKUS PUTIH HIPERGLIKEMIK Kirtishanti, Aguslina; Budiono, Ryanto; Ratih, .; Isfandiari, Fitria
Jurnal Farmasi Indonesia Vol 4, No 2 (2008)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i2.10

Abstract

Difficulties in finding anti-diabetics which are effective, tolerable by the patients, safe, cause people to try to find other alternative, such as taking traditional medicine like â??mengkuduâ? [Morinda citrifolia L.]. Mengkudu fruit had been proven to be able to increase the number of protein GLUT4 at type 2 diabetic male white ratâ??s sceletal muscle. Fruit of mengkudu has similar chemical ingredient with its leaves. So far, however, mengkudu leaves had not been studied to increase the number of protein GLUT4 at sceletal muscle. This study use male white rats Wistar strain. Total number of white rats involved in this study were 40 rats which treated : 10 rats as negative control group [no treatment], 10 rats as positive control group and they are treated with exogen insulin 0,35 U per body weight three times daily for 10 days. The last 20 rats is divided into 2 groups with 10 rat for each group as first trial group and second trial group. The trial group are treated with exogen insulin and first trial group were given water extract of mengkudu leaves 7,5 g per body weight and second trial group were given alcohol extract of mengkudu leaves 1,8 g per body weight twice daily which were administered starting from the seventh to tenth day of exogen insulin administration. After ten days of administration, blood glucose level of all rats was measured and all rats were killed afterwards. The next step is sceletal muscle tissue processing to be painted immunohistochemistry to GLUT4. Conclusion of the result is water extract and alcohol extract of mengkudu leaves  could not increase the number of protein GLUT4 at type 2 diabetic male white rats. ABSTRAK Kesulitan mendapatkan obat antidiabetes yang efektif dan aman menyebabkan pasien mencoba obat alternatif, misalnya dengan menggunakan obat tradisional â??mengkuduâ? (Morinda citrifolia L.). Buah mengkudu telah terbukti dapat meningkatkan jumlah protein Glut4 pada otot rangka tikus putih jantan diabetik. Buah mengkudu memiliki kandungan kimia yang hampir sama dengan daunnya. Oleh sebab itu dalam penelitian ini dilakukan penelitian untuk mengetahui apakah daun mengkudu juga dapat meningkatkan jumlah protein Glut4 seperti buahnya. Dalam penelitian ini digunakan 40 tikus putih jantan strain Wistar yang dibagi menjadi 4 kelompok, yaitu kelompok kontrol negatif, kelompok kontrol positif yang diberi insulin eksogen 0,35 U per berat badan tiga kali sehari selama 10 hari, kelompok perlakuan pertama yang diberi ekstrak air daun mengkudu 7,5 g per kg berat badan, dan kelompok perlakuan kedua yang diberi ekstrak alkohol daun mengkudu 1,8 g per kg berat badan dua kali sehari mulai hari ke-7 sampai hari ke-10. Kadar gula darah diukur setelah hari ke-10. Jaringan otot rangka diambil dan dilakukan pewarnaan untuk melihat protein Glut4. Dari hasil penelitian yang diperoleh disimpulkan bahwa ekstrak air dan alkohol daun mengkudu tidak dapat meningkatkan jumlah protein Glut4 pada tikus putih jantan diabetik tipe 2.
PENINGKATAN LAJU PELARUTAN TRIMETOPRIM MELALUI METODE KO-KRISTALISASI DENGAN NIKOTINAMIDA Zaini, Erizal; Halim, Auzal; Soewandhi, Sundani N.; Setyawan, Dwi
Jurnal Farmasi Indonesia Vol 5, No 4 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i4.57

Abstract

Co-crystallization of trimethoprim with nicotinamide had been done using solvent (methanol as a solvent) and melted technique. Koflerâ??s hot contact methode was used to identify the solid state interaction between these two components. The solid phase was characterized by microscopic, powder X-ray diffraction, thermal DTA and FT-IR spectroscopy analysis. Dissolution rate profile was performed by  paddle methode (Type II USP), distilled water as a medium. Solid state interaction between trimethoprim and nicotinamide show a formation of  conglomerate (simple eutectic) at eutectical point 125 0C. Dissolution rate of co-crystallization product of trimethoprim and nicotinamide increase  significantly compare to physical mixture and intact trimethoprim. ABSTRAK Telah dilakukan ko-kristalisasi trimetoprim dengan bahan tambahan nikotinamida dengan metode pelarutan (menggunakan pelarut metanol) dan peleburan. Metode kontak panas Kofler digunakan untuk identifikasi awal pembentukan interaksi antar kedua komponen. Padatan hasil ko-kristalisasi dikarakterisasi  dengan analisis mikroskopik, difraksi sinar-X, termal DTA dan spektrofotometer FT-IR. Uji laju pelarutan dilakukan dengan metode dayung (tipe II USP) dengan medium air. Hasil interaksi menunjukkan pembentukan konglomerat (eutektikal) antara kedua fase kristalin dalam keadaan padat, dengan titik eutektik pada temperatur 125 0C. Laju pelarutan trimetoprim hasil ko-kristalisasi meningkat secara signifikan dibandingkan dengan campuran fisika dan senyawa tunggal trimetprim.
KEJADIAN REAKSI OBAT YANG TIDAK DIKEHENDAKI YANG MENYEBABKAN PASIEN USIA LANJUT DIRAWAT DI RSCM Christianie, Merry; Setiati, Siti; Trisna, Yulia; Andrajati, Retnosari
Jurnal Farmasi Indonesia Vol 3, No 4 (2007)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i4.89

Abstract

Study had been conducted on adverse drug reaction (ADR) that cause older patient enter the internist ward Rumah Sakit Dr. Cipto Mangunkusumo in Mei-Juli 2005, to study the incidence proportion, frequent clinical manifestation, and the medication cause the event. Study had been done using cross-sectional design, and the causal evaluation was done using Naranjo algorithm. Total patient included in this study was 102. Incidence proportion of ADR that cause older patient enter the internist ward Rumah Sakit Dr. Cipto Mangunkusumo was 14.7%. One of 15 ADR was catagorized as â?definiteâ?, while the other 14 were categorized as â??probableâ?. The most clinical manifestations were gastrointestinal bleeding and hypoglicaemic shock. Medications responsible for these event were mostly NSAID (non-steroidal anti inflammation drug) dan oral hypoglycaemic drug.   ABSTRAK Telah dilakukan penelitian tentang kejadian reaksi obat yang tidak dikehendaki (ROTD) yang menyebabkan pasien usia lanjut dirawat di ruang perawatan penyakit dalam Instalasi Rawat Inap B Rumah Sakit Dr. Cipto Mangunkusumo, periode Mei-Juli 2005 untuk mengetahui proporsi kejadian, manifestasi klinik yang sering terjadi dan obat yang sering menyebabkannya. Penelitian dilakukan dengan menggunakan desain studi potong lintang (cross-sectional) dan untuk penilaian kausalitas ROTD digunakan algoritma Naranjo. Total pasien yang ikut serta dalam penelitian ini berjumlah 102 orang. Diperoleh proporsi kejadian ROTD yang menyebabkan pasien usia lanjut dirawat di ruang perawatan penyakit dalam Instalasi Rawat Inap B Rumah Sakit Dr. Cipto Mangunkusumo sebesar 14,7% (interval kepercayaan 95%: 11,2-18,2%). Satu dari 15 ROTD yang terjadi dikategorikan pasti (definite) dan 14 kejadian dikategorikan besar kemungkinan (probable). Manifestasi klinik terbesar adalah perdarahan saluran cerna dan penurunan kesadaran karena hipoglikemi. Obat yang sering menyebabkan pasien dirawat karena ROTD tersebut adalah obat anti-inflamasi non-steroid (NSAID) dan obat hipoglikemi oral.
Rasionalitas Penggunaan Antibiotil dan Antijamur Pasien Infeksi Menular Seksual di Puskesmas Sekabupaten Banyumas Purnamasari, Rizky; Purnomo, Dwi Kristian; Susanti, .; Setiawan, Didik
Jurnal Farmasi Indonesia Vol 6, No 4 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (406.81 KB) | DOI: 10.35617/jfi.v6i4.146

Abstract

This study aimed to find out hte rational in the use of antibiotic and antifungal of the patients with sexually transmitted infections at community health centers at banyumas district. Type of research was observational descriptive with cross sectional study and the data was taken retrospectively from medical records of patients. From all patients  who entered the study population, 112 patiens positive vulvavaginal candidiasis, 57 patients positive cervicitis and 39 patients positive bacterial vaginosis. Average age of patients affected by STIs were 24 years, female. Based on patients complaints, symptoms, and the laboratory results, we have found that candidiasis patients were treated with nystatin, cervicitis with a combination of azithromycin and cefixime, whereas patients with bacterial vaginosis were treated with metronidazole. The use of antibiotic and antifungals as the treatment of sexually transmitted infections at community health centers at Banyumas district is based on parameters of the right medicine, right dose, proper indications, appropriate patient, and at the lowest cost to them and always available to their community are 100% rational.Keywords : rationality, antibiotic, sexually transmitted infections
CHEMICAL CONSTITUENTS AND ANTIBACTERIAL ACTIVITIES OF LEAVES OF SUMATRAN KING FERN (Angiopteris evecta G. Forst HOFFM.) Anggia, Vivi -; Bakhtiar, Amri; Arbain, Dayar -
Jurnal Farmasi Indonesia Vol 7, No 4 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (676.668 KB) | DOI: 10.35617/jfi.v7i4.193

Abstract

ABSTRACT : 4,5-dihydro-4-hydroxy-5-methyl-1H-pyran-1-one (2), angiopteroside (3) and well known stigmast-5-en-3--ol (1) have been isolated from the leaves of  Sumatran King fern Angiopteris evecta G. Forst HOFFM. and investigated for their antimicrobial activities towards some human pathogenic bacteria. Angiopteroside (3) showed potential activities to inhibit the growth of Bacillus subtilis. Keywords: Angiopteris evecta, 4,5-dihydro-4-hydroxy-5-methyl-1H-pyran-1-one,  Angiopteroside, antibacterial. ABSTRAK : 4,5-dihidro-4-hidroksi-5-metil-1H-piran-1-one (2), angiopteroside (3) dan senyawa yang umum stigmast-5-en-3--ol (1) berhasil diisolasi dari daun tumbuhan paku gajah Angiopteris evecta G. Forst HOFFM. dan diuji aktivitas antibakterinya terhadap beberapa bakteri patogen manusia. Angiopteroside (3) menunjukan aktivitas daya hambat terhadap pertumbuhan bakteri Bacillus subtilis. Kata kunci: Angiopteris evecta, 4,5-dihidro-4-hidroksi-5-metil-1H-piran-1-one, angiopteroside, antibakteri
Tonic Effects Test of Pegagan (Centella asiatica L.) Syrups on White Male Mice Sunarti, Sunarti; Keswara, Yane Dila; Purnamasari, Nuraini Dewi
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.933 KB) | DOI: 10.35617/jfi.v8i2.518

Abstract

Centella asiatica L., or known as pegagan leaf, empirically can be used as a tonic for organs such as liver, kidneys and brain. It also can increase memory. In our society, Centella asiatica L., hasnâ??t been optimally processed as atonic. Commonly, it is processed by boiling or grating the leaf. Raw consumption of this leaf inflicts bad taste. The aim of this research is to find out tonic effect and determine the effective dose of herbal syrup Centella asiatica L. The effect of tonic can be determined using natatory exhaustion method, by observing stimulant effect of a certain drug to an animal.Methods : This research used male mice were divided into 5 groups of treatment. The first group: negative control without herbal syrup Centella asiatica L., substance, positive control 50 mg/kg body weight, first dose group 120 mg/kg miceâ??s body weight, second dose group 150 mg/kg miceâ??s body weight and third dose group 180 mg/kg miceâ??s body weight. The effect of tonic was observed through the increasing duration of the miceâ??s self-defense ability when it was swum.Result: This research resulted that the use of herbal syrup Centella asiatica L., gave tonic effect on dose 120 mg/kg miceâ??s body weight, 150 mg/kg miceâ??s body weight, and 180 mg/kg miceâ??s body weight. The most effective dose of the use of herbal syrup Centella asiatica L., is on dose 180 mg/kg miceâ??s body weight.
PROBLEM PEMILIHAN OBAT PADA PASIEN RAWAT INAP GERIATRI DI RSUP DR. SARDJITO YOGYAKARTA Rahmawati, Fita; Ellykusuma, Nany Yusuf; Pramantara, I Dewa Putu; Sulaiman, Syed Azhar Syed
Jurnal Farmasi Indonesia Vol 4, No 1 (2008)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i1.6

Abstract

Old age is associated with chronic diseases and disabilities, which in turn require multiple medications. This often complicate diagnosed and appropriate drug therapy. The aim of the study was to determine types and number of inappropriate drug in geriatric patients in Bougenville Ward Dr. Sardjito Hospital Yogyakarta. Research type is descriptive. Data taken prospectively during two period, January to February 2006 and Agust to October 2006. The study was conducted in 100 geriatric patients hospitalized with inclusion criteria 65 years old and above and admission into Bougainville ward (interne department) RSUP Dr. Sardjito Hospital, Yogyakarta. Data collecting was conducted through medical record then adjustment of inappropriate drug of choice was identified by pharmacist-physician discussion. Evaluation of the data was carried out descriptively. The result of the study showed that inappropriate drug of choice occurred in 48 cases. This problem include more effective drug available 12 cases, contraindication present 15 cases, dosage form inappropriate 2 cases, condition refractory to drug 1 case, drug not indicated (unsafe) for condition 9 cases, patient received unnecessary multiple drug combination 9 cases. The finding of our study support pharmacist in collaboration between physician-pharmacist-nurse can effectively reduce incidence of Drug Related Problems in geriatric patient. ABSTRAK Penelitian ini bertujuan untuk mengetahui jumlah dan persentase Drug-Related Problems (DRPs) yang terjadi pada pasien geriatri di Bangsal Bougenville IRNA I RSUP Dr. Sardjito Yogyakarta. Penelitian bersifat deskriptif, pengambilan data dilakukan secara prospektif pada 100 pasien dengan kriteria pasien berumur lebih dari 60 tahun dan menjalani rawat inap di bangsal Bougenville IRNA I bagian Penyakit Dalam RSUP Dr. Sardjito. Data diambil pada 2 periode waktu yaitu bulan Januari â?? Februari 2006 dan bulan Agustus-Oktober 2006. Identifikasi Drug Related Problem (DRP) terkait dengan pemilihan obat yang tidak tepat dilakukan melalui diskusi dengan klinisi. Analisis data selanjutnya dilakukan secara deskriptif. Hasil penelitian menunjukkan bahwa problem pemilihan obat yang tidak tepat terjadi sejumlah 48 kasus. Problem ini meliputi obat yang diterima pasien bukan merupakan obat yang paling tepat 12 kasus, pasien menerima kombinasi obat yang tidak diperlukan sebanyak 9 kasus, obat dikontraindikasikan pemakaiannya untuk pasien sejumlah 15 kasus, obat tidak aman bagi kondisi pasien 9 kasus, bentuk sediaan tidak tepat 2 kasus, obat yang digunakan sudah merupakan obat yang paling tepat namun pada kasus tersebut tidak efektif sejumlah 1 kasus. Untuk mengurangi kejadian Drug-Related Problems (DRPs) pada pasien geriatri diperlukan peningkatan peran aktif farmasis serta kerja sama diantara tenaga medis dalam memberikan pelayanan kesehatan.
EFFECTS OF PENTAGAMAVUNONAT-0 SODIUM ON RAT ISOLATED-AORTIC SMOOTH MUSCLE CONTRACTION Nugroho, Agung Endro; Sendari, Siti; Soraya, Fenthy; Margono, Supardjan A.
Jurnal Farmasi Indonesia Vol 5, No 2 (2010)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i2.38

Abstract

Natrium pentagamavunonat-0 merupakan bentuk garam dari senyawa pentagamavunon (PGV-0). Modifikasi PGV-0 menjadi bentuk garam dimaksudkan untuk meningkatkan kelarutannya. Pada penelitian ini, natrium PGV-0 diuji pengaruhnya terhadap kontraksi otot polos aorta terisolasi yang diinduksi agonis reseptor a1 adrenergik, yaitu fenilefrin. Disamping itu, natrium PGV-0 juga dipelajari efek relaksasi pada organ tersebut. Hasil penelitian menunjukkan bahwa natrium PGV-0 menghambat kontraksi otot polos aorta tikus secara bermakna. Senyawa tersebut dapat menurunkan baik harga pD2 maupun efek maksimum dari fenilefrin. Disampimg itu, natrium PGV-0 menunjukkan efek relaksasi yang poten pada organ tersebut, dengan nilai pD2 sebesar 4,41. Berdasarkan hasil tersebut disimpulkan bahwa natrium PGV-0 menunjukkan efek yang poten pada otot polos aorta terisolasi yang diinduksi agonis reseptor a1 adrenergik.   ABSTRACT PGV-0 is reported possessing some pharmacological effects such as anti-cancer, anti-allergy, anti-inflammatory, anti-oxidative etc. Its effects are more potent than curcumin. However, this compound has limitation in its solubility. Modifying the compound to its salt form is supposed to overcome this problem. The aim of the research is to investigate the effects of PGV-0 sodium on rat isolated-aortic smooth muscle contraction, and its relaxant effect on the tissue. The study was conducted using an isolated organ technique with an isotonic transducer. The percentage of response either contraction or relaxation was then plotted as a logaritmic scale of concentration-response curve to calculate pD2 value, a negative logaritmic of concentration of drug inducing 50% of maximum effect. The results have shown that treatment of PGV-0 sodium obviously inhibited the contraction of rat isolated-aortic smooth muscle induced by phenylephrine. The compound could decrease both pD2 and Emax values of phenylephrine significantly. The results indicate that PGV-0 sodium could attenuate both potency and intrinsic activity of contraction effect of phephylephrine. Besides, the compound also stimulated relaxant effects to a single phenylephrine contraction with pD2 value of 4.41. The compound could restore phenylephrine-induced tension into baseline level. Based on the results, PGV-0 sodium showed potent effects on rat isolated-aortic smooth muscle.
PENGARUH 1,5-BIS(4’-HIDROKSI-3’-METOKSIFENIL)-1,4-PENTADIEN-3-ON DAN KURKUMIN PADA AKTIVITAS ENZIM GLUTATION S-TRANSFERASE PARU TIKUS Yuniarti, Nunung; Martono, Sudibyo
Jurnal Farmasi Indonesia Vol 3, No 1 (2006)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i1.70

Abstract

Curcumin was proved to have activity as GST inhibitor. 1,5-bis(4â??-hydroxy-3â??-methoxyphenyl)-1,4-pentadien-3-on which is curcumin analog, was predicted to have  same activity as curcumin. This experiment was conduct to verify that prediction, aimed to revealed the influence of 1,5-bis(4â??-hydroxy-3â??-methoxyphenyl)-1,4-pentadien-3-on as well as curcumin on rat lung GST activity  in vitro, using  1-chloro-2,4-dinitrobenzene (CDNB) as substrate. GST activity was determined using conjugation reaction of glutathione (GSH) with CDNB. GS-DNB conjugate formed was measured using spectrophotometry at l 345 nm between 0-3 minutes by simple kinetic program, result in certain rate (D absorption/minute). Using similar method, conjugation reaction was done, however with addition of 1,5-bis(4â??-hydroxy-3â??-methoxyphenyl)-1,4-pentadien-3-on and curcumin as inhibitor. Inhibition effect followed by the decreasing of reaction rate.  From the result it was concluded that  1,5-bis(4â??-hydroxy-3â??-methoxyphenyl)-1,4-pentadien-3-on and curcumin can inhibit mice lung GST activity with  IC50 value 9,13 mM and 13,32 mM. ABSTRAK Kurkumin dilaporkan memiliki aktivitas sebagai inhibitor GST. Senyawa 1,5-bis(4â??-hidroksi-3â??-metoksifenil)-1,4-pentadien-3-on yang merupakan senyawa analog kurkumin, diprediksikan memiliki aktivitas yang relatif sama dengan kurkumin. Oleh karena itu, dari hasil prediksi tersebut perlu dilakukan verifikasi dengan uji laboratoris. Penelitian ini bertujuan untuk mengetahui pengaruh senyawa 1,5-bis(4â??-hidroksi-3â??-metoksifenil)-1,4-pentadien-3-on dan kurkumin pada aktivitas GST paru tikus dengan substrat 1-kloro-2,4-dinitrobenzen (CDNB) secara in vitro. Aktivitas GST ditentukan menggunakan reaksi konjugasi glutation (GSH) dengan substrat CDNB. Konjugat GS-DNB yang terbentuk diukur secara spektrofotometri pada l 345 nm antara menit ke 0-3 menggunakan program simple kinetic, menghasilkan suatu rate (D serapan/menit). Dengan cara yang sama dilakukan reaksi konjugasi namun dengan penambahan senyawa 1,5-bis(4â??-hidroksi-3â??-metoksifenil)-1,4-pentadien-3-on dan kurkumin sebagai inhibitor. Adanya efek inhibisi diketahui dari penurunan rate. Dari hasil penelitian dapat disimpulkan bahwa senyawa 1,5-bis(4â??-hidroksi-3â??-metoksifenil)-1,4-pentadien-3-on dan kurkumin menghambat GST paru tikus dengan IC50 berturut-turut adalah 9,13 mM dan 13,32 mM.

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