Jurnal Ilmu Kefarmasian Indonesia
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
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<![CDATA[Sintesis Analog 3-0-Benzylstentorin sebagai Prekursor untuk Kerangka Dasar Blepharismin ]]>
<![CDATA[TENI ERNAWATI]]>;
<![CDATA[YOSHINOSUKE USUKI]]>;
<![CDATA[HIDEO IIO]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[A Method for the synthesis of precursor for the basic skeleton of blepharismin and structural analog was described. Such compound is identified as potential drug for the treatment of antiviral and photodynamic therapy. Benzyl stentorin analog as the basic skeleton of blepharismin was effectively synthesized via reaction one of hydroxyl groups in bianthraquinone derivative with p-methoxybenzylchloride in the presence of potassium carbonate as base. Dimerization of bromo anthraquinone derivative produced dimmer in 55% while the formation of compounds analogous of 3-0-benzylstentorin resulted in 70% yield.]]>
<![CDATA[Transformasi Plasmid pTRLI ke dalam Protoplas Aspergillus terreus dengan Penambahan Polietilenglikol ]]>
<![CDATA[DUDI HARDIANTO]]>;
<![CDATA[MARLIA SINGGIH]]>;
<![CDATA[AMIR MUSADAD]]>;
<![CDATA[WAHONO SUMARYONO]]>;
<![CDATA[TUTUS GUSDINAR]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Plasmid transformation is the introduction and incorporation of exogenous plasmid into cells or protoplast. The purpose of this research is transformation of pTRLI plasmid into protoplasts of Aspergillus terreus and obtain stable transformants. The research was initiated by isolation of pTRLI plasmid and determining its purity and concentration by nanodrop machine. Furthermore, protoplasts of A. terreus were isolated enzymatically by addition of chitinase, cellulase, and maserozyme enzymes. pTRLI plasmid was transformed into protoplasts of A. terreus by addition of calcium chloride and polyethyleneglycol (PEG) solutions. These transformants were grown in Czapek-Dox agar medium containing pyrithiamine 1 mg/L and the number of transformants/µg of pTRLI plasmid was calculated. The number of transformants were produced ranging from 12 to 19 transformants/µg of pTRLI plasmid. The success of the transformation was indicated by ptrA gene in transformants that could be amplified by PCR of 801 base pairs in size. It was concluded that PEG solution could be used to transform pTRLI plasmid into protoplasts of A. terreus and transformants are stable up to live generations by growing the transformants in Czapek-Dox agar medium containing pyrithiamine 1 mg/L.]]>
<![CDATA[Isolasi dan Karakterisasi Golongan Senyawa Antibakteri Streptococcus mutans dari Ekstrak Etanol Daun Sosor Bebek (Kalanchoe pinnata (Lamk.) Pers. ]]>
<![CDATA[NOVI YANTIH]]>;
<![CDATA[LISIA MARGARET]]>;
<![CDATA[KARTININGSIH KARTININGSIH]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Streptococcus mutans is one of the microbes which is responsible for the cause of bad breath. The activity of Kalanchoe pinnata (Lamk.) Pers. leaves ethanol extract is four times stronger than the water extract in inhibiting the growth of Streptococcus mutans. The aim of research is to isolate and characterize an antibacterial compound of ethanol extract of Kalanchoe pinnata (Lamk.) Pers. leaves. The extract was fractionated using column chromatography. The fractions were purified by TLC and the isolate were tested for its purity using HPLC. Isolate was characterized using UV-Vis spectrophotometry and FTIR. Fractionation by column chromatography generated 9 fractions. The fraction VII have the highest diameter of inhibitory against Streptococcus mutans. The yield of isolate was 9.18% of the fraction VII or 0.84% of the ethanol extract with purity of 95%. Isolate was suspected as a group of saponin compound.]]>
<![CDATA[Uji Aktivitas Antioksidan, Kandungan Fenolik Total, dan Kandungan Flavonoid Total Buah Merah ]]>
<![CDATA[NI MADE DWI SANDHIUTAMI]]>;
<![CDATA[A.A WIWIEK INDRAYANI]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Antioxidants are compounds which have ability to inhibit free radical reactions in the human body. Objectives of this research are to evaluate the antioxidant activities of extract and fractions from Pandanus canoideus Lam. fruits, to determine total phenolic and total flavonoid contents, and to correlate the total phenolic and total flavonoid contents of those fractions with their antioxidant activities. The Pandanus conoideus Lam. fruits or locally known as “buah merah” were extracted by methanol, then evaporated and dissolved in aquadest. This solution is subsequently partitioned using chloroform and ethyl acetate to obtain chloroform, ethyl acetate, and water fractions. The antioxidant activities were determined by radical scavenging assay using DPPH (2,2-diphenyl-1-picrylhydrazyl) radical. The total phenolic and total flavonoid contents were determined by mean of spectrophotometry. The results showed that fractions of water, ethyl acetate, and chloroform revealed antioxidant activities with IC50 values of 399.06, 10.41, 1416.68 µg/mL respectively, whereas the methanolic extract of Pandanus conoideus Lam. fruits before partition has IC50 of 186.31 µg/mL. The antioxidant activities of these extract and fractions are lower than that of vitamin E (IC50 8.27 µg/ml). A linier positive relationship existed between the total phenolic contents of these extract and fractions with their antioxidant activities as shown by equation of y = 13.085x + 754.91; r2 = 0,3641, while the correlation between the total flavonoid contents and their antioxidant activities revealed a linier regression of y = -282.9x + 868.05; r2 = 0.4484.]]>
<![CDATA[Produksi Beta-Glukan dari Saccharomyces cerevisiae dan Aktivitas Antioksidan pada Sel Darah Merah yang Diinduksi t-BHP ]]>
<![CDATA[KUSMIATI KUSMIATI]]>;
<![CDATA[NI WAYAN S. AGUSTINI]]>;
<![CDATA[SWASONO R. TAMAT]]>;
<![CDATA[BAYU RIANTO]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Beta glucan is a polysaccharide that can be found in cereals, yeast, bacteria, and algae. Beta glucan produced by Saccharomyces cerevisiae has the ability to enhance the body’s defense system. The study aims to investigate the antioxidant activity of B glucan produced by three strains of Saccharomyces sp BR 1, BR 2,and SC. Antioxidant activity assay was carried out in vitro on t BHP induced red blood cells (REC) by observing the level of catalase activity, SOD activity and MDA levels as lipid peroxidation product. The investigation was performed on 6 groups: normal control, negative control, positive control (RBC+ t-BHP + vitamin E 100 IU), and samples (RBC+t-BHP) treated with 1.4 µg/mL β-glucan from Saccharomyces strain BR1, BR2 and SC respectively. Saccharomyces cerevisiae strain SC produced the highest β-glucan of 88.70% (glucose equivalent), while the BR1 and BR2 of 22.56% and 46.28% respectively. Antioxidant activity assay showed that the highest increase in catalase activity (581.48%) was given by the B glucan from SC strain, the highest increase of SOD activity and decrease of MDA levels were given by the β- glucan from BR1 strain (359.17% and 48.18%) as compared to negative controls. Statistical test (α = 0.05) showed antioxidant activity of β-glucan from Saccharomyces Sp BR2 and SC did not differ significantly from the activity of vitamin E (100 IU).]]>
<![CDATA[Pemodelan Statistik Pemberian Air Susu Ibu (ASI) Eksklusif Berdasarkan Faktor Demograli ]]>
<![CDATA[SARAH ZAIDAN]]>;
<![CDATA[SWASONO R. TAMAT]]>;
<![CDATA[NURITA ANDAYANI]]>;
<![CDATA[ANNY VICTOR PURBA]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Exclusive breastfeeding is defined as giving breast milk to a baby without any additional drink, food or beverages during the first 6 months after birth. Today there is a decline in exclusive breastfeeding, and among others, one reason is the increase in the participation of mothers in the workforce, especially in urban areas. Many factors that affect the regularity of exclusive breastfeeding by working mothers, one of which, is the demographic factor. This study aims to obtain profile data of exclusive breastfeeding by working mothers and statistical modelling of exclusive breastfeeding by working mothers based on demographic factor, by conducting a survey on 384 respondents. This research uses descriptive analysis and logistic regression analysis with SPSS software version 15.0. Descriptive analysis showed that most mothers working in Jakarta (61.2%) did not give exclusive breastfeeding. Logistic regression statistical analysis showed that age, occupation, distance to work, and travel time to the workplace of working mothers are dominant factors that influence exclusive breastfeedings, with the p-value is smaller than the p value (Sig) = 0.05.]]>
<![CDATA[Aktivitas Anti Agregasi Platelet dan Aktivitas Antitrombosis Ekstrak Etanol Daun Cinco (Cyclea barbata Miers.) ]]>
<![CDATA[MARISSA ANGELINA]]>;
<![CDATA[SRI HARTATI]]>;
<![CDATA[INDAH DEWI]]>;
<![CDATA[LIA MEILAWATI]]>;
<![CDATA[IMACULATA IWO]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[The research about anti aggregation platelet and antithrornbotic activity of ethanol extract of Cinco (Cyclea barbata Miers.) (Cb) leaves in mice has been conducted. The background of the research has been reported in vitro anti aggregation platelet and antithrombotic activity of Cb extract. The purpose of this research to know the effect of Cb extract in anti aggregation platelet, antithrombotic activity, prolonged the tail bleeding and coagulation time. The results of the present study indicate that the extract of Cb leaves significantly inhibit platelet aggregation in mice, prolonged tail bleeding time, coagulation time in mice, and thrombotic forming (acute). All of the above measurement have been analyzed significantly using One Way ANOVA programme. Cyclea barbata Miers. significantly prevented death due to thrombus protection whereas as in dose dependent manner. Cyclea barbata Miers. showed significant prolongation of the mice tail bleeding time compared to the control in low dose (150 mg/kg BW). Cyclea barbata Miers. significantly prolonged coagulation time compared to the control in dose dependent manner. The experiment on in vivo anti platelet aggregation showed that Cb (150 mg/kg BW and 300 mg/kg BW) could significantly inhibit aggregation which induced by ADP compared with control. The conclusion of this research is that the extract of Cb leaves has an anti aggregation platelet activity and antithrombotic activity in dose 150. mg/kg BW and 300 rug/kg BW.]]>
<![CDATA[Pengaruh Pemberian Ekstrak Akar Pasak Bumi Terstandar terhadap Gambaran Histopatologik Testis dan Konsentrasi Testosteron pada Tikus ]]>
<![CDATA[FARIDA HAYATI]]>;
<![CDATA[SITARINA WIDYARINI]]>;
<![CDATA[LUKMAN HAKIM]]>;
<![CDATA[NGATIDJAN NGATIDJAN]]>;
<![CDATA[MUSTOFA MUSTOFA]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[The root of pasak bumi (Eurycoma longifolia, Jack) is one of plant from Indonesia known as aphrodisiac. This study was conducted to evaluate the influence of pasak bumi standardized extract to testosterone level and histopathological changes of the testes in male Wistar rats. Sample were 50 adult male rats aged 3 4 months were divided into 5 groups. Group I (control) was given distilled water, group II (positive control), was given testosterone (Andriol ®), group III, IV, and V were each given a standardized extract of the roots of pasak bumi doses of 50, 100, and 200 mg/kg of body weight, respectively. The extract was given orally twice a day for six days and forty nine days and then testes was taken out on 7th and 50th day. Testosterone level was assayed on 7th and 50th day by the ELISA methods. The results were analyzed using one way ANOVA, and post hoc Dunnet (2-sided) (p < 0.05). The data of this study shows that treatment with water extract of pasak bumi root influence the number of Leydig cells that would also increase the concentration of testosterone in Wistar male rats positively at a dose of 100 mg/kg and 200 mg/kg body weight.]]>
<![CDATA[Uji Sitotoksisitas Fraksi Aktif dan Senyawa Murninya yang Dihasilkan oleh Kapang Endoiit Tanaman Obat dari Lombok Timur terhadap Sel MCF-7 ]]>
<![CDATA[ERWAHYUNI ENDANG PRABANDARI]]>;
<![CDATA[TUN TEDJA IRAWADI]]>;
<![CDATA[WAHONO SUMARYONO]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[Screening for citotoxicity has been conducted on 36 endophytic fungi isolated from medicinal plants in East Lombok. Isolates were cultivated in 100 mL potato dextrose yeast extract medium in 250 mL Erlenmeyer, incubated at 28°C and shaked in 150 rpm for 10 days. Broth was extracted with buthanol, ethyl acetate and dichloromethane. Extracts were concentrated under vacuum concentrator and assayed for citotoxicity against Artemia salina using the BSLT method. Screening using 100 mg/L of crude extract showed that 9 extracts were active out of 108 extracts assayed. Further screening based on LC50 showed that the ethyl acetate extract from fungus ENLT 74.3d.2 was the most active with LC 50=30.21 mg/L. Fungus was isolated from Cibotium barometz and described as Curvularia lunata. The most active extract was fractionated by column silica gel 60 and eluted using hexane, ethyl acetate, and methanol. These fractions showed that the ethyl acetate fraction was the most active fraction (LC50 = 4.69 mg/L). Purification was conducted by HPLC using column C18 and eluted by gradient system of acetonitril water 15% to 100% in 25 minutes. The active compound retention time was 14-16 min, λmax = 233 nm, and at 5 mg/L could inhibit 28% MCF-7 cell proliferation.]]>
<![CDATA[Sitotoksisitas terhadap Sel Leukemia L1210 dan Profil Kromatogram dari Serbuk Temu Putih Curcuma zedoaria (Berg) Rosc. yang Diradiasi ]]>
<![CDATA[ERMIN KATRIN W.]]>;
<![CDATA[JOHANS RICHARD ALBERT]]>;
<![CDATA[SWASONO R. TAMAT]]>;
<![CDATA[SUSANTO SUSANTO]]>;
<![CDATA[HENDIG WINARNO]]>
<![CDATA[ JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 1 (2012): JIFI ]]>
Publisher : <![CDATA[Fakultas Farmasi Universitas Pancasila ]]>
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<![CDATA[White turmeric Curcuma zedoaria (Berg) Rosc. is useful for treating cancer disease. It is very susceptible to microbial, therefore gamma irradiation technique to reduce microbial contamination is necessary in order to extend the storing period. Gamma irradiation on white tumeric was carried out by cobalt-60 source at doses of 5, 7.5, 10, and 15 kGy. Then they gradually were maeerated with n-hexane, ethyl acetate, and ethanol. The purpose of this research was to study the effect of gamma irradiation by observing parameters on the cytotoxic activity of ethyl acetate extract and active fraction of white tumeric rhizome against L1210 leukemia cells, also profiles of thin layer and HPLC chromatograms of active fraction as anticancer agent. Ethyl acetate extract of irradiated and control samples were the most active to inhibit the growth of L1210 leukemia cells with IC50 value of 4.71 ug/mL. Ethyl acetate extracts from irradiated and control samples were fractionated using column chromatography and obtained 7 fractions (Fr), respectively. Fraction 3 of control sample was the most active fraction with IC50 values 1.43 µg/ ml. The IC50 value of Fr 3 decreased with increasing irradiation doses and chromatogram profiles of radiated samples with doses of > 5 kGy were changed. The maximum radiation dose for white turmeric preservation is 7.5 kGy, at this dose its anticancer efficacy was maintained.]]>
