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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 18 Documents
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Search results for , issue "Vol 14 No 1 (2016): JIFI" : 18 Documents clear
Efek Antioksidan Ekstrak Etanol Biji Pepaya (Carica papaya L.) terhadap Aktivitas Enzim Superoksida Dismutase dan Kadar Malondialdehid pada Mencit Stress Oksidatif dengan Perenangan NI MADE DWI SANDHIUTAMI; YESI DESMIATY; AFIZZA ANBAR
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Biji pepaya mengandung vitamin E dan flavonoid yang diketahui memiliki aktivitas sebagai antioksidan. Tujuan penelitian ini untuk mengetahui efek antioksidan ekstrak etanol biji pepaya (Carica papaya L.) terhadap aktivitas SOD sel darah merah dengan metode adenokrom dan kadar MDA plasma dengan metode TBARs pada mencit yang diberi aktivitas fisik perenangan. Mencit diberi ekstrak etanol biji pepaya selama 7 hari dan perenangan selama 65 menit pada hari ke-7. Pengujian ini menggunakan 36 ekor mencit yang dibagi 6 kelompok, yaitu kelompok I (normal), kelompok II (kontrol negatif), kelompok III (kontrol positif vitamin E), kelompok IV (dosis 0,105 g/kg bb), kelompok V (dosis 0,210 g/kg bb) dan kelompok VI (dosis 0,420 g/kg bb). Hasil penelitian kelompok I, II, III, IV, V, VI berturut-turut untuk aktivitas SOD sel darah merah adalah 89±6,4329; 47,37±3,8225; 85,56±3,9210; 46,35±10,0929; 58,89±3,8271 dan 81,59±5,7700 U/mL, kadar MDA plasma berturut-turut adalah 1,6831±0,0942; 6,3567±0,1046; 1,3697±0,2254; 4,7914±0,2139; 3,8231±0,3574 dan 1,7560±0,1215 nmol/mL. Ekstrak etanol biji pepaya dosis 0,420 g/kg bb memberikan efek antioksidan paling tinggi.
Isolasi Senyawa Flavonoid dari Ekstrak Metanol Daun Katuk (Sauropus androgynus (L.) Merr), Euphorbiaceae RATNA DJAMIL; SARAH ZAIDAN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Katuk (Sauropus androgyrus (L.) Merr) is one of the plants used for medicinal purposes. It has been carried out the research to isolate and to identify flavonoid compounds in the methanol extract of katuk leaves using paper chromatography and spectrophotometry ultraviolet-visible. The results demonstrated that light spectrum of uv-visible in the presence of a reagent gave an isolate NB-3 which was a compound suspected of flavonol with OH group in positions 5,7,4 ‘and o-di OH groups in the position of the A-ring (6,7 or 7,8) whrereas NB-4 isolate was suspected as flavonoids with OH groups at 5.7 and the prenil groups in position 6, methylation or glycosylation at OH group in a position 3 and o-di OH groupsin position of the a-ring (6,7 or 7,8).
Synthesis and Structure Elucidation of 1,3 bis(p-Hydroxyphenyl)urea HARI PURNOMO; UMAR ANGGARA JENIE; AGUNG ENDRO NUGROHO; HARNO DWI PRANOWO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Paracetamol is a well known and commonly used analgesic-antipyretical agent. However, it exhibits hepatotoxic side effect if used for the long term or using exessive dose (10-15 g for single dose). A new compound of 1.3 bis (p-hydroxyphenyl)urea (code-name as HP2009) is an analgesic agent, and it is predicted that its hepatotoxic side effect is lower than that of paracetamol. The compound HP2009 was succesfully synthesized. The result showed that by using molar ratios of p-aminophenol and urea 2:9.5, pH 1 for reaction condition, refluxing for about 1 hr and evaporating time was set up for 30 minutes, the yield of HP 2009 will be 99.49%. The crystals obtained was characterized using spectroscopic methods, and showed undoubtedly that the product was 1.3 bis(p-hydroxyphenyl)urea.
Pemodelan Molekul, Sintesis dan Penentuan Aktivitas Antineoplastik 1-(4-Trifluorometilbenzoiloksi)Urea SUKO HARDJONO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

To design new drugs, physical-chemical characteristics of drug molecules can be predicted by in silico test before drugs are synthesized. Ribonucleotide reductase is the main target or receptor of antineoplastic compounds such as hydroxyurea (HU) and its derivatives like 1-(4-trifluoromethylbenzoyloxy)urea or 4-CF3BOU. This compound forms a complex with crystal structure of ribonucleotide reductase I enzyme, which is 2EUD. The hydrogen bond and bond energy in the form of rerank score from both complexes was calculated with Molegro program. Theoretically, compound activity is indicated by rerank score. The compound whose rerank score is small is predicted to have greater activity. The activity of 4-CF3BOU was found to be greater than HU. The reaction mechanism of synthesis 4-CF3BOU was the substitution of nucleophilic hydroxyl group from HU to carbonyl group of 4–trifluoromethylbenzoyl chloride (4-CF3BCl). Purity test was conducted using TLC and melting point. Structure identification was performed based on the spectra of UV-VIS, FT-IR, H/C-NMR and MS. In this study, 4-CF3BOU was discovered to have antineoplastic activity with the IC50 value of 82.37 μg/mL and was tested towards HeLa cells. On the other hand, HU had the IC50 value of 430.21 μg/mL. The antineoplastic activity of 4-CF3BOU was greater than HU.
Uji Efek Anti-Inflamasi dan Analgesik Infusa Daun Senggani (Melastoma malabathricum L.) LESTARI RAHAYU; RIKA SARI DEWI; GUSRITA AYU
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Secara empiris penggunaan daun senggani mempunyai kemampuan sebagai anti-inflamasi dan analgesik. Penelitian ini bertujuan menguji efek anti-inflamasi dan analgesik dari infusa daun senggani. Pada uji anti-inflamasi menggunakan metode Winter, tikus dibagi menjadi 5 kelompok yaitu kelompok kontrol negatif diberi air suling, kontrol positif diberi natrium diklofenak 1,8 mg/200 g bb, kelompok uji diberi infusa daun senggani 2,8 mL/200 g bb dengan konsentrasi 10%, 20% dan 40%. Setelah 30 menit diinduksi karagenan 1%, 0,2 mL/200 g bb. Pada pengujian analgesik menggunakan metode Sigmund, mencit dibagi menjadi 5 kelompok yaitu kelompok kontrol negatif diberi air suling, kontrol positif diberi natrium diklofenak 0,26 mg/20 g bb, kelompok uji diberi infusa daun senggani 0,4 mL/20 g bb dengan konsentrasi 10%, 20% dan 40%. Setelah 30 menit diinduksi asam asetat 3%, 0,2 mL/20 g bb. Dari hasil ANOVA satu arah infusa daun senggani dengan dosis 2,8 mL/200 g bb dengan konsentrasi 10%, 20% dan 40% mempunyai efek sebagai anti-inflamasi dan infusa daun senggani dosis 0,4 mL/20 g bb dengan konsentrasi 10%, 20% dan 40% mempunyai efek sebagai analgesik. Infusa daun senggani dengan dosis 2,8 mL/200 g bb dengan konsentrasi 10%, 20% dan 40% mempunyai efek anti-inflamasi yang lebih rendah dibandingkan natrium diklofenak dan infusa daun senggani dosis 0,4 mL/20 g bb dengan konsentrasi 10%, 20% dan 40% mempunyai efek analgesik yang lebih rendah dibandingkan natrium diklofenak. Peningkatan dosis infusa daun senggani tidak memberikan peningkatan efek sebagai anti-inflamasi maupun analgesik.
Penentuan Kadar Genistein dan Aktivitas Hambatan Tirosinase Kedelai (Glycine max) Terfermentasi Aspergillus oryzae ESTIKA YUNINDARWATI; EVI UMAYAH ULFA; ENDAH PUSPITASARI; MOCHAMMAD AMRUN HIDAYAT
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Tujuan dari penelitian ini adalah menentukan kadar genistein dan aktivitas hambatan dari ekstrak kedelai terfermentasi dan non-fermentasi. Kedelai difermentasi oleh Aspergillus oryzae selama 4 hari dan dimonitor kadar genistein serta aktivitas hambatan tirosinase setiap hari. Kadar genistein ditentukan menggunakan densitometer-KLT sedangkan aktivitas hambatan tirosinase dievaluasi menggunakan metode spektrofotometri. Hasil penelitian menunjukkan bahwa kadar genistein meningkat pada saat fermentasi hari ke-1 sampai ke-3 (45,645-1256,042 μg/g ekstrak) tetapi pada hari ke-4 kadarnya menurun (54,373 μg/g ekstrak). Aktivitas hambatan tirosinase juga mengalami peningkatan pada saat fermentasi hari ke-1 sampai ke-3 (dilihat pada nilai IC50) dan menurun saat fermentasi hari ke-4. Disimpulkan bahwa kadar genistein berkaitan dengan aktivitas hambatan tirosinase (R2 = 0,949).
Isocratic High Performance Liquid Chromatographic Method for Determination of Metoprolol and Its Metabolite in Human Urine PRI ISWATI UTAMI; SUGIYANTO SUGIYANTO; SUDIBYO MARTONO; LUKMAN HAKIM
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

An isocratic reversed phase high performance liquid chromatographic (HPLC) method has been developed for the determination of metoprolol (MET) and α-hydroxymetoprolol (α-OH MET) in human urine. Analytes were extracted using dichloromethane. The optimized separations were performed on a Purospher® STAR RP-18e LiChroCART® (250 x 4.6 mm, 5μm) HPLC column within 12 min by an isocratic elution with 25 mmol/L aqueous potassium dihydrogen phosphate buffer (pH 3.0) containing 15% (v/v) acetonitrile and 15% (v/v) methanol, and UV detection at 234 nm. The method was validated for linearity, accuracy, precision and specificity. The calibration curves for both analytes were linear over the range investigated (1.0-64.0 μg/mL) with correlation coefficients of 0.999. Relative standard deviation (RSD) values were below 2%. For all of the analytes, recoveries value from 98.36±1.68 to 101.32±1.36 % and the limits of detection for MET and α-OH MET were 0.22 and 0.14 μg/mL, respectively. The method developed has been demonstrated to be sensitive and reliable for the measurement of MET and α-OH MET simultaneously in human urine.
Antihypertensive and Diuretic Effects of The Ethanol Extract of Colocasia esculenta (L.) Schott. Leaves RINI PRASTIWI; SISKA SISKA; ERVINA BHAKTI UTAMI; GIGIH PANGESTU WITJI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Colocasia esculenta (L.) Schott (CE) is traditionally used for the treatment of various ailments such as high blood pressure, diarrhea, rheumatic pain, pulmonary congestion, etc. Hence in present study, the effect of ethanol extract of CE leaves (EECE) was evaluated for antihypertensive and diuretic activity in rats. Male Sprague dawley rats were randomly divided into five groups (n=5), and treated as follow: positive control group (hydrochlortiazide 0.2569 mg/ 200 g bw), negative control (NaCl 8%) and EECE (20, 40 and 80 mg/ 200 g bw) was given 14 days. The parameters systole blood pressure (SBP) and diastole blood pressure (DBP) was estimate by Kent Scientific’s CODA Non-invasive Blood Pressure on the days 0, 15 and 29. Diuretic activity of EECE was studied based on the volume of urine for 6 hours and measuring the levels of sodium in urine 24 hours. The result of the study showed that EECE 40 mg/ 200 g bw/ day significant (p<0.05) decreased in SBP 16.07% and in DBP 13.67%. EECE 40 mg/ 200 g bw/day showed positive diuretic activity and significantly (p < 0.05) increased sodium levels in urine. Preliminary phytochemical evaluation revealed the presence of saponins, tannin, triterpenoid and flavonoids in EECE.
Activity Tests of Bioactive Material of Salung Leaf (Psychotria viridiflora Reinw. Ex. Blume) against Salmonella thypi Bacteria In Vitro And In Vivo SALNI SALNI; HANIFA MARISA; HARMIDA HARMIDA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Activity test of bioactive material of Salung leaf (Psychotria viridiflora Reinw. ex. Blume) against Salmonella thypi in vitro and in vivo has been carried out. Bioactive material was obtained from the maceration and followed by fractionation of liquid-liquid fractionation. Antibacterial activity test performed in vitro to determine the value of the minimum inhibitory concentration (MIC) and in vivo to determine the ability of bioactive cure diarrhea in in rats (Rattus norvegicus) infected by Salmonella typhi. Treatment of bioactive material given is 0, 10, 50 and 100 mg kg-1 of weight. The results showed that the MIC of salung leaf’s bioactive material to Salmonella typhi was 250 μg mL-1. Bioactive ingredient at dose of 10 and 50 mg kg-1 were able to decrease the number of bacterial colonies to 4.14x106 cfu g-1 and 5.4x105 cfu g-1, less than 5.04x106 cfu g-1 as control. Bioactive material in weight of 100 mg kg-1 of weight could reduce the population of Salmonella typhi to zero after 12 days of treatment. The ability to reduce the amount of bacterial colonies of the bioactive material 100 mg kg-1 of weight is equal to the ability of positive control chloramphenicol 10 mg kg-1 of weight.
The Effectiveness of GABA Agonist in Decreasing Expression of NR2B Subunit of N-Methyl-D-Aspartate (NMDA) Receptor in Neuropathic Mice by Partial Sciatic Nerve Ligation (PSNL) Method FIFTEEN APRILA FAJRIN; JUNAIDI KHOTIB; IMAM SUSILO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Neuropathy pain is a pain that caused by nerves injury. Nowadays, treatment for neuropathic pain change to drugs that works as GABA agonist and cause reimbalance between excitatory and inhibitory neurotransmitter in central nervous system (CNS). The present study was designed to investigate the effectiveness of gabapentin and baclofen in decreasing N-Methyl-D-Aspartate (NMDA) receptor NR2B subunit activity in neuropathic pain. Fourty mice were divided into 8 groups i.e sham, negative control, gabapentin (10, 30, 100 nmol) and baclofen (1, 10, 30 nmol). Neuropathic pain was induced by ligation of sciatic nerve with Partial Sciatic Nerve Ligation (PSNL) method). Treatments were administrated intrathecally once a day for seven consecutive days, at a week after induction. On day 15th, mice were sacrified and the spinal cord were removed quickly. The expression of NMDA receptor NR2B subunit were examined with imunohistochemistry and data were analyzed by one way anova. The result from this research was gabapentin and baclofen administration significantly decrease expression of NMDA receptor NR2B subunit in mice compared to sham group. The higher the dose, the more effective to decrease the number of neuron that express NR2B. The conclusion of this research was gabapentin and baclofen treat neuropatic pain by decreased the number of NMDA receptor NR2B subunit.

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