Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Jurnal Ilmu Kefarmasian Indonesia

jifi
Website

Published by Universitas Pancasila

ISSN : 16931831 EISSN : 26146495 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 20 Documents

1 2

Search results for , issue "Vol 17 No 2 (2019): JIFI" : 20 Documents clear

¬Potensi Biduri [Calotropis gigantea (L.) W.T. Aiton] sebagai Tanaman Obat Meutia Faradilla; Hilda Maysarah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (414.716 KB)

Calotropis gigantea (L.) W.T. Aiton or known as Biduri in Indonesia has been used in traditional medicine as an anti-inflammatory, antitoxin and antipyretic. This plant is often found in hot and arid climates. Research on the potential of this plant has not been done much in Indonesia. This article aims to examine the potential of Biduri as a source of medicinal plants. The study was carried out by reviewing research literatures of the botanical plants both sourced from international and national journals. The results of the study indicate that various types of extracts from the biduri plant have therapeutic activities for further development. The phytochemical testing and isolation has also been carried out to look for active substances that play a role in the pharmacological activity being tested. Based on the studies that have been carried out, biduri plants have great potential to be researched and further developed to become one of the sources of medicinal plants in Indonesia.

Hewan Model Kanker Ovarium untuk Studi Preklinik dan Pengembangan Obat Kanker Ovarium Ni Made Dwi Sandhiutami; Puspita Eka Wuyung; Wawaimuli Arozal; Melva Louisa; Deni Rahmat
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Treatment for ovarian carcinoma is still far from optimal, animal models are still needed to study human epithelial ovarian cancer. Animal models of ovarian cancer are very important for understanding the pathogenesis of the disease and for testing new treatment strategies. Ovarian carcinogenesis models in mice have been modified and repaired to produce preneoplastic lesions and neoplastic ovaries that are pathogens resembling human ovarian cancer. Although spontaneous ovarian tumors in mice have been reported, some of the shortcomings of existing studies preclude their use as animal models of ovarian cancer. Because of this, many efforts have been made to develop animal models that are relevant for ovarian cancer. Experimental animal models are developed accurately to represent cellular and molecular changes associated with the initiation and development of human ovarian cancer. Accurate experimental models have significant potential in facilitating the development of better methods for early detection and treatment of ovarian cancer. Several animal models of ovarian cancer have been reported, including manipulation of various reproductive factors or exposure to carcinogens. The latest advance in ovarian cancer modeling is using genetically engineered mice.

Formulasi dan Uji Anti Inflamasi Masker Peel Off Ekstrak Etanol Buah Mengkudu (Morinda citrifolia L.) Miratun Syarifah; Nining Sugihartini; Laela Hayu Nurani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Infl ammation of the skin often occurs in acne-prone skin. Acne can be prevented in variousways, one of them by maintaining clean skin. Noni fruit (Morinda citrifolia L.) with the active ingredientof scopoletin has been proven to be eff ective as an anti-infl ammatory. Noni is dried into simplicia,extracted was ethanol 96% solvent until it becomes concentrated extract. The extract is formulated intoa peel off mask with a concentration variation of 5%, 10 and 15%. The masks produced is evaluated forphysical characteristic of pH, viscosity, spreadability, and adhesivity test), as well as anti-infl ammatoryproperties using mice with the parameters of COX-2 expression and irritation test using rabbit. Theevaluation results of the physical characteristic of the peel off mask fulfi lled the physical characteristicrequirements of the peel off mask preparation. Whereas in the viscosity test there were groups thatmet the viscosity requirements, namely the formula I and II groups and the group that did not meet theviscosity requirements, namely the formula III group. Anti-infl ammatory test in mice showed that themask lead to reduction in the amount of COX-2 expression. The best formula in 3 preparations wasindicated in formula I with COX-2 expression value of 22.635%. The results of irritation test on rabbitsdid not cause irritation. According to the test results it can be concluded that the optimum value of theethanol extract concentration is shown in formula I with a concentration of 5%.

Uji In Vitro dan Studi In Silico Senyawa Turunan n’-benzoylisonicotinohydr Ruswanto Ruswanto; Nur Rahayuningsih; Nur Laeli Dwi Hidayati; Ginna Sri Nuryani; Richa Mardianingrum
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

There have been in silico and in vitro studies of N-Benzoylisonicotinohydrazide derivatives as antituberculosis candidates. The aims of this research were determined that the N'-benzoylisonicotinohydrazide derivatives could inhibit the activity of gram-positive, gram-negative and Mycobacterium tuberculosis, as well as having good interactions with Enoyl-Acyl Carrier Protein Reductase from Mycobacterium Tuberculosis. From the in vitro test it was found that the N'-benzoylisonicotinohydrazide compound had a Minimum Inhibitor Concentration (MIC) of 0.33 µg / ml against the Basillus subtilis, while the Minimum Inhibitor Concentration (MIC) of N '- (2-chlorobenzoyl) isonicotinohydrazide against Mycobacterium tuberculosis (H37Rv) was 3.125 µg / ml. From the in silico study, it was found that the binding affinity value between N '- (2-chlorobenzoyl) isonicotinohydrazide enzyme Enoyl-Acyl Carrier Protein Reductase (2X23) had the smallest binding affinity so that it could be predicted that it had a stable interaction than other compounds so that the N '- (2-chlorobenzoyl) isonicotinohydrazide could be used as a more potent antituberculosis candidate.

Analisis In-silico Senyawa Kimia dalam Teh Hijau yang Bekerja pada Aktivator (PPAR-γ) sebagai Antiobesitas Faridah Faridah; Esti Mumpuni; Yudha Iswara Yunanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Teh hijau dikenal banyak memiliki manfaat dan umum digunakan masyarakat sebagai antiobesitas, tetapi senyawa aktif yang berpotensi sebagai antiobesitas. Tujuan penelitian untuk mencari bahwa senyawa kimia yang terdapat dalam tanaman teh hijau mempunyai aktivitas sebagai antiobesitas pada reseptor PPAR-γ. Metode penelitian dilakukan dengan cara analisis in silico melalui molecular docking terhadap senyawa yang terdapat dalam tanaman teh hijau untuk mencari senyawa aktif dan memodelkan interaksi senyawa aktif pada reseptor yang berperan sebagai antiobesitas. Software yang digunakan adalah PLANTS, YASARA, ChemSketch, dan Pymol. Mula-mula dilakukan validasi internal pada reseptor PPAR-γ dengan kode 2ATH. Proses docking dilakukan terhadap native ligand, senyawa pembanding dan masing-masing senyawa uji dengan reseptor PPAR-γ yang sama, dan senyawa pembanding yang digunakan sebagai kontrol positif ialah Pioglitazone. Hasil penelitian menunjukan sisi aktif terdapat 3 senyawa aktif dengan sisi aktif ikatan ligan pada reseptor PPAR-γ yaitu ARG288, LYS367, PHE363, HIS323, HIS449, ILE326, MET364, LEU340, CYS285, SER342. Terdapat 3 senyawa aktif yaitu epigalokatekin-3-galat, epikatekin-3-galat dan teaflavin sebagai antiobesitas dengan mekanisme kerja mengaktivasi PPAR-γ.

Optimasi Nanoemulsi A/M/A Ekstrak Etanol Daun Binahong dan Konjugat AG-Kitosan Menggunakan Desain Box-Behnken Malinda Prihantini; Irda Fidrianny; Tri Suciati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Skin premature aging which is characterized by fine wrinkles can be overcome by stimulating collagen production and inhibiting its degradation, and also reducing corneocyte buildup. Madeira vein has been shown to induce collagen production and inhibit its degradation, while glycolic acid increase desquamation. The aim of this research was to optimize W/O/W multiple nanoemulsion formula of Madeira vein-leaves extract in W1 phase and glycolic acid in W2 phase. Glycolic acid was added after conjugated with chitosan to reduce its stinging effect on skin. The W/O/W multiple nanoemulsion was prepared through two emulsification steps: W1/O primary emulsion using high speed homogenizer, and the secondary emulsion using magnetic stirrer. W1/O was optimized including the selection of co surfactant and extract concentration, followed by secondary emulsion optimization using response surface methodology consisted of 2-level factorial and Box-Behnken design. The W1/O consisted of extract, polysorbate 80 as surfactant, PEG 400 as co surfactant and isopropyl myristate as oil phase. The 2-level factorial gave the three significant factors: W1/O sonication time, W1/O concentration, and secondary emulsification stirring time. Box-Behnken optimization for globule size below 400 nm was obtained by 6-10 minutes W1/O sonication time, 12-16% W1/O concentration, and 32-42 minutes stirring time of secondary emulsification.

Isolasi dan Identifikasi Snyawa Geraniol dari Minyak Atsiri Tanaman Sereh Wangi Cymbopogon nardus (L.) Rendle Yelfi Anwar; Shirly Kumala; Elvina Dhiaul Iftitah; Partomuan Simanjuntak
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Background: Indonesia is a major producer of several essential oils such as citronella oil, clove oil, cananga oil, vetiver oil, sandalwood oil, and patchouli oil. The Cymbopogon (Poaceae) genus has the most important components of essential oils, namely citral, geraniol, citronellol, citronellal. Geraniol is one of the most important chemical compounds in the aroma and fragrance industry and shows the nature of insecticides and natural insect repellents which show low toxicity and is suggested to represent a new class of chemoprevention agents for cancer, antimicrobial, anti-oxidant, anti-inflammatory and some vascular effects Transdermal drugs also attract the attention of researchers and scientists in the field of formulation. Objective: This study aimed to obtain geraniol compounds obtained from Cymbopogon nardus (L.) Rendle and identification. Methodology: The citronella, essential oil was obtained from the Cymbopogon nardus (L) Rendle plant using a water-steam distillation method, then fractionation was carried out and continued by purification isolation by column chromatography. Results: Based on the interpretation of IR data, Core magnetic resonance (proton and carbon RMI) and mass spectra for isolate 5 were determined as geraniol compounds. Conclusion: Geraniol can be obtained from Cymbopogon nardus (L) Rendle plants by water-steam distillation, fractionation and isolation methods.

Pengaruh Metode Ekstraksi Terhadap Kandungan Senyawa Polifenol dan Aktivitas Antioksidan pada Rubus fraxinifolius Yesi Desmiaty; Berna Elya; Fadlina Chany Saputri; Iis Irawatty Dewi; Muhammad Hanafi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Rubus fraxinifolius can be founded in the mountainous regions of West Java. Previous studies have shown that this plant has potent antioxidant activity. The content of polyphenol compounds in this species contributes substantially to antioxidant activity, and the extraction method will affect the content of the compound. In this study an evaluation of the extraction method effect on leaves, young fruits and stems of R. fraxinifolius on the content of polyphenols and their antioxidant activity, have been done. Method: The leaves, fruits, and stems of R. fraxinifolius were extracted by maceration, reflux, and soxhlet using methanol as a solvent. Each extract was determined the total polyphenol content using Folin-Ciocalteu reagent and antioxidant activity test using DPPH reduction method. Result: The highest extract yield was R. fraxinifolius leaf reflux extract (30.20%). The highest total polyphenol content was given by the Soxhlet extract of leaf R. fraxinifolius (48.79 mg GAE / g extract). The highest antioxidant activity was leaf Soxhlet extract of R. fraxinifolius (98.29% at 100 ppm). Conclusion: From this study it was shown that the methanol extract of R. fraxinifolius leaves extracted by Soxhlet gave the highest polyphenol content and antioxidant activity.

Uji Aktivitas Immunomodulator Berbagai Tanaman Famili Piperaceae pada Mencit Galur Balb/C dengan Metode Carbon Clearance Mohammad Roseno; Yayat Sudaryat; Widyastiwi Widyastiwi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Plants of Piperaceae family are widespread in the tropics region and have been widely used as medicinal plants, these includes kemukus (Piper cubeba), kiseureuh (Piper aduncum), and Java chili (Piper retrofractum). The purpose of this study was to evaluate the immunomodulatory activity of ethanol extracts of several plants from the Piperaceae family in Balb/C strain mice with carbon clearance method. The study was conducted by dividing the experimental animals into 12 groups : normal control group, immunosuppressant comparison, immunostimulant comparison, and low, moderate, and high dose of kemukus, kiseureuh, and Java chili, resepctively. Immunomodulatory activity was measured by phagocytosis index, peripheral blood leukocyte levels, and splenic leukocyte levels. The results showed that ethanol kemukus extract (Piper cubeba) acts as an immunosuppressant, increasing the dose increased the immunosuppressant effect. Low doses of ethanol extract of kiseureh (Piper aduncum) also acts as immunosuppressant, whereas at medium and high doses has a tendency to be immunostimulant. Ethanol extract of Java chili (Piper retrofractum) acts as an immunostimulant, with the highest activity achieved at moderate doses. Ethanol extract of kemukus (Piper cubeba), kiseureh (Piper aduncum), and Java chili (Piper retrofractum) affect the number of peripheral blood granulocyte components, neutrophils levels affects the increase in phagocytic effects. Ethanol extract of kemukus (Piper cubeba), kiseureh (Piper aduncum), and Java chili (Piper retrofractum) did not affect the number of splenic blood granulocyte components.

Efek Pemberian Eugenol Isolat Bunga Cengkeh (Syzygium aromaticum) terhadap Histologi Pankreas Tikus Diabetes Sinta wahyu utami; I Made Sudarma; Candra Dwipayana Hamdin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Diabetes mellitus is disease with a high prevalence rate and continuously increase in Indonesia. So some researchers began to glance at natural rescource for prevention and treatment of diabetes mellitus. Clove Flower (Syzygium aromaticum) contains eugenol that can chemically lower blood sugar levels. The aimed of this research is to know the effect of eugenol on pancreas histology of diabetic rats. Clove flowers was extracted used maseration method use n-hexan and eugenol was isolated tested with TLC. Alloxan-induced rats were dosed 125 mg / kg BW IP and then the eugenol was administered in dosage 10 mg / kg BW compared with glibenclamid 1,35 mg /Kg BW orally for 14 days. Observation of pancreatic histology results were made pancreatic preparations using Hematoxilin Eosin (HE) staining. The results showed that alloxan-induced rats had pancreatic cell damage. How ever, after being treated with Glibenclamide and Eugenol showed the improvement of damage organs. Giving the eugenol at a dose of 15 mg / kg BW showed the most significant improvement.

Page 1 of 2 | Total Record : 20

1 2

Filter by Year

2019 2019

Filter By Issues

All Issue Vol 23 No 2 (2025): JIFI Vol. 23 No. 2 (2025): JIFI Vol. 23 No. 1 (2025): JIFI Vol 23 No 1 (2025): JIFI Vol 22 No 2 (2024): JIFI Vol 22 No 1 (2024): JIFI Vol 21 No 2 (2023): JIFI Vol 21 No 1 (2023): JIFI Vol 20 No 2 (2022): JIFI Vol 20 No 1 (2022): JIFI Vol 19 No 2 (2021): JIFI Vol 19 No 1 (2021): JIFI Vol. 18 No. 2 (2020): JIFI Vol 18 No 2 (2020): JIFI Vol 18 No 1 (2020): JIFI Vol 17 No 2 (2019): JIFI Vol 17 No 1 (2019): JIFI Vol 16 No 2 (2018): JIFI Vol 16 No 1 (2018): JIFI Vol 15 No 2 (2017): JIFI Vol 15 No 1 (2017): JIFI Vol 14 No 2 (2016): JIFI Vol 14 No 1 (2016): JIFI Vol 13 No 2 (2015): JIFI Vol 13 No 1 (2015): JIFI Vol 12 No 2 (2014): JIFI Vol 12 No 1 (2014): JIFI Vol 11 No 2 (2013): JIFI Vol 11 No 1 (2013): JIFI Vol 10 No 2 (2012): JIFI Vol 10 No 1 (2012): JIFI Vol 9 No 2 (2011): JIFI Vol 9 No 1 (2011): JIFI Vol 8 No 2 (2010): JIFI Vol 8 No 1 (2010): JIFI Vol 7 No 2 (2009): JIFI Vol 7 No 1 (2009): JIFI Vol 6 No 2 (2008): JIFI Vol 6 No 1 (2008): JIFI Vol 5 No 2 (2007): JIFI Vol 5 No 1 (2007): JIFI Vol 4 No 2 (2006): JIFI Vol 4 No 1 (2006): JIFI Vol 3 No 2 (2005): JIFI Vol 3 No 1 (2005): JIFI Vol 2 No 2 (2004): JIFI Vol 2 No 1 (2004): JIFI Vol 1 No 2 (2003): JIFI Vol 1 No 1 (2003): JIFI More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Syafira Dwi Cahyani

Contact Email
adminjifi@univpancasila.ac.id

Phone
+6287780957284

Journal Mail Official
syafira.ffup@univpancasila.ac.id

Editorial Address
Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

Location
Kota adm. jakarta selatan,

Dki jakarta

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Syafira Dwi Cahyani

Contact Email adminjifi@univpancasila.ac.id

Phone +6287780957284

Journal Mail Official syafira.ffup@univpancasila.ac.id

Editorial Address Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

Location Kota adm. jakarta selatan, Dki jakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Syafira Dwi Cahyani

Contact Email
adminjifi@univpancasila.ac.id

Phone
+6287780957284

Journal Mail Official
syafira.ffup@univpancasila.ac.id

Editorial Address
Editorial Office: Lenteng Agung St, Srengseng Sawah District, Jagakarsa Regency, Jakarta Selatan, Special Region of Jakarta 12640, Indonesia.

Location
Kota adm. jakarta selatan,

Dki jakarta

INDONESIA