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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Studi Hubungan Struktur dan Aktivitas Senyawa Antioksidan dari Kulit Batang Kandis Gajah (Garcinia griffithii T. Anders) ELFITA ELFITA; DACHRIYANUS DACHRIYANUS; SUPRIYATNA SUPRIYATNA; HUSEIN H. BAHTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 1 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Four xanthones and two benzophenones from the stem bark of kandis gajah (Garcinia griffithii) by extraction and chromatographic methods have been isolated. The six compounds were determined as: 1,7-dihydroxyxanthone (1), 1,6,7-trihydroxyxanthone (2), 1,6-dihydroxy-3-methoxy-4,7-di-(3-methylbut-2-enyl)xanthone (3), 1,5-dihydroxy-3,6-di-methoxy-2,7-di-(-3-methylbut-2-enyl)xanthone (4), guttipherone I (5), and isoxanthochymol (6). All of the isolated compounds were submitted to antioxidant activity assay using three methods: (i) free radical scavenging method, (ii) xanthine-xanthine oxidase (XO) method, and (iii) nitroblue tetrazolium xanthine oxidase (NBT/ XO). Guttipherone I (5) and isoxanthochymol (6) have strong antioxidant activity (IC50 ≤10.2 µg/mL), 1,6,7-trihydroxyxanthone (2) and 1,6-dihydroxy-3-methoxy-4,7-di-(3-methylbut-2-enyl)xanthone (3) as active compounds (IC50 ≤ 100 µg/mL), while 1,7-dihydroxyxanthone (1) and 1,5-dihydroxy-3,6-dimethoxy-2,7-di-(3-methylbut-2-enyl)xanthone (4) were inactive (IC50 > 100 µg/mL). Base on the data, antioxidant activity of isolated compounds was inhuenced by dihydroxyl groups at ortho position, number of hydroxyl group, and hydroxyl group at para position to C carbonyl at heterocyclic.
Perkembangan Bioteknologi Masa Kini Sumaryanto Sumaryanto
JURNAL ILMU KEFARMASIAN INDONESIA Vol 1 No 1 (2003): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

The modern products of biotechnology are, vaccine, interferon, interleukin, monoclonal antibody, new rice varieties, antibiotics, biological pesticides such as bacteria Bacillus thuringiensis which are active against specific insect species and their application through transgenic plants. There is a great difference in the products if compared with those of the conventional biotechnology, such as soy sauce, fish sauce, yoghurt, ethanol and tempe. Nowadays HIV/AIDS, pneumonia virus SARS (severe acute respiratory syndrome), genetic disorder, cloning, biological weapon such as anthrax from Bacillus anthraxis, are the kinds of several diseases, discoveries and conditions which look for development and clarification through biotechnology. It was shown in this paper some new biotechnology products, technology scope closely related to biotechnology and also the comparation of national priorities and strategy for developing of biotechnology in developed and developing countries.
Partial Validation of High Performance Liquid Chromatography for Analysis of Isoniazid in Rat Plasma Novi Yantih; Siti Hafilah; Yahdiana Harahap; WAHONO SUMARYONO; Rianto Setiabudy
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1786.506 KB) | DOI: 10.35814/jifi.v16i1.497

Abstract

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Nicotinic acid derivatives such as isoniazid have the strongest anti-tuberculosis properties. For pharmacokinetics studying of isoniazid (INH), a method is needed to determine the levels of INH in plasma. Objective: The aim of this research is to partial validate of high performance liquid chromatography (HPLC) for analysis of INH in rat plasma. Method: For the preliminary study, rat plasma was used. The HPLC system used is a stationary phase C18 with length 250mm and temperature of 30°C, mobile phase hexane sulphonate acid 20mM pH 2.47–methanol (65:35). The analytical parameters in partial validated were linearity, lower limit of quantification (LLOQ), precision, accuracy, and recovery. Results: The results of linearity test of INH showed r value of 0.9996. LLOQ of this method was 0.1258μg/mL. The resulting accuracy and precision value met FDA requirements with a percent recovery ranging from 96.57–107.99%. Conclusion: The HPLC system was a valid method for analysis of INH in rat plasma.
Gambaran Histopatologi Pankreas Tikus Hiperglikemia setelah Mengkonsumsi K-Karagenan dan í-Karagenan Lestahari Rahayu; Rahma Damayanti; Thamrin Wikanta
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 2 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Research on the effect of K-carrageen and i-carrageen feeding on the representation of pancreatic B-cell histopathology of hyperglycemic rat has been carried out. Rats were previously damaged by aloxan monohydrat induction. There were 6 groups of rats, each group containing 5 animals. Group I normal control, group II negative control, group III 1st positive control, group IV 2nd positive control, group V K-carrageen treatment, group VI i-carrageen treatment. Group I, II, IV, V, and VI, were given orally, while group III was given subcutaneously. All the treatments were given during 15 days. All the rats were then killed and pancreatic hystopathology were carried out. The results revealed that aloxan monohydrat induction resulting the rat pancreatic weight reduction in all treatment groups. The ratio of rat body weight to the pancreatic weight was not significant difference in all treatment groups. Insulin injection was unable to increase the size of Langerhans islet and unable to support the recovery process of pancreatic damaged due to aloxan induction. On the other hand, chlorpropamide, K-carrageenan, and i-carrageenan were able to increase the size of Langerhans islet because they can support the recovery process of pancreatic organ damaged due to aloxsan induction. Insulin injection was unable to increase the ratio of Langerhans islet diameter to the amount of B-cells. While, chlorpropamide, K-carrageenan, and i-carrageenan were able to increase the ratio of Langerhans islet diameter to the amount of ß-cells. The macroscopic observation revealed that there was a black spot on the rat intestine receiving carrageen.
Preparasi 125I-Nimotuzumab dan Uji Biodistribusi Pada Mencit Normal WIDYASTUTI WIDYASTUTI; ADANG HARDI GUNAWAN; FITRI RAHMAWATI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Nimotuzumab labeled with gamma emitting radionuclide is a monoclonal antibody used to detect cancer that overexpress EGFR (epidermal growth factor receptor). Preparation, characterization and biodistribution study on normal mice of 125I nimotuzumab has been carried out. Labeling was carried out using iodogen as oxidator, variation in radioactivity of 125I and reaction time, followed by radiochemical purity test, stability test, biodistribution test on mice and clearance test on Wistar rats. Characterisation and radiochemical purity test were carried out using size exclusion HPLC and paper chromatography with 85% methanol as eluents. Stability on storage at 4°C was observed within 4 weeks. Biodistribution and clearance through urine and faeces was observed within 24 hours and 3 days post injection respectively. Optimal radiolabeling of nimotuzumab was obtained using 1 mCi of 125I in 20 minutes reaction time with radiochemical purity of 98,1% ± 1,2%, and upon storage at 4°C within 2 weeks decreased to 95,3% ± 0,9%. SE HPLC showed similar retention time of nimotuzumab before and after radiolabeling. Biodistribution showed high accumulation of radioactivity in kidneys, liver, spleen, and thyroid, among which the kidneys was the highest. Clearance at 24 and 72 hrs post injection showed faecal excretion of 8,8% ± 0,4% and 14,7% ± 1,1% respectively and renal excretion of 52,7% ± 2,9% and 82% ± 0,6%. respectively. From this experiments it can be concluded that nimotuzumab can be highly labeled with 125I with good stability, and excreted from the body mainly through kidneys.
The Role of Fennel Infusion on Estrous Cycle and Follicles Development of White Rats HERA MAHESHWARI; ARYANI SISMIN SATYANINGTIJAS; EVA HARLINA; UMI CAHYANINGSIH; MULYATI EFFENDI; MUHAMMAD ADIB MUSTOFA; YENI KEZIA BEKALANI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

This study aims to describe the estrous cycle and follicles development in female rats given infusion of fennel fruit that known to have phytoestrogen compound. Twenty five of female rats were used in this research and were divided into 5 groups. Group I was negative control group (NC), given 1 mL/100g bw of distilled water, group II was positive control group (PC), given 0.0045 mg/100g bw of ethinyl estradiol, groups III, IV and V were treatment groups (TI, T2 and T3), given fennel infusion at 36.5; 73 and 146 mg/100g bw respectively. All treatments were conducted every morning for 20 days by oral route. Changes of vaginal epithelium were observed through vaginal swabs previously stained with Giemsa stain. Histopathological examination of ovarian swere examined to reveal follicles development. Results showed that fennel fruit infusion extended the duration of estrous and metestrous phases, while shortened the proestrous and diestrous phases. Eventhough the longest estrous phase was found in T3 group, there was no significant effect on the lengthening of estrous cycle. Moreover, infusion of fennel fruit had no effect on the development of ovarian follicles, except tended to increase the number of corpus luteum.
Ekstrak Etanolik Daun Awar-Awar (Ficus septica Burm F.) secara Sinergis Meningkatkan Efektivitas Doxorubicin terhadap Sel Kanker Payudara T47D RATIH HARDIKA PRATAMA; YURISTA GILANG IKHTIARSYAH; ANINDYAJATI ANINDYAJATI; ADTYA FITRIASARI; MUTHI IKAWATI; EDY MEIYANTO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 1 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Awar awar leaves which have not been optimally utilized in cancer treatment, are potential to be used in combination with doxorubicin (DOX), an agent used for chemotherapy. The aim of this experiment is to find out cytotoxic effect of awar-awar leaves ethanolic extract (ALE) and its combination with DOX towards breast cancer cells of T47D. ALE was prepared by macerating the dried-leaves powder with ethanol 70%. The cytotoxic effect of ALE toward breast cancer cells was tested employing MTT assay to the treatments both as a single agent and as a combination with doxorubicin (ALE DOX). The cytotoxicity was determined as IC50 value, while effectiveness of combination was measured by combination index (CI) to determine whether the effect is synergic, addictive, or antagonistic. Cytotoxic tests on single treatment ALE for a period of 24 hours resulted to a cytotoxic effect with IC so value of 13 µg/mL. ALE-DOX combination showed synergistic effect (CI < 1) on the concentration of 4.88 µg/mL (ALE) and 3.75 nM (DOX). The results showed that ALE is potential to be used as doxorubicin co-chemotherapeutic agent in breast cancer therapy.
Peningkatan Efek Sitotoksik Doxorubicin oleh Naringenin pada Sel Kanker Payudara T47D melalui Induksi Apoptosis SENDY JUNEDI; RATNA ASMAH SUSIDARTI; EDY MEIYANTO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 2 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Doxorubicin is one of the standard regiment for breast cancer chemotherapy, but resistance to this agent is often occured and long period usage will induce cardiotoxicity, Therefore, combination therapy (co-chemotherapy) is needed to improve the efficacy of doxorubicin and to reduce its systemic toxicity. Naringenin is one of the most abundant ilavonoids in citrus fruits which showed cytotoxicity in various human cancer cell lines and has mechanisms through pathways except p53. This research is aimed to examine the effect of naringenin in combination with doxorubicin against T47D breast cancer cell which is resistant to doxorubicin due to p53 mutation. The IC50 dan CI (combination index) values were detennined by the MTT assay, The apoptotic stimulation effect of narigenin and doxorubicin was performed by DNA staining using cthidum bromide-acridine orange. Naringenin and doxorubicin exhibited cytotoxic effect with IC50 of 509 µM and 15 nM, respectively. The CI value in all ratios of naringenin-doxorubicin showed synergistic effect (CI 0.20-0.89). Combination ofnaringenin-doxorubicin with concentration smaller than 12,5 µM-0.6 nM in 1:1 ratio exhibited an additive combination effect, The combined treatment increased the apoptotic effect of doxorubicin.These results show that naringenin is potential to be developed as co-chemotherapeutic agent with doxonibicin, although the molecular mechanism is still needed to be explored.
Analysis of SGPT and SGOT on Rats Induced By Isoniazid to Determine Dose and Hepatoprotective Characteristic of Unripe Pineapple Juice (Ananas comosus L. Merr) Lestari Rahayu; Novi Yantih; Yoana Supomo
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (265.565 KB) | DOI: 10.35814/jifi.v16i1.443

Abstract

As a consequence of Isoniazid (INH) consumption in longterm is the damage on the liver cells which is detected in high level of SGPT and SGOT in blood. Unripe pineapple fruits contained higher level of phenolic acid and flavonoids compounds than the ripe pineapple fruits, and as a result the unripe pineapple fruits juice has higher hepatoprotective potency than ripe pineapple fruits juice. The hepatoprotective activity of unripe pineapple fruits juice was determined by measuring the SGPT and SGOT level on rat blood. There were prepared 24 rats, divided into 6 groups, i.e. normal control group, positive control group, negative control group, and 3 test goups that were induced by INH and each was given the unripe pineapple fruits juice at 1 hour before and 1 hour after INH induction, with the dose of 2 mL and 4 mL. Treatment was conducted in 14 days, consecutively. To each of the rat groups, blood was taken out through the eye orbital sinus, i.e. on the first day, on the hour-0 and hour-3, and then the SGPT and SGOT level were measured. Later on, blood were taken out on the day-4, day-7, and day-14. On the rat blood that were taken out, were analyzed descriptively and statistically to determined the optimum dose and the time of the unripe pineapple fruits juice feeding in related with a hepatoprotective potency. Result showed that feeding of the unripe pineapple fruit juice 1 hour after INH induction with the dose of 2 mL during 14 days has the best hepatoprotective activity.
Identifikasi, Uji Antioksidan, dan Uji Toksisitas Senyawa Bioaktif dalam Caulerpa sertularioides (Vahl.) C. Agard. Thamrin Wikanta; Swasono R. Tamat; Magdalena Sinta Maryati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Caulerpa sertularioides (Vahl.) C. Agard. is a green seaweed species in the Caulerpaceae family which has been used for medication. Extraction of bioactive compounds from Caulerpa sertularioides have been carried out and screened based on the antioxidative property against DPPH and on toxicity test by the brine shrimp lethality test (BSLT) method. Phytochemical screening of the methanol extract indicated the presence of a triterpen. The methanol extract was partitioned in sequence with n-hexanewater (1:1) and chloroform-water (1:1). The IC50 value of the water extract was found 327 ug/ml and the LCs value was 115 ug/ml as compared to the ICs of vitamin C positive control of 21 ug/ml. Fractination of the water extract in a silica gel column with various ratio of chloroform-methanol did not produce distinct separation. Fractions were analyzed on TLC and fractions of similar components were collected. Fraction I has IC50 value of 326 ug/ml and LC50 value of 68 ug/ml. Further separation and purification of fraction I on a preparative thin layer chromatographic system using chloroform-methanol (50:1) produced five isolates bearing antioxidative activity. The third isolate that showed the strongest activity, when analyzed using a GC-MS system indicating seven compounds, but only [(2-fluorophenyl)methyl)-1H-purin-6-amine that may have an antioxidative activity.

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